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The map label for this gene is pepA [H]

Identifier: 13474667

GI number: 13474667

Start: 4496611

End: 4498086

Strand: Direct

Name: pepA [H]

Synonym: mlr5606

Alternate gene names: 13474667

Gene position: 4496611-4498086 (Clockwise)

Preceding gene: 13474665

Following gene: 13474668

Centisome position: 63.91

GC content: 65.65

Gene sequence:

>1476_bases
ATGCGCGCGGCCATTGCGTGGCCATCTTCCCTCCCGCAGAAATATTCTGTTAACCCTAACGGAGAGTTAAGAAGCGCCGA
CTCGCGAAGGGTCGGCAGGAGAGAACATCGAATGCCTGTCGAACTCGTCGAGACGAAATTGCAAGGTGCGCTGCCGGTAC
ATCTGGTGGCCCGTGACGGCCTCGAGGCCGCGGGCCTTGCGCCATCGGCGGTCAGCTGGGCCAAGGCCAACGGCTTTTCC
GGCGAGGCAGGCAGGATGCTCGCCTTGCCCGGCGAAAACGGCGCGCTTGCCGGCGCGCTGTTCGGCATCGGCGACGGGGA
GGGCGCGCTCGCGCTCGGCGCACTGTCGAAAACCCTGCCGGAAGGCGACTGGCATTTCGCCTCCATTCCTGCCGAGCCGG
AACTCGCGGCAATCGCGCTGGCGCTCGGCGGCTATGTCTTTACCCGTTACGGCAAGAAGCCGGGCAAGGCGCTGCGTTTC
GACGTGCCGGCCGGTGTCGACGCGGCGCGCGTTCGCCGCATCGCCGATGGCGTCTTCCTGGCCCGTGATCTGGTCAACAC
ACCGACCAGCGACATGGGACCGGATGATCTGGAGATGGCGGTGCGCACCTTGGCCGCGGCTCACAAGGCCGAAGTCTCTG
TCACCAAGGGCGACGATCTGCTGACGCGGAACTTCCCGATGATCCACGCCGTCGGTCGTGCTTCGACCGGCGCGCCGCGT
CTGATCGACATGATCTGGGGGAACCCGGGCGCGCCGAAGGTGACGCTGGTCGGCAAGGGCGTCTGCTTCGACACAGGCGG
TCTCGACATCAAGCCGTCATCCGGCATGCTCTTGATGAAGAAGGACATGGGCGGTGCCGCCAATGTGCTTGGCCTGGCCT
CGATGATCATGGCCGCCGGGCTGAACGTGCAGCTGCGCGTGCTGATCCCCGCGGTCGAGAACTCGATTGCCGGCAACGCT
TTTCGACCCGGAGACGTGCTGACGAGCCGCAAGGGCATCACTGTCGAGATCGGCAACACCGACGCTGAAGGCAGGCTCGT
GCTGGCGGACGCGCTGGCGCTGGCCGACGACGAGGAGCCGCAGCTGCTGGTCGACATGGCGACGCTGACCGGAGCTGCCC
GTGTCGCGCTTGGCCCCGATCTGCCGCCTTTCTATACCGGCGACGAGGCGCTGGCCTCGAACCTCGCCGCGGCGTCGCTG
GCTGTCGAGGATCCGCTGTGGCGCATGCCGCTGTGGCGGCCCTACGATGCGAAACTGTCGTCGAAGATCGCCGACATCAA
CAATGTCACCACGGATGGTTTCGCCGGTTCGATCACGGCGGCGCTGTTCCTCAAGCGCTTTGTCGAGAAGACGGCGAGCT
GGGCGCATTTAGACATCTTTGCCTGGAACCCCGCCGACCGTGCGCATGGCCCCGCGGGTGGTGAGGCGCAAGGCATTCGC
GCTTTGGAGCGGATCATATCGACACGCTTTGGCTGA

Upstream 100 bases:

>100_bases
ACGGCAGCCGTGAGCGCCAGCATGAGGGCCGTGGTGACGAACCGTTTTCCCCTGGCATTCACTGTGCGGTTGGTCGCCAT
CGACACCTAAGCCTCCATTC

Downstream 100 bases:

>100_bases
TGGGGTGGTAGCAAGCAGAGCCGGCAAATCGCTAAAAACTGAAACGGAACCGAAACAATTTGCCGTCATGCTGGCGCGAT
GTCGATTGCGATGCGCCCGA

Product: leucine aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MRAAIAWPSSLPQKYSVNPNGELRSADSRRVGRREHRMPVELVETKLQGALPVHLVARDGLEAAGLAPSAVSWAKANGFS
GEAGRMLALPGENGALAGALFGIGDGEGALALGALSKTLPEGDWHFASIPAEPELAAIALALGGYVFTRYGKKPGKALRF
DVPAGVDAARVRRIADGVFLARDLVNTPTSDMGPDDLEMAVRTLAAAHKAEVSVTKGDDLLTRNFPMIHAVGRASTGAPR
LIDMIWGNPGAPKVTLVGKGVCFDTGGLDIKPSSGMLLMKKDMGGAANVLGLASMIMAAGLNVQLRVLIPAVENSIAGNA
FRPGDVLTSRKGITVEIGNTDAEGRLVLADALALADDEEPQLLVDMATLTGAARVALGPDLPPFYTGDEALASNLAAASL
AVEDPLWRMPLWRPYDAKLSSKIADINNVTTDGFAGSITAALFLKRFVEKTASWAHLDIFAWNPADRAHGPAGGEAQGIR
ALERIISTRFG

Sequences:

>Translated_491_residues
MRAAIAWPSSLPQKYSVNPNGELRSADSRRVGRREHRMPVELVETKLQGALPVHLVARDGLEAAGLAPSAVSWAKANGFS
GEAGRMLALPGENGALAGALFGIGDGEGALALGALSKTLPEGDWHFASIPAEPELAAIALALGGYVFTRYGKKPGKALRF
DVPAGVDAARVRRIADGVFLARDLVNTPTSDMGPDDLEMAVRTLAAAHKAEVSVTKGDDLLTRNFPMIHAVGRASTGAPR
LIDMIWGNPGAPKVTLVGKGVCFDTGGLDIKPSSGMLLMKKDMGGAANVLGLASMIMAAGLNVQLRVLIPAVENSIAGNA
FRPGDVLTSRKGITVEIGNTDAEGRLVLADALALADDEEPQLLVDMATLTGAARVALGPDLPPFYTGDEALASNLAAASL
AVEDPLWRMPLWRPYDAKLSSKIADINNVTTDGFAGSITAALFLKRFVEKTASWAHLDIFAWNPADRAHGPAGGEAQGIR
ALERIISTRFG
>Mature_491_residues
MRAAIAWPSSLPQKYSVNPNGELRSADSRRVGRREHRMPVELVETKLQGALPVHLVARDGLEAAGLAPSAVSWAKANGFS
GEAGRMLALPGENGALAGALFGIGDGEGALALGALSKTLPEGDWHFASIPAEPELAAIALALGGYVFTRYGKKPGKALRF
DVPAGVDAARVRRIADGVFLARDLVNTPTSDMGPDDLEMAVRTLAAAHKAEVSVTKGDDLLTRNFPMIHAVGRASTGAPR
LIDMIWGNPGAPKVTLVGKGVCFDTGGLDIKPSSGMLLMKKDMGGAANVLGLASMIMAAGLNVQLRVLIPAVENSIAGNA
FRPGDVLTSRKGITVEIGNTDAEGRLVLADALALADDEEPQLLVDMATLTGAARVALGPDLPPFYTGDEALASNLAAASL
AVEDPLWRMPLWRPYDAKLSSKIADINNVTTDGFAGSITAALFLKRFVEKTASWAHLDIFAWNPADRAHGPAGGEAQGIR
ALERIISTRFG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=352, Percent_Identity=36.0795454545455, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI47155554, Length=294, Percent_Identity=35.3741496598639, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI87082123, Length=350, Percent_Identity=37.7142857142857, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI1790710, Length=336, Percent_Identity=37.797619047619, Blast_Score=174, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=369, Percent_Identity=33.0623306233062, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=227, Percent_Identity=32.5991189427313, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24661038, Length=282, Percent_Identity=32.2695035460993, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21355725, Length=282, Percent_Identity=31.5602836879433, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI221379063, Length=284, Percent_Identity=35.9154929577465, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI221379062, Length=284, Percent_Identity=35.9154929577465, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21357381, Length=284, Percent_Identity=35.9154929577465, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24662227, Length=288, Percent_Identity=26.7361111111111, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19922386, Length=288, Percent_Identity=30.5555555555556, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21355645, Length=290, Percent_Identity=26.2068965517241, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24662223, Length=290, Percent_Identity=26.2068965517241, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI20129969, Length=288, Percent_Identity=28.4722222222222, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI161077148, Length=339, Percent_Identity=30.0884955752212, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20130057, Length=339, Percent_Identity=30.0884955752212, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20129963, Length=370, Percent_Identity=28.3783783783784, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646701, Length=258, Percent_Identity=32.1705426356589, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24646703, Length=258, Percent_Identity=32.1705426356589, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21358201, Length=258, Percent_Identity=32.1705426356589, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51410; Mature: 51410

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAIAWPSSLPQKYSVNPNGELRSADSRRVGRREHRMPVELVETKLQGALPVHLVARDG
CCCEECCCCCCCCCEECCCCCCCCCCHHHHHCHHHHCCCHHHHHHHHCCCCEEEEEECCC
LEAAGLAPSAVSWAKANGFSGEAGRMLALPGENGALAGALFGIGDGEGALALGALSKTLP
CCCCCCCCCHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCEEEHHHHHHCC
EGDWHFASIPAEPELAAIALALGGYVFTRYGKKPGKALRFDVPAGVDAARVRRIADGVFL
CCCCEEEECCCCCCHHHHHHHHHHHHEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
ARDLVNTPTSDMGPDDLEMAVRTLAAAHKAEVSVTKGDDLLTRNFPMIHAVGRASTGAPR
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCEEECCCCEEEEECCCCCCCCC
LIDMIWGNPGAPKVTLVGKGVCFDTGGLDIKPSSGMLLMKKDMGGAANVLGLASMIMAAG
EEHEEECCCCCCEEEEEECCEEEECCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHCC
LNVQLRVLIPAVENSIAGNAFRPGDVLTSRKGITVEIGNTDAEGRLVLADALALADDEEP
CCEEEEEEEEEHHCCCCCCCCCCCCHHCCCCCEEEEECCCCCCCEEEEEEHHHHCCCCCC
QLLVDMATLTGAARVALGPDLPPFYTGDEALASNLAAASLAVEDPLWRMPLWRPYDAKLS
EEEEEEHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHEECCCHHCCCCCCCCCHHHH
SKIADINNVTTDGFAGSITAALFLKRFVEKTASWAHLDIFAWNPADRAHGPAGGEAQGIR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCHHHHH
ALERIISTRFG
HHHHHHHHCCC
>Mature Secondary Structure
MRAAIAWPSSLPQKYSVNPNGELRSADSRRVGRREHRMPVELVETKLQGALPVHLVARDG
CCCEECCCCCCCCCEECCCCCCCCCCHHHHHCHHHHCCCHHHHHHHHCCCCEEEEEECCC
LEAAGLAPSAVSWAKANGFSGEAGRMLALPGENGALAGALFGIGDGEGALALGALSKTLP
CCCCCCCCCHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCEEEHHHHHHCC
EGDWHFASIPAEPELAAIALALGGYVFTRYGKKPGKALRFDVPAGVDAARVRRIADGVFL
CCCCEEEECCCCCCHHHHHHHHHHHHEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
ARDLVNTPTSDMGPDDLEMAVRTLAAAHKAEVSVTKGDDLLTRNFPMIHAVGRASTGAPR
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCEEECCCCEEEEECCCCCCCCC
LIDMIWGNPGAPKVTLVGKGVCFDTGGLDIKPSSGMLLMKKDMGGAANVLGLASMIMAAG
EEHEEECCCCCCEEEEEECCEEEECCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHCC
LNVQLRVLIPAVENSIAGNAFRPGDVLTSRKGITVEIGNTDAEGRLVLADALALADDEEP
CCEEEEEEEEEHHCCCCCCCCCCCCHHCCCCCEEEEECCCCCCCEEEEEEHHHHCCCCCC
QLLVDMATLTGAARVALGPDLPPFYTGDEALASNLAAASLAVEDPLWRMPLWRPYDAKLS
EEEEEEHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHEECCCHHCCCCCCCCCHHHH
SKIADINNVTTDGFAGSITAALFLKRFVEKTASWAHLDIFAWNPADRAHGPAGGEAQGIR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCHHHHH
ALERIISTRFG
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA