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The map label for this gene is ubiE [H]

Identifier: 13474067

GI number: 13474067

Start: 3860578

End: 3861390

Strand: Reverse

Name: ubiE [H]

Synonym: mll4858

Alternate gene names: 13474067

Gene position: 3861390-3860578 (Counterclockwise)

Preceding gene: 13474068

Following gene: 13474065

Centisome position: 54.88

GC content: 63.1

Gene sequence:

>813_bases
ATGTTGGAAGCGGACAAACTGTTTGCCGGCTCGATCCCGGAAAACTACGACCGCTATATGGTGCCGTTGATTTTCGAGCC
GTTCGCCGTGGACCTTGCACGGCGGGCAGCGTCCTTCTCGCCCCAAGCCGTGCTGGAAGTCGCCGCCGGCACCGGGGTCG
TCACCCGCGTCTTGGCGCCAAAACTATCCCCTGACGCAATCTATGTCGTGACCGACCTCAACCAGCCGATGCTCGACTAT
GCCGCTTCGCGACAAGCTCCCGACGCTCGCGTCCATTGGCGCCAGGCCGATGCGCTCGCGCTGCCGTTCGAGGACGCGGC
CTTCGATCTGGTTTGCTGCCAGTTCGGCGCGATGTTCTTTCCCAGCCGTCCATCCGCCTACCGCGAGGCCAGGCGGGTGC
TGAAGCCCGGCGGACATTTCCTGTTCAACGTATGGGACCGCATCGAGGAGAATATCTTCGCCGATGATGTGACCAATGCG
CTGGCCAGGATTTTCCCGAACGATCCGCCGCGCTTTCTCGCCCGCACACCGCATGGCTATCACGATACGGCATTGATCCG
CGGCGAGCTGGAAGAGGCCGGTTTCTCCGATGTGGCGATCGAGACGAGAGCCGAACAAAGCCGTGCCCCTTCGCCGCGCA
TTCCGGCCGTCGCCTATTGCCAGGGAACCGTGCTTCGCACCGAAATCGAGGCCAGGGACCCCGGGAAACTCGACGTGGCA
ACGGACTACGCCGCATCCGCGATTGCGGCCAGACATGGCAGCGGCGCTGTTGCCGCCAAAATCCAGGCACATGTCATCGT
GGCGTTGGCCTAG

Upstream 100 bases:

>100_bases
GCATCGTGGAGGAGCAGTAGCGCCGGCCTCTCGGTCGAAAGCCGCCCAGGACAAGCAATTCTATGCTAGCTTCGCTCACC
ATCAAGGGCGGGCGATAGCG

Downstream 100 bases:

>100_bases
TCGTCGCCTTCGACGACCCGCAGCCTGAGCTGCCCGGTCTTTGAATCGGCAACGCGCGGGCCGGGCTCGAGTTTCGCGGC
CGGCGCCCGTGACGGCGTCT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MLEADKLFAGSIPENYDRYMVPLIFEPFAVDLARRAASFSPQAVLEVAAGTGVVTRVLAPKLSPDAIYVVTDLNQPMLDY
AASRQAPDARVHWRQADALALPFEDAAFDLVCCQFGAMFFPSRPSAYREARRVLKPGGHFLFNVWDRIEENIFADDVTNA
LARIFPNDPPRFLARTPHGYHDTALIRGELEEAGFSDVAIETRAEQSRAPSPRIPAVAYCQGTVLRTEIEARDPGKLDVA
TDYAASAIAARHGSGAVAAKIQAHVIVALA

Sequences:

>Translated_270_residues
MLEADKLFAGSIPENYDRYMVPLIFEPFAVDLARRAASFSPQAVLEVAAGTGVVTRVLAPKLSPDAIYVVTDLNQPMLDY
AASRQAPDARVHWRQADALALPFEDAAFDLVCCQFGAMFFPSRPSAYREARRVLKPGGHFLFNVWDRIEENIFADDVTNA
LARIFPNDPPRFLARTPHGYHDTALIRGELEEAGFSDVAIETRAEQSRAPSPRIPAVAYCQGTVLRTEIEARDPGKLDVA
TDYAASAIAARHGSGAVAAKIQAHVIVALA
>Mature_270_residues
MLEADKLFAGSIPENYDRYMVPLIFEPFAVDLARRAASFSPQAVLEVAAGTGVVTRVLAPKLSPDAIYVVTDLNQPMLDY
AASRQAPDARVHWRQADALALPFEDAAFDLVCCQFGAMFFPSRPSAYREARRVLKPGGHFLFNVWDRIEENIFADDVTNA
LARIFPNDPPRFLARTPHGYHDTALIRGELEEAGFSDVAIETRAEQSRAPSPRIPAVAYCQGTVLRTEIEARDPGKLDVA
TDYAASAIAARHGSGAVAAKIQAHVIVALA

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Escherichia coli, GI48994983, Length=208, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557039, Length=172, Percent_Identity=29.6511627906977, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 29481; Mature: 29481

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEADKLFAGSIPENYDRYMVPLIFEPFAVDLARRAASFSPQAVLEVAAGTGVVTRVLAP
CCCCCCEEECCCCCCCCCEEEEEEECHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHCC
KLSPDAIYVVTDLNQPMLDYAASRQAPDARVHWRQADALALPFEDAAFDLVCCQFGAMFF
CCCCCEEEEEECCCCHHHHHHHCCCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHHCC
PSRPSAYREARRVLKPGGHFLFNVWDRIEENIFADDVTNALARIFPNDPPRFLARTPHGY
CCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
HDTALIRGELEEAGFSDVAIETRAEQSRAPSPRIPAVAYCQGTVLRTEIEARDPGKLDVA
CCCEEEECCHHHCCCCCEEEECCHHHHCCCCCCCCEEEEECCEEEEEEECCCCCCCEEEH
TDYAASAIAARHGSGAVAAKIQAHVIVALA
HHHHHHHHHHHCCCCCEEEEEEEEEEEEEC
>Mature Secondary Structure
MLEADKLFAGSIPENYDRYMVPLIFEPFAVDLARRAASFSPQAVLEVAAGTGVVTRVLAP
CCCCCCEEECCCCCCCCCEEEEEEECHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHCC
KLSPDAIYVVTDLNQPMLDYAASRQAPDARVHWRQADALALPFEDAAFDLVCCQFGAMFF
CCCCCEEEEEECCCCHHHHHHHCCCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHHCC
PSRPSAYREARRVLKPGGHFLFNVWDRIEENIFADDVTNALARIFPNDPPRFLARTPHGY
CCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
HDTALIRGELEEAGFSDVAIETRAEQSRAPSPRIPAVAYCQGTVLRTEIEARDPGKLDVA
CCCEEEECCHHHCCCCCEEEECCHHHHCCCCCCCCEEEEECCEEEEEEECCCCCCCEEEH
TDYAASAIAARHGSGAVAAKIQAHVIVALA
HHHHHHHHHHHCCCCCEEEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA