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The map label for this gene is pgi

Identifier: 13474512

GI number: 13474512

Start: 4327402

End: 4329045

Strand: Direct

Name: pgi

Synonym: mlr5411

Alternate gene names: 13474512

Gene position: 4327402-4329045 (Clockwise)

Preceding gene: 13474509

Following gene: 13474513

Centisome position: 61.5

GC content: 65.88

Gene sequence:

>1644_bases
GTGGATAAATCAGCCTTCCAGAAACAGCTTGCCGCCTTGCGCGATCATCGCTCGGCGGCACCTGCCAGCATGCGCCAGGC
CTTCGCCGCCGATCCACAGCGTTTCCAGGCATTCACAGCCACCGACGGCGACCTTTTGCTCGACTGGTCGAAATGCGCCG
TCGACGCAACCACCATGGACTTGCTGGAAAAGCTCGCCGCTGCCGCCGATCTCGAGGGCCGCCGCGCCGCCATGTTCGCC
GGCAAGAAGATCAACATCACCGAAGACCGCGCCGTGCTGCACACGGCGCTGCGCAATCTCAGCGGCACGGGCGTCACGGT
CGACGGCCAGGACGTCAAGGCCGATGTCCTTTCCGTGCTCGACGCGATGGGCGCCTTCGCCGATGCCATCCGCTCCGGCA
AGGCGCTAGGTGCCACCGGCAAGAAGATCACCGACATCGTCAACATCGGCATTGGCGGCTCCGACCTCGGCCCGGCCATG
GCGACGCTGGCGCTGGCGCCCTATCATGACGGGCCGCGCGCGCACTACGTCTCCAACATCGACGGCGCCCATATCCATGA
CACGCTGAAAGGCCTGTCCGCCGAAACCACGCTGTTCATCGTCGCCTCCAAGACCTTCACCACGGTCGAGACGATGACCA
ATGCGCAGACGGCGCGCGACTGGGTGCAGAAGGCGCTCGGCAAGCAGGCGGTCGGCAAGCATTTCGCCGCCGTCTCGACC
GCGCTCGACCTGGTGGCCAAGTTTGGCATCGAGGCGGACCGCGTCTTCGGTTTCTGGGACTGGGTCGGCGGCCGCTATTC
GGTCTGGGGCGCGATCGGCCTGCCCGTCATGATCGCCGTCGGTCCCAGGAATTTTCGCGCCTTCCTCGATGGCGCGCACG
AGATGGACCAGCATTTCCGCACTGCGCCGCTCGCCGGGAACCTGCCGGCGCTTCTCGGCCTGGTCGGCTGGTGGCATCGT
GTGATCTGCGGCTATCCGGCCCGCGCGGTCATCCCCTATGACCAGCGGCTGTCCCGGCTGCCGGCCTATCTGCAGCAGCT
CGATATGGAATCGAACGGCAAGGGCGTCACCCTCGACGGCACGCCCGTGGCGACGCCGACCGGGCCGCTGGTCTGGGGCG
AGCCGGGCACCAATGGCCAGCACGCCTTCTTCCAGCTGCTGCACCAGGGCACCGACTTCATCCCGGTCGAGTTCCTTGCC
GCGGCCGTCGGCCATGAGCCGGAGCTCAAGCATCAGCATGATTTGCTGCTCGCCAATTGCCTGGCGCAATCGGAAGCCCT
GATGAAGGGCCGCACGCTGGACGAGGCGCGCGCGCAGATGCTGGCCAAGGGCATGAAGCCGGCCGATGTCGACAAAATAG
CGCCGCATCGTGTCTTCTCCGGCAACCGGCCTTCGCTGACCATCCTCTATCGCAAGCTCGACCCGCGCACTTTCGGGCGG
CTGATCGCGCTCTATGAGCACCGCGTCTTCGTCGAGGGCACGCTGTTCAACATCAATTCCTTCGACCAGTGGGGCGTCGA
GCTCGGCAAGGAGCTGGCGACCGGCCTGCTGCCTGTCGTGGAAGGCAAGGAAAGCGCCGCAAACCGGGACGCCTCGACCA
GGGGCCTTGTGGAACGCATCCACCAATTGCGTGGTTCGGAGTGA

Upstream 100 bases:

>100_bases
GACCGCACGGAATTCGGCTCAATAGGTTTGTCGCGACGACACGCGCCGGAAACATCCGGTCTGATAAAATACGTCGAAAA
ACGCCAGGAGCTCCCCGCCA

Downstream 100 bases:

>100_bases
CTGATTTGGCAGACATCAAGGGGATATTGTTCGACAAGGACGGGACACTTGTCGACTTCAACGCGACCTGGCTCGGCGTC
GCCGATTTCATGGCCATGGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MDKSAFQKQLAALRDHRSAAPASMRQAFAADPQRFQAFTATDGDLLLDWSKCAVDATTMDLLEKLAAAADLEGRRAAMFA
GKKINITEDRAVLHTALRNLSGTGVTVDGQDVKADVLSVLDAMGAFADAIRSGKALGATGKKITDIVNIGIGGSDLGPAM
ATLALAPYHDGPRAHYVSNIDGAHIHDTLKGLSAETTLFIVASKTFTTVETMTNAQTARDWVQKALGKQAVGKHFAAVST
ALDLVAKFGIEADRVFGFWDWVGGRYSVWGAIGLPVMIAVGPRNFRAFLDGAHEMDQHFRTAPLAGNLPALLGLVGWWHR
VICGYPARAVIPYDQRLSRLPAYLQQLDMESNGKGVTLDGTPVATPTGPLVWGEPGTNGQHAFFQLLHQGTDFIPVEFLA
AAVGHEPELKHQHDLLLANCLAQSEALMKGRTLDEARAQMLAKGMKPADVDKIAPHRVFSGNRPSLTILYRKLDPRTFGR
LIALYEHRVFVEGTLFNINSFDQWGVELGKELATGLLPVVEGKESAANRDASTRGLVERIHQLRGSE

Sequences:

>Translated_547_residues
MDKSAFQKQLAALRDHRSAAPASMRQAFAADPQRFQAFTATDGDLLLDWSKCAVDATTMDLLEKLAAAADLEGRRAAMFA
GKKINITEDRAVLHTALRNLSGTGVTVDGQDVKADVLSVLDAMGAFADAIRSGKALGATGKKITDIVNIGIGGSDLGPAM
ATLALAPYHDGPRAHYVSNIDGAHIHDTLKGLSAETTLFIVASKTFTTVETMTNAQTARDWVQKALGKQAVGKHFAAVST
ALDLVAKFGIEADRVFGFWDWVGGRYSVWGAIGLPVMIAVGPRNFRAFLDGAHEMDQHFRTAPLAGNLPALLGLVGWWHR
VICGYPARAVIPYDQRLSRLPAYLQQLDMESNGKGVTLDGTPVATPTGPLVWGEPGTNGQHAFFQLLHQGTDFIPVEFLA
AAVGHEPELKHQHDLLLANCLAQSEALMKGRTLDEARAQMLAKGMKPADVDKIAPHRVFSGNRPSLTILYRKLDPRTFGR
LIALYEHRVFVEGTLFNINSFDQWGVELGKELATGLLPVVEGKESAANRDASTRGLVERIHQLRGSE
>Mature_547_residues
MDKSAFQKQLAALRDHRSAAPASMRQAFAADPQRFQAFTATDGDLLLDWSKCAVDATTMDLLEKLAAAADLEGRRAAMFA
GKKINITEDRAVLHTALRNLSGTGVTVDGQDVKADVLSVLDAMGAFADAIRSGKALGATGKKITDIVNIGIGGSDLGPAM
ATLALAPYHDGPRAHYVSNIDGAHIHDTLKGLSAETTLFIVASKTFTTVETMTNAQTARDWVQKALGKQAVGKHFAAVST
ALDLVAKFGIEADRVFGFWDWVGGRYSVWGAIGLPVMIAVGPRNFRAFLDGAHEMDQHFRTAPLAGNLPALLGLVGWWHR
VICGYPARAVIPYDQRLSRLPAYLQQLDMESNGKGVTLDGTPVATPTGPLVWGEPGTNGQHAFFQLLHQGTDFIPVEFLA
AAVGHEPELKHQHDLLLANCLAQSEALMKGRTLDEARAQMLAKGMKPADVDKIAPHRVFSGNRPSLTILYRKLDPRTFGR
LIALYEHRVFVEGTLFNINSFDQWGVELGKELATGLLPVVEGKESAANRDASTRGLVERIHQLRGSE

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=546, Percent_Identity=52.9304029304029, Blast_Score=569, Evalue=1e-162,
Organism=Homo sapiens, GI296080693, Length=546, Percent_Identity=49.4505494505495, Blast_Score=516, Evalue=1e-146,
Organism=Escherichia coli, GI1790457, Length=543, Percent_Identity=50.4604051565378, Blast_Score=556, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI71996703, Length=527, Percent_Identity=50.853889943074, Blast_Score=535, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI71996708, Length=527, Percent_Identity=50.853889943074, Blast_Score=535, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6319673, Length=528, Percent_Identity=49.8106060606061, Blast_Score=500, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24651916, Length=546, Percent_Identity=50.7326007326007, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24651914, Length=546, Percent_Identity=50.7326007326007, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI17737445, Length=546, Percent_Identity=50.7326007326007, Blast_Score=552, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_RHILO (Q98BV5)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106081.1
- ProteinModelPortal:   Q98BV5
- SMR:   Q98BV5
- GeneID:   1228742
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5411
- NMPDR:   fig|266835.1.peg.4185
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59096; Mature: 59096

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 350-350 ACT_SITE 381-381 ACT_SITE 510-510

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKSAFQKQLAALRDHRSAAPASMRQAFAADPQRFQAFTATDGDLLLDWSKCAVDATTMD
CCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHEEEECCCCCEEEEHHHHHCCHHHHH
LLEKLAAAADLEGRRAAMFAGKKINITEDRAVLHTALRNLSGTGVTVDGQDVKADVLSVL
HHHHHHHHHCCCCCEEHEECCCEECCCHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHH
DAMGAFADAIRSGKALGATGKKITDIVNIGIGGSDLGPAMATLALAPYHDGPRAHYVSNI
HHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCCCCHHHHHHHHEECCCCCCCCCCEECCC
DGAHIHDTLKGLSAETTLFIVASKTFTTVETMTNAQTARDWVQKALGKQAVGKHFAAVST
CCCHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDLVAKFGIEADRVFGFWDWVGGRYSVWGAIGLPVMIAVGPRNFRAFLDGAHEMDQHFR
HHHHHHHHCCCHHHEEEEHHHCCCCEEEEECCCCCEEEEECCCHHHHHHCCHHHHHHHHC
TAPLAGNLPALLGLVGWWHRVICGYPARAVIPYDQRLSRLPAYLQQLDMESNGKGVTLDG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCEEEECC
TPVATPTGPLVWGEPGTNGQHAFFQLLHQGTDFIPVEFLAAAVGHEPELKHQHDLLLANC
CCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
LAQSEALMKGRTLDEARAQMLAKGMKPADVDKIAPHRVFSGNRPSLTILYRKLDPRTFGR
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCEEEEEEECCHHHHHH
LIALYEHRVFVEGTLFNINSFDQWGVELGKELATGLLPVVEGKESAANRDASTRGLVERI
HHHHHHCEEEEEEEEEECCCCHHHHHHHHHHHHHCCHHHCCCCHHHCCCCCHHHHHHHHH
HQLRGSE
HHHCCCC
>Mature Secondary Structure
MDKSAFQKQLAALRDHRSAAPASMRQAFAADPQRFQAFTATDGDLLLDWSKCAVDATTMD
CCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHEEEECCCCCEEEEHHHHHCCHHHHH
LLEKLAAAADLEGRRAAMFAGKKINITEDRAVLHTALRNLSGTGVTVDGQDVKADVLSVL
HHHHHHHHHCCCCCEEHEECCCEECCCHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHH
DAMGAFADAIRSGKALGATGKKITDIVNIGIGGSDLGPAMATLALAPYHDGPRAHYVSNI
HHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCCCCHHHHHHHHEECCCCCCCCCCEECCC
DGAHIHDTLKGLSAETTLFIVASKTFTTVETMTNAQTARDWVQKALGKQAVGKHFAAVST
CCCHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDLVAKFGIEADRVFGFWDWVGGRYSVWGAIGLPVMIAVGPRNFRAFLDGAHEMDQHFR
HHHHHHHHCCCHHHEEEEHHHCCCCEEEEECCCCCEEEEECCCHHHHHHCCHHHHHHHHC
TAPLAGNLPALLGLVGWWHRVICGYPARAVIPYDQRLSRLPAYLQQLDMESNGKGVTLDG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCEEEECC
TPVATPTGPLVWGEPGTNGQHAFFQLLHQGTDFIPVEFLAAAVGHEPELKHQHDLLLANC
CCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
LAQSEALMKGRTLDEARAQMLAKGMKPADVDKIAPHRVFSGNRPSLTILYRKLDPRTFGR
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCEEEEEEECCHHHHHH
LIALYEHRVFVEGTLFNINSFDQWGVELGKELATGLLPVVEGKESAANRDASTRGLVERI
HHHHHHCEEEEEEEEEECCCCHHHHHHHHHHHHHCCHHHCCCCHHHCCCCCHHHHHHHHH
HQLRGSE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968