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The map label for this gene is pncB

Identifier: 13474093

GI number: 13474093

Start: 3886681

End: 3887985

Strand: Reverse

Name: pncB

Synonym: mll4892

Alternate gene names: 13474093

Gene position: 3887985-3886681 (Counterclockwise)

Preceding gene: 13474094

Following gene: 13474092

Centisome position: 55.26

GC content: 62.07

Gene sequence:

>1305_bases
ATGGCAAGAACCGATATAGCGCGGCGTGTCTACAACCACACCTGGAAGCTCGACCCGATCGTGCGCAGCCTGCTCGACAC
GGACTTCTACAAGCTTTTGATGCTGCAGATGATCTGGGGCATGTACCCAAAGGTCGATGCCACCTTCTCGCTGATCAACC
GCACCACCTCGGTGCGGCTTGCCGACGAGATTGACGAGGGCGAACTGCGCGAGCAGCTCGATCATGCCCGCACCTTGCGC
TTCTCCAAGAAGGAGATGATCTGGCTCGGCGGCAACAATTTCTATGGCCGCAAGCAGATCTTCGAACCGGAATTCCTGGC
CTGGCTGGAAGGTTTCCGGCTGCCGGACTACGAGCTGTCCAAGCGTGACGGCCAGTATGAGCTCTCCTTCAGCGGCCCGT
GGATGTACACCACGCTGTGGGAAATCCCGGCGCTCGCCATCATCAACGAACTGCGCTCCCGGGCCGCCATGCGGGCCTTC
GGCCCCTTCGCGCTCGATGTGCTCTATGCCCGCGCCAAGGCCAAGATGTGGGCCAAGACCGAGCGGCTGAAGGCGCTGCC
GGGCATCCGCATTTCCGATTTCGGCACGCGCCGCCGGCATTCCTTCCTGTGGCAGCGCTGGTGCGTCGAAGCGCTGAAGG
AAGGCATAGGCGAGGCGTTCACCGGCACCTCCAACGTGCTGCTTGCGATGGACAACGACCTCGAAGCGCTCGGCACCAAT
GCGCATGAGCTGCCGATGGTGTTTGCAGCCCTTGCCAATTCGGAGAAGGAGCTGAAACAGGCTCCCTACAAGGTGCTGCA
GGACTGGCAGCGCTACTATGGCGGCAACCTCCTGATCGTGCTGCCCGACGCTTTTGGCACCGCCTCCTTCCTGCGCGACG
CGCCGGACTGGGTGGCCGACTGGACCGGATTTCGCCCCGACAGCGCGCCGCCGATCGAGGGCGGCGAAAAGATCCTGTCC
TGGTGGCGCGAGAGGGGCAAGGACCCGAAGCAAAAGCTGCTGATCTTCTCCGACGGTCTCGAAGTGGAAACCATCGAGGA
GACCTACCGCCACTTCAAGGGCAAGGTGCGCATGTCCTTCGGCTGGGGCACCAATCTCACCAATGATTTCGAGGGCTGCG
CGCCGACCGAAACCAACAGCCTCGACGCCATATCGCTGGTCTGCAAGGTGACGGAAGCCAATGGCAGGCCGGCGGTGAAG
CTGTCCGACAATCCCGCCAAGGCGACGGGGGACGAGAAGGAAATCGAGCGGTATCTCAGGATTTTCGGCGAGAAGGACCG
GGTGGAGCAACTGGTCAAGGTGTGA

Upstream 100 bases:

>100_bases
TTTTGTCGGGCCAGCCTGAAAGCGGGCAGCGCTTTGGCCAATTCGATGCTATGAGGCCTGTCGCGATTGTGGATGGCAGG
CAGCGAAGGCGGCAGCAAGC

Downstream 100 bases:

>100_bases
GGTGACCGGTGCTTCCGGCATCGCCATACGAGACGGCAAAGTTGGATAGGCGGAGTTCTACGGCGCCCCCCTCTGTCCTG
CCGGACATCTCCCCCAAGAG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MARTDIARRVYNHTWKLDPIVRSLLDTDFYKLLMLQMIWGMYPKVDATFSLINRTTSVRLADEIDEGELREQLDHARTLR
FSKKEMIWLGGNNFYGRKQIFEPEFLAWLEGFRLPDYELSKRDGQYELSFSGPWMYTTLWEIPALAIINELRSRAAMRAF
GPFALDVLYARAKAKMWAKTERLKALPGIRISDFGTRRRHSFLWQRWCVEALKEGIGEAFTGTSNVLLAMDNDLEALGTN
AHELPMVFAALANSEKELKQAPYKVLQDWQRYYGGNLLIVLPDAFGTASFLRDAPDWVADWTGFRPDSAPPIEGGEKILS
WWRERGKDPKQKLLIFSDGLEVETIEETYRHFKGKVRMSFGWGTNLTNDFEGCAPTETNSLDAISLVCKVTEANGRPAVK
LSDNPAKATGDEKEIERYLRIFGEKDRVEQLVKV

Sequences:

>Translated_434_residues
MARTDIARRVYNHTWKLDPIVRSLLDTDFYKLLMLQMIWGMYPKVDATFSLINRTTSVRLADEIDEGELREQLDHARTLR
FSKKEMIWLGGNNFYGRKQIFEPEFLAWLEGFRLPDYELSKRDGQYELSFSGPWMYTTLWEIPALAIINELRSRAAMRAF
GPFALDVLYARAKAKMWAKTERLKALPGIRISDFGTRRRHSFLWQRWCVEALKEGIGEAFTGTSNVLLAMDNDLEALGTN
AHELPMVFAALANSEKELKQAPYKVLQDWQRYYGGNLLIVLPDAFGTASFLRDAPDWVADWTGFRPDSAPPIEGGEKILS
WWRERGKDPKQKLLIFSDGLEVETIEETYRHFKGKVRMSFGWGTNLTNDFEGCAPTETNSLDAISLVCKVTEANGRPAVK
LSDNPAKATGDEKEIERYLRIFGEKDRVEQLVKV
>Mature_433_residues
ARTDIARRVYNHTWKLDPIVRSLLDTDFYKLLMLQMIWGMYPKVDATFSLINRTTSVRLADEIDEGELREQLDHARTLRF
SKKEMIWLGGNNFYGRKQIFEPEFLAWLEGFRLPDYELSKRDGQYELSFSGPWMYTTLWEIPALAIINELRSRAAMRAFG
PFALDVLYARAKAKMWAKTERLKALPGIRISDFGTRRRHSFLWQRWCVEALKEGIGEAFTGTSNVLLAMDNDLEALGTNA
HELPMVFAALANSEKELKQAPYKVLQDWQRYYGGNLLIVLPDAFGTASFLRDAPDWVADWTGFRPDSAPPIEGGEKILSW
WRERGKDPKQKLLIFSDGLEVETIEETYRHFKGKVRMSFGWGTNLTNDFEGCAPTETNSLDAISLVCKVTEANGRPAVKL
SDNPAKATGDEKEIERYLRIFGEKDRVEQLVKV

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Escherichia coli, GI1787162, Length=406, Percent_Identity=34.7290640394089, Blast_Score=198, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6324783, Length=430, Percent_Identity=31.1627906976744, Blast_Score=165, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB_RHILO (Q98D24)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105661.1
- ProteinModelPortal:   Q98D24
- SMR:   Q98D24
- GeneID:   1228322
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll4892
- NMPDR:   fig|266835.1.peg.3765
- HOGENOM:   HBG325503
- OMA:   GNTFYGK
- ProtClustDB:   PRK05321
- BRENDA:   2.4.2.11
- GO:   GO:0005737
- HAMAP:   MF_00570
- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01514

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 49890; Mature: 49758

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTDIARRVYNHTWKLDPIVRSLLDTDFYKLLMLQMIWGMYPKVDATFSLINRTTSVRL
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEE
ADEIDEGELREQLDHARTLRFSKKEMIWLGGNNFYGRKQIFEPEFLAWLEGFRLPDYELS
CCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHC
KRDGQYELSFSGPWMYTTLWEIPALAIINELRSRAAMRAFGPFALDVLYARAKAKMWAKT
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ERLKALPGIRISDFGTRRRHSFLWQRWCVEALKEGIGEAFTGTSNVLLAMDNDLEALGTN
HHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCHHCCCCCCEEEEECCCHHHHCCC
AHELPMVFAALANSEKELKQAPYKVLQDWQRYYGGNLLIVLPDAFGTASFLRDAPDWVAD
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCHHHHH
WTGFRPDSAPPIEGGEKILSWWRERGKDPKQKLLIFSDGLEVETIEETYRHFKGKVRMSF
CCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHEEEEEECCCCCHHHHHHHHHHCCCEEEEE
GWGTNLTNDFEGCAPTETNSLDAISLVCKVTEANGRPAVKLSDNPAKATGDEKEIERYLR
CCCCCCCCCCCCCCCCCCCCCHHEEHEEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHH
IFGEKDRVEQLVKV
HHCCHHHHHHHHCC
>Mature Secondary Structure 
ARTDIARRVYNHTWKLDPIVRSLLDTDFYKLLMLQMIWGMYPKVDATFSLINRTTSVRL
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEE
ADEIDEGELREQLDHARTLRFSKKEMIWLGGNNFYGRKQIFEPEFLAWLEGFRLPDYELS
CCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHC
KRDGQYELSFSGPWMYTTLWEIPALAIINELRSRAAMRAFGPFALDVLYARAKAKMWAKT
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ERLKALPGIRISDFGTRRRHSFLWQRWCVEALKEGIGEAFTGTSNVLLAMDNDLEALGTN
HHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCHHCCCCCCEEEEECCCHHHHCCC
AHELPMVFAALANSEKELKQAPYKVLQDWQRYYGGNLLIVLPDAFGTASFLRDAPDWVAD
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCHHHHH
WTGFRPDSAPPIEGGEKILSWWRERGKDPKQKLLIFSDGLEVETIEETYRHFKGKVRMSF
CCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHEEEEEECCCCCHHHHHHHHHHCCCEEEEE
GWGTNLTNDFEGCAPTETNSLDAISLVCKVTEANGRPAVKLSDNPAKATGDEKEIERYLR
CCCCCCCCCCCCCCCCCCCCCHHEEHEEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHH
IFGEKDRVEQLVKV
HHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968