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The map label for this gene is acdA [H]

Identifier: 13472548

GI number: 13472548

Start: 2318234

End: 2319430

Strand: Reverse

Name: acdA [H]

Synonym: mll2878

Alternate gene names: 13472548

Gene position: 2319430-2318234 (Counterclockwise)

Preceding gene: 13472550

Following gene: 13472547

Centisome position: 32.96

GC content: 63.41

Gene sequence:

>1197_bases
ATGGCCGCCGACAAGAATGCATTCGTGTGGGAAGACCCGTTCCTGATCGAGGACCAGCTTTCGGAAGAAGAGCGCATGGT
GCGCGACGGCGCGGCGGCCTTCGCCGCCGACAAGCTCGCGCCGCGCATCGAGGATGCCTATCTCAATGAAAAGACTGATG
CCGGCATCTTTCGTGAGATGGGTGAGGCCGGCCTGCTCGGCATTACCATCCCGGAAGAGTATGGCGGCCTCGGCGCCAAC
TATGTGACCTACGGGCTGGTCGCGCGGGAAGTCGAACGCGTCGATTCCGGCTATCGCTCGATGATGTCGGTGCAGTCGTC
GCTGGTGATGTATCCGATCCACGCCTATGGCTCGGACGAACAGCGCAAGAAATATCTGCCCAAGCTCGCCAGCGGCGAGT
GGATCGGCTGTTTCGGCCTGACCGAGCCGGATGCCGGCTCGGACCCGGGCGGCATGAAGACGCGCGCCGAGAAGACCGCG
AACGGCTACAAGCTCAGCGGCTCCAAGATGTGGATTTCCAACGCGCCGATCGCCGACGTCTTCGTCGTCTGGGCCAAGCT
GAAAGGCGAGACCGGCAAGGACGAGATCCGTGGTTTCGTGTTGGAAAAGGGCATGAAGGGGCTGTCGGCGCCGAAGATCG
GCGGCAAGCTGTCGTTGCGCGCGTCGATCACCGGTGAAGTGGTGATGGAAGGCGTCGAGGTCGGCGAGGACGCGCTGCTG
CCCAACGCCAAGGGCCTTGGCGGCCCGTTCGGCTGTCTCAACCGGGCTCGCTATGGCATCTCCTGGGGCTCGATGGGTGC
GGCGGAAGATTGCTGGCACCGCGCCCGCCAGTATGGTCTCGACCGCAAGCAGTTCGGCAAGCCGCTGGCCGGCACGCAGC
TTTACCAGAAGAAGCTTGCCGACATGCAGACCGAGATCGCGCTCGGGCTTCAGGCATCCTTGCGCGTCGGGCGACTGCTC
GATGCAGGCAAGATGGCGCCGGAGATGATCTCGATCGTCAAGCGCAACAATTGCGGCAAGGCGCTCGACATCGCCCGCCA
GGCCCGCGACATGCATGGCGGCAACGGCATCCAGATCGGCTACCACGTCATGCGCCACGCGCAGAATTTGGAGACGGTCA
ACACCTATGAAGGCACGCATGACGTGCACGCGCTGATCCTCGGACGGGCGCAGACGGGTATCCAGGCGTTCTTTTAA

Upstream 100 bases:

>100_bases
TCTATTCCTAACGCTCATTGATCCGTGAAGCAATTTCGTTTGATTTTTTTAGGCCGCGGGCCGATAAGCCGGGCTTCATC
CCGTTTGAGGACCGATTGCC

Downstream 100 bases:

>100_bases
GCTGTGCCGATATTCAGGTGAGGCCGGCCTGCGAATGGCGGCTTCCTGCGCTTCCCCGTTCTACTGCGTCGCAGTAGAAC
TGAGCTCCCGTACCCAAAAG

Product: glutaryl Co-A dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MAADKNAFVWEDPFLIEDQLSEEERMVRDGAAAFAADKLAPRIEDAYLNEKTDAGIFREMGEAGLLGITIPEEYGGLGAN
YVTYGLVAREVERVDSGYRSMMSVQSSLVMYPIHAYGSDEQRKKYLPKLASGEWIGCFGLTEPDAGSDPGGMKTRAEKTA
NGYKLSGSKMWISNAPIADVFVVWAKLKGETGKDEIRGFVLEKGMKGLSAPKIGGKLSLRASITGEVVMEGVEVGEDALL
PNAKGLGGPFGCLNRARYGISWGSMGAAEDCWHRARQYGLDRKQFGKPLAGTQLYQKKLADMQTEIALGLQASLRVGRLL
DAGKMAPEMISIVKRNNCGKALDIARQARDMHGGNGIQIGYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF

Sequences:

>Translated_398_residues
MAADKNAFVWEDPFLIEDQLSEEERMVRDGAAAFAADKLAPRIEDAYLNEKTDAGIFREMGEAGLLGITIPEEYGGLGAN
YVTYGLVAREVERVDSGYRSMMSVQSSLVMYPIHAYGSDEQRKKYLPKLASGEWIGCFGLTEPDAGSDPGGMKTRAEKTA
NGYKLSGSKMWISNAPIADVFVVWAKLKGETGKDEIRGFVLEKGMKGLSAPKIGGKLSLRASITGEVVMEGVEVGEDALL
PNAKGLGGPFGCLNRARYGISWGSMGAAEDCWHRARQYGLDRKQFGKPLAGTQLYQKKLADMQTEIALGLQASLRVGRLL
DAGKMAPEMISIVKRNNCGKALDIARQARDMHGGNGIQIGYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF
>Mature_397_residues
AADKNAFVWEDPFLIEDQLSEEERMVRDGAAAFAADKLAPRIEDAYLNEKTDAGIFREMGEAGLLGITIPEEYGGLGANY
VTYGLVAREVERVDSGYRSMMSVQSSLVMYPIHAYGSDEQRKKYLPKLASGEWIGCFGLTEPDAGSDPGGMKTRAEKTAN
GYKLSGSKMWISNAPIADVFVVWAKLKGETGKDEIRGFVLEKGMKGLSAPKIGGKLSLRASITGEVVMEGVEVGEDALLP
NAKGLGGPFGCLNRARYGISWGSMGAAEDCWHRARQYGLDRKQFGKPLAGTQLYQKKLADMQTEIALGLQASLRVGRLLD
AGKMAPEMISIVKRNNCGKALDIARQARDMHGGNGIQIGYHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=63.4760705289673, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI7669494, Length=377, Percent_Identity=62.0689655172414, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI4501859, Length=365, Percent_Identity=32.3287671232877, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=33.5106382978723, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI226958414, Length=360, Percent_Identity=33.0555555555556, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=30.6451612903226, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=28.5333333333333, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=28.5333333333333, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI76496475, Length=388, Percent_Identity=29.1237113402062, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI4557235, Length=388, Percent_Identity=29.1237113402062, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=28.4182305630027, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=29.5514511873351, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI21361497, Length=396, Percent_Identity=28.2828282828283, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786223, Length=352, Percent_Identity=24.4318181818182, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081958, Length=342, Percent_Identity=26.0233918128655, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081702, Length=369, Percent_Identity=24.9322493224932, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17534353, Length=394, Percent_Identity=61.4213197969543, Blast_Score=496, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=34.9333333333333, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=31.5508021390374, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=29.5890410958904, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=246, Percent_Identity=36.5853658536585, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=401, Percent_Identity=29.426433915212, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=29.023746701847, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=28.2722513089005, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=28.3819628647215, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=34.7826086956522, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71985192, Length=308, Percent_Identity=30.8441558441558, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=29.4117647058824, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17533517, Length=368, Percent_Identity=26.0869565217391, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17551932, Length=307, Percent_Identity=25.7328990228013, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17505929, Length=244, Percent_Identity=25.4098360655738, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19920834, Length=394, Percent_Identity=59.1370558375635, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=31.4516129032258, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21356377, Length=379, Percent_Identity=30.6068601583113, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=30.6451612903226, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=31.4666666666667, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI281363737, Length=356, Percent_Identity=32.3033707865169, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=30.6878306878307, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43292; Mature: 43161

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADKNAFVWEDPFLIEDQLSEEERMVRDGAAAFAADKLAPRIEDAYLNEKTDAGIFREM
CCCCCCCEEECCCEEEHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHC
GEAGLLGITIPEEYGGLGANYVTYGLVAREVERVDSGYRSMMSVQSSLVMYPIHAYGSDE
CCCCEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCH
QRKKYLPKLASGEWIGCFGLTEPDAGSDPGGMKTRAEKTANGYKLSGSKMWISNAPIADV
HHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCEEECCCEEEECCCCHHHH
FVVWAKLKGETGKDEIRGFVLEKGMKGLSAPKIGGKLSLRASITGEVVMEGVEVGEDALL
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCHHCC
PNAKGLGGPFGCLNRARYGISWGSMGAAEDCWHRARQYGLDRKQFGKPLAGTQLYQKKLA
CCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHH
DMQTEIALGLQASLRVGRLLDAGKMAPEMISIVKRNNCGKALDIARQARDMHGGNGIQIG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEHH
YHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF
HHHHHHHHCCCCCCCCCCCCCEEHHEECCHHCCHHHCC
>Mature Secondary Structure 
AADKNAFVWEDPFLIEDQLSEEERMVRDGAAAFAADKLAPRIEDAYLNEKTDAGIFREM
CCCCCCEEECCCEEEHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHC
GEAGLLGITIPEEYGGLGANYVTYGLVAREVERVDSGYRSMMSVQSSLVMYPIHAYGSDE
CCCCEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCH
QRKKYLPKLASGEWIGCFGLTEPDAGSDPGGMKTRAEKTANGYKLSGSKMWISNAPIADV
HHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCEEECCCEEEECCCCHHHH
FVVWAKLKGETGKDEIRGFVLEKGMKGLSAPKIGGKLSLRASITGEVVMEGVEVGEDALL
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCHHCC
PNAKGLGGPFGCLNRARYGISWGSMGAAEDCWHRARQYGLDRKQFGKPLAGTQLYQKKLA
CCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHH
DMQTEIALGLQASLRVGRLLDAGKMAPEMISIVKRNNCGKALDIARQARDMHGGNGIQIG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEHH
YHVMRHAQNLETVNTYEGTHDVHALILGRAQTGIQAFF
HHHHHHHHCCCCCCCCCCCCCEEHHEECCHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]