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The map label for this gene is fabF [H]

Identifier: 13472507

GI number: 13472507

Start: 2264632

End: 2265933

Strand: Direct

Name: fabF [H]

Synonym: mlr2832

Alternate gene names: 13472507

Gene position: 2264632-2265933 (Clockwise)

Preceding gene: 13472506

Following gene: 13472508

Centisome position: 32.19

GC content: 64.82

Gene sequence:

>1302_bases
ATGCGACGGATTGTTGTTACAGGCATGGGAGCGGTCACGCCCCTAGCTGCCAATGTCGAAGCGTCATGGTCGCGTCTGCT
GGCCGGTCGTTCGGGCATCCGTAGGCTTCCGGACGATGTGGTGGGAGACCTGCCGGCGAAGATTGGCGGCGTGGTGCCCT
CCTTGGATGAAGATCCGGGCGCTGGTTTCGATCCTGATGGCATCCTGGCTGCGAAGGATCAGCGCAGGGTAGATCGGTTT
ATTCTCTTTGCGCTGGCGGCGGCGGAAGAGGCGCTTGCACAGGCGAAATGGAAGCCTGCCTTGGAGACGGATCGCCTGCG
CACAGCAACGATTATCGCTTCAGGGGTCGGCGGATTCCCCGCCATCACCGAGGCGGTGCGCACGGTCGATCTGCGTGGCG
CCCGCCGCCTGTCGCCCTTCACGGTGCCGTCCTTCCTGGTGAACCTCGCAGCGGGCCACATCTCGATCCGTCATGGCTTC
AAAGGCCCATTGGGCGCACCAGTGACAGCGTGCGCGGCCGGCATCCAGGCGATCGGCGACGCCGCCCGTCTCATCCGCGC
GAACGAGGCTGATATTGCCGTGTGCGGGGGCACGGAAGCATGCATGAACACCGTCAGTCTCGGTGGGTTTGCTGCCGCAC
GCTCCCTTTCAACCGGCTTCAATTGGGCGCCGGCTCAAGCCTCACGTCCCTTCGACATTTCGCGGGACGGCTTCGTCATG
GGCGAAGGCGCCGGCGTGCTGGTCATCGAGGCGTTGGGCCACGCGCTGGCGCGCGGCGCAAAACCGCTCGCCGAGCTCGT
CGGCTACGGAACGACGGCCGATGCTTATCACGTCACTTCTGGTCCCGAGGACGGCGGCGGTGCGCGCCGGGCCATGGAGA
TCGCGATTGCGCAAGCAGGGATTTCACCGAGCGAGGTTCGTCATCTCAATGCACATGCGACCTCCACGCCAGTCGGCGAC
CTGGGTGAAATCGAAGCGATCAAGAGCGTATTCGGGCGCGATTTAGCGATAGCTGTCAGCGCAACGAAATCCGCGACCGG
GCACCTGCTGGGCGCGGCCGGCGGGCTTGGTGCCATCTTCTCGATCCTGGCGATCAGGGACCAGGTGGCACCGCCGACAC
TCAATTTGAGCGCACCCGATCCGGCCGCCGACGGCATCGACTTCGTCGCAAACGAGCCCCGGCCAATGGAGATGGAATAC
GCAATCTCCAATGGCTTCGGTTTTGGCGGCGTGAATGCCAGCGCCTTGTTCAGGCGCTGGATCGCCCCGGCGGCCCGACG
CGAGCGCCAGGGGCAGTCATGA

Upstream 100 bases:

>100_bases
CAGGCTTTTCTGGATGCAGCGACCGATCAGGTGCGCGAAGCAGTCGCCGCTTGAACGGCGTGGGCAGCGCTGTCGGCGCA
CCCAAGTGATAGGAGAATAG

Downstream 100 bases:

>100_bases
TTGGCACCCTTCACCACAACCTTTCGTGCTTATGCCATCCCGATCCAACACAAAGAAAGAAATGATTTCCATGAACAAGA
TCAATCCTGGCGTCGCCCTG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRRIVVTGMGAVTPLAANVEASWSRLLAGRSGIRRLPDDVVGDLPAKIGGVVPSLDEDPGAGFDPDGILAAKDQRRVDRF
ILFALAAAEEALAQAKWKPALETDRLRTATIIASGVGGFPAITEAVRTVDLRGARRLSPFTVPSFLVNLAAGHISIRHGF
KGPLGAPVTACAAGIQAIGDAARLIRANEADIAVCGGTEACMNTVSLGGFAAARSLSTGFNWAPAQASRPFDISRDGFVM
GEGAGVLVIEALGHALARGAKPLAELVGYGTTADAYHVTSGPEDGGGARRAMEIAIAQAGISPSEVRHLNAHATSTPVGD
LGEIEAIKSVFGRDLAIAVSATKSATGHLLGAAGGLGAIFSILAIRDQVAPPTLNLSAPDPAADGIDFVANEPRPMEMEY
AISNGFGFGGVNASALFRRWIAPAARRERQGQS

Sequences:

>Translated_433_residues
MRRIVVTGMGAVTPLAANVEASWSRLLAGRSGIRRLPDDVVGDLPAKIGGVVPSLDEDPGAGFDPDGILAAKDQRRVDRF
ILFALAAAEEALAQAKWKPALETDRLRTATIIASGVGGFPAITEAVRTVDLRGARRLSPFTVPSFLVNLAAGHISIRHGF
KGPLGAPVTACAAGIQAIGDAARLIRANEADIAVCGGTEACMNTVSLGGFAAARSLSTGFNWAPAQASRPFDISRDGFVM
GEGAGVLVIEALGHALARGAKPLAELVGYGTTADAYHVTSGPEDGGGARRAMEIAIAQAGISPSEVRHLNAHATSTPVGD
LGEIEAIKSVFGRDLAIAVSATKSATGHLLGAAGGLGAIFSILAIRDQVAPPTLNLSAPDPAADGIDFVANEPRPMEMEY
AISNGFGFGGVNASALFRRWIAPAARRERQGQS
>Mature_433_residues
MRRIVVTGMGAVTPLAANVEASWSRLLAGRSGIRRLPDDVVGDLPAKIGGVVPSLDEDPGAGFDPDGILAAKDQRRVDRF
ILFALAAAEEALAQAKWKPALETDRLRTATIIASGVGGFPAITEAVRTVDLRGARRLSPFTVPSFLVNLAAGHISIRHGF
KGPLGAPVTACAAGIQAIGDAARLIRANEADIAVCGGTEACMNTVSLGGFAAARSLSTGFNWAPAQASRPFDISRDGFVM
GEGAGVLVIEALGHALARGAKPLAELVGYGTTADAYHVTSGPEDGGGARRAMEIAIAQAGISPSEVRHLNAHATSTPVGD
LGEIEAIKSVFGRDLAIAVSATKSATGHLLGAAGGLGAIFSILAIRDQVAPPTLNLSAPDPAADGIDFVANEPRPMEMEY
AISNGFGFGGVNASALFRRWIAPAARRERQGQS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=43.1654676258993, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI223972627, Length=189, Percent_Identity=35.4497354497354, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI41872631, Length=430, Percent_Identity=24.8837209302326, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1787337, Length=420, Percent_Identity=45.9523809523809, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI1788663, Length=428, Percent_Identity=35.0467289719626, Blast_Score=206, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71983541, Length=425, Percent_Identity=37.4117647058824, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=39.8496240601504, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI212642053, Length=435, Percent_Identity=27.816091954023, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=271, Percent_Identity=28.4132841328413, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=451, Percent_Identity=37.9157427937916, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=44.9172576832151, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI19920632, Length=443, Percent_Identity=25.2821670428894, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221330659, Length=440, Percent_Identity=24.7727272727273, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24581345, Length=446, Percent_Identity=23.3183856502242, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44517; Mature: 44517

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIVVTGMGAVTPLAANVEASWSRLLAGRSGIRRLPDDVVGDLPAKIGGVVPSLDEDPG
CCEEEEECCCCCCCHHCCCHHHHHHHHHCHHHHHHCCHHHHHHCCHHHCCCCCCCCCCCC
AGFDPDGILAAKDQRRVDRFILFALAAAEEALAQAKWKPALETDRLRTATIIASGVGGFP
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCCH
AITEAVRTVDLRGARRLSPFTVPSFLVNLAAGHISIRHGFKGPLGAPVTACAAGIQAIGD
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHH
AARLIRANEADIAVCGGTEACMNTVSLGGFAAARSLSTGFNWAPAQASRPFDISRDGFVM
HHHHHCCCCCCEEEECCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
GEGAGVLVIEALGHALARGAKPLAELVGYGTTADAYHVTSGPEDGGGARRAMEIAIAQAG
ECCCCEEHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCC
ISPSEVRHLNAHATSTPVGDLGEIEAIKSVFGRDLAIAVSATKSATGHLLGAAGGLGAIF
CCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCHHHHH
SILAIRDQVAPPTLNLSAPDPAADGIDFVANEPRPMEMEYAISNGFGFGGVNASALFRRW
HHHHHHHHCCCCEEECCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHH
IAPAARRERQGQS
HHHHHHHHHCCCC
>Mature Secondary Structure
MRRIVVTGMGAVTPLAANVEASWSRLLAGRSGIRRLPDDVVGDLPAKIGGVVPSLDEDPG
CCEEEEECCCCCCCHHCCCHHHHHHHHHCHHHHHHCCHHHHHHCCHHHCCCCCCCCCCCC
AGFDPDGILAAKDQRRVDRFILFALAAAEEALAQAKWKPALETDRLRTATIIASGVGGFP
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCCCH
AITEAVRTVDLRGARRLSPFTVPSFLVNLAAGHISIRHGFKGPLGAPVTACAAGIQAIGD
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHH
AARLIRANEADIAVCGGTEACMNTVSLGGFAAARSLSTGFNWAPAQASRPFDISRDGFVM
HHHHHCCCCCCEEEECCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
GEGAGVLVIEALGHALARGAKPLAELVGYGTTADAYHVTSGPEDGGGARRAMEIAIAQAG
ECCCCEEHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCC
ISPSEVRHLNAHATSTPVGDLGEIEAIKSVFGRDLAIAVSATKSATGHLLGAAGGLGAIF
CCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCHHHHH
SILAIRDQVAPPTLNLSAPDPAADGIDFVANEPRPMEMEYAISNGFGFGGVNASALFRRW
HHHHHHHHCCCCEEECCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHH
IAPAARRERQGQS
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]