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The map label for this gene is 13474339

Identifier: 13474339

GI number: 13474339

Start: 4136253

End: 4137125

Strand: Direct

Name: 13474339

Synonym: mlr5205

Alternate gene names: NA

Gene position: 4136253-4137125 (Clockwise)

Preceding gene: 13474333

Following gene: 13474340

Centisome position: 58.79

GC content: 63.69

Gene sequence:

>873_bases
ATGAGCGCTTTCGGATCACAATCCATGGCAGCGCCGCTGCGACGCGTGCTGATGCGGTCGGCGGCCAACGCCATGCGCGA
CGCCGACAGAGCTGCCTGGCACTATGGCCCAGGTTTCAATCCGGCGAAAGCGGCATCGCAGCACGCGGCGCTTGCTGAAT
TGGTTGCCGCCTCCGGGGCCGAAATCGAATGGATCGAGGACAAGGCCGATGGACTTTCGGATTCGGTGTTCACGCACGAC
CCATCGCTGATGACCGACCGCGGCGCATTGATTCTGTCCATGGGCAAGCCGTTGCGCGCCAGCGAGCCCTCGCTGCATGA
GGAGACCTATAGAAGACTGGGCATTCCGATCCTCGGCCGCGTCGAGGCCCCAGGCCAGGTCGAAGGCGGTGACTGTGTCT
GGCTGGATGCGCGCACGCTGGTGATCGGGCGCGGTGTCCGTTCCAACCAGGAAGGCATCCAGCAGGTCTCCAACCTGCTG
ACGCCGCTGGGCATTTCCGTCTACGGCTTTGACCTTCCGTTGTGGCAGGGTGAAGAGGCCTGCCTGCATCTGATGTCGGT
GATCAGCCCGCTGGCCGACGACCTCGCTTTGGTCTATTCACCGCTTTTGCCGGCCCCGTTCTATCAGATGCTGAAGGCGC
GCGGCATCCGCCTGGTCGAAGGCGATGCCGAAGAGTTCGCGGCTTCCAACGGCCTCAGCCTGAACGTGCTGCCGACCAAC
CCGCTCAAGGTCATTGCCGTTGCAGGCTTTCCAAAGACCAAAGCCGCGATGGAAGCCGCCGGCTGCACGGTCGAAATCTT
CGAGGCGGACGCGCTCTGCATCGCCTGCGAAGGCGGGCCGACATGCCTGACGCGGCCGATTCTGCGCCAATGA

Upstream 100 bases:

>100_bases
TCAATCCCGCTCATTACGGCACTTGCGAGCTTGTTGTGCAAGTGTATAAATAGCCCTCCATGAAATTTTCTCGGTTTTTT
TCAGCCAAAAAAGGGCTTCG

Downstream 100 bases:

>100_bases
ATGCGCCATCCCGCCGCAGGTTCCGTCGCGAGGGCGAGGAGCGGCGGCGGCAGGATTTGATCGAGGCAACTCTGGACAGC
GTGGCGGAACGTGGCCTGCA

Product: hypothetical protein

Products: NA

Alternate protein names: DDAH; Dimethylarginine dimethylaminohydrolase; Dimethylargininase [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSAFGSQSMAAPLRRVLMRSAANAMRDADRAAWHYGPGFNPAKAASQHAALAELVAASGAEIEWIEDKADGLSDSVFTHD
PSLMTDRGALILSMGKPLRASEPSLHEETYRRLGIPILGRVEAPGQVEGGDCVWLDARTLVIGRGVRSNQEGIQQVSNLL
TPLGISVYGFDLPLWQGEEACLHLMSVISPLADDLALVYSPLLPAPFYQMLKARGIRLVEGDAEEFAASNGLSLNVLPTN
PLKVIAVAGFPKTKAAMEAAGCTVEIFEADALCIACEGGPTCLTRPILRQ

Sequences:

>Translated_290_residues
MSAFGSQSMAAPLRRVLMRSAANAMRDADRAAWHYGPGFNPAKAASQHAALAELVAASGAEIEWIEDKADGLSDSVFTHD
PSLMTDRGALILSMGKPLRASEPSLHEETYRRLGIPILGRVEAPGQVEGGDCVWLDARTLVIGRGVRSNQEGIQQVSNLL
TPLGISVYGFDLPLWQGEEACLHLMSVISPLADDLALVYSPLLPAPFYQMLKARGIRLVEGDAEEFAASNGLSLNVLPTN
PLKVIAVAGFPKTKAAMEAAGCTVEIFEADALCIACEGGPTCLTRPILRQ
>Mature_289_residues
SAFGSQSMAAPLRRVLMRSAANAMRDADRAAWHYGPGFNPAKAASQHAALAELVAASGAEIEWIEDKADGLSDSVFTHDP
SLMTDRGALILSMGKPLRASEPSLHEETYRRLGIPILGRVEAPGQVEGGDCVWLDARTLVIGRGVRSNQEGIQQVSNLLT
PLGISVYGFDLPLWQGEEACLHLMSVISPLADDLALVYSPLLPAPFYQMLKARGIRLVEGDAEEFAASNGLSLNVLPTNP
LKVIAVAGFPKTKAAMEAAGCTVEIFEADALCIACEGGPTCLTRPILRQ

Specific function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS [H]

COG id: COG1834

COG function: function code E; N-Dimethylarginine dimethylaminohydrolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DDAH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003198 [H]

Pfam domain/function: PF02274 Amidinotransf [H]

EC number: =3.5.3.18 [H]

Molecular weight: Translated: 30908; Mature: 30777

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFGSQSMAAPLRRVLMRSAANAMRDADRAAWHYGPGFNPAKAASQHAALAELVAASGA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
EIEWIEDKADGLSDSVFTHDPSLMTDRGALILSMGKPLRASEPSLHEETYRRLGIPILGR
CEEEECCCCCCCCCCCEECCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCEEEE
VEAPGQVEGGDCVWLDARTLVIGRGVRSNQEGIQQVSNLLTPLGISVYGFDLPLWQGEEA
CCCCCCCCCCCEEEEECEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
CLHLMSVISPLADDLALVYSPLLPAPFYQMLKARGIRLVEGDAEEFAASNGLSLNVLPTN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCHHHHHHCCCCEEEEECCC
PLKVIAVAGFPKTKAAMEAAGCTVEIFEADALCIACEGGPTCLTRPILRQ
CEEEEEEECCCCHHHHHHHCCCEEEEEECCEEEEEECCCCHHHCCHHHCC
>Mature Secondary Structure 
SAFGSQSMAAPLRRVLMRSAANAMRDADRAAWHYGPGFNPAKAASQHAALAELVAASGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
EIEWIEDKADGLSDSVFTHDPSLMTDRGALILSMGKPLRASEPSLHEETYRRLGIPILGR
CEEEECCCCCCCCCCCEECCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCEEEE
VEAPGQVEGGDCVWLDARTLVIGRGVRSNQEGIQQVSNLLTPLGISVYGFDLPLWQGEEA
CCCCCCCCCCCEEEEECEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
CLHLMSVISPLADDLALVYSPLLPAPFYQMLKARGIRLVEGDAEEFAASNGLSLNVLPTN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCHHHHHHCCCCEEEEECCC
PLKVIAVAGFPKTKAAMEAAGCTVEIFEADALCIACEGGPTCLTRPILRQ
CEEEEEEECCCCHHHHHHHCCCEEEEEECCEEEEEECCCCHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 11473257 [H]