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The map label for this gene is zitB [H]

Identifier: 13472628

GI number: 13472628

Start: 2396481

End: 2397578

Strand: Reverse

Name: zitB [H]

Synonym: mll2984

Alternate gene names: 13472628

Gene position: 2397578-2396481 (Counterclockwise)

Preceding gene: 13472629

Following gene: 13472627

Centisome position: 34.08

GC content: 65.94

Gene sequence:

>1098_bases
ATGGCTCGACCCGGCCAATTTCGACGGCGCCGGCCAGCAGAAGCGACGGCTCGAGGATTGTCGCGCAGAATTCGGCGCTT
AAGTCCGGCTGGGGCGCATGACAGGAGCTGCCATTTGGCGCACACCCATTCCCACGACCATAGCGGGCATGATCACGAGG
GCGCCGGCCATGTGCATGGCGCGACCGACAAGAAGCGCGTGCTGATCGCCGCCTGCCTGACGGCGGGCTTCATGGTGGCG
GAAGCGCTTGGCGGCCTGTTCACCGGGTCGCTGGCGCTGCTGGCGGACGCCGGCCACATGCTGGCCGACGCCATCGCCCT
CGGCCTTGCCTGGTATGCCTTCCATCTAGCCGGGCGGCCGGCGACGGGCCAGCTCACCTATGGTTTTGGCCGGGTCAAGA
CGCTGGTCGCCTACACCAACGGCATCGCCATCTTCGTCATCGCGCTGTGGATCGTCTACGAGGCCTGGCAGCGCCTGCTC
ACACCGGCGCCGGTGCTTGGCGGACCGATGCTGGTCGTGGCGATCCTCGGCCTGCTGGTCAATATCGGTTCCTTCCTGGT
GCTGCATGGCGGCGATCGCGAAAGCCTCAACATGCGCGGCGCCATCCTGCATGTGCTTGGCGACCTGCTCGGCTCGGCGG
CGGCGATCGTGGCGGCGGTGGTGATCCTTGTTACCGGCTGGACGCCGATCGACCCGATCCTGTCGGTGCTGGTCTCGCTG
CTGATCCTGTCGACGGCCTGGTCGCTGATGCGCGCCGCCGCCCATGTGCTGCTCGAAGGCGTGCCGCCAAGCCTCGACCG
CGACCTCATCGCAACGGACTTGGAAACCACGATCCAAGGCGTGCGCGAAGTGCACCATATGCATGTCTGGTCGATCGATG
GGTCAAGCAACATGGCGACGCTGCATGCCTGCCTTGACGAGGGTGTCGATGCGCATCGGGCCGTCAGCGCCATCAAGAAG
CGGCTTGCCAGCGAGCACGGCATCAGCCATGCCACCGTGGAACCGGAATTCGGCCAATGCGCCGACGAGGCCGGCGACCA
CGAGCATGAACATGAGCATGAGCACGATGCGGCCGCGCATCACAGCCACCATCACTAA

Upstream 100 bases:

>100_bases
TTTTCCGCCAGCACCTCATCGTCAAGGGTGAAAACCGCGATACCGCATGGTATTCGATCATCGACAAGGAATGGCCGGCC
CTGCGCAAAGCCTATGAGGC

Downstream 100 bases:

>100_bases
GCCCGGTCGATAGCCGGCGCTGCCTCAGGAGTTGCACAGCTTTGAAAGCCAGCCTGACGAATGCCCGCTGCCCCGGTGCT
GCATGATGGACCGCGACACC

Product: cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MARPGQFRRRRPAEATARGLSRRIRRLSPAGAHDRSCHLAHTHSHDHSGHDHEGAGHVHGATDKKRVLIAACLTAGFMVA
EALGGLFTGSLALLADAGHMLADAIALGLAWYAFHLAGRPATGQLTYGFGRVKTLVAYTNGIAIFVIALWIVYEAWQRLL
TPAPVLGGPMLVVAILGLLVNIGSFLVLHGGDRESLNMRGAILHVLGDLLGSAAAIVAAVVILVTGWTPIDPILSVLVSL
LILSTAWSLMRAAAHVLLEGVPPSLDRDLIATDLETTIQGVREVHHMHVWSIDGSSNMATLHACLDEGVDAHRAVSAIKK
RLASEHGISHATVEPEFGQCADEAGDHEHEHEHEHDAAAHHSHHH

Sequences:

>Translated_365_residues
MARPGQFRRRRPAEATARGLSRRIRRLSPAGAHDRSCHLAHTHSHDHSGHDHEGAGHVHGATDKKRVLIAACLTAGFMVA
EALGGLFTGSLALLADAGHMLADAIALGLAWYAFHLAGRPATGQLTYGFGRVKTLVAYTNGIAIFVIALWIVYEAWQRLL
TPAPVLGGPMLVVAILGLLVNIGSFLVLHGGDRESLNMRGAILHVLGDLLGSAAAIVAAVVILVTGWTPIDPILSVLVSL
LILSTAWSLMRAAAHVLLEGVPPSLDRDLIATDLETTIQGVREVHHMHVWSIDGSSNMATLHACLDEGVDAHRAVSAIKK
RLASEHGISHATVEPEFGQCADEAGDHEHEHEHEHDAAAHHSHHH
>Mature_364_residues
ARPGQFRRRRPAEATARGLSRRIRRLSPAGAHDRSCHLAHTHSHDHSGHDHEGAGHVHGATDKKRVLIAACLTAGFMVAE
ALGGLFTGSLALLADAGHMLADAIALGLAWYAFHLAGRPATGQLTYGFGRVKTLVAYTNGIAIFVIALWIVYEAWQRLLT
PAPVLGGPMLVVAILGLLVNIGSFLVLHGGDRESLNMRGAILHVLGDLLGSAAAIVAAVVILVTGWTPIDPILSVLVSLL
ILSTAWSLMRAAAHVLLEGVPPSLDRDLIATDLETTIQGVREVHHMHVWSIDGSSNMATLHACLDEGVDAHRAVSAIKKR
LASEHGISHATVEPEFGQCADEAGDHEHEHEHEHDAAAHHSHHH

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=307, Percent_Identity=28.0130293159609, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI20070323, Length=325, Percent_Identity=28.6153846153846, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI21361112, Length=308, Percent_Identity=29.5454545454545, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI64762489, Length=302, Percent_Identity=28.8079470198675, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI21359890, Length=272, Percent_Identity=31.25, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI289803013, Length=302, Percent_Identity=28.8079470198675, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI289803009, Length=302, Percent_Identity=28.8079470198675, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI289803007, Length=302, Percent_Identity=28.8079470198675, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI289803003, Length=302, Percent_Identity=28.8079470198675, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI14210520, Length=218, Percent_Identity=27.0642201834862, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI52351208, Length=118, Percent_Identity=35.5932203389831, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI52352803, Length=212, Percent_Identity=31.1320754716981, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786966, Length=280, Percent_Identity=47.8571428571429, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17555794, Length=341, Percent_Identity=32.8445747800587, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17555796, Length=349, Percent_Identity=31.5186246418338, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI193210990, Length=328, Percent_Identity=29.5731707317073, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI32564488, Length=315, Percent_Identity=30.7936507936508, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17550440, Length=153, Percent_Identity=32.0261437908497, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17550442, Length=153, Percent_Identity=32.0261437908497, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324892, Length=170, Percent_Identity=32.3529411764706, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=146, Percent_Identity=36.986301369863, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320411, Length=179, Percent_Identity=34.6368715083799, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24656728, Length=335, Percent_Identity=29.2537313432836, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24656724, Length=335, Percent_Identity=29.2537313432836, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24656720, Length=335, Percent_Identity=29.2537313432836, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24656715, Length=335, Percent_Identity=29.2537313432836, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21357035, Length=335, Percent_Identity=29.2537313432836, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24583858, Length=363, Percent_Identity=27.8236914600551, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=29.2517006802721, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=29.2517006802721, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=29.2517006802721, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=29.2517006802721, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24584409, Length=172, Percent_Identity=29.0697674418605, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574430, Length=156, Percent_Identity=28.8461538461538, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24645863, Length=120, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 38980; Mature: 38849

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPGQFRRRRPAEATARGLSRRIRRLSPAGAHDRSCHLAHTHSHDHSGHDHEGAGHVHG
CCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
ATDKKRVLIAACLTAGFMVAEALGGLFTGSLALLADAGHMLADAIALGLAWYAFHLAGRP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ATGQLTYGFGRVKTLVAYTNGIAIFVIALWIVYEAWQRLLTPAPVLGGPMLVVAILGLLV
CCCCEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
NIGSFLVLHGGDRESLNMRGAILHVLGDLLGSAAAIVAAVVILVTGWTPIDPILSVLVSL
HHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LILSTAWSLMRAAAHVLLEGVPPSLDRDLIATDLETTIQGVREVHHMHVWSIDGSSNMAT
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHH
LHACLDEGVDAHRAVSAIKKRLASEHGISHATVEPEFGQCADEAGDHEHEHEHEHDAAAH
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHH
HSHHH
CCCCC
>Mature Secondary Structure 
ARPGQFRRRRPAEATARGLSRRIRRLSPAGAHDRSCHLAHTHSHDHSGHDHEGAGHVHG
CCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
ATDKKRVLIAACLTAGFMVAEALGGLFTGSLALLADAGHMLADAIALGLAWYAFHLAGRP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ATGQLTYGFGRVKTLVAYTNGIAIFVIALWIVYEAWQRLLTPAPVLGGPMLVVAILGLLV
CCCCEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
NIGSFLVLHGGDRESLNMRGAILHVLGDLLGSAAAIVAAVVILVTGWTPIDPILSVLVSL
HHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LILSTAWSLMRAAAHVLLEGVPPSLDRDLIATDLETTIQGVREVHHMHVWSIDGSSNMAT
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHH
LHACLDEGVDAHRAVSAIKKRLASEHGISHATVEPEFGQCADEAGDHEHEHEHEHDAAAH
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHH
HSHHH
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]