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The map label for this gene is ykgC [H]

Identifier: 13472464

GI number: 13472464

Start: 2222681

End: 2224057

Strand: Direct

Name: ykgC [H]

Synonym: mlr2769

Alternate gene names: 13472464

Gene position: 2222681-2224057 (Clockwise)

Preceding gene: 13472463

Following gene: 13472465

Centisome position: 31.59

GC content: 65.5

Gene sequence:

>1377_bases
ATGACGGCAAAGACTTTCGACGCCATCATCATTGGCGCCGGCCAGGCCGGCACACCACTCGCCGGCAGGCTGAACGCAGC
CGGCATGAGCGTGGCGCTGATCGAGCGCAAGCTGGTCGGCGGCACCTGCGTCAACACCGGTTGCATCCCGACCAAGACAA
TGGTGGCGAGCGCCTATGCCGCGCATCTGGCGCGGCGCGCCACCGATTATGGCGTGACGCTCGGTGGCCCTGTCGGCGTC
GACTACAAGGCGATCAAGGCGCGCAAGGACAAGGTTTCGGGCGCCTCCCGCACCGGGCTGGAAAGCTGGATCGCCGGCAT
GGACAAATGCACGCTCTATCGCGGCCATGCGCGCTTCGAATCCGCCAATACGGTGCGCGTCGGCGACGACCTTCTGACCG
CCGACAAGATCTTCCTCAACACCGGCGGCCGGGCTTCCGTGCCTGATTTGCCCGGCATCCACGACATCGACTATCTGACC
AATTCCTCGATGATGGATCTCGAGGTCCTGCCGCGCCACCTGATCGTCGTCGGCGGCAGCTACATCTCGCTCGAATTCGC
GCAGATGTTCCGCCGTTTCGGCAGCGAAATCACCGTCATCGAGAAGAGCCCGCGCCTGACCGGCCGCGAGGACGAGGACG
TCTCGGCAACCATCCTGTCCATCCTCGAAAATGAAGGCATTACGGTCCATGTCGGCGCCGACGACATCGGCTTCGCCAAA
CAGGGCGACGATATCGCCGTGACCTTCTCGGCCGGCAAGCCGCCGGCCGTCGGCTCGCATGTGCTGCTGGCGCTCGGCCG
AACGCTCAACACCGACGATCTCGGCCTCGACAGAGCCGGCGTCGCCGTCGACAAGCGTGGTGCCATTATCGTGGACGACC
AGCTGCGCACCAGCGTCCCAGGCATCTGGGCGATGGGCGACTGCAACGGCAAGGGCGCCTTCACCCACACCTCCTACAAT
GACTACGAGATCGTCGCCGCCAACCTGCTCGACAACGACCCACGCAAGGTCAGCGACCGCATCGAGGCCTATGCGCTCTA
CATCGACCCGCCGCTCGGCCGCTGCGGCATGACCGAGGCGGCAGTGAAGAAATCCGGACGCCGCGCGCTGGTCGGCCAGC
GGCCGATGACCCGCGTCGGCCGCGCGGTCGAAAAAGGCGAGACGCAAGGCTTCATGAAGATCCTCGTCGATGCCGACACG
CGGCAGATCCTCGGCTGTTCCGTTCTCGGTCCCGGCGGCGACGAGGCGGTGCATTGCGTGCTCGACCTGATGTACGCCAA
GGCACCGGTCGACACGCTTGCGCGCGCGACGCACATCCACCCCACTGTCTCGGAACTGCTGCCCACCATTGCCCAGGAGC
TGAAGCCGCTGGCCTGA

Upstream 100 bases:

>100_bases
GCGGCCGGCTGGCGGCCGCCTTCGGCAAAGATCAGCCCGCCGCCTTCATCGAGGACGCGGTGGCGATCATCGGCGGCCTG
CTGATCGTGGCGGCGGTGGC

Downstream 100 bases:

>100_bases
GGCACCTCAAGCTCCCGACATTCTGCATTGGTGCATTGCAGCAATGTGCATTGCGCATAGCTCATTTCCTCGCGCAATCT
CTGGATTGAACCGATTCAGT

Product: mercuric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTAKTFDAIIIGAGQAGTPLAGRLNAAGMSVALIERKLVGGTCVNTGCIPTKTMVASAYAAHLARRATDYGVTLGGPVGV
DYKAIKARKDKVSGASRTGLESWIAGMDKCTLYRGHARFESANTVRVGDDLLTADKIFLNTGGRASVPDLPGIHDIDYLT
NSSMMDLEVLPRHLIVVGGSYISLEFAQMFRRFGSEITVIEKSPRLTGREDEDVSATILSILENEGITVHVGADDIGFAK
QGDDIAVTFSAGKPPAVGSHVLLALGRTLNTDDLGLDRAGVAVDKRGAIIVDDQLRTSVPGIWAMGDCNGKGAFTHTSYN
DYEIVAANLLDNDPRKVSDRIEAYALYIDPPLGRCGMTEAAVKKSGRRALVGQRPMTRVGRAVEKGETQGFMKILVDADT
RQILGCSVLGPGGDEAVHCVLDLMYAKAPVDTLARATHIHPTVSELLPTIAQELKPLA

Sequences:

>Translated_458_residues
MTAKTFDAIIIGAGQAGTPLAGRLNAAGMSVALIERKLVGGTCVNTGCIPTKTMVASAYAAHLARRATDYGVTLGGPVGV
DYKAIKARKDKVSGASRTGLESWIAGMDKCTLYRGHARFESANTVRVGDDLLTADKIFLNTGGRASVPDLPGIHDIDYLT
NSSMMDLEVLPRHLIVVGGSYISLEFAQMFRRFGSEITVIEKSPRLTGREDEDVSATILSILENEGITVHVGADDIGFAK
QGDDIAVTFSAGKPPAVGSHVLLALGRTLNTDDLGLDRAGVAVDKRGAIIVDDQLRTSVPGIWAMGDCNGKGAFTHTSYN
DYEIVAANLLDNDPRKVSDRIEAYALYIDPPLGRCGMTEAAVKKSGRRALVGQRPMTRVGRAVEKGETQGFMKILVDADT
RQILGCSVLGPGGDEAVHCVLDLMYAKAPVDTLARATHIHPTVSELLPTIAQELKPLA
>Mature_457_residues
TAKTFDAIIIGAGQAGTPLAGRLNAAGMSVALIERKLVGGTCVNTGCIPTKTMVASAYAAHLARRATDYGVTLGGPVGVD
YKAIKARKDKVSGASRTGLESWIAGMDKCTLYRGHARFESANTVRVGDDLLTADKIFLNTGGRASVPDLPGIHDIDYLTN
SSMMDLEVLPRHLIVVGGSYISLEFAQMFRRFGSEITVIEKSPRLTGREDEDVSATILSILENEGITVHVGADDIGFAKQ
GDDIAVTFSAGKPPAVGSHVLLALGRTLNTDDLGLDRAGVAVDKRGAIIVDDQLRTSVPGIWAMGDCNGKGAFTHTSYND
YEIVAANLLDNDPRKVSDRIEAYALYIDPPLGRCGMTEAAVKKSGRRALVGQRPMTRVGRAVEKGETQGFMKILVDADTR
QILGCSVLGPGGDEAVHCVLDLMYAKAPVDTLARATHIHPTVSELLPTIAQELKPLA

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=27.3913043478261, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=28.1720430107527, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI148277065, Length=433, Percent_Identity=25.635103926097, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI33519430, Length=433, Percent_Identity=25.635103926097, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI33519428, Length=433, Percent_Identity=25.635103926097, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI33519426, Length=433, Percent_Identity=25.635103926097, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI148277071, Length=433, Percent_Identity=25.635103926097, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI22035672, Length=440, Percent_Identity=27.7272727272727, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI291045266, Length=438, Percent_Identity=26.4840182648402, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI291045268, Length=429, Percent_Identity=25.8741258741259, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI87081717, Length=450, Percent_Identity=36.6666666666667, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1786307, Length=446, Percent_Identity=28.0269058295964, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=27.6102088167053, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI87082354, Length=461, Percent_Identity=25.8134490238612, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=457, Percent_Identity=26.4770240700219, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71983419, Length=465, Percent_Identity=30.3225806451613, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71983429, Length=465, Percent_Identity=30.3225806451613, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17557007, Length=478, Percent_Identity=26.9874476987448, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=451, Percent_Identity=26.3858093126386, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=29.6137339055794, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=483, Percent_Identity=26.7080745341615, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=482, Percent_Identity=22.1991701244813, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=29.0393013100437, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=26.4150943396226, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24640551, Length=477, Percent_Identity=26.4150943396226, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=26.4150943396226, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=26.1052631578947, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 48615; Mature: 48484

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKTFDAIIIGAGQAGTPLAGRLNAAGMSVALIERKLVGGTCVNTGCIPTKTMVASAYA
CCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHCCCEEECCCCCCHHHHHHHHHH
AHLARRATDYGVTLGGPVGVDYKAIKARKDKVSGASRTGLESWIAGMDKCTLYRGHARFE
HHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEECCCCCC
SANTVRVGDDLLTADKIFLNTGGRASVPDLPGIHDIDYLTNSSMMDLEVLPRHLIVVGGS
CCCEEEECCCHHCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCEEHHHCCCEEEEECCC
YISLEFAQMFRRFGSEITVIEKSPRLTGREDEDVSATILSILENEGITVHVGADDIGFAK
EEEHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCC
QGDDIAVTFSAGKPPAVGSHVLLALGRTLNTDDLGLDRAGVAVDKRGAIIVDDQLRTSVP
CCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEECCCHHHCCC
GIWAMGDCNGKGAFTHTSYNDYEIVAANLLDNDPRKVSDRIEAYALYIDPPLGRCGMTEA
CEEEEECCCCCCCEEECCCCCEEEEEEECCCCCHHHHHCCEEEEEEEECCCCCCCCCCHH
AVKKSGRRALVGQRPMTRVGRAVEKGETQGFMKILVDADTRQILGCSVLGPGGDEAVHCV
HHHHCCCEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEECCCCHHHHHHH
LDLMYAKAPVDTLARATHIHPTVSELLPTIAQELKPLA
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TAKTFDAIIIGAGQAGTPLAGRLNAAGMSVALIERKLVGGTCVNTGCIPTKTMVASAYA
CCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHCCCEEECCCCCCHHHHHHHHHH
AHLARRATDYGVTLGGPVGVDYKAIKARKDKVSGASRTGLESWIAGMDKCTLYRGHARFE
HHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEECCCCCC
SANTVRVGDDLLTADKIFLNTGGRASVPDLPGIHDIDYLTNSSMMDLEVLPRHLIVVGGS
CCCEEEECCCHHCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCEEHHHCCCEEEEECCC
YISLEFAQMFRRFGSEITVIEKSPRLTGREDEDVSATILSILENEGITVHVGADDIGFAK
EEEHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCC
QGDDIAVTFSAGKPPAVGSHVLLALGRTLNTDDLGLDRAGVAVDKRGAIIVDDQLRTSVP
CCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEECCCHHHCCC
GIWAMGDCNGKGAFTHTSYNDYEIVAANLLDNDPRKVSDRIEAYALYIDPPLGRCGMTEA
CEEEEECCCCCCCEEECCCCCEEEEEEECCCCCHHHHHCCEEEEEEEECCCCCCCCCCHH
AVKKSGRRALVGQRPMTRVGRAVEKGETQGFMKILVDADTRQILGCSVLGPGGDEAVHCV
HHHHCCCEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEECCCCHHHHHHH
LDLMYAKAPVDTLARATHIHPTVSELLPTIAQELKPLA
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]