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The map label for this gene is hisN [H]

Identifier: 13472670

GI number: 13472670

Start: 2444839

End: 2445627

Strand: Reverse

Name: hisN [H]

Synonym: mll3039

Alternate gene names: 13472670

Gene position: 2445627-2444839 (Counterclockwise)

Preceding gene: 13472671

Following gene: 13472665

Centisome position: 34.76

GC content: 66.92

Gene sequence:

>789_bases
ATGCGGGAGAATCAGTTGGACGTCAGCATCGATTTCATGCGCCGCATCGCGCAGGCGGCAGCGGCCGAGACCTTGCCGCG
CTTTCGCGCCCAGGGGGCCGTGGCCAACAAGGAAAAGGGCAGTTTCGACCCGGTCACGGAAGCCGACCGCGAGACCGAAC
GTGCCATCCGGGCGCTGATAGCGGCGCAGTATCCCGACCATGGCATTCTCGGGGAGGAGCACGGCAGCGAGAACATCTCC
AGCCGGCATGTGTGGGTGATCGATCCAATCGACGGCACGCGCGCCTTCATCTCCGGCCTGCCGGTGTGGGGGACGCTGGT
CGGACTGACGGTCGACGGCGACGCGGTCGCCGGCATGATGGCGCAGCCCTTCACCGGCGAGCTGTTCTACGCCAACGCCT
CGGGCTCGCACTATGAGGGGCCGGGCGGTCCGCGCAAGCTTTCGACCCGCAAGACGACAAGGCTCGATGAGGCGACACTG
TTCACGACCACGCCGGCGCTGTTCAAGGGCGAGGCGCGCACGCGCTATGACGCGTTCGAGAAACAGGTCCAGCTCGCTCG
CTATGGCGCCGATTGCTATGCCTTCGCCATGATCGCCTCAGGGAGCGTCGACATCGTCGCCGATCCCGGCCTGAAACCCT
ACGACATCGTGGCGCTGATCCCGATCATCGAGAAGGCCGGCGGCGTTGTCACCACCTTCGATGGCGGACCGGCGGAAAAG
GGCGGCGATGTGCTGGCGGCGGCGACGCCGGAACTTCACGCGGCCGCCATGGCTGCCCTGCGCGGCTGA

Upstream 100 bases:

>100_bases
TTGATGTGACATTTGGGCAACAAATGTCGCGGCGAATAAATCGATAAACAGGCTTGTTTTGGCGGGAAAGTGTCGGCAGA
GCCCGGTTGGGCACTCGGCA

Downstream 100 bases:

>100_bases
TATCTCGCGCTTTCTTTGAAGCAGTTGCTTCAGCGCGATCTGATCGAGCGCTGGAATTCCGCCGGCGTGCGTCCGTAGAC
CTGTCTGAACGACGCGCTGA

Product: Mono-phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MRENQLDVSIDFMRRIAQAAAAETLPRFRAQGAVANKEKGSFDPVTEADRETERAIRALIAAQYPDHGILGEEHGSENIS
SRHVWVIDPIDGTRAFISGLPVWGTLVGLTVDGDAVAGMMAQPFTGELFYANASGSHYEGPGGPRKLSTRKTTRLDEATL
FTTTPALFKGEARTRYDAFEKQVQLARYGADCYAFAMIASGSVDIVADPGLKPYDIVALIPIIEKAGGVVTTFDGGPAEK
GGDVLAAATPELHAAAMAALRG

Sequences:

>Translated_262_residues
MRENQLDVSIDFMRRIAQAAAAETLPRFRAQGAVANKEKGSFDPVTEADRETERAIRALIAAQYPDHGILGEEHGSENIS
SRHVWVIDPIDGTRAFISGLPVWGTLVGLTVDGDAVAGMMAQPFTGELFYANASGSHYEGPGGPRKLSTRKTTRLDEATL
FTTTPALFKGEARTRYDAFEKQVQLARYGADCYAFAMIASGSVDIVADPGLKPYDIVALIPIIEKAGGVVTTFDGGPAEK
GGDVLAAATPELHAAAMAALRG
>Mature_262_residues
MRENQLDVSIDFMRRIAQAAAAETLPRFRAQGAVANKEKGSFDPVTEADRETERAIRALIAAQYPDHGILGEEHGSENIS
SRHVWVIDPIDGTRAFISGLPVWGTLVGLTVDGDAVAGMMAQPFTGELFYANASGSHYEGPGGPRKLSTRKTTRLDEATL
FTTTPALFKGEARTRYDAFEKQVQLARYGADCYAFAMIASGSVDIVADPGLKPYDIVALIPIIEKAGGVVTTFDGGPAEK
GGDVLAAATPELHAAAMAALRG

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI221625487, Length=227, Percent_Identity=25.5506607929515, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI5031789, Length=206, Percent_Identity=26.2135922330097, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788882, Length=253, Percent_Identity=30.4347826086957, Blast_Score=98, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI193202572, Length=257, Percent_Identity=28.0155642023346, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193202570, Length=260, Percent_Identity=26.5384615384615, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320493, Length=209, Percent_Identity=28.2296650717703, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321836, Length=224, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24664918, Length=272, Percent_Identity=28.6764705882353, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357957, Length=235, Percent_Identity=28.5106382978723, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357329, Length=228, Percent_Identity=29.8245614035088, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24664922, Length=227, Percent_Identity=29.0748898678414, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24664926, Length=271, Percent_Identity=22.140221402214, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357303, Length=207, Percent_Identity=27.536231884058, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27883; Mature: 27883

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRENQLDVSIDFMRRIAQAAAAETLPRFRAQGAVANKEKGSFDPVTEADRETERAIRALI
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AAQYPDHGILGEEHGSENISSRHVWVIDPIDGTRAFISGLPVWGTLVGLTVDGDAVAGMM
HHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCHHHEEEEEEECCHHHHHHH
AQPFTGELFYANASGSHYEGPGGPRKLSTRKTTRLDEATLFTTTPALFKGEARTRYDAFE
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCCCCCEEEEEECHHHHCCCCHHHHHHHH
KQVQLARYGADCYAFAMIASGSVDIVADPGLKPYDIVALIPIIEKAGGVVTTFDGGPAEK
HHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCC
GGDVLAAATPELHAAAMAALRG
CCCEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MRENQLDVSIDFMRRIAQAAAAETLPRFRAQGAVANKEKGSFDPVTEADRETERAIRALI
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AAQYPDHGILGEEHGSENISSRHVWVIDPIDGTRAFISGLPVWGTLVGLTVDGDAVAGMM
HHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCHHHEEEEEEECCHHHHHHH
AQPFTGELFYANASGSHYEGPGGPRKLSTRKTTRLDEATLFTTTPALFKGEARTRYDAFE
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCCCCCEEEEEECHHHHCCCCHHHHHHHH
KQVQLARYGADCYAFAMIASGSVDIVADPGLKPYDIVALIPIIEKAGGVVTTFDGGPAEK
HHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCC
GGDVLAAATPELHAAAMAALRG
CCCEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]