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The map label for this gene is gyaR [H]

Identifier: 13474305

GI number: 13474305

Start: 4096578

End: 4097561

Strand: Direct

Name: gyaR [H]

Synonym: mlr5162

Alternate gene names: 13474305

Gene position: 4096578-4097561 (Clockwise)

Preceding gene: 13474304

Following gene: 13474306

Centisome position: 58.22

GC content: 66.57

Gene sequence:

>984_bases
ATGACCAAGGCCGAACAACTGCAAGCCGTCGCCATTCTGGTGCCGGCGGACTTCAGCGACCATGCCGTCCGGCGCATCGA
CCGTACCTTCAAACAGGTGAGCATCGAGCGCGCCGATCCGGCGCTGGTCACCGACGAGATGCGGCGCATGGTGCGTGGCA
TTGCCTCCTTTGCCGGCATCAGCGCGGCGATGATGGATGCGCTGCCCAATCTCGAACTCATCGCCTCCTTCGGCGTCGGC
TATGATTCGGTCGATGTCGGCCATGCGGCGGCGAAGAACATCATGGTCACCAACACGCCCGACGTGCTGACCGAGGAGGT
CGCCGACACCGCGATCGGCCTGCTGATCAACACGATCCGCGACCTGCCGCGTGCGGAAAACTGGCTGCGCGACGGCAGCT
GGGTGCGCAAGGGCAACTATCCGCTGAGCCGGCTGACCTTGCGCGCGCGCCGCGTCGGGATTTTCGGCATGGGCCGCATC
GGGCAGGCCATCGCCCGGCGGCTCGAGGCGTTCGGACTGCCCATCGCCTACCACAACCGGCGCCGTGTCGAAGGTCTTGC
GTATCAGTATCACCCGACACTGAGAGGTCTGGCGGAAGCGGTCGATACGCTGATTTCGGTGGCGCCTGGTGGTGCTTCGA
CGCAGAAGGCGGTCAATGCCGAGATCCTGTCGGCGCTCGGCGCCAATGGCGTTTTCGTCAATATCGGCCGCGGCAGCACG
GTCGACGAGGCAGCACTCGCGGCGGCGCTCGCCGACGGCACCATCGCCGCCGCCGGGCTCGATGTCTTCGCCGACGAGCC
GAACGTGCCCAAGGCATTGCTCGACGCCCCCAACGCCTCCCTGTTGCCGCATGTCGGCTCGGCCTCGGAACACACGCGCC
GCGCCATGGCCGATCTGTGCGTCGACAATCTGGTGTCCTGGTTCACCGAGCGCCAGCCGCTGACGCCGGTTCCGGAAACG
GCGCATGTGAAGGCTCGCGGCTGA

Upstream 100 bases:

>100_bases
TGCTCGACAAGCTCAATGGGCAGACGGTGCGGCCCTCGCAGGAATTGATCAAGCCGGAACTGCATGTGCGCCAGTCGACC
GGCAAGCCGGTGGAGCGGGC

Downstream 100 bases:

>100_bases
CTTGGCAGTTTGCCACATTTATTAACGCCGGCTTAACCCTTTGAAATCATTCTTCATCCTGCCCGTGCGCGGGGATGAAG
AATGATGAAAACGCTTTCCG

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTKAEQLQAVAILVPADFSDHAVRRIDRTFKQVSIERADPALVTDEMRRMVRGIASFAGISAAMMDALPNLELIASFGVG
YDSVDVGHAAAKNIMVTNTPDVLTEEVADTAIGLLINTIRDLPRAENWLRDGSWVRKGNYPLSRLTLRARRVGIFGMGRI
GQAIARRLEAFGLPIAYHNRRRVEGLAYQYHPTLRGLAEAVDTLISVAPGGASTQKAVNAEILSALGANGVFVNIGRGST
VDEAALAAALADGTIAAAGLDVFADEPNVPKALLDAPNASLLPHVGSASEHTRRAMADLCVDNLVSWFTERQPLTPVPET
AHVKARG

Sequences:

>Translated_327_residues
MTKAEQLQAVAILVPADFSDHAVRRIDRTFKQVSIERADPALVTDEMRRMVRGIASFAGISAAMMDALPNLELIASFGVG
YDSVDVGHAAAKNIMVTNTPDVLTEEVADTAIGLLINTIRDLPRAENWLRDGSWVRKGNYPLSRLTLRARRVGIFGMGRI
GQAIARRLEAFGLPIAYHNRRRVEGLAYQYHPTLRGLAEAVDTLISVAPGGASTQKAVNAEILSALGANGVFVNIGRGST
VDEAALAAALADGTIAAAGLDVFADEPNVPKALLDAPNASLLPHVGSASEHTRRAMADLCVDNLVSWFTERQPLTPVPET
AHVKARG
>Mature_326_residues
TKAEQLQAVAILVPADFSDHAVRRIDRTFKQVSIERADPALVTDEMRRMVRGIASFAGISAAMMDALPNLELIASFGVGY
DSVDVGHAAAKNIMVTNTPDVLTEEVADTAIGLLINTIRDLPRAENWLRDGSWVRKGNYPLSRLTLRARRVGIFGMGRIG
QAIARRLEAFGLPIAYHNRRRVEGLAYQYHPTLRGLAEAVDTLISVAPGGASTQKAVNAEILSALGANGVFVNIGRGSTV
DEAALAAALADGTIAAAGLDVFADEPNVPKALLDAPNASLLPHVGSASEHTRRAMADLCVDNLVSWFTERQPLTPVPETA
HVKARG

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=278, Percent_Identity=35.9712230215827, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI23308577, Length=238, Percent_Identity=31.5126050420168, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=30.1158301158301, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=30.1158301158301, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI61743967, Length=259, Percent_Identity=29.3436293436293, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4557497, Length=259, Percent_Identity=29.3436293436293, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=30.1158301158301, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI87082289, Length=257, Percent_Identity=36.1867704280156, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789279, Length=302, Percent_Identity=26.158940397351, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787645, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081824, Length=245, Percent_Identity=25.7142857142857, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=303, Percent_Identity=26.7326732673267, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI25147481, Length=267, Percent_Identity=26.5917602996255, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=280, Percent_Identity=32.8571428571429, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=291, Percent_Identity=27.4914089347079, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=334, Percent_Identity=25.1497005988024, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=35.5704697986577, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=153, Percent_Identity=28.7581699346405, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585516, Length=275, Percent_Identity=32.7272727272727, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45552429, Length=286, Percent_Identity=32.8671328671329, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585514, Length=286, Percent_Identity=32.8671328671329, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574282, Length=286, Percent_Identity=32.8671328671329, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45551003, Length=286, Percent_Identity=32.8671328671329, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574284, Length=286, Percent_Identity=32.8671328671329, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571528, Length=271, Percent_Identity=32.1033210332103, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI28574286, Length=266, Percent_Identity=31.9548872180451, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646446, Length=238, Percent_Identity=32.3529411764706, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646448, Length=238, Percent_Identity=32.3529411764706, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646452, Length=238, Percent_Identity=32.3529411764706, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646450, Length=238, Percent_Identity=32.3529411764706, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI62472511, Length=240, Percent_Identity=32.5, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19921140, Length=233, Percent_Identity=26.6094420600858, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34944; Mature: 34813

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAEQLQAVAILVPADFSDHAVRRIDRTFKQVSIERADPALVTDEMRRMVRGIASFAGI
CCCHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
SAAMMDALPNLELIASFGVGYDSVDVGHAAAKNIMVTNTPDVLTEEVADTAIGLLINTIR
HHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHH
DLPRAENWLRDGSWVRKGNYPLSRLTLRARRVGIFGMGRIGQAIARRLEAFGLPIAYHNR
HCHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCEECCHHHHHHHHHHHHHHCCCEEECCC
RRVEGLAYQYHPTLRGLAEAVDTLISVAPGGASTQKAVNAEILSALGANGVFVNIGRGST
HHHHCCEEEECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCC
VDEAALAAALADGTIAAAGLDVFADEPNVPKALLDAPNASLLPHVGSASEHTRRAMADLC
HHHHHHHHHHHCCCHHHHCCHHCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
VDNLVSWFTERQPLTPVPETAHVKARG
HHHHHHHHHCCCCCCCCCCCCCEECCC
>Mature Secondary Structure 
TKAEQLQAVAILVPADFSDHAVRRIDRTFKQVSIERADPALVTDEMRRMVRGIASFAGI
CCHHHEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
SAAMMDALPNLELIASFGVGYDSVDVGHAAAKNIMVTNTPDVLTEEVADTAIGLLINTIR
HHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHH
DLPRAENWLRDGSWVRKGNYPLSRLTLRARRVGIFGMGRIGQAIARRLEAFGLPIAYHNR
HCHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCEECCHHHHHHHHHHHHHHCCCEEECCC
RRVEGLAYQYHPTLRGLAEAVDTLISVAPGGASTQKAVNAEILSALGANGVFVNIGRGST
HHHHCCEEEECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCC
VDEAALAAALADGTIAAAGLDVFADEPNVPKALLDAPNASLLPHVGSASEHTRRAMADLC
HHHHHHHHHHHCCCHHHHCCHHCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
VDNLVSWFTERQPLTPVPETAHVKARG
HHHHHHHHHCCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA