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The map label for this gene is thiD [H]

Identifier: 13474818

GI number: 13474818

Start: 4668665

End: 4669435

Strand: Reverse

Name: thiD [H]

Synonym: mll5788

Alternate gene names: 13474818

Gene position: 4669435-4668665 (Counterclockwise)

Preceding gene: 13474819

Following gene: 13474814

Centisome position: 66.36

GC content: 62.65

Gene sequence:

>771_bases
ATGGCGCTGAGGCGAGAACCGCATGTGCTTGTCGTTGGCGGGTCGGACTCCAGCGGTGGAGCTGGAATTGCCCGCGATAT
AGAAACGGTTTCCGCCTTCGGGGTGCGAAGTTGTCTTGCCATCACCGCCGTGACAGTCCAGACGCACTCGGCTGTCGAGC
ACGTCAAGCTTGTGCCGTCGGAGCTTGTCGCCGCTCAGATGCGCGCCGCGTTCGCTGCCAACGCTGTCGCGGCCGTCAAG
ATAGGCATGATTGGGACATCGGCGGCTGTTGAGGCAGTCGGCGCTGTTTTGGTCAACCGCCAAGTGCCTGTGGTACTCGA
CCCGGTCCTGGCCTCTACCTCGGGACGCAATCTGCTGGCGGACGATGCCATTAATATGCTGCGCCACGATCTGATGCCGA
TCTGCCGGCTTGTAACGCCTAACCTGGTCGAGCTGGCTGCGTTTACCGGCTCGTCACCGGCCGCGGACGAAGAAGGGGCT
TGTCGTCAGGCTGAAGAGCTATCGAGGACGGTGAGGACCGCTGTACTCGTCAAGGGCGGCCATGCACAAGGAACCCGTTG
CGTCGACGTGCTTTTGCAGCCGAACCAACCGGCAGTTCGGTTCGAGGCGCCCCGCTTGCCGCGAGGGATGCGCGGAACGG
GTTGCATGATGGCCAGCGCAGTCGCCGCCTCGCTTGCTCTTGGAGCGTCGCTGGAAGCGAGCGTGCGCCAAGGCAAGCAA
TATGTTTTCGATGCGCTTGCCGGATCGAAGGACCTCGGGCCGAAAAGCTGA

Upstream 100 bases:

>100_bases
TCTTTGCGGCTGGCGTGGACAGCGCGGCCGTCGTGACCGACATCACGCTGAATGCCGATCCCGAAGCGCGCACACGAGAA
TGGATCGAAAAGACGGAGCG

Downstream 100 bases:

>100_bases
TCGGGCCGAACGTATCCAACGCTCCGATCAAGTCTGGCAGGCGATCGTGGGTCTACTCCTAGGACATGAAGGCCCTATCC
GAGGGGTGAGAATGCGGCAT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MALRREPHVLVVGGSDSSGGAGIARDIETVSAFGVRSCLAITAVTVQTHSAVEHVKLVPSELVAAQMRAAFAANAVAAVK
IGMIGTSAAVEAVGAVLVNRQVPVVLDPVLASTSGRNLLADDAINMLRHDLMPICRLVTPNLVELAAFTGSSPAADEEGA
CRQAEELSRTVRTAVLVKGGHAQGTRCVDVLLQPNQPAVRFEAPRLPRGMRGTGCMMASAVAASLALGASLEASVRQGKQ
YVFDALAGSKDLGPKS

Sequences:

>Translated_256_residues
MALRREPHVLVVGGSDSSGGAGIARDIETVSAFGVRSCLAITAVTVQTHSAVEHVKLVPSELVAAQMRAAFAANAVAAVK
IGMIGTSAAVEAVGAVLVNRQVPVVLDPVLASTSGRNLLADDAINMLRHDLMPICRLVTPNLVELAAFTGSSPAADEEGA
CRQAEELSRTVRTAVLVKGGHAQGTRCVDVLLQPNQPAVRFEAPRLPRGMRGTGCMMASAVAASLALGASLEASVRQGKQ
YVFDALAGSKDLGPKS
>Mature_255_residues
ALRREPHVLVVGGSDSSGGAGIARDIETVSAFGVRSCLAITAVTVQTHSAVEHVKLVPSELVAAQMRAAFAANAVAAVKI
GMIGTSAAVEAVGAVLVNRQVPVVLDPVLASTSGRNLLADDAINMLRHDLMPICRLVTPNLVELAAFTGSSPAADEEGAC
RQAEELSRTVRTAVLVKGGHAQGTRCVDVLLQPNQPAVRFEAPRLPRGMRGTGCMMASAVAASLALGASLEASVRQGKQY
VFDALAGSKDLGPKS

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=245, Percent_Identity=36.3265306122449, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325378, Length=263, Percent_Identity=30.7984790874525, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324517, Length=254, Percent_Identity=32.6771653543307, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324997, Length=254, Percent_Identity=33.0708661417323, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 26354; Mature: 26223

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRREPHVLVVGGSDSSGGAGIARDIETVSAFGVRSCLAITAVTVQTHSAVEHVKLVPS
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
ELVAAQMRAAFAANAVAAVKIGMIGTSAAVEAVGAVLVNRQVPVVLDPVLASTSGRNLLA
HHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCEEECHHHHCCCCCCCHH
DDAINMLRHDLMPICRLVTPNLVELAAFTGSSPAADEEGACRQAEELSRTVRTAVLVKGG
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECC
HAQGTRCVDVLLQPNQPAVRFEAPRLPRGMRGTGCMMASAVAASLALGASLEASVRQGKQ
CCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
YVFDALAGSKDLGPKS
HHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ALRREPHVLVVGGSDSSGGAGIARDIETVSAFGVRSCLAITAVTVQTHSAVEHVKLVPS
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
ELVAAQMRAAFAANAVAAVKIGMIGTSAAVEAVGAVLVNRQVPVVLDPVLASTSGRNLLA
HHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCEEECHHHHCCCCCCCHH
DDAINMLRHDLMPICRLVTPNLVELAAFTGSSPAADEEGACRQAEELSRTVRTAVLVKGG
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECC
HAQGTRCVDVLLQPNQPAVRFEAPRLPRGMRGTGCMMASAVAASLALGASLEASVRQGKQ
CCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
YVFDALAGSKDLGPKS
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]