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The map label for this gene is moeZ [H]

Identifier: 13474645

GI number: 13474645

Start: 4473967

End: 4474719

Strand: Reverse

Name: moeZ [H]

Synonym: mll5577

Alternate gene names: 13474645

Gene position: 4474719-4473967 (Counterclockwise)

Preceding gene: 13474646

Following gene: 13474644

Centisome position: 63.6

GC content: 66.4

Gene sequence:

>753_bases
ATGACCACCACGCTCACCGCCGACGAGATCGAACGCTATGCCCGCCACATCGTGCTGCCGGAGGTCGGCGGTGCGGGCCA
ACAGAAGCTCAAGCAGGCGCGCGTTCTGGTGATCGGCGCCGGCGGGCTGGGCGCGCCGGTGCTCGAATACCTTGCGGCGG
CCGGCGTCGGCACGCTCGGCATTGTCGACGACGACACTGTGTCGCTCTCCAATTTGCAGCGTCAGGTCATCCACGCCACC
GATGCGGTCGGCAAGCTGAAAACCGATAGCGCCAGGGCGGCAATCGCCCACATCAATCCCAACACCGCGGTCGAGACGCA
CACATTCCGGCTGAGCGCGGACAACGCCCCTGCCCTCGTGACCCGCTATGACATAGTGGTCGACGGTTCGGACAATTTCG
AGACCCGTTACACGGTGGCCGACGCCTGTGCGAGCGCGCGTAAACCCCTGGTGCATGCCGCCGTCGGCCGCTTCGACGGC
TCAGTGACGGTGCTGAAGCCTTTCGAGGTCGGCAAGGATGGCAAGCCTAATCCGGGGTACCGCGATCTCTTTCCCGAAGC
CCCACCGCCGGGCCTTGTGCCGTCCTGCGCCGAGGCCGGGGTGCTTGGCGCGCTGACCGGCGTCGTCGGCACGCTGCAGG
CGATGGAGGCGATCAAGCTGATCACCGGCATTGGCGAGCCGCTGATCGGCCGACTGCTGCTCTACGATGCGCTCGCCGCA
CGCTTCGAAACGATCCGCTACAGCAGACGCTGA

Upstream 100 bases:

>100_bases
AGCCTCATGGGGCGTGCGCAGTTCCTGACCGTCGACCATGGCACGGTTGGGCCAACCGAAGACGCCTGACAAGGTTTTTC
GGCCGCTGTATTGTCCTGAT

Downstream 100 bases:

>100_bases
CCTTGGAGCGGACCATGCCCCTTACAATCGACCGCATTCCGGCCGATTTCGGCCGCTGGGACGAGGTGCTTGCCTTGATC
ATGCATGCCTTCGCCTTCAT

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTTTLTADEIERYARHIVLPEVGGAGQQKLKQARVLVIGAGGLGAPVLEYLAAAGVGTLGIVDDDTVSLSNLQRQVIHAT
DAVGKLKTDSARAAIAHINPNTAVETHTFRLSADNAPALVTRYDIVVDGSDNFETRYTVADACASARKPLVHAAVGRFDG
SVTVLKPFEVGKDGKPNPGYRDLFPEAPPPGLVPSCAEAGVLGALTGVVGTLQAMEAIKLITGIGEPLIGRLLLYDALAA
RFETIRYSRR

Sequences:

>Translated_250_residues
MTTTLTADEIERYARHIVLPEVGGAGQQKLKQARVLVIGAGGLGAPVLEYLAAAGVGTLGIVDDDTVSLSNLQRQVIHAT
DAVGKLKTDSARAAIAHINPNTAVETHTFRLSADNAPALVTRYDIVVDGSDNFETRYTVADACASARKPLVHAAVGRFDG
SVTVLKPFEVGKDGKPNPGYRDLFPEAPPPGLVPSCAEAGVLGALTGVVGTLQAMEAIKLITGIGEPLIGRLLLYDALAA
RFETIRYSRR
>Mature_249_residues
TTTLTADEIERYARHIVLPEVGGAGQQKLKQARVLVIGAGGLGAPVLEYLAAAGVGTLGIVDDDTVSLSNLQRQVIHATD
AVGKLKTDSARAAIAHINPNTAVETHTFRLSADNAPALVTRYDIVVDGSDNFETRYTVADACASARKPLVHAAVGRFDGS
VTVLKPFEVGKDGKPNPGYRDLFPEAPPPGLVPSCAEAGVLGALTGVVGTLQAMEAIKLITGIGEPLIGRLLLYDALAAR
FETIRYSRR

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=238, Percent_Identity=48.7394957983193, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI23510338, Length=151, Percent_Identity=31.7880794701987, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI23510340, Length=151, Percent_Identity=31.7880794701987, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI38045948, Length=159, Percent_Identity=35.2201257861635, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4885649, Length=134, Percent_Identity=30.5970149253731, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1787048, Length=245, Percent_Identity=42.0408163265306, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI87082356, Length=242, Percent_Identity=39.6694214876033, Blast_Score=154, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17540406, Length=239, Percent_Identity=42.6778242677824, Blast_Score=197, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI193203301, Length=140, Percent_Identity=30.7142857142857, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71984476, Length=117, Percent_Identity=32.4786324786325, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508819, Length=253, Percent_Identity=25.6916996047431, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=237, Percent_Identity=43.8818565400844, Blast_Score=188, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6320598, Length=161, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24582879, Length=244, Percent_Identity=45.9016393442623, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24660640, Length=141, Percent_Identity=34.0425531914894, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573937, Length=165, Percent_Identity=29.0909090909091, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26279; Mature: 26148

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTLTADEIERYARHIVLPEVGGAGQQKLKQARVLVIGAGGLGAPVLEYLAAAGVGTLG
CCCCCCHHHHHHHHHHEECCCCCCCCHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCEEE
IVDDDTVSLSNLQRQVIHATDAVGKLKTDSARAAIAHINPNTAVETHTFRLSADNAPALV
ECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEEEECCCCCEEE
TRYDIVVDGSDNFETRYTVADACASARKPLVHAAVGRFDGSVTVLKPFEVGKDGKPNPGY
EEEEEEEECCCCCCEEHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCH
RDLFPEAPPPGLVPSCAEAGVLGALTGVVGTLQAMEAIKLITGIGEPLIGRLLLYDALAA
HHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RFETIRYSRR
HHHHHHHCCC
>Mature Secondary Structure 
TTTLTADEIERYARHIVLPEVGGAGQQKLKQARVLVIGAGGLGAPVLEYLAAAGVGTLG
CCCCCHHHHHHHHHHEECCCCCCCCHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCEEE
IVDDDTVSLSNLQRQVIHATDAVGKLKTDSARAAIAHINPNTAVETHTFRLSADNAPALV
ECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEEEECCCCCEEE
TRYDIVVDGSDNFETRYTVADACASARKPLVHAAVGRFDGSVTVLKPFEVGKDGKPNPGY
EEEEEEEECCCCCCEEHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCH
RDLFPEAPPPGLVPSCAEAGVLGALTGVVGTLQAMEAIKLITGIGEPLIGRLLLYDALAA
HHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RFETIRYSRR
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]