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The map label for this gene is lysA [H]

Identifier: 13473029

GI number: 13473029

Start: 2831619

End: 2832887

Strand: Direct

Name: lysA [H]

Synonym: mlr3508

Alternate gene names: 13473029

Gene position: 2831619-2832887 (Clockwise)

Preceding gene: 13473028

Following gene: 13473031

Centisome position: 40.24

GC content: 65.01

Gene sequence:

>1269_bases
GTGAACCATTTCGACTACCGCGACGGCGTGCTGCATGCCGAGGACGTGGCAATCCCTGATATCGCCGCTCAGGTCGGCAC
GCCGTTCTACTGCTATTCGACGGCCACGCTGACCAGGCACTACCGTGTGTTTGCACAGGCCTTTGCCGGCCTCGACGCGC
TGGTCTGCTACGCCATGAAGGCCAACTCCAACCAGGCCGTGCTGCGCACCCTGGCCAGGCTCGGCGCCGGCGCCGACGTG
GTCTCGGAAGGCGAGTTGCGCCGAGCGCTGGCGGCCGGCATCCCGGCCAGCAAGATCCTGTTTTCCGGCGTCGGCAAGAC
CGCCCGCGAAATTGACCTCGCGCTCGAAGCGGGCATCCTTTGCTTCAACGTCGAATCCGAGCCGGAGCTTGAACTGTTGT
CGGCCCGCGCCGTGGCACTCGGCAAGGTGGCGCCGATCTCGCTACGCATCAATCCCGATGTCGACGCCAAGACCCACAAG
AAGATCTCCACGGGCAAGGCCGAGAACAAGTTCGGCATTGCATGGCAGCGCGCGCGGCAGGTCTATGCCCGCGCGGCGAC
GCTTCCGGGCATCAAGGTCACCGGCATCGACACCCATATCGGCAGCCAGATCACCGAGCTGCAGCCCTTTGACGACGCCT
TCGCCCTTTTGGTCGATCTGGTCGGCGCGCTGCGCGCCGATGGCCACGCCATCGAGCATGTCGATCTCGGCGGTGGCCTC
GGTATTCCCTACCGCGTCGACAACAACCCGCCGCCCTTGCCCGACGCCTATGCCCAGATCGTCAGGAAGCATGTCACCAA
GCTCGGTCTCAAGGTGATGTTCGAGCCAGGACGCCTGATCGTTGGCAATGCCGGCATCCTCGTCTCGGAAGTGATCTTCG
TGAAGGAAGGCGACGCCAAGAATTTCCTGGTTGTCGACGCCGCCATGAACGATCTGATCCGGCCGACGCTTTACGACGCC
TTCCACGACATCAGGCCCGTCGTGCAGCCGCCGGCCGACACGCCGCGCATGATGGTCGACGTGGTCGGCCAGGTCTGCGA
GACCGGTGACTATCTCGGCCTCGACCGCGACCTGCCGAGGCTGAAGGCCGGCGATCTCGTTGCCGTTTCCACAGCCGGTG
CCTACGGTGCCGTGCAGGCCGGCACCTACAACACCCGCCTGCTGGTGCCGGAGGTGCTGGTCGACGGCGACCGTTTCCAC
ATCGTGCGCCCGCGCCTGACCTATGACGATCTGATCGGGCTGGATTCGGTGCCCGACTGGCTGGCATAG

Upstream 100 bases:

>100_bases
GACAAGAAGTTCATCCTCGACCCGCTGATCTAGAACCGATCAGGCCGGGTTTGGCCTCCAAGCCCGATCTCATCGTGCTC
CAACTTCCGGAATCACTCTC

Downstream 100 bases:

>100_bases
AAGCCGCCCGCCGGCAGCCTACAGCCGGTTCTGGAGGAGCGTTCTTGTCTCGGCAATCCCGTCTTCGTCGCGGCGGTAGA
ACGTCCATTGCTTGATGCGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MNHFDYRDGVLHAEDVAIPDIAAQVGTPFYCYSTATLTRHYRVFAQAFAGLDALVCYAMKANSNQAVLRTLARLGAGADV
VSEGELRRALAAGIPASKILFSGVGKTAREIDLALEAGILCFNVESEPELELLSARAVALGKVAPISLRINPDVDAKTHK
KISTGKAENKFGIAWQRARQVYARAATLPGIKVTGIDTHIGSQITELQPFDDAFALLVDLVGALRADGHAIEHVDLGGGL
GIPYRVDNNPPPLPDAYAQIVRKHVTKLGLKVMFEPGRLIVGNAGILVSEVIFVKEGDAKNFLVVDAAMNDLIRPTLYDA
FHDIRPVVQPPADTPRMMVDVVGQVCETGDYLGLDRDLPRLKAGDLVAVSTAGAYGAVQAGTYNTRLLVPEVLVDGDRFH
IVRPRLTYDDLIGLDSVPDWLA

Sequences:

>Translated_422_residues
MNHFDYRDGVLHAEDVAIPDIAAQVGTPFYCYSTATLTRHYRVFAQAFAGLDALVCYAMKANSNQAVLRTLARLGAGADV
VSEGELRRALAAGIPASKILFSGVGKTAREIDLALEAGILCFNVESEPELELLSARAVALGKVAPISLRINPDVDAKTHK
KISTGKAENKFGIAWQRARQVYARAATLPGIKVTGIDTHIGSQITELQPFDDAFALLVDLVGALRADGHAIEHVDLGGGL
GIPYRVDNNPPPLPDAYAQIVRKHVTKLGLKVMFEPGRLIVGNAGILVSEVIFVKEGDAKNFLVVDAAMNDLIRPTLYDA
FHDIRPVVQPPADTPRMMVDVVGQVCETGDYLGLDRDLPRLKAGDLVAVSTAGAYGAVQAGTYNTRLLVPEVLVDGDRFH
IVRPRLTYDDLIGLDSVPDWLA
>Mature_422_residues
MNHFDYRDGVLHAEDVAIPDIAAQVGTPFYCYSTATLTRHYRVFAQAFAGLDALVCYAMKANSNQAVLRTLARLGAGADV
VSEGELRRALAAGIPASKILFSGVGKTAREIDLALEAGILCFNVESEPELELLSARAVALGKVAPISLRINPDVDAKTHK
KISTGKAENKFGIAWQRARQVYARAATLPGIKVTGIDTHIGSQITELQPFDDAFALLVDLVGALRADGHAIEHVDLGGGL
GIPYRVDNNPPPLPDAYAQIVRKHVTKLGLKVMFEPGRLIVGNAGILVSEVIFVKEGDAKNFLVVDAAMNDLIRPTLYDA
FHDIRPVVQPPADTPRMMVDVVGQVCETGDYLGLDRDLPRLKAGDLVAVSTAGAYGAVQAGTYNTRLLVPEVLVDGDRFH
IVRPRLTYDDLIGLDSVPDWLA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=353, Percent_Identity=27.4787535410765, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI16506287, Length=342, Percent_Identity=26.0233918128655, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1789203, Length=418, Percent_Identity=31.1004784688995, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17562780, Length=345, Percent_Identity=24.3478260869565, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24586472, Length=346, Percent_Identity=26.878612716763, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24586474, Length=357, Percent_Identity=25.2100840336134, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45436; Mature: 45436

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFDYRDGVLHAEDVAIPDIAAQVGTPFYCYSTATLTRHYRVFAQAFAGLDALVCYAMK
CCCCCCCCCCEECCCCCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCHHHHHHHHHC
ANSNQAVLRTLARLGAGADVVSEGELRRALAAGIPASKILFSGVGKTAREIDLALEAGIL
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCEE
CFNVESEPELELLSARAVALGKVAPISLRINPDVDAKTHKKISTGKAENKFGIAWQRARQ
EEECCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCHHHCCCCCCCCCCCCCHHHHHHHH
VYARAATLPGIKVTGIDTHIGSQITELQPFDDAFALLVDLVGALRADGHAIEHVDLGGGL
HHHHHHCCCCEEEEECCHHHCCHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GIPYRVDNNPPPLPDAYAQIVRKHVTKLGLKVMFEPGRLIVGNAGILVSEVIFVKEGDAK
CCCEEECCCCCCCCHHHHHHHHHHHHHHCEEEEECCCEEEEECCCEEEEEEEEEECCCCC
NFLVVDAAMNDLIRPTLYDAFHDIRPVVQPPADTPRMMVDVVGQVCETGDYLGLDRDLPR
CEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
LKAGDLVAVSTAGAYGAVQAGTYNTRLLVPEVLVDGDRFHIVRPRLTYDDLIGLDSVPDW
CCCCCEEEEECCCCCCCEECCCCCCEEEEHHHHCCCCEEEEECCCCCHHHHCCCCCCCHH
LA
CC
>Mature Secondary Structure
MNHFDYRDGVLHAEDVAIPDIAAQVGTPFYCYSTATLTRHYRVFAQAFAGLDALVCYAMK
CCCCCCCCCCEECCCCCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCHHHHHHHHHC
ANSNQAVLRTLARLGAGADVVSEGELRRALAAGIPASKILFSGVGKTAREIDLALEAGIL
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCEE
CFNVESEPELELLSARAVALGKVAPISLRINPDVDAKTHKKISTGKAENKFGIAWQRARQ
EEECCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCHHHCCCCCCCCCCCCCHHHHHHHH
VYARAATLPGIKVTGIDTHIGSQITELQPFDDAFALLVDLVGALRADGHAIEHVDLGGGL
HHHHHHCCCCEEEEECCHHHCCHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GIPYRVDNNPPPLPDAYAQIVRKHVTKLGLKVMFEPGRLIVGNAGILVSEVIFVKEGDAK
CCCEEECCCCCCCCHHHHHHHHHHHHHHCEEEEECCCEEEEECCCEEEEEEEEEECCCCC
NFLVVDAAMNDLIRPTLYDAFHDIRPVVQPPADTPRMMVDVVGQVCETGDYLGLDRDLPR
CEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
LKAGDLVAVSTAGAYGAVQAGTYNTRLLVPEVLVDGDRFHIVRPRLTYDDLIGLDSVPDW
CCCCCEEEEECCCCCCCEECCCCCCEEEEHHHHCCCCEEEEECCCCCHHHHCCCCCCCHH
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]