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The map label for this gene is gbsB [H]

Identifier: 13474759

GI number: 13474759

Start: 4605463

End: 4606689

Strand: Reverse

Name: gbsB [H]

Synonym: mll5720

Alternate gene names: 13474759

Gene position: 4606689-4605463 (Counterclockwise)

Preceding gene: 13474763

Following gene: 13474758

Centisome position: 65.47

GC content: 66.91

Gene sequence:

>1227_bases
ATGAGCCTCTTCGCCGCCCTCCGGCTTCCGCGTGAAATCCTTTTCGGGAAAGGCCAGCGCCACGCACTGTCGACAGTCGC
CGGCAGGTTCGGCCGGCACGCCCTGGTCTGTACCGACGAGCGTTTCGCCGGCACGGCGGTGTTCGCGGAAATTGTCCAAT
CGCTCCAGGCCGCCTCGATCGAGGTGCTGGTGCATGACCGCGTGCTTCCCGACGTGCCACGTGACAGCGTCGGCATTTGC
GTCGACGAGGCCGAGAAATTCCAGCCCGAGATGGTGATCGGCATCGGCGGCGGCAGCTGCCTCGATTTCGCCAAATGCGC
CGACTTGCTGCTCAGCCATGGCGGCAAGCTTCAGGACTACTATGGGGAGTTCAAGGTGCCCGGCCCGACGCTGCCGCTGA
TCGCCGTGCCCACGACAGCGGGCACCGGCTCCGAAGTGACGCCCGTCGCGGTGATCTCCGATCCGGATCGGACGCTCAAG
GTCGGCATATCGAGCCCCTATCTAATCGCGGCAGTTGCCTTGTGCGACCCCGAACTGACGATGACCTGCCCCCCTGCCCT
GACTGCGATAGCCGGCGCCGACGCCCTGACCCATGCGATCGAGGCCTTCACCGCGAAGCAGCGCGGCGAGGACCCCAGCC
TGGCGCAACAGCATGTCTTCATCGGCAAGACCGCGCTGACCGACCATTTCGCCCTCCTGGCCATAAAGCTGCTGGGCCGC
AGCCTGGAGAAAGCCTGCACCGACGGCACGGATGCCGATGCGCGCGCCGATGTGATGATGGGCGCACTGGCGGCGGGCTG
CGCATTCGGCACCGCCGGCACTGCGGCGGCGCATGCCGTGCAATATCCCGCGGGCGCCCTCACCCACACCGCGCACGGAT
TGGGCGTGGCGACGATGATGCCTTACGTCATGACCTACAACAGCCGCGTGGTCGCCGCCGAAATGGCCGAGATCGGCGAC
GCGCTTGGCCTTGAGGCCAAGGGGCGGAGCGCCGAGGAGATGGCGGACGCCACCATCAAGGAAATCCGGCGGCTATTCAC
GGCGATCGGCATCACGCCGACGCTGGCCGATCTCGGCCTTCCCGCCGACAAGCTCGACTGGACCGCCGATCAGGCGCTCG
GCATCGACCGCCTGATCAAGAACAACCCGCGCCCCTTCGATCTCACCGCCATGCGACGCCTGGTCCAGGCCGCCCATGAC
GGCGACCTCGCAGCCTGCGCCATGTAA

Upstream 100 bases:

>100_bases
CATAGGTGCTGAGGGTGTCCAGGCGCCGTTGCGGACAGATGGCGGATCCGTCGCGACAAGCCTTGTCAGTTCAGCCGCCT
TCAAAGGACGAAAGATCATC

Downstream 100 bases:

>100_bases
TCCACGGAACAAGACAATGAACCTTCCTCCCAATGCGTTGTGGATCGACCAGGACGACTATGATGTTCGCGGCTTTTCGC
ACGGACTCTACATCGACGGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSLFAALRLPREILFGKGQRHALSTVAGRFGRHALVCTDERFAGTAVFAEIVQSLQAASIEVLVHDRVLPDVPRDSVGIC
VDEAEKFQPEMVIGIGGGSCLDFAKCADLLLSHGGKLQDYYGEFKVPGPTLPLIAVPTTAGTGSEVTPVAVISDPDRTLK
VGISSPYLIAAVALCDPELTMTCPPALTAIAGADALTHAIEAFTAKQRGEDPSLAQQHVFIGKTALTDHFALLAIKLLGR
SLEKACTDGTDADARADVMMGALAAGCAFGTAGTAAAHAVQYPAGALTHTAHGLGVATMMPYVMTYNSRVVAAEMAEIGD
ALGLEAKGRSAEEMADATIKEIRRLFTAIGITPTLADLGLPADKLDWTADQALGIDRLIKNNPRPFDLTAMRRLVQAAHD
GDLAACAM

Sequences:

>Translated_408_residues
MSLFAALRLPREILFGKGQRHALSTVAGRFGRHALVCTDERFAGTAVFAEIVQSLQAASIEVLVHDRVLPDVPRDSVGIC
VDEAEKFQPEMVIGIGGGSCLDFAKCADLLLSHGGKLQDYYGEFKVPGPTLPLIAVPTTAGTGSEVTPVAVISDPDRTLK
VGISSPYLIAAVALCDPELTMTCPPALTAIAGADALTHAIEAFTAKQRGEDPSLAQQHVFIGKTALTDHFALLAIKLLGR
SLEKACTDGTDADARADVMMGALAAGCAFGTAGTAAAHAVQYPAGALTHTAHGLGVATMMPYVMTYNSRVVAAEMAEIGD
ALGLEAKGRSAEEMADATIKEIRRLFTAIGITPTLADLGLPADKLDWTADQALGIDRLIKNNPRPFDLTAMRRLVQAAHD
GDLAACAM
>Mature_407_residues
SLFAALRLPREILFGKGQRHALSTVAGRFGRHALVCTDERFAGTAVFAEIVQSLQAASIEVLVHDRVLPDVPRDSVGICV
DEAEKFQPEMVIGIGGGSCLDFAKCADLLLSHGGKLQDYYGEFKVPGPTLPLIAVPTTAGTGSEVTPVAVISDPDRTLKV
GISSPYLIAAVALCDPELTMTCPPALTAIAGADALTHAIEAFTAKQRGEDPSLAQQHVFIGKTALTDHFALLAIKLLGRS
LEKACTDGTDADARADVMMGALAAGCAFGTAGTAAAHAVQYPAGALTHTAHGLGVATMMPYVMTYNSRVVAAEMAEIGDA
LGLEAKGRSAEEMADATIKEIRRLFTAIGITPTLADLGLPADKLDWTADQALGIDRLIKNNPRPFDLTAMRRLVQAAHDG
DLAACAM

Specific function: Essential for the utilization of choline as a precursor [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=378, Percent_Identity=26.984126984127, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI48994951, Length=339, Percent_Identity=31.5634218289086, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1789163, Length=392, Percent_Identity=29.8469387755102, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI87082107, Length=308, Percent_Identity=36.6883116883117, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1787493, Length=429, Percent_Identity=28.2051282051282, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789386, Length=409, Percent_Identity=24.9388753056235, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17537053, Length=282, Percent_Identity=31.9148936170213, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321181, Length=403, Percent_Identity=29.7766749379653, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24657991, Length=378, Percent_Identity=28.3068783068783, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 42729; Mature: 42597

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFAALRLPREILFGKGQRHALSTVAGRFGRHALVCTDERFAGTAVFAEIVQSLQAASI
CCHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHE
EVLVHDRVLPDVPRDSVGICVDEAEKFQPEMVIGIGGGSCLDFAKCADLLLSHGGKLQDY
EEEEECCCCCCCCCCCCCEEECCHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCHHH
YGEFKVPGPTLPLIAVPTTAGTGSEVTPVAVISDPDRTLKVGISSPYLIAAVALCDPELT
CCCEECCCCCCCEEEECCCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHCCCCCE
MTCPPALTAIAGADALTHAIEAFTAKQRGEDPSLAQQHVFIGKTALTDHFALLAIKLLGR
EECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEECHHHHHHHHHHHHHHHHHH
SLEKACTDGTDADARADVMMGALAAGCAFGTAGTAAAHAVQYPAGALTHTAHGLGVATMM
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHCCCCHHHHH
PYVMTYNSRVVAAEMAEIGDALGLEAKGRSAEEMADATIKEIRRLFTAIGITPTLADLGL
HHHHHCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
PADKLDWTADQALGIDRLIKNNPRPFDLTAMRRLVQAAHDGDLAACAM
CHHHCCCCHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure 
SLFAALRLPREILFGKGQRHALSTVAGRFGRHALVCTDERFAGTAVFAEIVQSLQAASI
CHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHE
EVLVHDRVLPDVPRDSVGICVDEAEKFQPEMVIGIGGGSCLDFAKCADLLLSHGGKLQDY
EEEEECCCCCCCCCCCCCEEECCHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCHHH
YGEFKVPGPTLPLIAVPTTAGTGSEVTPVAVISDPDRTLKVGISSPYLIAAVALCDPELT
CCCEECCCCCCCEEEECCCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHCCCCCE
MTCPPALTAIAGADALTHAIEAFTAKQRGEDPSLAQQHVFIGKTALTDHFALLAIKLLGR
EECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEECHHHHHHHHHHHHHHHHHH
SLEKACTDGTDADARADVMMGALAAGCAFGTAGTAAAHAVQYPAGALTHTAHGLGVATMM
HHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHCCCCHHHHH
PYVMTYNSRVVAAEMAEIGDALGLEAKGRSAEEMADATIKEIRRLFTAIGITPTLADLGL
HHHHHCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
PADKLDWTADQALGIDRLIKNNPRPFDLTAMRRLVQAAHDGDLAACAM
CHHHCCCCHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8752328; 9384377 [H]