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The map label for this gene is ldc [H]

Identifier: 13472621

GI number: 13472621

Start: 2389301

End: 2390434

Strand: Reverse

Name: ldc [H]

Synonym: mll2974

Alternate gene names: 13472621

Gene position: 2390434-2389301 (Counterclockwise)

Preceding gene: 13472626

Following gene: 13472620

Centisome position: 33.97

GC content: 64.99

Gene sequence:

>1134_bases
ATGGCTACCCAGCGCATCCTCGACTTCCTCGCCACCCGACGTCCGTCCGGCCCCTGCCTCGTCGTCGACCTCGATGTCGT
GCGCGACAATTTCCGCGCCTTCGAGAAGGCGTTGCCCGATTCCAAGATCTACTATGCGGTGAAAGCAAACCCGGCGCCGG
AAATCCTGCGCCTCCTTGCTGCGATGGGCTCGTCCTTCGACACCGCTTCCGTTGCCGAGGTCGAGATGGCGATGGACGCG
GGTGCGCCCGCGGACCGCATCTCCTTCGGCAACACTATCAAGAAGGAGCGTGACATCGCACGCGCCTACCAGCTCGGCAT
CCGTCTGTTCGCGGTCGATTGCGTCGAGGAGGTCGAGAAGATCGCCCGCGTCGCTCCCGGCGCGCGCGTGTTCTGCCGCG
TGCTGACCGACGGCGAAGGCGCCGAATGGCCTCTGTCGCGCAAGTTCGGCTGCGTGCCGGCCATGGCCGTCGACGTGCTG
CGCCATGCCAAGGGCCTCGGCCTCGACGCCTATGGCGTGTCGTTCCATGTCGGCTCGCAGCAGACCGATCTGACCGCCTG
GGACCGTGCGCTCGCCGACGCCAAGAAGGTGTTCGCGACGCTCGCCGAGGAAGGCATCGTGCTCAAGATGGTCAATATGG
GCGGCGGTTTCCCGACGCGCTATCTGCGTGACGTGCCGGCGGCCCAGGCCTATGGCCAGGCGATCTTCTCGGCGCTGCGC
AAGCATTTCGGCAATGCCATTCCCGAAACCATCATCGAGCCAGGCCGCGGCATGGTCGGCAATGCCGGCGTCATCAAGTC
GGAAGTCGTGCTGATCTCGAAGAAGGCCGACAATGACAATGTGCGCTGGGTGTTCCTCGACATCGGCAAGTTCGGCGGTC
TGGCCGAGACGATGGACGAGGCGATCCGCTATCCCCTCGTCACCCGCCATGACGGCTCGGAGACCGCGCCTTGCGTGCTC
GCCGGACCGACCTGCGATTCGGCCGACGTGATGTACGAGAAGACACCGTATCCGCTGCCTCTGTCGCTGACCATCGGCGA
CGAGGTGCTGATCGAAGGCACCGGCGCCTACACGACCACCTACTCGGCGGTCGCCTTCAACGGCTTCGAGCCTCTCCGAT
CCTACGTGATCTGA

Upstream 100 bases:

>100_bases
ATGGATTTTCCGTCCCGCCTTTGTCCACCGCGTGTTCGCGAGGCCGACAGCCCGCGTCCGCACCCTTGTGCGCGCCGAAA
GGCGTGTTTGGAGAAACCCG

Downstream 100 bases:

>100_bases
CGGTTCTTTATTTGGCGCATTTTCGGACGGCGAACCGGATACCACTTCGCCTGAAAATGCGCTGAGAGCCGATCAGATCA
TCCCAGGTGGGCGCTTGTCG

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MATQRILDFLATRRPSGPCLVVDLDVVRDNFRAFEKALPDSKIYYAVKANPAPEILRLLAAMGSSFDTASVAEVEMAMDA
GAPADRISFGNTIKKERDIARAYQLGIRLFAVDCVEEVEKIARVAPGARVFCRVLTDGEGAEWPLSRKFGCVPAMAVDVL
RHAKGLGLDAYGVSFHVGSQQTDLTAWDRALADAKKVFATLAEEGIVLKMVNMGGGFPTRYLRDVPAAQAYGQAIFSALR
KHFGNAIPETIIEPGRGMVGNAGVIKSEVVLISKKADNDNVRWVFLDIGKFGGLAETMDEAIRYPLVTRHDGSETAPCVL
AGPTCDSADVMYEKTPYPLPLSLTIGDEVLIEGTGAYTTTYSAVAFNGFEPLRSYVI

Sequences:

>Translated_377_residues
MATQRILDFLATRRPSGPCLVVDLDVVRDNFRAFEKALPDSKIYYAVKANPAPEILRLLAAMGSSFDTASVAEVEMAMDA
GAPADRISFGNTIKKERDIARAYQLGIRLFAVDCVEEVEKIARVAPGARVFCRVLTDGEGAEWPLSRKFGCVPAMAVDVL
RHAKGLGLDAYGVSFHVGSQQTDLTAWDRALADAKKVFATLAEEGIVLKMVNMGGGFPTRYLRDVPAAQAYGQAIFSALR
KHFGNAIPETIIEPGRGMVGNAGVIKSEVVLISKKADNDNVRWVFLDIGKFGGLAETMDEAIRYPLVTRHDGSETAPCVL
AGPTCDSADVMYEKTPYPLPLSLTIGDEVLIEGTGAYTTTYSAVAFNGFEPLRSYVI
>Mature_376_residues
ATQRILDFLATRRPSGPCLVVDLDVVRDNFRAFEKALPDSKIYYAVKANPAPEILRLLAAMGSSFDTASVAEVEMAMDAG
APADRISFGNTIKKERDIARAYQLGIRLFAVDCVEEVEKIARVAPGARVFCRVLTDGEGAEWPLSRKFGCVPAMAVDVLR
HAKGLGLDAYGVSFHVGSQQTDLTAWDRALADAKKVFATLAEEGIVLKMVNMGGGFPTRYLRDVPAAQAYGQAIFSALRK
HFGNAIPETIIEPGRGMVGNAGVIKSEVVLISKKADNDNVRWVFLDIGKFGGLAETMDEAIRYPLVTRHDGSETAPCVLA
GPTCDSADVMYEKTPYPLPLSLTIGDEVLIEGTGAYTTTYSAVAFNGFEPLRSYVI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=374, Percent_Identity=33.1550802139037, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI16506287, Length=355, Percent_Identity=30.9859154929577, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI22538418, Length=368, Percent_Identity=26.6304347826087, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI21361583, Length=368, Percent_Identity=26.6304347826087, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1789203, Length=378, Percent_Identity=26.1904761904762, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562780, Length=373, Percent_Identity=31.6353887399464, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI25141365, Length=362, Percent_Identity=24.0331491712707, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322664, Length=379, Percent_Identity=32.4538258575198, Blast_Score=158, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24586472, Length=382, Percent_Identity=30.6282722513089, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24586474, Length=358, Percent_Identity=29.0502793296089, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 40781; Mature: 40650

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQRILDFLATRRPSGPCLVVDLDVVRDNFRAFEKALPDSKIYYAVKANPAPEILRLLA
CCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
AMGSSFDTASVAEVEMAMDAGAPADRISFGNTIKKERDIARAYQLGIRLFAVDCVEEVEK
HHCCCCCCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARVAPGARVFCRVLTDGEGAEWPLSRKFGCVPAMAVDVLRHAKGLGLDAYGVSFHVGSQ
HHHHCCCHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECEEEEECCC
QTDLTAWDRALADAKKVFATLAEEGIVLKMVNMGGGFPTRYLRDVPAAQAYGQAIFSALR
CCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHH
KHFGNAIPETIIEPGRGMVGNAGVIKSEVVLISKKADNDNVRWVFLDIGKFGGLAETMDE
HHHCCCCCHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHH
AIRYPLVTRHDGSETAPCVLAGPTCDSADVMYEKTPYPLPLSLTIGDEVLIEGTGAYTTT
HHHCCCEEECCCCCCCCEEEECCCCCCCCCEECCCCCCCEEEEEECCEEEEECCCCCEEE
YSAVAFNGFEPLRSYVI
EHHEEECCHHHHHHHCC
>Mature Secondary Structure 
ATQRILDFLATRRPSGPCLVVDLDVVRDNFRAFEKALPDSKIYYAVKANPAPEILRLLA
CHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
AMGSSFDTASVAEVEMAMDAGAPADRISFGNTIKKERDIARAYQLGIRLFAVDCVEEVEK
HHCCCCCCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARVAPGARVFCRVLTDGEGAEWPLSRKFGCVPAMAVDVLRHAKGLGLDAYGVSFHVGSQ
HHHHCCCHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECEEEEECCC
QTDLTAWDRALADAKKVFATLAEEGIVLKMVNMGGGFPTRYLRDVPAAQAYGQAIFSALR
CCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHH
KHFGNAIPETIIEPGRGMVGNAGVIKSEVVLISKKADNDNVRWVFLDIGKFGGLAETMDE
HHHCCCCCHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHH
AIRYPLVTRHDGSETAPCVLAGPTCDSADVMYEKTPYPLPLSLTIGDEVLIEGTGAYTTT
HHHCCCEEECCCCCCCCEEEECCCCCCCCCEECCCCCCCEEEEEECCEEEEECCCCCEEE
YSAVAFNGFEPLRSYVI
EHHEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]