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The map label for this gene is degP [H]

Identifier: 13474189

GI number: 13474189

Start: 3976371

End: 3977912

Strand: Reverse

Name: degP [H]

Synonym: mll5022

Alternate gene names: 13474189

Gene position: 3977912-3976371 (Counterclockwise)

Preceding gene: 13474190

Following gene: 13474179

Centisome position: 56.54

GC content: 65.63

Gene sequence:

>1542_bases
ATGTCACCTCTTGGTATTCTTCGTAGGCATCGCGTCGCGGCCCTGCTGGGCGCTGCGCTGATCATCTCCCCCGTCGTCGT
CTCGTTCGCCCAGAGCGCGAACAGCACCGGCGTCAGCAAAATTGTCGCGACGACCCAGACCCCGGTTGCCGGCATCACCG
CCCCCAACGGCTCGTTCGCGCCGATCGTGGCGGCCGACAAGCCGGCGGTGGTCACGGTCACCAGCATCATGAAGGGGCAG
CCGGCAAGTGACGACGACGGCATGCCTCTCGGCAACTCGCCGTTCGACCAGTATTTCCGCCAGTTCTTCGGCGACCAGGG
CATGCCCGCTCCGCAGACGCCGCCGCAACAGGCGCAACGGGCCGAAGCGCTCGGTTCCGGCTTCATTGTCACAGCCGACG
GCACCGTCGTCACCAACAATCACGTCGTCGACGGCGCCTCTTCGATCAAGGTGACGCTCGATGACGGCACCGAACTTCCC
GCCAAGCTTGTCGGCCGCGACGCCAAGAACGACCTCGCCGTGCTCAAGATCAAATCCGACAAGCCCTTGCCGACGGTCAA
ATGGGGCGATTCCGACAGGCTGATGACCGGCGATCAGGTGCTGGCGATCGGCAATCCGTTCGGCATCGGCACCACGGTCA
CCGCCGGCATCGTTTCGGCACGCGGCCGCGACCTGCATAGCGGGCCGTTCGACGACTTCATCCAGATCGACGCGCCGATC
AACCACGGCAATTCCGGCGGCCCGCTTGTGGATGTGAACGGCAATGTCGTCGGCATCAACACGGCGATCTATTCGCCCAA
TGGCGGCAGTGTCGGCGTCGGCTTCGCCATCCCGTCGGACCAGGCCCAAAAGGTCGTCGCCAAGCTGATGAAGGACGGTT
CCATCCAGTACGGCTATCTCGGCGTCGAGATCCAAGAGGTGACGCCGGACGTGGCAAGCGCCATCGGGCTCGATCATGCC
GGCGGCGCGCTGGTTTCCAAGGTCAATGACAGCTCGCCCGCCGCCAGCGCCGGCGTCGAGGCCGGCGACGTCATCACCGG
CTTCGCCGGTCAGGACGTGAAAGACCCCAAGGATCTGTCGCGCGCCGTCGCCGATGTCGCACCCGGCGCCAAGGAAACGC
TGGATGTCTGGCGCAAGGGCAAGGCGATGCAGATTTCCGTCGAAGTCGGGCAAAACAGCGACGATGTGAAGACGGCGTCG
GCCGGCGAATCCGGCGCACCGAGCGCCGAGCAGGGCTCGCGTGCGCCGGCGATTGGCCTTGGCCTGATGGACATCACGCC
TGACATTCGCCAGGAAATGAACCTCGCCGGCAATGAGCATGGCGCGGTGGTTGCGCGCGTCAATCCCGACAAGGCGGCCG
CCGCTGCCGGCATTCAGCCGGGCGACATCATCGTCGCCGTCAACCAGGCCCCGGTGAAGAGCGCCAGGCAGGTCACGCAG
GCGATTGCGCAGGCCAGCAAATCGGGCCGCAAGTCGGTGCTGCTTTTGGTCGAACGCGACGGCGGCCAGCTCTATGTCGC
CGTGCCGTTCGCCAATGGCTGA

Upstream 100 bases:

>100_bases
ATGTACGGCGAGACAGGCAATCCGGTCGTCGACACGCCGGCGGGCGCTCCTCCCAAGGTGCCCGCGGCGCCGGATCAACC
CTCGCCCGGACAGAACGACC

Downstream 100 bases:

>100_bases
GCCGCGACGCCGATGACATGAACGTCGAGGTGGCGGGCCTGCCGGTGGCAGGGCCGCCACATTTCCTGGAATTGCCCTAA
AGTTTGCGCAGCGCCACTTC

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSPLGILRRHRVAALLGAALIISPVVVSFAQSANSTGVSKIVATTQTPVAGITAPNGSFAPIVAADKPAVVTVTSIMKGQ
PASDDDGMPLGNSPFDQYFRQFFGDQGMPAPQTPPQQAQRAEALGSGFIVTADGTVVTNNHVVDGASSIKVTLDDGTELP
AKLVGRDAKNDLAVLKIKSDKPLPTVKWGDSDRLMTGDQVLAIGNPFGIGTTVTAGIVSARGRDLHSGPFDDFIQIDAPI
NHGNSGGPLVDVNGNVVGINTAIYSPNGGSVGVGFAIPSDQAQKVVAKLMKDGSIQYGYLGVEIQEVTPDVASAIGLDHA
GGALVSKVNDSSPAASAGVEAGDVITGFAGQDVKDPKDLSRAVADVAPGAKETLDVWRKGKAMQISVEVGQNSDDVKTAS
AGESGAPSAEQGSRAPAIGLGLMDITPDIRQEMNLAGNEHGAVVARVNPDKAAAAAGIQPGDIIVAVNQAPVKSARQVTQ
AIAQASKSGRKSVLLLVERDGGQLYVAVPFANG

Sequences:

>Translated_513_residues
MSPLGILRRHRVAALLGAALIISPVVVSFAQSANSTGVSKIVATTQTPVAGITAPNGSFAPIVAADKPAVVTVTSIMKGQ
PASDDDGMPLGNSPFDQYFRQFFGDQGMPAPQTPPQQAQRAEALGSGFIVTADGTVVTNNHVVDGASSIKVTLDDGTELP
AKLVGRDAKNDLAVLKIKSDKPLPTVKWGDSDRLMTGDQVLAIGNPFGIGTTVTAGIVSARGRDLHSGPFDDFIQIDAPI
NHGNSGGPLVDVNGNVVGINTAIYSPNGGSVGVGFAIPSDQAQKVVAKLMKDGSIQYGYLGVEIQEVTPDVASAIGLDHA
GGALVSKVNDSSPAASAGVEAGDVITGFAGQDVKDPKDLSRAVADVAPGAKETLDVWRKGKAMQISVEVGQNSDDVKTAS
AGESGAPSAEQGSRAPAIGLGLMDITPDIRQEMNLAGNEHGAVVARVNPDKAAAAAGIQPGDIIVAVNQAPVKSARQVTQ
AIAQASKSGRKSVLLLVERDGGQLYVAVPFANG
>Mature_512_residues
SPLGILRRHRVAALLGAALIISPVVVSFAQSANSTGVSKIVATTQTPVAGITAPNGSFAPIVAADKPAVVTVTSIMKGQP
ASDDDGMPLGNSPFDQYFRQFFGDQGMPAPQTPPQQAQRAEALGSGFIVTADGTVVTNNHVVDGASSIKVTLDDGTELPA
KLVGRDAKNDLAVLKIKSDKPLPTVKWGDSDRLMTGDQVLAIGNPFGIGTTVTAGIVSARGRDLHSGPFDDFIQIDAPIN
HGNSGGPLVDVNGNVVGINTAIYSPNGGSVGVGFAIPSDQAQKVVAKLMKDGSIQYGYLGVEIQEVTPDVASAIGLDHAG
GALVSKVNDSSPAASAGVEAGDVITGFAGQDVKDPKDLSRAVADVAPGAKETLDVWRKGKAMQISVEVGQNSDDVKTASA
GESGAPSAEQGSRAPAIGLGLMDITPDIRQEMNLAGNEHGAVVARVNPDKAAAAAGIQPGDIIVAVNQAPVKSARQVTQA
IAQASKSGRKSVLLLVERDGGQLYVAVPFANG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=254, Percent_Identity=37.007874015748, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4506141, Length=253, Percent_Identity=39.1304347826087, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI22129776, Length=263, Percent_Identity=36.1216730038023, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI7019477, Length=255, Percent_Identity=37.6470588235294, Blast_Score=142, Evalue=9e-34,
Organism=Escherichia coli, GI1786356, Length=468, Percent_Identity=37.3931623931624, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1789629, Length=432, Percent_Identity=38.4259259259259, Blast_Score=256, Evalue=4e-69,
Organism=Escherichia coli, GI1789630, Length=272, Percent_Identity=40.0735294117647, Blast_Score=177, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24646839, Length=295, Percent_Identity=32.5423728813559, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 52258; Mature: 52127

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLGILRRHRVAALLGAALIISPVVVSFAQSANSTGVSKIVATTQTPVAGITAPNGSFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCEE
PIVAADKPAVVTVTSIMKGQPASDDDGMPLGNSPFDQYFRQFFGDQGMPAPQTPPQQAQR
EEEECCCCCEEEEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
AEALGSGFIVTADGTVVTNNHVVDGASSIKVTLDDGTELPAKLVGRDAKNDLAVLKIKSD
HHHHCCCEEEEECCEEEECCEEECCCCEEEEEECCCCCCCHHHHCCCCCCCEEEEEECCC
KPLPTVKWGDSDRLMTGDQVLAIGNPFGIGTTVTAGIVSARGRDLHSGPFDDFIQIDAPI
CCCCEEEECCCCCEEECCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
NHGNSGGPLVDVNGNVVGINTAIYSPNGGSVGVGFAIPSDQAQKVVAKLMKDGSIQYGYL
CCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEE
GVEIQEVTPDVASAIGLDHAGGALVSKVNDSSPAASAGVEAGDVITGFAGQDVKDPKDLS
EEEEHHCCCHHHHHHCCCCCCCCEEEECCCCCCCHHCCCCCCCEEECCCCCCCCCHHHHH
RAVADVAPGAKETLDVWRKGKAMQISVEVGQNSDDVKTASAGESGAPSAEQGSRAPAIGL
HHHHHHCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEECCCCCCCCCCCCCCCCCCEEEE
GLMDITPDIRQEMNLAGNEHGAVVARVNPDKAAAAAGIQPGDIIVAVNQAPVKSARQVTQ
EHHHCCHHHHHHHHCCCCCCCEEEEEECCCHHHHHCCCCCCCEEEEECCCCHHHHHHHHH
AIAQASKSGRKSVLLLVERDGGQLYVAVPFANG
HHHHHHCCCCCEEEEEEECCCCEEEEEEECCCC
>Mature Secondary Structure 
SPLGILRRHRVAALLGAALIISPVVVSFAQSANSTGVSKIVATTQTPVAGITAPNGSFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCEE
PIVAADKPAVVTVTSIMKGQPASDDDGMPLGNSPFDQYFRQFFGDQGMPAPQTPPQQAQR
EEEECCCCCEEEEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
AEALGSGFIVTADGTVVTNNHVVDGASSIKVTLDDGTELPAKLVGRDAKNDLAVLKIKSD
HHHHCCCEEEEECCEEEECCEEECCCCEEEEEECCCCCCCHHHHCCCCCCCEEEEEECCC
KPLPTVKWGDSDRLMTGDQVLAIGNPFGIGTTVTAGIVSARGRDLHSGPFDDFIQIDAPI
CCCCEEEECCCCCEEECCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
NHGNSGGPLVDVNGNVVGINTAIYSPNGGSVGVGFAIPSDQAQKVVAKLMKDGSIQYGYL
CCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEE
GVEIQEVTPDVASAIGLDHAGGALVSKVNDSSPAASAGVEAGDVITGFAGQDVKDPKDLS
EEEEHHCCCHHHHHHCCCCCCCCEEEECCCCCCCHHCCCCCCCEEECCCCCCCCCHHHHH
RAVADVAPGAKETLDVWRKGKAMQISVEVGQNSDDVKTASAGESGAPSAEQGSRAPAIGL
HHHHHHCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEECCCCCCCCCCCCCCCCCCEEEE
GLMDITPDIRQEMNLAGNEHGAVVARVNPDKAAAAAGIQPGDIIVAVNQAPVKSARQVTQ
EHHHCCHHHHHHHHCCCCCCCEEEEEECCCHHHHHCCCCCCCEEEEECCCCHHHHHHHHH
AIAQASKSGRKSVLLLVERDGGQLYVAVPFANG
HHHHHHCCCCCEEEEEEECCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]