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The map label for this gene is thiP [H]

Identifier: 13473310

GI number: 13473310

Start: 3101102

End: 3102748

Strand: Reverse

Name: thiP [H]

Synonym: mll3865

Alternate gene names: 13473310

Gene position: 3102748-3101102 (Counterclockwise)

Preceding gene: 13473311

Following gene: 13473309

Centisome position: 44.1

GC content: 67.58

Gene sequence:

>1647_bases
GTGTCGCTATGCGGAGACTGGCGGTCGAGCGTGCGACGCGCTGATCCCCGCGTCAGCGCCGGAATCATTGCGCTCGCCGC
GATCACGCTGCTTATCGGCGGCGCATTCGCGGGCCTGCTTGTCGAAGGCGCTCATAATTTCTCGGGCGCCTGGGCCGCCT
TCGATCCCTATCTGCTGCGCGTCGTGCGCTTCACGCTCTGGCAGGCCATCCTCTCGACCCTGCTTTCGGTCATCCCGGCC
CTGTTCGTCGCACGCGCCCTGTCGCGGCATCCGCGTTTTTTCGGCCGCGCTTTCATCCTGCAGCTCTTCGCCGTGCCGCT
GGCGCTGCCGGCGATCGTCGCGGCGCTCGGCATACTGGCGCTCTATGGCCGTGCCGGTTATTTCGCGGGGCTGTTCAGCG
CCGTCGGCGGCCAGGGCTGGCCAGGCATTTACGGCCTGTCCGGCATTCTCGTGGCCCACGTCTTCTTCAATCTGCCGTTG
GCGACCCGGCTGTTCCTCGAGGCGCTGCAGACGATTCCCGCCGACCAGTGGCGACTGGCGAGCCAGCTCGGCATGGGCGC
GCGGCCGGCCTTCCGGCTGATTGAATGGCCGACTCTGCGCGCCGCTCTGCCGGGTGTCGCCGGGCTGGTCTTCATGCTCT
GCATCACTTCATTCACCATCGTTTTGACGCTTGGCGGCGGGCCGGCGGCGACGACGCTGGAGGTCGGCATCTACCAGGCG
CTGCGCTTCGATTTCGATCCCGCGCGGGCCGTCGCCCTGACATTGCTGCAGATCGCGCTGACCTTCATCGTGGTGCTGGC
GCTGACGCGGCTTGGCGCCAATGTCGTCGGCGACACCAACCTGCCGGTGGCGCCGCGCCGTTATCTCTCGGTCAAAGGAA
CCGAAACCACACTGAACGCAGTGCTCATCGTGCTGGCCCTGCTGTTCGTTGTCGGACCGATGGCCGCGACCGTCTCGGCA
GGCTTGGGCGCCGATCTCGGCCGGCTCGCCGGCGAGGCCACTGTCCGGCAGGCGACGCTGACCAGTGCGGTGCTCGCTTG
CCTGTCGGCGCTGCTTTCGGTGATGTTGTCGCTGGCGCTGACCATGGCGCGACGGGCACTCGCGTTGAACCGCCGCGCCG
GTCCGAGAACACTACTCGAACATGCCACGGATACCGGCGCCGGTTTTGTGCTGGTCGTGCCGCCGATCGTCATCGGCGCC
GGCTGGTTCCTGCTGCTGCGCCATGCCGGCGATGTCTTTGCCATCGCCCCGGTCATGGTCGTCACCGTCAATTCTGTCAT
GGCGATGCCTTTCGCGCTGCGCGCCGTCCGTCCCGCCTATGACGCGGCGAGCGAGCGCCACGAACGGCTCTGCGCGCAGC
TCGGCATTTCGGGCTGGGCCAGGCTGCGGCTGGTCGACTGGCCGTCATTGCGGCGGCCGCTCGCCACCGCCTTCGCCTTC
GCCATGGCGCTGTCGCTCGGCGATCTCGGTGTGATCGCACTGTTCGGCAGTGATTCCGTGCAGACCTTGCCCTACCTTCT
CCTGGCGCGCATGGGCAGCTACCGCACGCAGGACGCCGCCGGCCTGGCGCTGTTGCTTGGCCTCGTTTGCCTCGCCCTGG
TGCTAGCGGCGGACTGGCTGGGAAGAGACAAGGTCCGCAATGTCTGA

