Click here to switch to the map view.

The map label for this gene is yogA [H]

Identifier: 13472320

GI number: 13472320

Start: 2083339

End: 2084361

Strand: Reverse

Name: yogA [H]

Synonym: mll2578

Alternate gene names: 13472320

Gene position: 2084361-2083339 (Counterclockwise)

Preceding gene: 13472323

Following gene: 13472318

Centisome position: 29.62

GC content: 65.49

Gene sequence:

>1023_bases
ATGAGCACCCAAATCAACCGATCCTGGCAAATGAGCGGTTTCGGCCTGTCCAGGCTGAGCCAGGTGACGGGCAAGATGCC
GCAACCCGGGCCGCACGAGCTTCTGGTGCGCACGAAGGCCGTGTCGCTGAACTACAAGGACAGACTGATCGTGGACGGCA
CGCTGATCCCCGAGCTCACCTTTCCCTTCGTGCCGACATCGGATGCCGTGGGTGAGATCGTCGCTGTCGGCAGCGCGGTC
AGCCGCTTCCAGGTCGGGCAACGCGTGCTCGGCCAGGTCATCGCCGACTGGCCGGATGGCGACGCGCCGCCCGTGCCGCA
CAAGCACACGCTGGGGTCCTCGCTGCCGGGCATGCTTTCAGACCATGTGGTCTTTGGCGAGGACGCCGCCGCGCTGGCGC
CGCCGTCGCTCAGCGATATCGAGGCGGCAACGCTGCCGATCGCGGCCTTGAGCGCCTGGTTTGCGATGGCCGAGGCGACA
AGGCCGGTGGCGGGCCAGACCGTCCTCATCCAGGGCACTGGCGGCGTGTCGCTGTTTGCGCTGCAATTCGCCAGGGCGTT
CGGCCTGCGTGCCATCGTCACCTCGAGCAGCGACGACAAGCTTGAACGGGCAAAAAATCTCGGCGCCTGGCAGGTGATCA
ACTATCGCACCCGGCCGGCATGGGACGAGGCCGCACGTGAACTGACCAATGGGTTGGGGGTGAACCATATTCTGGAAATG
GTCGGCGGCGACAATGCGCGGCGATCGCTGAACGCGCTGGCCGCGGGCGGCCGGCTGTCGGTCATCGGCCTCTTGGGCGC
GATGGAGCTCAATTTCCCGATCGTGCCATTCATGCGCAACCGCATTGTCGTGCAGGGTCTGTCGATCGGCCATCGCCGGG
CCTTCGAGCGGATGAACCAGGCGATCGAGGCGCTCGGCATCAAGCCGGTCATCGACAAGGTCTTTGGCTTCGACGAGGTG
CCGCAGGCCCTCCAGCATCTCGAGAAGGGGCCGTTCGGCAAGATCGTGATCAGCACGACCTGA

Upstream 100 bases:

>100_bases
GTCCTCAATCAGTCGTGGAATATGCCGCATGGGAGCTCTATTTTCCATAGTCGAAAAGCATAAATCTCTCGCGGACCATC
AATCACGGAGCGCGAGCAAT

Downstream 100 bases:

>100_bases
CCTCGCCGTCCGGTCACTGCGGCTGCTTCAGCACGCCGATGATTGCCTTGCCGTCGGTGAAATAGGGATCGCCGCCGCCA
TTGCGGCCGGTCCTGGTGGC

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSTQINRSWQMSGFGLSRLSQVTGKMPQPGPHELLVRTKAVSLNYKDRLIVDGTLIPELTFPFVPTSDAVGEIVAVGSAV
SRFQVGQRVLGQVIADWPDGDAPPVPHKHTLGSSLPGMLSDHVVFGEDAAALAPPSLSDIEAATLPIAALSAWFAMAEAT
RPVAGQTVLIQGTGGVSLFALQFARAFGLRAIVTSSSDDKLERAKNLGAWQVINYRTRPAWDEAARELTNGLGVNHILEM
VGGDNARRSLNALAAGGRLSVIGLLGAMELNFPIVPFMRNRIVVQGLSIGHRRAFERMNQAIEALGIKPVIDKVFGFDEV
PQALQHLEKGPFGKIVISTT

Sequences:

>Translated_340_residues
MSTQINRSWQMSGFGLSRLSQVTGKMPQPGPHELLVRTKAVSLNYKDRLIVDGTLIPELTFPFVPTSDAVGEIVAVGSAV
SRFQVGQRVLGQVIADWPDGDAPPVPHKHTLGSSLPGMLSDHVVFGEDAAALAPPSLSDIEAATLPIAALSAWFAMAEAT
RPVAGQTVLIQGTGGVSLFALQFARAFGLRAIVTSSSDDKLERAKNLGAWQVINYRTRPAWDEAARELTNGLGVNHILEM
VGGDNARRSLNALAAGGRLSVIGLLGAMELNFPIVPFMRNRIVVQGLSIGHRRAFERMNQAIEALGIKPVIDKVFGFDEV
PQALQHLEKGPFGKIVISTT
>Mature_339_residues
STQINRSWQMSGFGLSRLSQVTGKMPQPGPHELLVRTKAVSLNYKDRLIVDGTLIPELTFPFVPTSDAVGEIVAVGSAVS
RFQVGQRVLGQVIADWPDGDAPPVPHKHTLGSSLPGMLSDHVVFGEDAAALAPPSLSDIEAATLPIAALSAWFAMAEATR
PVAGQTVLIQGTGGVSLFALQFARAFGLRAIVTSSSDDKLERAKNLGAWQVINYRTRPAWDEAARELTNGLGVNHILEMV
GGDNARRSLNALAAGGRLSVIGLLGAMELNFPIVPFMRNRIVVQGLSIGHRRAFERMNQAIEALGIKPVIDKVFGFDEVP
QALQHLEKGPFGKIVISTT

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=319, Percent_Identity=26.3322884012539, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI13236495, Length=319, Percent_Identity=26.3322884012539, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI22538446, Length=330, Percent_Identity=27.5757575757576, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI22538444, Length=330, Percent_Identity=27.5757575757576, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI28557745, Length=278, Percent_Identity=29.136690647482, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI47519420, Length=374, Percent_Identity=25.4010695187166, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI194239676, Length=319, Percent_Identity=23.8244514106583, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI24308257, Length=363, Percent_Identity=23.4159779614325, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI197927207, Length=181, Percent_Identity=29.2817679558011, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI18379349, Length=335, Percent_Identity=22.6865671641791, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790485, Length=236, Percent_Identity=30.5084745762712, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790045, Length=328, Percent_Identity=24.6951219512195, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=328, Percent_Identity=26.5243902439024, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=216, Percent_Identity=25.462962962963, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319621, Length=325, Percent_Identity=24, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=325, Percent_Identity=24, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=289, Percent_Identity=25.6055363321799, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=289, Percent_Identity=25.6055363321799, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581341, Length=383, Percent_Identity=24.8041775456919, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24581339, Length=382, Percent_Identity=24.869109947644, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36396; Mature: 36265

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQINRSWQMSGFGLSRLSQVTGKMPQPGPHELLVRTKAVSLNYKDRLIVDGTLIPELT
CCCCCCCCEECCCCCHHHHHHHHCCCCCCCHHHHEEEEEEEEECCCCEEEECCEECCCCC
FPFVPTSDAVGEIVAVGSAVSRFQVGQRVLGQVIADWPDGDAPPVPHKHTLGSSLPGMLS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
DHVVFGEDAAALAPPSLSDIEAATLPIAALSAWFAMAEATRPVAGQTVLIQGTGGVSLFA
CCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHH
LQFARAFGLRAIVTSSSDDKLERAKNLGAWQVINYRTRPAWDEAARELTNGLGVNHILEM
HHHHHHHCCEEEEECCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHH
VGGDNARRSLNALAAGGRLSVIGLLGAMELNFPIVPFMRNRIVVQGLSIGHRRAFERMNQ
HCCCHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCHHHHHCEEEEECCCHHHHHHHHHHHH
AIEALGIKPVIDKVFGFDEVPQALQHLEKGPFGKIVISTT
HHHHHCCHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
STQINRSWQMSGFGLSRLSQVTGKMPQPGPHELLVRTKAVSLNYKDRLIVDGTLIPELT
CCCCCCCEECCCCCHHHHHHHHCCCCCCCHHHHEEEEEEEEECCCCEEEECCEECCCCC
FPFVPTSDAVGEIVAVGSAVSRFQVGQRVLGQVIADWPDGDAPPVPHKHTLGSSLPGMLS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
DHVVFGEDAAALAPPSLSDIEAATLPIAALSAWFAMAEATRPVAGQTVLIQGTGGVSLFA
CCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHH
LQFARAFGLRAIVTSSSDDKLERAKNLGAWQVINYRTRPAWDEAARELTNGLGVNHILEM
HHHHHHHCCEEEEECCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHH
VGGDNARRSLNALAAGGRLSVIGLLGAMELNFPIVPFMRNRIVVQGLSIGHRRAFERMNQ
HCCCHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCHHHHHCEEEEECCCHHHHHHHHHHHH
AIEALGIKPVIDKVFGFDEVPQALQHLEKGPFGKIVISTT
HHHHHCCHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]