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The map label for this gene is hisQ [H]

Identifier: 13474336

GI number: 13474336

Start: 4133502

End: 4134167

Strand: Reverse

Name: hisQ [H]

Synonym: mll5200

Alternate gene names: 13474336

Gene position: 4134167-4133502 (Counterclockwise)

Preceding gene: 13474337

Following gene: 13474335

Centisome position: 58.76

GC content: 64.41

Gene sequence:

>666_bases
ATGCTCGGGCTACTGCATTCGCTCGAGATTGCCGTCGGCGCCACGATCGTCGGCCTGCTCATCGGGATCTGCGGCGCCTA
TGGCAAGCTCTATGGCGGACCGGTCGTGCGCGACCTGCTCGCGGTCTACACCACCGTGGTGCGCGCCGTGCCGGAACTGG
TGCTGATCCTGCTGCTCTACTATGCCGGCACCGACCTGATAAACCAGGTGCTGACCGCGATCGGTTACCAGCGTGTCGAT
ATTAGCGGGCTGGTGGCCGGCATAGCCGTGCTTGGCTTCTGCCAGGGCGCCTATTCGACAGAGGTCATGCGCGGCGCGAT
CCTGGCCATCCCGCAGGGCCAGATCGAAGCCGCCCGCGCCTTCGGCATGTCTCCCAGCCTTCTCTTGCGGCGCATCACGC
TGCCGGCGATGCTGCCCTTTGCCATTCCAGGTCTCGCCAATCTGTGGCTGATCGCGACCAAGGACACCGCGCTGCTGGCC
GTCGTCGGTTTCTTCGAGCTGACGCTGGCGACACGGCAGGCAGCCGGCGTCACCAAGGCCTATCTGATATTCTATCTCGC
CGCCGGCGTTCTCTATCTTGCGGTGACGCTGTTTTCGAACTTCCTGCTTGGCCGCGCCGAGAAATGGGCGCGGCGGGGCA
TGCCTTCGATCAAGGAGGCACGCTGA

Upstream 100 bases:

>100_bases
CAATCCGGGGGCAAAGCTGATCGACGCGTTTCTTCCGGCCTCGGCGGCCGGTATCATCGAACTCCTCTCGCCCGCGCCCG
TCGGCTGGGGCGGCACACTC

Downstream 100 bases:

>100_bases
TGGCGGGCGAAGCGGCCATCATCAACACCGCGGCGCGCGCCTCGCTCTGGCTGCAGCCGCACCGCATCGTCCTCATCCTG
ATCGCCCTGGGGCTGGTGCT

Product: amino acid ABC transporter, permease protein

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MLGLLHSLEIAVGATIVGLLIGICGAYGKLYGGPVVRDLLAVYTTVVRAVPELVLILLLYYAGTDLINQVLTAIGYQRVD
ISGLVAGIAVLGFCQGAYSTEVMRGAILAIPQGQIEAARAFGMSPSLLLRRITLPAMLPFAIPGLANLWLIATKDTALLA
VVGFFELTLATRQAAGVTKAYLIFYLAAGVLYLAVTLFSNFLLGRAEKWARRGMPSIKEAR

Sequences:

>Translated_221_residues
MLGLLHSLEIAVGATIVGLLIGICGAYGKLYGGPVVRDLLAVYTTVVRAVPELVLILLLYYAGTDLINQVLTAIGYQRVD
ISGLVAGIAVLGFCQGAYSTEVMRGAILAIPQGQIEAARAFGMSPSLLLRRITLPAMLPFAIPGLANLWLIATKDTALLA
VVGFFELTLATRQAAGVTKAYLIFYLAAGVLYLAVTLFSNFLLGRAEKWARRGMPSIKEAR
>Mature_221_residues
MLGLLHSLEIAVGATIVGLLIGICGAYGKLYGGPVVRDLLAVYTTVVRAVPELVLILLLYYAGTDLINQVLTAIGYQRVD
ISGLVAGIAVLGFCQGAYSTEVMRGAILAIPQGQIEAARAFGMSPSLLLRRITLPAMLPFAIPGLANLWLIATKDTALLA
VVGFFELTLATRQAAGVTKAYLIFYLAAGVLYLAVTLFSNFLLGRAEKWARRGMPSIKEAR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=198, Percent_Identity=41.4141414141414, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1787087, Length=216, Percent_Identity=31.4814814814815, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1787030, Length=191, Percent_Identity=30.8900523560209, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788226, Length=214, Percent_Identity=29.9065420560748, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1788645, Length=211, Percent_Identity=28.9099526066351, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI87082239, Length=161, Percent_Identity=32.9192546583851, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786873, Length=209, Percent_Identity=25.3588516746411, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787086, Length=221, Percent_Identity=29.4117647058824, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 23514; Mature: 23514

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGLLHSLEIAVGATIVGLLIGICGAYGKLYGGPVVRDLLAVYTTVVRAVPELVLILLLY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAGTDLINQVLTAIGYQRVDISGLVAGIAVLGFCQGAYSTEVMRGAILAIPQGQIEAARA
HHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
FGMSPSLLLRRITLPAMLPFAIPGLANLWLIATKDTALLAVVGFFELTLATRQAAGVTKA
HCCCHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
YLIFYLAAGVLYLAVTLFSNFLLGRAEKWARRGMPSIKEAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLGLLHSLEIAVGATIVGLLIGICGAYGKLYGGPVVRDLLAVYTTVVRAVPELVLILLLY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAGTDLINQVLTAIGYQRVDISGLVAGIAVLGFCQGAYSTEVMRGAILAIPQGQIEAARA
HHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
FGMSPSLLLRRITLPAMLPFAIPGLANLWLIATKDTALLAVVGFFELTLATRQAAGVTKA
HCCCHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
YLIFYLAAGVLYLAVTLFSNFLLGRAEKWARRGMPSIKEAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]