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The map label for this gene is 13475489

Identifier: 13475489

GI number: 13475489

Start: 5382496

End: 5384103

Strand: Direct

Name: 13475489

Synonym: mlr6574

Alternate gene names: NA

Gene position: 5382496-5384103 (Clockwise)

Preceding gene: 13475488

Following gene: 13475490

Centisome position: 76.5

GC content: 62.13

Gene sequence:

>1608_bases
ATGAAAGGCGACACTGATCCTGTTCTGCGTTTCCACGGCGCAGCCCATGGCGTTACCGGCTCATGCCATGAGATCGAGAC
GCCGCATTCGCGCATTCTTATCGACTGCGGCCTGTTCCAGGGATCAAAGTCGGAACGGGAACTGAATTATGGCCAATTTC
CGTTCCCGTCGGAGGCGATTGACGCTGTCATCCTGACGCATGCGCATATCGACCACAGCGGGCTGTTGGCGAAGCTGGTC
AAGCAGGGCTTTTCCGGCCCCATCCATACGACCCGCGCCACCATCGATCTCTGCTCGGTGATGCTGCCCGACGCGGCGCA
TGTCCAGGAAATGGAAGTGGAGCAACTGAACCGCCGCAACGCACAGCGCGGCCGGCCGCCTGTCGAGCCGATCTACAGTC
TTTCAGACGCGGCGGCCTGCATGACCTTGTTCCGGGCCGTGGAATACGGCGAATGGACAACCGTCGCCAAAGGCCTTCGA
ACCCGCTTCTGGAACGCCGGTCACCTGCTCGGCTCCGCCTCAGTCGAACTCGAGATCGATCTGGATCATCAGAAGAGACC
GATGCGCATTCTGTTTTCAGGCGATATAGGGCCTGGACACAAGTTGCTGCAGACCGACCCGGAAGGTCCGGCCGGGGTCG
ACTACCTCATCTGCGAATCGACCTATGGCGACCGCGAGCGGCCAGACGTCTCGCCCGAACAGCGGCGATCCCAGCTCGGC
GACATTGTGCGTCGCGCCGCCGAGGCCGGCGGCCCCCTCATCATTCCGTCCTTCGCAGTCGAAAGGACGCAAGAACTGCT
GGTCGACCTGTATTTGCTCATGCAAGCGGGGGAGGTGCTGACAGCTCCGGTCTTCGTTGACTCGCCACTGGCGACGCGGG
CCAGCGCTATTTTCGAGCGGCATGCCAACGACATCGAACAGGGAGACGTGCTGCGCCAGGCCCTCAACTCACGGGAGCTA
CGCTTCACCGAGACGGTTGAGCAAAGCAAGGCGATCAATCGCCTGAGCGGCTTCTTCGTGGTGATCGCCGCCAGCGGGAT
GTGCGACGCGGGCCGGATCCGCCATCACCTCAAGGCCAATCTCTGGCGCCGGAACGCCACGGTCATGATGGCCGGATATC
AGGCCCAGGGCTCTCTCGGCAGGATCCTGCTCGACGGCGCGCAGCGCGTGCGCATCCAGGGCGAAGAGGTTGAGGTCAAG
GCACGTATCAGCCTGTTCGACCTCTATTCTGGGCATGCAGACGCGGGCGAACTGGTCGCATGGGTCAAGGCCCGAACTCC
GGTGAAGCAGCAGGTGTTCCTGACGCATGGAGAGGAGGCTGGACTCAGCGGCCTGCGTGGAAGGCTTGCAGGACTGATAC
CCGACGACAAGGTCATCATCCCGAGGCTAGACGATGCTTTCCAATTGACCCCCGGTCGTTGTTTGCCGGTCGAGGTCAAC
GAGCCCCGCCGTCTGAGGCCGGAAAAGATCGCCCGCCTCGACTGGCACAACGACCTTTCAAGACTTCTCATGGACGTAAA
CGAGGCGGTCAGCGCCGCAGCCGATGAACGAGGTCGCGCAGCGGTGATCAGGCGCATGCGCAGGGCACTTGAGGACAAGG
ATGCATAG

Upstream 100 bases:

>100_bases
TGGCCATTCCCGCGTCAGGGACTTCGTTCTTGGCGGTGCCACGGAAGACATTCTCACGGATCTGCGCCTGCCCGTCCTCC
TGTCTCACTAGGTCGTCGAG

Downstream 100 bases:

>100_bases
AGGCCGCGAAGCGATGAACTGAAAGCGCGCGAGCGCGTTGGTGTCCATTCGCTGCAGATCGACGAACACAAGCCCATGCC
GCAATCCAGGCGACAGGGCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MKGDTDPVLRFHGAAHGVTGSCHEIETPHSRILIDCGLFQGSKSERELNYGQFPFPSEAIDAVILTHAHIDHSGLLAKLV
KQGFSGPIHTTRATIDLCSVMLPDAAHVQEMEVEQLNRRNAQRGRPPVEPIYSLSDAAACMTLFRAVEYGEWTTVAKGLR
TRFWNAGHLLGSASVELEIDLDHQKRPMRILFSGDIGPGHKLLQTDPEGPAGVDYLICESTYGDRERPDVSPEQRRSQLG
DIVRRAAEAGGPLIIPSFAVERTQELLVDLYLLMQAGEVLTAPVFVDSPLATRASAIFERHANDIEQGDVLRQALNSREL
RFTETVEQSKAINRLSGFFVVIAASGMCDAGRIRHHLKANLWRRNATVMMAGYQAQGSLGRILLDGAQRVRIQGEEVEVK
ARISLFDLYSGHADAGELVAWVKARTPVKQQVFLTHGEEAGLSGLRGRLAGLIPDDKVIIPRLDDAFQLTPGRCLPVEVN
EPRRLRPEKIARLDWHNDLSRLLMDVNEAVSAAADERGRAAVIRRMRRALEDKDA

Sequences:

>Translated_535_residues
MKGDTDPVLRFHGAAHGVTGSCHEIETPHSRILIDCGLFQGSKSERELNYGQFPFPSEAIDAVILTHAHIDHSGLLAKLV
KQGFSGPIHTTRATIDLCSVMLPDAAHVQEMEVEQLNRRNAQRGRPPVEPIYSLSDAAACMTLFRAVEYGEWTTVAKGLR
TRFWNAGHLLGSASVELEIDLDHQKRPMRILFSGDIGPGHKLLQTDPEGPAGVDYLICESTYGDRERPDVSPEQRRSQLG
DIVRRAAEAGGPLIIPSFAVERTQELLVDLYLLMQAGEVLTAPVFVDSPLATRASAIFERHANDIEQGDVLRQALNSREL
RFTETVEQSKAINRLSGFFVVIAASGMCDAGRIRHHLKANLWRRNATVMMAGYQAQGSLGRILLDGAQRVRIQGEEVEVK
ARISLFDLYSGHADAGELVAWVKARTPVKQQVFLTHGEEAGLSGLRGRLAGLIPDDKVIIPRLDDAFQLTPGRCLPVEVN
EPRRLRPEKIARLDWHNDLSRLLMDVNEAVSAAADERGRAAVIRRMRRALEDKDA
>Mature_535_residues
MKGDTDPVLRFHGAAHGVTGSCHEIETPHSRILIDCGLFQGSKSERELNYGQFPFPSEAIDAVILTHAHIDHSGLLAKLV
KQGFSGPIHTTRATIDLCSVMLPDAAHVQEMEVEQLNRRNAQRGRPPVEPIYSLSDAAACMTLFRAVEYGEWTTVAKGLR
TRFWNAGHLLGSASVELEIDLDHQKRPMRILFSGDIGPGHKLLQTDPEGPAGVDYLICESTYGDRERPDVSPEQRRSQLG
DIVRRAAEAGGPLIIPSFAVERTQELLVDLYLLMQAGEVLTAPVFVDSPLATRASAIFERHANDIEQGDVLRQALNSREL
RFTETVEQSKAINRLSGFFVVIAASGMCDAGRIRHHLKANLWRRNATVMMAGYQAQGSLGRILLDGAQRVRIQGEEVEVK
ARISLFDLYSGHADAGELVAWVKARTPVKQQVFLTHGEEAGLSGLRGRLAGLIPDDKVIIPRLDDAFQLTPGRCLPVEVN
EPRRLRPEKIARLDWHNDLSRLLMDVNEAVSAAADERGRAAVIRRMRRALEDKDA

