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The map label for this gene is yybE [H]

Identifier: 13474483

GI number: 13474483

Start: 4295678

End: 4296583

Strand: Direct

Name: yybE [H]

Synonym: mlr5377

Alternate gene names: 13474483

Gene position: 4295678-4296583 (Clockwise)

Preceding gene: 13474482

Following gene: 13474485

Centisome position: 61.05

GC content: 64.9

Gene sequence:

>906_bases
ATGGCCTTCACCATCCGCCAGTTGCAATTCTTCATCGCCGTCGCCGAACAAGGCACGGTGTCGGGCGCCGCGCAGAATCT
CTCCATCTCGCAATCGTCGGTCACCGAAGCGATCAAGGAGCTCGAAAGCGATCTCGGCGTCGAATTGTTCGAACGCCATC
CGCGCGGCCTCAACATCACCCATAAGGGCCACCAGTTCCTGCGCCACGCGACCAAGATCCTTGCCGACGTGTCCGACGCC
CGCCGCTCTTTTTCCGGCGAACAAGCGGTGGCGGGAGGGCGGCTGCAGCTTGGCGTCACCTCGCTGGTCGCCGGCTATGT
GCTGTCGGATCTGCTTGCCCGCTACCGCCGCGCCTATCCGGGCGTCGAGGTCTCGGCCATCGAGGACAATGGCGACTACC
TCGAACACCTCTTGATCGGCGGCAAGCTGGACATCGCCGTCATGGTCACCTCCAATCTGCGCGACCGCACGGCGCTGCAA
TCGGAAATCCTCGAAGTCTCGGCCTATCGCCTGTGGCTGCCGCTTGGCCATTCGCTCGTCGGCGCCGACATTATCAGCAT
TGGCGATATCGCCGGCGAGCCGCTGATCATGCTCACCGTCGACGAGATCGAGGAGAACACGGGAAAGCTGCTGGCGGCGA
TCGGCGCCAAGCCGCATGTCGCCTTCCGCACCCGTTCGGTGGAAGCCGTGCGCAGCCTGGTCGCCACCGGCGCCGGCGTG
GCATTGCTGCCCGATCTCGTCTATCGGCCATGGTCGCTGGAAGGCGACCGCATCGAATCGCGCGATATTTCGGGCTCCTT
GCCGGTGGTGCAGGTCGGTATGGTCTGGCGGCGCGGTTCTAGCCTGCCGCAAGCGGCGCGCGATTTCATCGGCCTTGCCC
AGTCGCAGCGCACGGTCCGCCGCTAG

Upstream 100 bases:

>100_bases
GGCGCATCAGGCTGGCGCTCGGCTGAGCACCAGTCTCCGGTCATGGGATAAGTTCCGCCGTCGGCTTTCCTTCGCCCGGC
CGCCGGTGTTTAGTCCGGCC

Downstream 100 bases:

>100_bases
TATGGCCTACTCCAGGCGAACGTCGCCAGTCTCGCGCTTGCGCCTTGTGACGGAAACCGCCTCCGCCCTGAACGGCGCGA
GCGGAGCAACCTCGAAGCGG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MAFTIRQLQFFIAVAEQGTVSGAAQNLSISQSSVTEAIKELESDLGVELFERHPRGLNITHKGHQFLRHATKILADVSDA
RRSFSGEQAVAGGRLQLGVTSLVAGYVLSDLLARYRRAYPGVEVSAIEDNGDYLEHLLIGGKLDIAVMVTSNLRDRTALQ
SEILEVSAYRLWLPLGHSLVGADIISIGDIAGEPLIMLTVDEIEENTGKLLAAIGAKPHVAFRTRSVEAVRSLVATGAGV
ALLPDLVYRPWSLEGDRIESRDISGSLPVVQVGMVWRRGSSLPQAARDFIGLAQSQRTVRR

Sequences:

>Translated_301_residues
MAFTIRQLQFFIAVAEQGTVSGAAQNLSISQSSVTEAIKELESDLGVELFERHPRGLNITHKGHQFLRHATKILADVSDA
RRSFSGEQAVAGGRLQLGVTSLVAGYVLSDLLARYRRAYPGVEVSAIEDNGDYLEHLLIGGKLDIAVMVTSNLRDRTALQ
SEILEVSAYRLWLPLGHSLVGADIISIGDIAGEPLIMLTVDEIEENTGKLLAAIGAKPHVAFRTRSVEAVRSLVATGAGV
ALLPDLVYRPWSLEGDRIESRDISGSLPVVQVGMVWRRGSSLPQAARDFIGLAQSQRTVRR
>Mature_300_residues
AFTIRQLQFFIAVAEQGTVSGAAQNLSISQSSVTEAIKELESDLGVELFERHPRGLNITHKGHQFLRHATKILADVSDAR
RSFSGEQAVAGGRLQLGVTSLVAGYVLSDLLARYRRAYPGVEVSAIEDNGDYLEHLLIGGKLDIAVMVTSNLRDRTALQS
EILEVSAYRLWLPLGHSLVGADIISIGDIAGEPLIMLTVDEIEENTGKLLAAIGAKPHVAFRTRSVEAVRSLVATGAGVA
LLPDLVYRPWSLEGDRIESRDISGSLPVVQVGMVWRRGSSLPQAARDFIGLAQSQRTVRR

Specific function: Hydrogen Peroxide Sensor. Activates The Expression Of A Regulon Of Hydrogen Peroxide-Inducible Genes Such As Katg, Gor, Ahpc, Ahpf, Oxys (A Regulatory RNA), Dps, Fur And Grxa. Oxyr Expression Is Negatively Autoregulated By Binding To A 43 Bp Region Upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=291, Percent_Identity=28.1786941580756, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787879, Length=298, Percent_Identity=27.1812080536913, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI157672245, Length=289, Percent_Identity=23.5294117647059, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787601, Length=284, Percent_Identity=25.7042253521127, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787806, Length=279, Percent_Identity=27.5985663082437, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1788887, Length=303, Percent_Identity=26.4026402640264, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081904, Length=180, Percent_Identity=27.2222222222222, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367136, Length=258, Percent_Identity=25.5813953488372, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI145693105, Length=310, Percent_Identity=25.1612903225806, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786401, Length=277, Percent_Identity=26.3537906137184, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787530, Length=307, Percent_Identity=25.0814332247557, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788481, Length=148, Percent_Identity=27.7027027027027, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788296, Length=252, Percent_Identity=25.7936507936508, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788748, Length=302, Percent_Identity=22.1854304635762, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790262, Length=252, Percent_Identity=24.2063492063492, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788626, Length=242, Percent_Identity=28.9256198347107, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788297, Length=261, Percent_Identity=23.7547892720307, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI145693193, Length=120, Percent_Identity=28.3333333333333, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32631; Mature: 32500

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFTIRQLQFFIAVAEQGTVSGAAQNLSISQSSVTEAIKELESDLGVELFERHPRGLNIT
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
HKGHQFLRHATKILADVSDARRSFSGEQAVAGGRLQLGVTSLVAGYVLSDLLARYRRAYP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCC
GVEVSAIEDNGDYLEHLLIGGKLDIAVMVTSNLRDRTALQSEILEVSAYRLWLPLGHSLV
CCEEEEEECCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHEEECCCCHHH
GADIISIGDIAGEPLIMLTVDEIEENTGKLLAAIGAKPHVAFRTRSVEAVRSLVATGAGV
HHHHHHHHCCCCCCEEEEEHHHHHCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHCCCCH
ALLPDLVYRPWSLEGDRIESRDISGSLPVVQVGMVWRRGSSLPQAARDFIGLAQSQRTVR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHC
R
C
>Mature Secondary Structure 
AFTIRQLQFFIAVAEQGTVSGAAQNLSISQSSVTEAIKELESDLGVELFERHPRGLNIT
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
HKGHQFLRHATKILADVSDARRSFSGEQAVAGGRLQLGVTSLVAGYVLSDLLARYRRAYP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCC
GVEVSAIEDNGDYLEHLLIGGKLDIAVMVTSNLRDRTALQSEILEVSAYRLWLPLGHSLV
CCEEEEEECCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHEEECCCCHHH
GADIISIGDIAGEPLIMLTVDEIEENTGKLLAAIGAKPHVAFRTRSVEAVRSLVATGAGV
HHHHHHHHCCCCCCEEEEEHHHHHCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHCCCCH
ALLPDLVYRPWSLEGDRIESRDISGSLPVVQVGMVWRRGSSLPQAARDFIGLAQSQRTVR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]