Upstream 100 bases:

>100_bases
TATAGGTATGAGCGAGGCGCTGAAACAGCCAATCTCCCCCCTCGTGGGGGAGATGTCCGGCAGGACAGAGGGGGGCGCCA
AGGAACGCAACCCTCTATAA

Downstream 100 bases:

>100_bases
CGGGGCGATGAGAGGGAAGGGTGTTCCGGTGCGGCTGGACAAGGTCTCGTTCAGCTATGGCGAGGCGCCGCTCACCTTCG
ATGTCGCGTTCGCGGCCGCG

Product: thiamine transporter membrane protein

Products: ADP; phosphate; thiamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MSLCGDWRSSVRRADPRVSAGIIALAAITLLIGGAFAGLLVEGAHNFSGAWAAFDPYLLRVVRFTLWQAILSTLLSVIPA
LFVARALSRHPRFFGRAFILQLFAVPLALPAIVAALGILALYGRAGYFAGLFSAVGGQGWPGIYGLSGILVAHVFFNLPL
ATRLFLEALQTIPADQWRLASQLGMGARPAFRLIEWPTLRAALPGVAGLVFMLCITSFTIVLTLGGGPAATTLEVGIYQA
LRFDFDPARAVALTLLQIALTFIVVLALTRLGANVVGDTNLPVAPRRYLSVKGTETTLNAVLIVLALLFVVGPMAATVSA
GLGADLGRLAGEATVRQATLTSAVLACLSALLSVMLSLALTMARRALALNRRAGPRTLLEHATDTGAGFVLVVPPIVIGA
GWFLLLRHAGDVFAIAPVMVVTVNSVMAMPFALRAVRPAYDAASERHERLCAQLGISGWARLRLVDWPSLRRPLATAFAF
AMALSLGDLGVIALFGSDSVQTLPYLLLARMGSYRTQDAAGLALLLGLVCLALVLAADWLGRDKVRNV

Sequences:

>Translated_548_residues
MSLCGDWRSSVRRADPRVSAGIIALAAITLLIGGAFAGLLVEGAHNFSGAWAAFDPYLLRVVRFTLWQAILSTLLSVIPA
LFVARALSRHPRFFGRAFILQLFAVPLALPAIVAALGILALYGRAGYFAGLFSAVGGQGWPGIYGLSGILVAHVFFNLPL
ATRLFLEALQTIPADQWRLASQLGMGARPAFRLIEWPTLRAALPGVAGLVFMLCITSFTIVLTLGGGPAATTLEVGIYQA
LRFDFDPARAVALTLLQIALTFIVVLALTRLGANVVGDTNLPVAPRRYLSVKGTETTLNAVLIVLALLFVVGPMAATVSA
GLGADLGRLAGEATVRQATLTSAVLACLSALLSVMLSLALTMARRALALNRRAGPRTLLEHATDTGAGFVLVVPPIVIGA
GWFLLLRHAGDVFAIAPVMVVTVNSVMAMPFALRAVRPAYDAASERHERLCAQLGISGWARLRLVDWPSLRRPLATAFAF
AMALSLGDLGVIALFGSDSVQTLPYLLLARMGSYRTQDAAGLALLLGLVCLALVLAADWLGRDKVRNV
>Mature_547_residues
SLCGDWRSSVRRADPRVSAGIIALAAITLLIGGAFAGLLVEGAHNFSGAWAAFDPYLLRVVRFTLWQAILSTLLSVIPAL
FVARALSRHPRFFGRAFILQLFAVPLALPAIVAALGILALYGRAGYFAGLFSAVGGQGWPGIYGLSGILVAHVFFNLPLA
TRLFLEALQTIPADQWRLASQLGMGARPAFRLIEWPTLRAALPGVAGLVFMLCITSFTIVLTLGGGPAATTLEVGIYQAL
RFDFDPARAVALTLLQIALTFIVVLALTRLGANVVGDTNLPVAPRRYLSVKGTETTLNAVLIVLALLFVVGPMAATVSAG
LGADLGRLAGEATVRQATLTSAVLACLSALLSVMLSLALTMARRALALNRRAGPRTLLEHATDTGAGFVLVVPPIVIGAG
WFLLLRHAGDVFAIAPVMVVTVNSVMAMPFALRAVRPAYDAASERHERLCAQLGISGWARLRLVDWPSLRRPLATAFAFA
MALSLGDLGVIALFGSDSVQTLPYLLLARMGSYRTQDAAGLALLLGLVCLALVLAADWLGRDKVRNV