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=448, Percent_Identity=25.8928571428571, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI33300633, Length=453, Percent_Identity=25.60706401766, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32566029, Length=531, Percent_Identity=25.8003766478343, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI32564696, Length=451, Percent_Identity=25.7206208425721, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323307, Length=457, Percent_Identity=23.8512035010941, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI21358523, Length=454, Percent_Identity=26.6519823788546, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24648013, Length=440, Percent_Identity=26.1363636363636, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 59167; Mature: 59167

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGDTDPVLRFHGAAHGVTGSCHEIETPHSRILIDCGLFQGSKSERELNYGQFPFPSEAI
CCCCCCCHHEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHH
DAVILTHAHIDHSGLLAKLVKQGFSGPIHTTRATIDLCSVMLPDAAHVQEMEVEQLNRRN
HEEHEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AQRGRPPVEPIYSLSDAAACMTLFRAVEYGEWTTVAKGLRTRFWNAGHLLGSASVELEID
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEECCCEEEEEEE
LDHQKRPMRILFSGDIGPGHKLLQTDPEGPAGVDYLICESTYGDRERPDVSPEQRRSQLG
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHH
DIVRRAAEAGGPLIIPSFAVERTQELLVDLYLLMQAGEVLTAPVFVDSPLATRASAIFER
HHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCEECCEEECCCHHHHHHHHHHH
HANDIEQGDVLRQALNSRELRFTETVEQSKAINRLSGFFVVIAASGMCDAGRIRHHLKAN
HCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHH
LWRRNATVMMAGYQAQGSLGRILLDGAQRVRIQGEEVEVKARISLFDLYSGHADAGELVA
HHHCCCEEEEEEECCCCCCCCEEECCCCEEEECCCEEEEEEEEEEEEECCCCCCHHHHHH
WVKARTPVKQQVFLTHGEEAGLSGLRGRLAGLIPDDKVIIPRLDDAFQLTPGRCLPVEVN
HHHHCCCCHHEEEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCEEEEECC
EPRRLRPEKIARLDWHNDLSRLLMDVNEAVSAAADERGRAAVIRRMRRALEDKDA
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKGDTDPVLRFHGAAHGVTGSCHEIETPHSRILIDCGLFQGSKSERELNYGQFPFPSEAI
CCCCCCCHHEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHH
DAVILTHAHIDHSGLLAKLVKQGFSGPIHTTRATIDLCSVMLPDAAHVQEMEVEQLNRRN
HEEHEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AQRGRPPVEPIYSLSDAAACMTLFRAVEYGEWTTVAKGLRTRFWNAGHLLGSASVELEID
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEECCCEEEEEEE
LDHQKRPMRILFSGDIGPGHKLLQTDPEGPAGVDYLICESTYGDRERPDVSPEQRRSQLG
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHH
DIVRRAAEAGGPLIIPSFAVERTQELLVDLYLLMQAGEVLTAPVFVDSPLATRASAIFER
HHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCEECCEEECCCHHHHHHHHHHH
HANDIEQGDVLRQALNSRELRFTETVEQSKAINRLSGFFVVIAASGMCDAGRIRHHLKAN
HCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHH
LWRRNATVMMAGYQAQGSLGRILLDGAQRVRIQGEEVEVKARISLFDLYSGHADAGELVA
HHHCCCEEEEEEECCCCCCCCEEECCCCEEEECCCEEEEEEEEEEEEECCCCCCHHHHHH
WVKARTPVKQQVFLTHGEEAGLSGLRGRLAGLIPDDKVIIPRLDDAFQLTPGRCLPVEVN
HHHHCCCCHHEEEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCEEEEECC
EPRRLRPEKIARLDWHNDLSRLLMDVNEAVSAAADERGRAAVIRRMRRALEDKDA
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA