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The map label for this gene is alkK [H]

Identifier: 13475803

GI number: 13475803

Start: 5733471

End: 5735096

Strand: Direct

Name: alkK [H]

Synonym: mlr6974

Alternate gene names: 13475803

Gene position: 5733471-5735096 (Clockwise)

Preceding gene: 13475802

Following gene: 13475804

Centisome position: 81.49

GC content: 62.18

Gene sequence:

>1626_bases
ATGAGACAGCACTACGAAGCCGCCCTGCGCGATGACGCCAACTGTGTGGCCCTGTCTCCACTGTCGTTCCTGAAAAGGGC
CGAGTTGGTCTACGGCGCGCGCTCTGCGGTGACGTATGGCGACGTAAGGCGCACATGGGCACAGACGGGCGCTCGCTGCC
GTTCGGTCGCGGCGGGGCTGGCGGCTTTGGGCGTGGGGCCGGGGGACACGGTTTCGGTGCTGTCGCCAAACATTCCCGAG
CTCTTCGAACTGCACTATGCCGTGCCCTTGCTGGGGGCTGTGTTGAACACCATCAACACCCGCCTGGAGCCGGAAACCGT
CGCCTATATCCTGGCGCATTCGGACTCGACGCTGGTGATTGCCGATACGGCCTTCGCACCCTTGCTGCGAGAAGCCTTTC
GATTGAACGGCAACACGCTCCCGGTTGTCGATGTCGTCGATGCGCAGGCGCAGGCTTCTGCCGAGTTCGGCGAACGCAGC
TATGAGGATCTGGCGGCTCATCCTCCCATGGGGTGGGAACTGCCCAAGGATGAGTGGCAGGCGCTGGCGCTGAACTATAC
TTCCGGCACTTCGGGGCGGCCGAAGGGCGTGATTTATCACCATCGCGGCGCCTATCTGATGGCGATGGGGACGATTGCCG
CATGGGCCTTGCCGCAGCACCCGACTTACCTGTCGGTCGTGCCCATGTTCCACTGCAACGGCTGGACCCATCCCTGGTCG
ATGGCGATCGTCGGAGCCAACATGGTTTTCACCCGCGATGCGTCGCCGGGCAAACTGCTGGAGGCCATGGCGGCGCACCG
CGTCACCCATATGGGAGCTGCGCCAATCGTGCTGCAAATGCTCTGCGACGGCCGCGGTGCTTCCGCGCAACCCTTCAATC
CCCAGATCAGGGTCATGACCGCTGGTGCGCCGCCCCCGCCCGCGGTTCTTGAAAAGGCCGCGCAAATGGGTCTCGATGTG
ATGCAAGTGTACGGTCTGACCGAAACCTACGGTCATATTTCCCAATGTCTTTGGCAGGACGAATGGGAAGCCCTGTCTGT
TTCTGCAAGAGCTGAAAAACAGGCGATGCAGGGCGTCGCCTTTCCGATGGTCGAGGACATCCGCGTTGTCGACCGCGACA
CCGGCACGGATGTACCGCGCGATGGGCTGACACAAGGTGAGATCGCCATTCGCGGCAATACGGTGATGAAGGGATATTAC
AAGGACGCGACCTCCACCGCGGCGGCCTTCGAGTCTGGCTGGTTCTGGTCCGGTGATGCCGCGGTGGTCCATCCTGACGG
GTATATTCAGATCCGGGACCGGCTGAAGGATGTGATCATCTCAGGCGGGGAAAACATCTCGTCCGTCGAGGTCGAGTCCG
TTCTATACCGACACCCTGCGATCAGCGTTGCGGCCGTGGTGGCCCGCCCGCATCCGAAATGGGGCGAGAGCCCATGCGCC
TTTGTCGAACTGCGCGAGGGCGCGAGCGCGACCGAAGCGGAAATCATTGCCTTCTGTCGCGCCAATATCGCGCATTTCAA
AGCGCCGAAAACGGTGGTGTTCGGCCCTTTGCCAAAAACCGCGACAGGCAAGATTCAGAAGTTCATTCTGCGGGCGGCAG
CCCGTGACCTGGGGCCTCAGGCATGA

Upstream 100 bases:

>100_bases
GCGAAACAGTGCAGGTGATGCGCGATCAAGGGGCGGTTTCCGCCAAACTCGTAGAGCTGCCTTTTCTGTAACGCCGGGAC
CTTGGCCATAGGATCAGAGC

Downstream 100 bases:

>100_bases
CTTTTGAAGCACCATTAAAGGACTTGATGTTCAATATCACCCACATCGCGCCATGGTCCGGCGATGCGATGGGTGATCTC
GAGACGGCCGCAGCTGTCCT

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MRQHYEAALRDDANCVALSPLSFLKRAELVYGARSAVTYGDVRRTWAQTGARCRSVAAGLAALGVGPGDTVSVLSPNIPE
LFELHYAVPLLGAVLNTINTRLEPETVAYILAHSDSTLVIADTAFAPLLREAFRLNGNTLPVVDVVDAQAQASAEFGERS
YEDLAAHPPMGWELPKDEWQALALNYTSGTSGRPKGVIYHHRGAYLMAMGTIAAWALPQHPTYLSVVPMFHCNGWTHPWS
MAIVGANMVFTRDASPGKLLEAMAAHRVTHMGAAPIVLQMLCDGRGASAQPFNPQIRVMTAGAPPPPAVLEKAAQMGLDV
MQVYGLTETYGHISQCLWQDEWEALSVSARAEKQAMQGVAFPMVEDIRVVDRDTGTDVPRDGLTQGEIAIRGNTVMKGYY
KDATSTAAAFESGWFWSGDAAVVHPDGYIQIRDRLKDVIISGGENISSVEVESVLYRHPAISVAAVVARPHPKWGESPCA
FVELREGASATEAEIIAFCRANIAHFKAPKTVVFGPLPKTATGKIQKFILRAAARDLGPQA

Sequences:

>Translated_541_residues
MRQHYEAALRDDANCVALSPLSFLKRAELVYGARSAVTYGDVRRTWAQTGARCRSVAAGLAALGVGPGDTVSVLSPNIPE
LFELHYAVPLLGAVLNTINTRLEPETVAYILAHSDSTLVIADTAFAPLLREAFRLNGNTLPVVDVVDAQAQASAEFGERS
YEDLAAHPPMGWELPKDEWQALALNYTSGTSGRPKGVIYHHRGAYLMAMGTIAAWALPQHPTYLSVVPMFHCNGWTHPWS
MAIVGANMVFTRDASPGKLLEAMAAHRVTHMGAAPIVLQMLCDGRGASAQPFNPQIRVMTAGAPPPPAVLEKAAQMGLDV
MQVYGLTETYGHISQCLWQDEWEALSVSARAEKQAMQGVAFPMVEDIRVVDRDTGTDVPRDGLTQGEIAIRGNTVMKGYY
KDATSTAAAFESGWFWSGDAAVVHPDGYIQIRDRLKDVIISGGENISSVEVESVLYRHPAISVAAVVARPHPKWGESPCA
FVELREGASATEAEIIAFCRANIAHFKAPKTVVFGPLPKTATGKIQKFILRAAARDLGPQA
>Mature_541_residues
MRQHYEAALRDDANCVALSPLSFLKRAELVYGARSAVTYGDVRRTWAQTGARCRSVAAGLAALGVGPGDTVSVLSPNIPE
LFELHYAVPLLGAVLNTINTRLEPETVAYILAHSDSTLVIADTAFAPLLREAFRLNGNTLPVVDVVDAQAQASAEFGERS
YEDLAAHPPMGWELPKDEWQALALNYTSGTSGRPKGVIYHHRGAYLMAMGTIAAWALPQHPTYLSVVPMFHCNGWTHPWS
MAIVGANMVFTRDASPGKLLEAMAAHRVTHMGAAPIVLQMLCDGRGASAQPFNPQIRVMTAGAPPPPAVLEKAAQMGLDV
MQVYGLTETYGHISQCLWQDEWEALSVSARAEKQAMQGVAFPMVEDIRVVDRDTGTDVPRDGLTQGEIAIRGNTVMKGYY
KDATSTAAAFESGWFWSGDAAVVHPDGYIQIRDRLKDVIISGGENISSVEVESVLYRHPAISVAAVVARPHPKWGESPCA
FVELREGASATEAEIIAFCRANIAHFKAPKTVVFGPLPKTATGKIQKFILRAAARDLGPQA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=536, Percent_Identity=27.4253731343284, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI187761345, Length=554, Percent_Identity=27.4368231046931, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI187761343, Length=554, Percent_Identity=27.4368231046931, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI42544132, Length=510, Percent_Identity=26.8627450980392, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI38505220, Length=519, Percent_Identity=26.5895953757225, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI122937307, Length=520, Percent_Identity=25.9615384615385, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI58082049, Length=509, Percent_Identity=26.1296660117878, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI157311624, Length=492, Percent_Identity=26.219512195122, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI157311622, Length=492, Percent_Identity=26.219512195122, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI115511026, Length=519, Percent_Identity=23.8921001926782, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI28416953, Length=555, Percent_Identity=22.1621621621622, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI8923896, Length=152, Percent_Identity=34.8684210526316, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI253970489, Length=152, Percent_Identity=34.8684210526316, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI42544134, Length=297, Percent_Identity=26.2626262626263, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI145693145, Length=357, Percent_Identity=35.2941176470588, Blast_Score=165, Evalue=9e-42,
Organism=Escherichia coli, GI221142682, Length=517, Percent_Identity=27.6595744680851, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1786810, Length=523, Percent_Identity=26.5774378585086, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1788107, Length=533, Percent_Identity=25.891181988743, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1790505, Length=584, Percent_Identity=25.513698630137, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788595, Length=504, Percent_Identity=23.015873015873, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994703, Length=546, Percent_Identity=28.021978021978, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71994690, Length=546, Percent_Identity=28.021978021978, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994694, Length=546, Percent_Identity=28.021978021978, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17560308, Length=540, Percent_Identity=27.2222222222222, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17558820, Length=368, Percent_Identity=27.7173913043478, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32563687, Length=508, Percent_Identity=24.6062992125984, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17538037, Length=532, Percent_Identity=25.187969924812, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17557194, Length=538, Percent_Identity=25.2788104089219, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17559526, Length=510, Percent_Identity=24.7058823529412, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560140, Length=507, Percent_Identity=22.879684418146, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71982997, Length=550, Percent_Identity=25.8181818181818, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71983001, Length=550, Percent_Identity=25.8181818181818, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=577, Percent_Identity=24.0901213171577, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71996755, Length=534, Percent_Identity=22.6591760299625, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319699, Length=354, Percent_Identity=27.1186440677966, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6323182, Length=585, Percent_Identity=24.7863247863248, Blast_Score=109, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6319264, Length=581, Percent_Identity=23.407917383821, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581924, Length=548, Percent_Identity=27.7372262773723, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI18859661, Length=519, Percent_Identity=27.7456647398844, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21355181, Length=372, Percent_Identity=28.2258064516129, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24667955, Length=540, Percent_Identity=24.4444444444444, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI62472339, Length=540, Percent_Identity=24.4444444444444, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667959, Length=406, Percent_Identity=24.384236453202, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24648257, Length=483, Percent_Identity=23.1884057971014, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 58391; Mature: 58391

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQHYEAALRDDANCVALSPLSFLKRAELVYGARSAVTYGDVRRTWAQTGARCRSVAAGL
CCCHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHH
AALGVGPGDTVSVLSPNIPELFELHYAVPLLGAVLNTINTRLEPETVAYILAHSDSTLVI
HHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEE
ADTAFAPLLREAFRLNGNTLPVVDVVDAQAQASAEFGERSYEDLAAHPPMGWELPKDEWQ
ECHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHCE
ALALNYTSGTSGRPKGVIYHHRGAYLMAMGTIAAWALPQHPTYLSVVPMFHCNGWTHPWS
EEEEEECCCCCCCCCCEEEEECCCEEEEHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCE
MAIVGANMVFTRDASPGKLLEAMAAHRVTHMGAAPIVLQMLCDGRGASAQPFNPQIRVMT
EEEEECEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEEE
AGAPPPPAVLEKAAQMGLDVMQVYGLTETYGHISQCLWQDEWEALSVSARAEKQAMQGVA
CCCCCCHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHCCCC
FPMVEDIRVVDRDTGTDVPRDGLTQGEIAIRGNTVMKGYYKDATSTAAAFESGWFWSGDA
CCHHHHHEEEECCCCCCCCCCCCCCCEEEEECCEEEEEECCCCHHHHHHHCCCCEECCCE
AVVHPDGYIQIRDRLKDVIISGGENISSVEVESVLYRHPAISVAAVVARPHPKWGESPCA
EEECCCCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHEEEEEECCCCCCCCCCEE
FVELREGASATEAEIIAFCRANIAHFKAPKTVVFGPLPKTATGKIQKFILRAAARDLGPQ
EEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
A
C
>Mature Secondary Structure
MRQHYEAALRDDANCVALSPLSFLKRAELVYGARSAVTYGDVRRTWAQTGARCRSVAAGL
CCCHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHH
AALGVGPGDTVSVLSPNIPELFELHYAVPLLGAVLNTINTRLEPETVAYILAHSDSTLVI
HHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEE
ADTAFAPLLREAFRLNGNTLPVVDVVDAQAQASAEFGERSYEDLAAHPPMGWELPKDEWQ
ECHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHCE
ALALNYTSGTSGRPKGVIYHHRGAYLMAMGTIAAWALPQHPTYLSVVPMFHCNGWTHPWS
EEEEEECCCCCCCCCCEEEEECCCEEEEHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCE
MAIVGANMVFTRDASPGKLLEAMAAHRVTHMGAAPIVLQMLCDGRGASAQPFNPQIRVMT
EEEEECEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEEE
AGAPPPPAVLEKAAQMGLDVMQVYGLTETYGHISQCLWQDEWEALSVSARAEKQAMQGVA
CCCCCCHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHCCCC
FPMVEDIRVVDRDTGTDVPRDGLTQGEIAIRGNTVMKGYYKDATSTAAAFESGWFWSGDA
CCHHHHHEEEECCCCCCCCCCCCCCCEEEEECCEEEEEECCCCHHHHHHHCCCCEECCCE
AVVHPDGYIQIRDRLKDVIISGGENISSVEVESVLYRHPAISVAAVVARPHPKWGESPCA
EEECCCCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHEEEEEECCCCCCCCCCEE
FVELREGASATEAEIIAFCRANIAHFKAPKTVVFGPLPKTATGKIQKFILRAAARDLGPQ
EEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]