Specific function: Part of the ABC transporter complex thiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG1178

COG function: function code P; ABC-type Fe3+ transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transmembrane type-1 domains [H]

Homologues:

Organism=Escherichia coli, GI1786254, Length=466, Percent_Identity=45.2789699570815, Blast_Score=344, Evalue=7e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515
- InterPro:   IPR005947 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 57975; Mature: 57843

Theoretical pI: Translated: 11.09; Mature: 11.09

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLCGDWRSSVRRADPRVSAGIIALAAITLLIGGAFAGLLVEGAHNFSGAWAAFDPYLLR
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VVRFTLWQAILSTLLSVIPALFVARALSRHPRFFGRAFILQLFAVPLALPAIVAALGILA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGRAGYFAGLFSAVGGQGWPGIYGLSGILVAHVFFNLPLATRLFLEALQTIPADQWRLA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHH
SQLGMGARPAFRLIEWPTLRAALPGVAGLVFMLCITSFTIVLTLGGGPAATTLEVGIYQA
HHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHH
LRFDFDPARAVALTLLQIALTFIVVLALTRLGANVVGDTNLPVAPRRYLSVKGTETTLNA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEECCCHHHHHH
VLIVLALLFVVGPMAATVSAGLGADLGRLAGEATVRQATLTSAVLACLSALLSVMLSLAL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMARRALALNRRAGPRTLLEHATDTGAGFVLVVPPIVIGAGWFLLLRHAGDVFAIAPVMV
HHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VTVNSVMAMPFALRAVRPAYDAASERHERLCAQLGISGWARLRLVDWPSLRRPLATAFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHH
AMALSLGDLGVIALFGSDSVQTLPYLLLARMGSYRTQDAAGLALLLGLVCLALVLAADWL
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GRDKVRNV
CCHHHCCC
>Mature Secondary Structure 
SLCGDWRSSVRRADPRVSAGIIALAAITLLIGGAFAGLLVEGAHNFSGAWAAFDPYLLR
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VVRFTLWQAILSTLLSVIPALFVARALSRHPRFFGRAFILQLFAVPLALPAIVAALGILA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGRAGYFAGLFSAVGGQGWPGIYGLSGILVAHVFFNLPLATRLFLEALQTIPADQWRLA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHH
SQLGMGARPAFRLIEWPTLRAALPGVAGLVFMLCITSFTIVLTLGGGPAATTLEVGIYQA
HHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHH
LRFDFDPARAVALTLLQIALTFIVVLALTRLGANVVGDTNLPVAPRRYLSVKGTETTLNA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEECCCHHHHHH
VLIVLALLFVVGPMAATVSAGLGADLGRLAGEATVRQATLTSAVLACLSALLSVMLSLAL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMARRALALNRRAGPRTLLEHATDTGAGFVLVVPPIVIGAGWFLLLRHAGDVFAIAPVMV
HHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VTVNSVMAMPFALRAVRPAYDAASERHERLCAQLGISGWARLRLVDWPSLRRPLATAFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHH
AMALSLGDLGVIALFGSDSVQTLPYLLLARMGSYRTQDAAGLALLLGLVCLALVLAADWL
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GRDKVRNV
CCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; thiamine [Periplasm]; H2O [C]

Specific reaction: ATP + thiamine [Periplasm] + H2O = ADP + phosphate + thiamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA