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The map label for this gene is trxC [H]

Identifier: 13475502

GI number: 13475502

Start: 5396090

End: 5396539

Strand: Reverse

Name: trxC [H]

Synonym: mll6589

Alternate gene names: 13475502

Gene position: 5396539-5396090 (Counterclockwise)

Preceding gene: 13475503

Following gene: 13475501

Centisome position: 76.7

GC content: 63.11

Gene sequence:

>450_bases
ATGGCACAGGACAATCTGGTGGTTTGCGACAAATGCGGCGGGGTCAATCGCCTGCCGCCGGCCCGCAATGCCGACGAGGC
CAAGTGCGGAAAGTGCGGGAACAGGCTGTTTTCAGGTCACCCGCTGGACGTCGACGCCAAGGCGTTCGACCACCAGATTG
CGCGCAGCAGTATTGCCGTTGTCGTCGACATCTGGGCACCGTGGTGTGGCCCGTGCAAGATGATGGCTCCGGCCTACGAA
GCCGCAGCGCGCGAACTGGAGCCACATGTTCGCCTGCTCAAGCTCAATTCCGACAATGAGCAGGCTGTTGCGGCAAGGCT
CGGCATTCGCGGGATCCCGACGATGATCCTCTTCCATGGCGGACGTGAAATCGCGCGCACATCAGGCGCAATGACGGCAG
GCCAGATCGTCAGGTGGGTTCGCGATCGCCTGCCGACGGTCGCCGCCTGA

Upstream 100 bases:

>100_bases
GGAAGGGATCGACGTCGCGGTCATCCTGAACGCACTGCGCGCCCTTGGCGACGGACATCTCGGGCGCACATAGTGGACAA
CAACGGATCGGTGAACGGCC

Downstream 100 bases:

>100_bases
ACGTCGCCGCGCCAATGGATCCGCTCATCGCCCGGCTCGGACTTGCCCTCGCAATAGGTCTGCTTGTCGGTCTGGAGCGT
GGCTGGCAGGAGCGAGATGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MAQDNLVVCDKCGGVNRLPPARNADEAKCGKCGNRLFSGHPLDVDAKAFDHQIARSSIAVVVDIWAPWCGPCKMMAPAYE
AAARELEPHVRLLKLNSDNEQAVAARLGIRGIPTMILFHGGREIARTSGAMTAGQIVRWVRDRLPTVAA

Sequences:

>Translated_149_residues
MAQDNLVVCDKCGGVNRLPPARNADEAKCGKCGNRLFSGHPLDVDAKAFDHQIARSSIAVVVDIWAPWCGPCKMMAPAYE
AAARELEPHVRLLKLNSDNEQAVAARLGIRGIPTMILFHGGREIARTSGAMTAGQIVRWVRDRLPTVAA
>Mature_148_residues
AQDNLVVCDKCGGVNRLPPARNADEAKCGKCGNRLFSGHPLDVDAKAFDHQIARSSIAVVVDIWAPWCGPCKMMAPAYEA
AARELEPHVRLLKLNSDNEQAVAARLGIRGIPTMILFHGGREIARTSGAMTAGQIVRWVRDRLPTVAA

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=33, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI21361657, Length=104, Percent_Identity=33.6538461538462, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788936, Length=138, Percent_Identity=37.6811594202899, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI87082331, Length=97, Percent_Identity=40.2061855670103, Blast_Score=89, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17554386, Length=92, Percent_Identity=40.2173913043478, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=104, Percent_Identity=32.6923076923077, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17507915, Length=96, Percent_Identity=38.5416666666667, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=98, Percent_Identity=34.6938775510204, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=98, Percent_Identity=34.6938775510204, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=85, Percent_Identity=41.1764705882353, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=38.8235294117647, Blast_Score=71, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19921434, Length=106, Percent_Identity=34.9056603773585, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647799, Length=87, Percent_Identity=36.7816091954023, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573567, Length=105, Percent_Identity=30.4761904761905, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 16114; Mature: 15983

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQDNLVVCDKCGGVNRLPPARNADEAKCGKCGNRLFSGHPLDVDAKAFDHQIARSSIAV
CCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCEEE
VVDIWAPWCGPCKMMAPAYEAAARELEPHVRLLKLNSDNEQAVAARLGIRGIPTMILFHG
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEEC
GREIARTSGAMTAGQIVRWVRDRLPTVAA
CHHHHHHCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AQDNLVVCDKCGGVNRLPPARNADEAKCGKCGNRLFSGHPLDVDAKAFDHQIARSSIAV
CCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCEEE
VVDIWAPWCGPCKMMAPAYEAAARELEPHVRLLKLNSDNEQAVAARLGIRGIPTMILFHG
EEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEEEC
GREIARTSGAMTAGQIVRWVRDRLPTVAA
CHHHHHHCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]