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The map label for this gene is capA [H]

Identifier: 13472874

GI number: 13472874

Start: 2658794

End: 2660479

Strand: Direct

Name: capA [H]

Synonym: mlr3304

Alternate gene names: 13472874

Gene position: 2658794-2660479 (Clockwise)

Preceding gene: 13472873

Following gene: 13472877

Centisome position: 37.79

GC content: 63.76

Gene sequence:

>1686_bases
GTGATAGCCCGCCTGCTGACGGTCATCATCTTCTCCCTGGTTCTCGGCGGCACGGCACAGGCCGCCCCGATCGTCTGCCC
ACCCGGCACCGAAAACTTTCCACCCTTCTACGACGACGCCACGCTGTTCAGGGACGCCATCGCCAGCGTCGCCACTATCC
CGCCCTCCAACCAGCGGCTGACCGGCATCACCGTGCCACATCACTTGCTGGCCGCCGACCTCGTGGCGCTGGGTTTTCAT
GCCGTCTCCGGCTTTCGTTACAAGCGCATCGTCATCCTATCGCCGGATCATTTCCACAAGACGCACAAGCTCTACGCCAC
CACGGCGCGCGGCTTCGACACCGTGCTTGGTCCGGTGGCCGCCGACAGCGATGCCGTGCGCCTGCTGGAAGCACACGGCG
ACATGGTCGAGGAATCCTGTCTGTTCGATAAGGAACATGGCGTGCGCGCCATGCTGCCCTTCCTGCACCACTATTTCCCC
GAAGCGAAGATCGTGCCGGTGGCGATGTCGGTGAAGGCGAAGCGCGGCGACTGGGACAGGCTGGCCGAAGCGCTGAAACC
GATTGTCGACCAGGACACGCTGATCGTCGAATCCACCGACTTCTCGCACTATCTGCCCCAGCACGATTCCAGGCGTTTCG
ACCAGCAGACGCTGAACATGCTGGCCGCCGGATCGCTCGACGGCATCGCGGCGCTTCGCCAGCCCGATCATGCCGATTCC
GTCGGCGCGCTCTACATCCAGACCAAGCTGCAGCGCGAATTGTTCGGCGCCCAGCCACTGGTCGTCGCCAACGAGAACTC
GCAGGAACACACGTCCGACTATGTCGAGCGCACCACCAGCTATGTCGTGGCGCTGTTCGGCGCCTTCGGTCCCGGTTTCA
ACAACCCCGCGCTGCCAAAGGACAAGATCTACTATCTCGCCGGTGACGTGAATTTCGGCCGCGCCATGAAGAAGATCCTG
GTCCGCGACGACGTTGCCGACAAGATCGTCGACAGCATACTGGCACTGACCGGAGCGCGACCGCTGATCGTCAATCTCGA
AGGCGTCATCCTGCCCAACGTGCCGGAAGCGATCGACGACATGACGCTGGCCATGCCGGAAGACCTCGCCGCCAGCATGC
TGAAGCGGCTGCACGTCGCCGGCGTCAGCCTCGCCAACAATCACGCCCATGATCTCGGCCCCTCCGGCTATGCCGAGACG
CTGCGCGCGCTGGACGGAGCCGGCATCCCGCATTTCGGCCAGGGTGAGACGCTGGCGCTGGCCGGCCTCGACCTTGTCGG
CCTGACCGACATCGACACCAACGGTTCGAAGAACACCGACCTGCTCACCCCTGCCTTGCTCGACCGCCTGCTGCACGAGA
ATGCGCAGCGACCGGTGGTGGCCTTCGCCCATTGGGGCCGCGAATACAAGACCGAACCGTCGGCGCGCGAAGAGATGCTT
GCTGATGAGATGCGGCTGCGCGGCGTCTCGGTCATTGTCGGCGGCCATCCGCATGTCTCGAGTGAGGCGATCGTCCCGCT
CGCCGGCGGCGATGTGGCGGAGGTCTACTCGCTCGGCAATTTCCTGTTCGACCAGAGTGCGCAACGCTCCTCGGGTTCGA
TGGTGGAACTGCGCGTCTTCGCCCAGGGCACGATCTTTGTCAGGCTCATTCCGCTTCCCAACTATTTCGAGATGGGCCGA
AAGTAG

Upstream 100 bases:

>100_bases
TCGCCGATTTCATCTCACACGAAGTGGTGCGGCTGACTGCGTCGAAGCAGAAGCCGTTCTACTATGTCGGCGGCGTGGAG
AACATCGTGTTGGCCGAGCC

Downstream 100 bases:

>100_bases
GCACTCCCCAGGGTGTCGAGATTCGGGTCAGGCCCAGCCGAGAATGGTGGTCTCCGGGGTCGCTCTTGCGACGAGCGGAG
CGTACTTTTGGGTACGTGAG

Product: encapsulation protein CapA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MIARLLTVIIFSLVLGGTAQAAPIVCPPGTENFPPFYDDATLFRDAIASVATIPPSNQRLTGITVPHHLLAADLVALGFH
AVSGFRYKRIVILSPDHFHKTHKLYATTARGFDTVLGPVAADSDAVRLLEAHGDMVEESCLFDKEHGVRAMLPFLHHYFP
EAKIVPVAMSVKAKRGDWDRLAEALKPIVDQDTLIVESTDFSHYLPQHDSRRFDQQTLNMLAAGSLDGIAALRQPDHADS
VGALYIQTKLQRELFGAQPLVVANENSQEHTSDYVERTTSYVVALFGAFGPGFNNPALPKDKIYYLAGDVNFGRAMKKIL
VRDDVADKIVDSILALTGARPLIVNLEGVILPNVPEAIDDMTLAMPEDLAASMLKRLHVAGVSLANNHAHDLGPSGYAET
LRALDGAGIPHFGQGETLALAGLDLVGLTDIDTNGSKNTDLLTPALLDRLLHENAQRPVVAFAHWGREYKTEPSAREEML
ADEMRLRGVSVIVGGHPHVSSEAIVPLAGGDVAEVYSLGNFLFDQSAQRSSGSMVELRVFAQGTIFVRLIPLPNYFEMGR
K

Sequences:

>Translated_561_residues
MIARLLTVIIFSLVLGGTAQAAPIVCPPGTENFPPFYDDATLFRDAIASVATIPPSNQRLTGITVPHHLLAADLVALGFH
AVSGFRYKRIVILSPDHFHKTHKLYATTARGFDTVLGPVAADSDAVRLLEAHGDMVEESCLFDKEHGVRAMLPFLHHYFP
EAKIVPVAMSVKAKRGDWDRLAEALKPIVDQDTLIVESTDFSHYLPQHDSRRFDQQTLNMLAAGSLDGIAALRQPDHADS
VGALYIQTKLQRELFGAQPLVVANENSQEHTSDYVERTTSYVVALFGAFGPGFNNPALPKDKIYYLAGDVNFGRAMKKIL
VRDDVADKIVDSILALTGARPLIVNLEGVILPNVPEAIDDMTLAMPEDLAASMLKRLHVAGVSLANNHAHDLGPSGYAET
LRALDGAGIPHFGQGETLALAGLDLVGLTDIDTNGSKNTDLLTPALLDRLLHENAQRPVVAFAHWGREYKTEPSAREEML
ADEMRLRGVSVIVGGHPHVSSEAIVPLAGGDVAEVYSLGNFLFDQSAQRSSGSMVELRVFAQGTIFVRLIPLPNYFEMGR
K
>Mature_561_residues
MIARLLTVIIFSLVLGGTAQAAPIVCPPGTENFPPFYDDATLFRDAIASVATIPPSNQRLTGITVPHHLLAADLVALGFH
AVSGFRYKRIVILSPDHFHKTHKLYATTARGFDTVLGPVAADSDAVRLLEAHGDMVEESCLFDKEHGVRAMLPFLHHYFP
EAKIVPVAMSVKAKRGDWDRLAEALKPIVDQDTLIVESTDFSHYLPQHDSRRFDQQTLNMLAAGSLDGIAALRQPDHADS
VGALYIQTKLQRELFGAQPLVVANENSQEHTSDYVERTTSYVVALFGAFGPGFNNPALPKDKIYYLAGDVNFGRAMKKIL
VRDDVADKIVDSILALTGARPLIVNLEGVILPNVPEAIDDMTLAMPEDLAASMLKRLHVAGVSLANNHAHDLGPSGYAET
LRALDGAGIPHFGQGETLALAGLDLVGLTDIDTNGSKNTDLLTPALLDRLLHENAQRPVVAFAHWGREYKTEPSAREEML
ADEMRLRGVSVIVGGHPHVSSEAIVPLAGGDVAEVYSLGNFLFDQSAQRSSGSMVELRVFAQGTIFVRLIPLPNYFEMGR
K

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 60962; Mature: 60962

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARLLTVIIFSLVLGGTAQAAPIVCPPGTENFPPFYDDATLFRDAIASVATIPPSNQRL
CHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEE
TGITVPHHLLAADLVALGFHAVSGFRYKRIVILSPDHFHKTHKLYATTARGFDTVLGPVA
EEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHEEEECCCCHHHHHCCCC
ADSDAVRLLEAHGDMVEESCLFDKEHGVRAMLPFLHHYFPEAKIVPVAMSVKAKRGDWDR
CCCHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHH
LAEALKPIVDQDTLIVESTDFSHYLPQHDSRRFDQQTLNMLAAGSLDGIAALRQPDHADS
HHHHHHHHCCCCEEEEECCCCHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCC
VGALYIQTKLQRELFGAQPLVVANENSQEHTSDYVERTTSYVVALFGAFGPGFNNPALPK
CCEEEHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DKIYYLAGDVNFGRAMKKILVRDDVADKIVDSILALTGARPLIVNLEGVILPNVPEAIDD
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEECCCCCHHHHH
MTLAMPEDLAASMLKRLHVAGVSLANNHAHDLGPSGYAETLRALDGAGIPHFGQGETLAL
HHHCCCHHHHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEE
AGLDLVGLTDIDTNGSKNTDLLTPALLDRLLHENAQRPVVAFAHWGREYKTEPSAREEML
ECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHH
ADEMRLRGVSVIVGGHPHVSSEAIVPLAGGDVAEVYSLGNFLFDQSAQRSSGSMVELRVF
HHHHHHCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
AQGTIFVRLIPLPNYFEMGRK
ECCEEEEEEECCCCHHHCCCC
>Mature Secondary Structure
MIARLLTVIIFSLVLGGTAQAAPIVCPPGTENFPPFYDDATLFRDAIASVATIPPSNQRL
CHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEE
TGITVPHHLLAADLVALGFHAVSGFRYKRIVILSPDHFHKTHKLYATTARGFDTVLGPVA
EEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHEEEECCCCHHHHHCCCC
ADSDAVRLLEAHGDMVEESCLFDKEHGVRAMLPFLHHYFPEAKIVPVAMSVKAKRGDWDR
CCCHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHH
LAEALKPIVDQDTLIVESTDFSHYLPQHDSRRFDQQTLNMLAAGSLDGIAALRQPDHADS
HHHHHHHHCCCCEEEEECCCCHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCC
VGALYIQTKLQRELFGAQPLVVANENSQEHTSDYVERTTSYVVALFGAFGPGFNNPALPK
CCEEEHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DKIYYLAGDVNFGRAMKKILVRDDVADKIVDSILALTGARPLIVNLEGVILPNVPEAIDD
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEECCCCCHHHHH
MTLAMPEDLAASMLKRLHVAGVSLANNHAHDLGPSGYAETLRALDGAGIPHFGQGETLAL
HHHCCCHHHHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEE
AGLDLVGLTDIDTNGSKNTDLLTPALLDRLLHENAQRPVVAFAHWGREYKTEPSAREEML
ECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHH
ADEMRLRGVSVIVGGHPHVSSEAIVPLAGGDVAEVYSLGNFLFDQSAQRSSGSMVELRVF
HHHHHHCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
AQGTIFVRLIPLPNYFEMGRK
ECCEEEEEEECCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]