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The map label for this gene is nhaK [H]

Identifier: 13472691

GI number: 13472691

Start: 2467912

End: 2469465

Strand: Reverse

Name: nhaK [H]

Synonym: mll3064

Alternate gene names: 13472691

Gene position: 2469465-2467912 (Counterclockwise)

Preceding gene: 13472692

Following gene: 13472690

Centisome position: 35.1

GC content: 64.67

Gene sequence:

>1554_bases
ATGGCCCTTTTTGAACTCACCCTTGTCCTGCTTCTGACTGCTGTCGCGCTGACGGCGCTGTCGCGACGGCTGGAGGTCCC
CTATCCGTCGCTGCTGGCCTTGGCCGGGGTTGGCATCGCCTTCGTGCCTGGCGCACCAATGATCGAGATCGATCCGGAAC
TGGCGCTTGCCCTGTTCATCGCGCCGGTGCTTCTCGATGCCGCCTATGACACGTCGCTGCGCGACCTGAAGCGCTACCGG
CTGTCGCTGCTGCTTTTGGCGCTTGGCGCCGTCGTCTTCACCACTGTCGTGGTTGCCTTCGTCGGCTGGAAGATGGCCGG
CCTGCCGATCGCCGCGGCAATCGCGCTCGGCGCCATCGTCGCGCCGCCGGATGCGGTGGCGGCATCCGCCGTGCTCGGGC
AATTCAAGGTGCCGCACCGCATCACCGCCATCCTGCAGGGCGAAAGCCTGCTCAACGATGCCACCGCGCTCTTGATCTAC
CGGCTGGCGGTGTCGGCGGCACTCGGCTCGATCATGCTGAGCAACGCCATTCCGGTGATCCTGCTGTCAACGATCGGCAG
CCTGATCGCCGGTTACCTGCTTGGCCGCCTCTCGCTGCTGACGCTTACCCGCATCGAGGATGCGGCGAGCAGCACCGTGG
TGCAGTTCGCCGGGACATTCGGCGTGTGGATACTGGCCGACAAGCTCGGCCTTTCCGCCATCATCACCATCGTCGTCTAT
GCCATCACGATTGCGCGCAGGGCGCCGCGCCGCATGTCGGCGCGACGTCGTGTGAGCACCTATTCAGTCTGGGAGTCGGC
GGTGTTCGTTCTCAACGTGCTGGCTTTCGTGCTGATGGGCCTGCAGGCACGGTCGATCGTCGGCCGGCTTTCCGGCGAAG
GACAAGGTGAGGCCTTTCTGTTTGCCGCAACTGTGCTGGTTGTCGTCATCGTGGCACGCCTTGTCTGGGTGGCGAGCTAC
GTCGCGATCATACGGTGGTTTGCCCGCGTCGGCAGCGAAGACAAAAAGCGGGATTTGCCAACATTTGGCGGGGCCGTGCT
GGTCGGCTGGTGCGGCATGCGGGGGCTGGTGACGCTGGTGGTGGCCATTGCGCTGCCGGCCGGCTTTCCCGGGCGTGACC
CGATCGTGCTTGCCGCCTTCGCGGTGGTTCTGGGCACGCTGGTGCTGCAGGGGATGACGCTGAAGCCTTTGCTGCGGATA
CTCGACTTCGACCCGGACAGAACGATCGACAATGAGGTTGCGCAAGCGCGTGTTGCCGTCATGCAGGCGGCACTCGACGT
GCTGAGCCGCAAGACATCGGCTGCGGCGGCTGTTGTGCGCGAGCAGTACGAGGCCCAGCGCGTGATTGCGGAAAACCCGG
AAGACGCACAGGCGGCAACCGAATATGACCGGCTGCGCCTCTACGCCATCAACCGTCAACGCGACACGCTGGAGGAATTG
CGCAGCAACGGCACGATCGGCGACGAGGCCTACCACCGGTTGGAAGAGGAAATCGACTGGGCGGAACTGGCGGCGTCGCC
AGCGGGACGATTCCAGCCGTTGACGACAGATTAG

Upstream 100 bases:

>100_bases
TCAGTTGATCGCTTTTATATCCCAGGCCAAGGCTTCGACAATCAACAGTATCCTGCCCCGGGGTACTGCCAACCGTCGCT
CTTCGCCGCTACGATGACCC

Downstream 100 bases:

>100_bases
AAGATCGCGCGGCGGGGCAGGGGGACGCTCCTGGCACAAGCCGCTTGCGTTCTCGTTGCAAGCAATCCACTGAGCCGCTA
CTGCCATCACCGAAGGTGAG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MALFELTLVLLLTAVALTALSRRLEVPYPSLLALAGVGIAFVPGAPMIEIDPELALALFIAPVLLDAAYDTSLRDLKRYR
LSLLLLALGAVVFTTVVVAFVGWKMAGLPIAAAIALGAIVAPPDAVAASAVLGQFKVPHRITAILQGESLLNDATALLIY
RLAVSAALGSIMLSNAIPVILLSTIGSLIAGYLLGRLSLLTLTRIEDAASSTVVQFAGTFGVWILADKLGLSAIITIVVY
AITIARRAPRRMSARRRVSTYSVWESAVFVLNVLAFVLMGLQARSIVGRLSGEGQGEAFLFAATVLVVVIVARLVWVASY
VAIIRWFARVGSEDKKRDLPTFGGAVLVGWCGMRGLVTLVVAIALPAGFPGRDPIVLAAFAVVLGTLVLQGMTLKPLLRI
LDFDPDRTIDNEVAQARVAVMQAALDVLSRKTSAAAAVVREQYEAQRVIAENPEDAQAATEYDRLRLYAINRQRDTLEEL
RSNGTIGDEAYHRLEEEIDWAELAASPAGRFQPLTTD

Sequences:

>Translated_517_residues
MALFELTLVLLLTAVALTALSRRLEVPYPSLLALAGVGIAFVPGAPMIEIDPELALALFIAPVLLDAAYDTSLRDLKRYR
LSLLLLALGAVVFTTVVVAFVGWKMAGLPIAAAIALGAIVAPPDAVAASAVLGQFKVPHRITAILQGESLLNDATALLIY
RLAVSAALGSIMLSNAIPVILLSTIGSLIAGYLLGRLSLLTLTRIEDAASSTVVQFAGTFGVWILADKLGLSAIITIVVY
AITIARRAPRRMSARRRVSTYSVWESAVFVLNVLAFVLMGLQARSIVGRLSGEGQGEAFLFAATVLVVVIVARLVWVASY
VAIIRWFARVGSEDKKRDLPTFGGAVLVGWCGMRGLVTLVVAIALPAGFPGRDPIVLAAFAVVLGTLVLQGMTLKPLLRI
LDFDPDRTIDNEVAQARVAVMQAALDVLSRKTSAAAAVVREQYEAQRVIAENPEDAQAATEYDRLRLYAINRQRDTLEEL
RSNGTIGDEAYHRLEEEIDWAELAASPAGRFQPLTTD
>Mature_516_residues
ALFELTLVLLLTAVALTALSRRLEVPYPSLLALAGVGIAFVPGAPMIEIDPELALALFIAPVLLDAAYDTSLRDLKRYRL
SLLLLALGAVVFTTVVVAFVGWKMAGLPIAAAIALGAIVAPPDAVAASAVLGQFKVPHRITAILQGESLLNDATALLIYR
LAVSAALGSIMLSNAIPVILLSTIGSLIAGYLLGRLSLLTLTRIEDAASSTVVQFAGTFGVWILADKLGLSAIITIVVYA
ITIARRAPRRMSARRRVSTYSVWESAVFVLNVLAFVLMGLQARSIVGRLSGEGQGEAFLFAATVLVVVIVARLVWVASYV
AIIRWFARVGSEDKKRDLPTFGGAVLVGWCGMRGLVTLVVAIALPAGFPGRDPIVLAAFAVVLGTLVLQGMTLKPLLRIL
DFDPDRTIDNEVAQARVAVMQAALDVLSRKTSAAAAVVREQYEAQRVIAENPEDAQAATEYDRLRLYAINRQRDTLEELR
SNGTIGDEAYHRLEEEIDWAELAASPAGRFQPLTTD

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=425, Percent_Identity=23.5294117647059, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI41872703, Length=461, Percent_Identity=21.2581344902386, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI148727259, Length=441, Percent_Identity=21.9954648526077, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790501, Length=552, Percent_Identity=28.0797101449275, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71980847, Length=374, Percent_Identity=25.1336898395722, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320663, Length=342, Percent_Identity=21.0526315789474, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 55303; Mature: 55172

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALFELTLVLLLTAVALTALSRRLEVPYPSLLALAGVGIAFVPGAPMIEIDPELALALFI
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCEEEECHHHHHHHHH
APVLLDAAYDTSLRDLKRYRLSLLLLALGAVVFTTVVVAFVGWKMAGLPIAAAIALGAIV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
APPDAVAASAVLGQFKVPHRITAILQGESLLNDATALLIYRLAVSAALGSIMLSNAIPVI
CCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSTIGSLIAGYLLGRLSLLTLTRIEDAASSTVVQFAGTFGVWILADKLGLSAIITIVVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITIARRAPRRMSARRRVSTYSVWESAVFVLNVLAFVLMGLQARSIVGRLSGEGQGEAFL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
FAATVLVVVIVARLVWVASYVAIIRWFARVGSEDKKRDLPTFGGAVLVGWCGMRGLVTLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHH
VAIALPAGFPGRDPIVLAAFAVVLGTLVLQGMTLKPLLRILDFDPDRTIDNEVAQARVAV
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
MQAALDVLSRKTSAAAAVVREQYEAQRVIAENPEDAQAATEYDRLRLYAINRQRDTLEEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEEECCCHHHHHHH
RSNGTIGDEAYHRLEEEIDWAELAASPAGRFQPLTTD
HCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ALFELTLVLLLTAVALTALSRRLEVPYPSLLALAGVGIAFVPGAPMIEIDPELALALFI
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEECCCCCEEEECHHHHHHHHH
APVLLDAAYDTSLRDLKRYRLSLLLLALGAVVFTTVVVAFVGWKMAGLPIAAAIALGAIV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
APPDAVAASAVLGQFKVPHRITAILQGESLLNDATALLIYRLAVSAALGSIMLSNAIPVI
CCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSTIGSLIAGYLLGRLSLLTLTRIEDAASSTVVQFAGTFGVWILADKLGLSAIITIVVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITIARRAPRRMSARRRVSTYSVWESAVFVLNVLAFVLMGLQARSIVGRLSGEGQGEAFL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
FAATVLVVVIVARLVWVASYVAIIRWFARVGSEDKKRDLPTFGGAVLVGWCGMRGLVTLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHH
VAIALPAGFPGRDPIVLAAFAVVLGTLVLQGMTLKPLLRILDFDPDRTIDNEVAQARVAV
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
MQAALDVLSRKTSAAAAVVREQYEAQRVIAENPEDAQAATEYDRLRLYAINRQRDTLEEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEEECCCHHHHHHH
RSNGTIGDEAYHRLEEEIDWAELAASPAGRFQPLTTD
HCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA