Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 13475342

GI number: 13475342

Start: 5209353

End: 5211176

Strand: Direct

Name: glmS [H]

Synonym: mlr6386

Alternate gene names: 13475342

Gene position: 5209353-5211176 (Clockwise)

Preceding gene: 13475341

Following gene: 13475343

Centisome position: 74.04

GC content: 60.2

Gene sequence:

>1824_bases
ATGTGCGGAATTGTTGGCATCGTTGGGCAACAGCCGGTGTCGGAACGCCTGGTCGACGCATTGAAGCGTCTGGAATACCG
CGGCTATGATTCGGCCGGCATTGCGACGATCACCGATGGCACCTTGCACCGCCGGCGCGCGGAGGGCAAGCTCGTCAATC
TCGAGAGGAGACTCAAGGAAGAGCCGCTGGGTGGTACCATCGGCATCGCCCACACCCGCTGGGCAACCCATGGGCCACCG
ACGGAACGCAATGCACACCCGCACTTCACGGATGGTGTGGCCGTCGTCCATAACGGCATCATCGAGAATTTCGCCGAACT
GAAGGACGAATTGGCGGCGACGGGAGCCGAGTTCCAGACCGACACCGACACTGAGGTCCTTGCGCATCTCTTGGCAAGGC
ACCGCCGGGAGGGCATGAGGCGTGGTGAGGCGGTGCATGCCATGCTGAAAAGCGTCAGGGGTGCCTACGCGCTTGCCATC
CTCTTTGAGGATGATCCGTCGACCATCATCGCGGCGCGCAATGGACCACCGCTGGCGATCGGTCACGGCGACGGCGAGAT
GTTCCTGGGCTCCGACGCGATCGCGCTTGCTCCATTCACGAATGAAATCACCTATCTCATCGACGGTGACTGGGCCGTTG
TCGGCAGGACGGGCGCTGATATATTTGATTACGACGGCCACCCCGTCGCGCGTCCGCGCCAGACCTCCGTGGCCGTGGCC
ACTCTGGCCAACAAGGGCAGCCATCGCCACTTCATGGAGAAGGAAATCCTCGAGCAGCCCGAGGTCATCGCCGATGCGCT
CGGTCATTATATCAATTTCATCGAAAATGGTGCCGATGCGGTTTCTGGCATCGACTTCGCCAAGATCCCGAGCTTGGCGA
TCTCTGCCTGCGGCACCGCATATCTCGCCGGGCTGATCGGAAAATACTGGTTCGAGCGCTATGCGCGCCTGCCGGTCGAA
ATAGATGTTGCATCCGAATTCCGCTATCGCGAGATTCCATTGTCGCCGCAGTCTGCGGCTCTGTTCATTTCACAGTCGGG
CGAAACCGCCGATACGCTGGCATCGCTGAGGTACTGCAAGCAGCTTGGGCTGAAAATTGGCGCTGTCGTCAATGCGCGCG
AATCGACCATCGCTCGGGAGGCCGATGTGGTCTTCCCGATCCTTGCCGGCCCAGAGATCGGCGTCGCCTCCACCAAGGCC
TTCACCTGCCAGCTAGCCGCTCTTGCCGCACTCGCCATCCACGCAGCCAAGGCCCGCGGAACCGTGACCGAAGATGAGGT
GCAGGCGCTCGTCGAGAGCCTCGCCGAAATGCCGCGCCTCATGAGGCAGGTACTGGACAGCATCCAGCCGGAGATTGAGC
TTCTGTCGCGCGAACTGTCAAAGTGTCATCATGTCCTTTATCTCGGCCGTGGCACAAATTTCCCGCTGGCGATGGAGGGG
GCGCTGAAGCTCAAGGAGATTTCCTACATCCACGCCGAAGGCTATGCGGCGGGTGAATTGAAGCACGGTCCTATCGCATT
GATAGACGAGAACATGCCAGTGATCGTCATCGCGCCACATGATCGCTTTTTCGACAAGACCCTCTCCAACATGCAGGAAG
TGGCCGCCCGCGGAGGGCGCATTATCCTCATCACCGATGGAAAAGGGGCAGCCGCATCGAAACTCGATACGATGCACACG
ATCGTGCTGCCGGCCACCGACGAGATTATCGCGCCGATGATCTTCTCGCTGCCGATACAGCTTCTTGCGTACCACACGGC
GCTCTTCATGGGCACAGATCTCGACCAGCCACGCAACCTGGCAAAATCAGTCACCGTCGAATGA

Upstream 100 bases:

>100_bases
AACTGACTGGATTCCATTAGAAGACTCTAACTGAGCGCATGCCGGGCGGCGTCCCTCGTCTGCGTCGGCTAAGGCTGCCG
GGAAGACTTCGGAGAAGAAC

Downstream 100 bases:

>100_bases
TGTGACGCCTTCATTAGTCGCAACGCTCGCCCATTCGGAAAAAACTCCAAGCACTTCAACCGGGGCTCAAGCGCGCCGCT
ACCGCCTTGCCGTTATTTGC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIVGIVGQQPVSERLVDALKRLEYRGYDSAGIATITDGTLHRRRAEGKLVNLERRLKEEPLGGTIGIAHTRWATHGPP
TERNAHPHFTDGVAVVHNGIIENFAELKDELAATGAEFQTDTDTEVLAHLLARHRREGMRRGEAVHAMLKSVRGAYALAI
LFEDDPSTIIAARNGPPLAIGHGDGEMFLGSDAIALAPFTNEITYLIDGDWAVVGRTGADIFDYDGHPVARPRQTSVAVA
TLANKGSHRHFMEKEILEQPEVIADALGHYINFIENGADAVSGIDFAKIPSLAISACGTAYLAGLIGKYWFERYARLPVE
IDVASEFRYREIPLSPQSAALFISQSGETADTLASLRYCKQLGLKIGAVVNARESTIAREADVVFPILAGPEIGVASTKA
FTCQLAALAALAIHAAKARGTVTEDEVQALVESLAEMPRLMRQVLDSIQPEIELLSRELSKCHHVLYLGRGTNFPLAMEG
ALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFDKTLSNMQEVAARGGRIILITDGKGAAASKLDTMHT
IVLPATDEIIAPMIFSLPIQLLAYHTALFMGTDLDQPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIVGIVGQQPVSERLVDALKRLEYRGYDSAGIATITDGTLHRRRAEGKLVNLERRLKEEPLGGTIGIAHTRWATHGPP
TERNAHPHFTDGVAVVHNGIIENFAELKDELAATGAEFQTDTDTEVLAHLLARHRREGMRRGEAVHAMLKSVRGAYALAI
LFEDDPSTIIAARNGPPLAIGHGDGEMFLGSDAIALAPFTNEITYLIDGDWAVVGRTGADIFDYDGHPVARPRQTSVAVA
TLANKGSHRHFMEKEILEQPEVIADALGHYINFIENGADAVSGIDFAKIPSLAISACGTAYLAGLIGKYWFERYARLPVE
IDVASEFRYREIPLSPQSAALFISQSGETADTLASLRYCKQLGLKIGAVVNARESTIAREADVVFPILAGPEIGVASTKA
FTCQLAALAALAIHAAKARGTVTEDEVQALVESLAEMPRLMRQVLDSIQPEIELLSRELSKCHHVLYLGRGTNFPLAMEG
ALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFDKTLSNMQEVAARGGRIILITDGKGAAASKLDTMHT
IVLPATDEIIAPMIFSLPIQLLAYHTALFMGTDLDQPRNLAKSVTVE
>Mature_607_residues
MCGIVGIVGQQPVSERLVDALKRLEYRGYDSAGIATITDGTLHRRRAEGKLVNLERRLKEEPLGGTIGIAHTRWATHGPP
TERNAHPHFTDGVAVVHNGIIENFAELKDELAATGAEFQTDTDTEVLAHLLARHRREGMRRGEAVHAMLKSVRGAYALAI
LFEDDPSTIIAARNGPPLAIGHGDGEMFLGSDAIALAPFTNEITYLIDGDWAVVGRTGADIFDYDGHPVARPRQTSVAVA
TLANKGSHRHFMEKEILEQPEVIADALGHYINFIENGADAVSGIDFAKIPSLAISACGTAYLAGLIGKYWFERYARLPVE
IDVASEFRYREIPLSPQSAALFISQSGETADTLASLRYCKQLGLKIGAVVNARESTIAREADVVFPILAGPEIGVASTKA
FTCQLAALAALAIHAAKARGTVTEDEVQALVESLAEMPRLMRQVLDSIQPEIELLSRELSKCHHVLYLGRGTNFPLAMEG
ALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFDKTLSNMQEVAARGGRIILITDGKGAAASKLDTMHT
IVLPATDEIIAPMIFSLPIQLLAYHTALFMGTDLDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=693, Percent_Identity=36.2193362193362, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI205277386, Length=694, Percent_Identity=35.5907780979827, Blast_Score=370, Evalue=1e-102,
Organism=Escherichia coli, GI1790167, Length=614, Percent_Identity=48.2084690553746, Blast_Score=549, Evalue=1e-157,
Organism=Escherichia coli, GI1788651, Length=214, Percent_Identity=32.2429906542056, Blast_Score=90, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17539970, Length=722, Percent_Identity=32.6869806094183, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17532899, Length=719, Percent_Identity=33.1015299026426, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17532897, Length=512, Percent_Identity=34.5703125, Blast_Score=280, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6322745, Length=443, Percent_Identity=38.8261851015801, Blast_Score=269, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323731, Length=437, Percent_Identity=29.0617848970252, Blast_Score=176, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=35.7487922705314, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323958, Length=177, Percent_Identity=31.0734463276836, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=36.2844702467344, Blast_Score=388, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65741; Mature: 65741

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGIVGQQPVSERLVDALKRLEYRGYDSAGIATITDGTLHRRRAEGKLVNLERRLKE
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHCCCEECHHHHHHC
EPLGGTIGIAHTRWATHGPPTERNAHPHFTDGVAVVHNGIIENFAELKDELAATGAEFQT
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DTDTEVLAHLLARHRREGMRRGEAVHAMLKSVRGAYALAILFEDDPSTIIAARNGPPLAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEEEECCCCCEEE
GHGDGEMFLGSDAIALAPFTNEITYLIDGDWAVVGRTGADIFDYDGHPVARPRQTSVAVA
ECCCCCEEECCCCEEEEECCCCEEEEECCCEEEEECCCCCEECCCCCCCCCCCCCCEEEE
TLANKGSHRHFMEKEILEQPEVIADALGHYINFIENGADAVSGIDFAKIPSLAISACGTA
EHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCHHHCCHHHHHHHHHH
YLAGLIGKYWFERYARLPVEIDVASEFRYREIPLSPQSAALFISQSGETADTLASLRYCK
HHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCEEEEEECCCCHHHHHHHHHHHH
QLGLKIGAVVNARESTIAREADVVFPILAGPEIGVASTKAFTCQLAALAALAIHAAKARG
HHCCCCEEEECCHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
TVTEDEVQALVESLAEMPRLMRQVLDSIQPEIELLSRELSKCHHVLYLGRGTNFPLAMEG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEEECCCCCCEEECC
ALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFDKTLSNMQEVAARGGR
CEEEHHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCE
IILITDGKGAAASKLDTMHTIVLPATDEIIAPMIFSLPIQLLAYHTALFMGTDLDQPRNL
EEEEECCCCCCHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIVGIVGQQPVSERLVDALKRLEYRGYDSAGIATITDGTLHRRRAEGKLVNLERRLKE
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHCCCEECHHHHHHC
EPLGGTIGIAHTRWATHGPPTERNAHPHFTDGVAVVHNGIIENFAELKDELAATGAEFQT
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DTDTEVLAHLLARHRREGMRRGEAVHAMLKSVRGAYALAILFEDDPSTIIAARNGPPLAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEEEECCCCCEEE
GHGDGEMFLGSDAIALAPFTNEITYLIDGDWAVVGRTGADIFDYDGHPVARPRQTSVAVA
ECCCCCEEECCCCEEEEECCCCEEEEECCCEEEEECCCCCEECCCCCCCCCCCCCCEEEE
TLANKGSHRHFMEKEILEQPEVIADALGHYINFIENGADAVSGIDFAKIPSLAISACGTA
EHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCHHHCCHHHHHHHHHH
YLAGLIGKYWFERYARLPVEIDVASEFRYREIPLSPQSAALFISQSGETADTLASLRYCK
HHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCEEEEEECCCCHHHHHHHHHHHH
QLGLKIGAVVNARESTIAREADVVFPILAGPEIGVASTKAFTCQLAALAALAIHAAKARG
HHCCCCEEEECCHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
TVTEDEVQALVESLAEMPRLMRQVLDSIQPEIELLSRELSKCHHVLYLGRGTNFPLAMEG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEEECCCCCCEEECC
ALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFDKTLSNMQEVAARGGR
CEEEHHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCE
IILITDGKGAAASKLDTMHTIVLPATDEIIAPMIFSLPIQLLAYHTALFMGTDLDQPRNL
EEEEECCCCCCHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]