| Definition | Mesorhizobium loti MAFF303099 chromosome, complete genome. |
|---|---|
| Accession | NC_002678 |
| Length | 7,036,071 |
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The map label for this gene is fixR [H]
Identifier: 13472822
GI number: 13472822
Start: 2588527
End: 2589279
Strand: Reverse
Name: fixR [H]
Synonym: mll3237
Alternate gene names: 13472822
Gene position: 2589279-2588527 (Counterclockwise)
Preceding gene: 13472823
Following gene: 13472820
Centisome position: 36.8
GC content: 63.48
Gene sequence:
>753_bases ATGGCTGAATTCGACACCAGAAAAACCATCGTGCTGACCGGCGCCAGCCGCGGCATCGGCCATGCCACGGTCAAACGCTT TTCGCGCGAGGGCTGGCGCGTCATCACCTGTTCGCGCCAGGCCTTTGCCGAGGATTGCCCGTGGCCGGCCGGGCCGGAAG ACCACATCAAGGTCGATCTTGCCGATCAGGAAGATGTCGGCATCGCCGTCTCGGAAATCCGCCATCGGCTGGAAGCGCAT GGCGGCCAGCTCAATGCACTGGTCAACAATGCCGGCATTTCGCCCAAGCTCAAGGACGGCAACAGCCGCATGAACTCGAT CGACACGCCGATGCATGTCTGGCGCGACGTGTTCCAGGTCAATTTCTTCGCGCCGATCATGCTGGCGCGCGGCCTGTTCA AGGAACTGGCGACGGCCAAGGGCTCGATCGTCAACGTCACCTCGATCGCCGGCACCCGCGTGCATCCCTTCGCCGGCACC GCCTATGCGACATCGAAAGCGGCTCTCGGCTCGCTGACGCGCGAGATGGCGCATGATTTCGGCCCGCACGGCATTCGTGT GAACGCCATCGCGCCTGGCGAGATCGACACGGCGATCCTGTCGCCGGGCACGGAAAAGATCGTCGAGACGATCCCGCTCA GGCGCCTCGGCACCACGGCGGAGGTCGCCGACATCATCTTCTTCCTGTGCTCGCAGCAGGCCTCCTATGTGACCGGCTCG GAAATCCATATCAATGGCGGCCAGCACGTGTGA
Upstream 100 bases:
>100_bases CGGCGGCTGAAGGCTGTCGCCCCGGCGGTTCGCAGCGGCGTCAATCCGCCTCTCGCCAGCGCCACGCTGTTCGGCTACAC CTCCGGCCGGAGACCGCGAC
Downstream 100 bases:
>100_bases GCAAGCCGACTTCGGCCGGGATTGCTCATCCGGCCATGGTGAGAACAGCCTTGCCGCTGAAGCTGCGCTGCCGCAGTGCG TCCAGAGCCTGGGCGATATC
Product: short-chain dehydrogenase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 250; Mature: 249
Protein sequence:
>250_residues MAEFDTRKTIVLTGASRGIGHATVKRFSREGWRVITCSRQAFAEDCPWPAGPEDHIKVDLADQEDVGIAVSEIRHRLEAH GGQLNALVNNAGISPKLKDGNSRMNSIDTPMHVWRDVFQVNFFAPIMLARGLFKELATAKGSIVNVTSIAGTRVHPFAGT AYATSKAALGSLTREMAHDFGPHGIRVNAIAPGEIDTAILSPGTEKIVETIPLRRLGTTAEVADIIFFLCSQQASYVTGS EIHINGGQHV
Sequences:
>Translated_250_residues MAEFDTRKTIVLTGASRGIGHATVKRFSREGWRVITCSRQAFAEDCPWPAGPEDHIKVDLADQEDVGIAVSEIRHRLEAH GGQLNALVNNAGISPKLKDGNSRMNSIDTPMHVWRDVFQVNFFAPIMLARGLFKELATAKGSIVNVTSIAGTRVHPFAGT AYATSKAALGSLTREMAHDFGPHGIRVNAIAPGEIDTAILSPGTEKIVETIPLRRLGTTAEVADIIFFLCSQQASYVTGS EIHINGGQHV >Mature_249_residues AEFDTRKTIVLTGASRGIGHATVKRFSREGWRVITCSRQAFAEDCPWPAGPEDHIKVDLADQEDVGIAVSEIRHRLEAHG GQLNALVNNAGISPKLKDGNSRMNSIDTPMHVWRDVFQVNFFAPIMLARGLFKELATAKGSIVNVTSIAGTRVHPFAGTA YATSKAALGSLTREMAHDFGPHGIRVNAIAPGEIDTAILSPGTEKIVETIPLRRLGTTAEVADIIFFLCSQQASYVTGSE IHINGGQHV
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=261, Percent_Identity=30.6513409961686, Blast_Score=108, Evalue=4e-24, Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=29.3436293436293, Blast_Score=101, Evalue=6e-22, Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=30.9236947791165, Blast_Score=94, Evalue=8e-20, Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=30.5555555555556, Blast_Score=94, Evalue=9e-20, Organism=Homo sapiens, GI59889578, Length=242, Percent_Identity=27.6859504132231, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI7705925, Length=262, Percent_Identity=30.5343511450382, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI33667109, Length=204, Percent_Identity=28.4313725490196, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=26.8199233716475, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI126723750, Length=260, Percent_Identity=25.7692307692308, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI109715829, Length=243, Percent_Identity=27.5720164609054, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI66933014, Length=259, Percent_Identity=27.7992277992278, Blast_Score=74, Evalue=9e-14, Organism=Homo sapiens, GI10190704, Length=267, Percent_Identity=27.7153558052434, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI4503301, Length=224, Percent_Identity=29.0178571428571, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI20149619, Length=200, Percent_Identity=29.5, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI119392083, Length=196, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=8e-13, Organism=Homo sapiens, GI4758504, Length=257, Percent_Identity=25.6809338521401, Blast_Score=65, Evalue=6e-11, Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=29.4820717131474, Blast_Score=104, Evalue=6e-24, Organism=Escherichia coli, GI1788459, Length=203, Percent_Identity=33.4975369458128, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=31.6205533596838, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=30.188679245283, Blast_Score=94, Evalue=9e-21, Organism=Escherichia coli, GI2367365, Length=245, Percent_Identity=31.8367346938775, Blast_Score=92, Evalue=2e-20, Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=31.3492063492063, Blast_Score=89, Evalue=2e-19, Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=31.5175097276265, Blast_Score=87, Evalue=9e-19, Organism=Escherichia coli, GI1789378, Length=266, Percent_Identity=29.6992481203008, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI1790717, Length=260, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=27.906976744186, Blast_Score=71, Evalue=7e-14, Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=25.7692307692308, Blast_Score=70, Evalue=9e-14, Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=31.0756972111554, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17562990, Length=269, Percent_Identity=34.9442379182156, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=5e-25, Organism=Caenorhabditis elegans, GI71994600, Length=260, Percent_Identity=33.0769230769231, Blast_Score=110, Evalue=9e-25, Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=32.6996197718631, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=32.046332046332, Blast_Score=103, Evalue=8e-23, Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=31.1787072243346, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=30.0751879699248, Blast_Score=101, Evalue=5e-22, Organism=Caenorhabditis elegans, GI17560332, Length=268, Percent_Identity=31.7164179104478, Blast_Score=100, Evalue=7e-22, Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=30.6818181818182, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI71994604, Length=259, Percent_Identity=30.1158301158301, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17544670, Length=275, Percent_Identity=28, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=30.0380228136882, Blast_Score=97, Evalue=8e-21, Organism=Caenorhabditis elegans, GI115534694, Length=261, Percent_Identity=31.4176245210728, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17560676, Length=277, Percent_Identity=28.8808664259928, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI193204405, Length=270, Percent_Identity=31.1111111111111, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=30.5660377358491, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=29.9242424242424, Blast_Score=92, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=28.8973384030418, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17565030, Length=278, Percent_Identity=29.136690647482, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17560220, Length=271, Percent_Identity=29.8892988929889, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=29.3436293436293, Blast_Score=84, Evalue=5e-17, Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=28.1746031746032, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17538486, Length=274, Percent_Identity=27.007299270073, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=28.6259541984733, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17508651, Length=261, Percent_Identity=28.3524904214559, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17538182, Length=275, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17536025, Length=259, Percent_Identity=25.4826254826255, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=154, Percent_Identity=33.1168831168831, Blast_Score=81, Evalue=1e-16, Organism=Saccharomyces cerevisiae, GI6322067, Length=225, Percent_Identity=31.5555555555556, Blast_Score=81, Evalue=1e-16, Organism=Saccharomyces cerevisiae, GI6322227, Length=200, Percent_Identity=32, Blast_Score=72, Evalue=7e-14, Organism=Saccharomyces cerevisiae, GI6323882, Length=255, Percent_Identity=28.6274509803922, Blast_Score=68, Evalue=1e-12, Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=32.8, Blast_Score=117, Evalue=8e-27, Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=31.7647058823529, Blast_Score=116, Evalue=2e-26, Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-25, Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=33.5907335907336, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=32.046332046332, Blast_Score=98, Evalue=4e-21, Organism=Drosophila melanogaster, GI24644337, Length=187, Percent_Identity=37.9679144385027, Blast_Score=98, Evalue=5e-21, Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=32.1705426356589, Blast_Score=95, Evalue=3e-20, Organism=Drosophila melanogaster, GI24643142, Length=253, Percent_Identity=32.4110671936759, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI17737361, Length=265, Percent_Identity=29.0566037735849, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI21358495, Length=203, Percent_Identity=28.0788177339901, Blast_Score=69, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 26979; Mature: 26848
Theoretical pI: Translated: 7.35; Mature: 7.35
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAEFDTRKTIVLTGASRGIGHATVKRFSREGWRVITCSRQAFAEDCPWPAGPEDHIKVDL CCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCCCCEEEEE ADQEDVGIAVSEIRHRLEAHGGQLNALVNNAGISPKLKDGNSRMNSIDTPMHVWRDVFQV CCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEECCCCCCCCCCCCHHHHHHHHHHH NFFAPIMLARGLFKELATAKGSIVNVTSIAGTRVHPFAGTAYATSKAALGSLTREMAHDF HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHC GPHGIRVNAIAPGEIDTAILSPGTEKIVETIPLRRLGTTAEVADIIFFLCSQQASYVTGS CCCCEEEEEECCCCCCCEEECCCHHHHHHHCCCHHCCCHHHHHHHHHHHHCCCCCEECCC EIHINGGQHV EEEECCCCCC >Mature Secondary Structure AEFDTRKTIVLTGASRGIGHATVKRFSREGWRVITCSRQAFAEDCPWPAGPEDHIKVDL CCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCCCCEEEEE ADQEDVGIAVSEIRHRLEAHGGQLNALVNNAGISPKLKDGNSRMNSIDTPMHVWRDVFQV CCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEECCCCCCCCCCCCHHHHHHHHHHH NFFAPIMLARGLFKELATAKGSIVNVTSIAGTRVHPFAGTAYATSKAALGSLTREMAHDF HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHC GPHGIRVNAIAPGEIDTAILSPGTEKIVETIPLRRLGTTAEVADIIFFLCSQQASYVTGS CCCCEEEEEECCCCCCCEEECCCHHHHHHHCCCHHCCCHHHHHHHHHHHHCCCCCEECCC EIHINGGQHV EEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 3313281; 11157954; 12597275 [H]