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The map label for this gene is tetA [H]

Identifier: 13472258

GI number: 13472258

Start: 2022793

End: 2024058

Strand: Reverse

Name: tetA [H]

Synonym: mll2492

Alternate gene names: 13472258

Gene position: 2024058-2022793 (Counterclockwise)

Preceding gene: 13472259

Following gene: 13472257

Centisome position: 28.77

GC content: 64.06

Gene sequence:

>1266_bases
ATGATCGACCCTAAAACCGCCAGGCGGGGCCTCGCGCTGGTTTTCACCACGCTGCTGCTCGACATCATCGGCTTCGGCAT
CATCATGCCGGTACTCCCGGCCTATTTGCAGGAATTGACCGGGGTCGGCGTCAGCGAGGCGGCGATCGAGGGCGGCTGGC
TGTTCTTCGTCTACGCGGCCATGCAGTTCTTCTTCGCGCCGATCATGGGCGGGTTGAGCGACCGCTTCGGGCGGCGGCCG
ATCCTGCTTGCCTCGGTGCTGACTTTCTCCATCGACAATCTGATCTGCGCCATCGCATGGTCCTTTCCGATGCTGTTCAT
CGGCCGTGTGCTGGCCGGCATTTCGGGCGCCAGCTATTCGACGACGTCGGCCTTCATCGCCGACATCTCGAACGACGAGA
ACCGGGCGAAGAATTTCGGCCTGCTCGGCATCGCCTTTGGCGTCGGCTTCGTCATCGGCCCGGTGCTGGGCGGGCTGCTC
GGCACGTTCGGGCCGCGCGTGCCGTTCTTTTTCGCCGCCGGGCTCGCCTTGGTGAACTTCCTGATCGCGATGGTCTTCCT
GCCCGAAACGCTGGATGAAAAGCATCGCCGCCGCTTCGAGTGGAAACGCGCCAACCCGGTCGGCACGCTGCTGCAGATGC
GCCAATACAAAGGCATCGGCTGGATCGGCCTGGTCTTCTTCCTGATGACGCTCGGGCACATGATGTATCCGGCGGTGTGG
TCGTTCGTCTCCAGCTACCGCTACGGCTGGAGCGAGCAGCAGATCGGCTTTTCGCTCGGCGCCTTCGGCCTGTGCGGCGC
GATCGTCATGGCTGTCGTGTTGCCGCGTGTGATCCCCTGGCTCGGCGAATGGAAGACGGCGGTCATCGGCCTGACCTTCA
CGGCGGTGAGCGCCTTCGGCTATGCCTTCGCTTCGCAGGGATGGATGATTTATGCGGTGATCGTCGTCGGTTGCCTGGAA
GCGCTGGCCGACCCGCCGCTGAGAAGCCTCGCCGCCGCCAAGGTTCCCCCTTCTGCACAAGGCGAGTTGCAGGGCGCGAT
GACCTCGCTCTTCTCGATCACCTCGATCATCACGCCGCTGCTCTACACGGCGATCTTCTCCTGGTTCACCGGGCCAAGCG
CGCCCGTGACCTTCGGCGGCGCGCCCTATCTAGTCGGTGCGTGCTTCCTGGTGCTCGCGCTGATCGTCTTCGTTACCAAG
GTGGCGCGGCCGGCGACGATGACAAACGCCACGACCGTCGTCGCGGAAGATGGAGCGCAGGCATGA

Upstream 100 bases:

>100_bases
ATCAACGATTCCTGGCTGTTCCCGTATTGTTCCTTTTTGCGCGCTCGCCTATAAGGTTCGTCCGCCTGCGCCCCGGGCGA
TCAGAGGAGCCTGACCCATC

Downstream 100 bases:

>100_bases
GCCATGACGGCCGCATCGCGCTGACCAGGGACGGGGTATCGCTGTCGCGGCTGGTCTTCGGCGCCTGGCGCCTGCTCGAC
GGCGGTGTCCGCCCGGATGC

Product: transporter

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MIDPKTARRGLALVFTTLLLDIIGFGIIMPVLPAYLQELTGVGVSEAAIEGGWLFFVYAAMQFFFAPIMGGLSDRFGRRP
ILLASVLTFSIDNLICAIAWSFPMLFIGRVLAGISGASYSTTSAFIADISNDENRAKNFGLLGIAFGVGFVIGPVLGGLL
GTFGPRVPFFFAAGLALVNFLIAMVFLPETLDEKHRRRFEWKRANPVGTLLQMRQYKGIGWIGLVFFLMTLGHMMYPAVW
SFVSSYRYGWSEQQIGFSLGAFGLCGAIVMAVVLPRVIPWLGEWKTAVIGLTFTAVSAFGYAFASQGWMIYAVIVVGCLE
ALADPPLRSLAAAKVPPSAQGELQGAMTSLFSITSIITPLLYTAIFSWFTGPSAPVTFGGAPYLVGACFLVLALIVFVTK
VARPATMTNATTVVAEDGAQA

Sequences:

>Translated_421_residues
MIDPKTARRGLALVFTTLLLDIIGFGIIMPVLPAYLQELTGVGVSEAAIEGGWLFFVYAAMQFFFAPIMGGLSDRFGRRP
ILLASVLTFSIDNLICAIAWSFPMLFIGRVLAGISGASYSTTSAFIADISNDENRAKNFGLLGIAFGVGFVIGPVLGGLL
GTFGPRVPFFFAAGLALVNFLIAMVFLPETLDEKHRRRFEWKRANPVGTLLQMRQYKGIGWIGLVFFLMTLGHMMYPAVW
SFVSSYRYGWSEQQIGFSLGAFGLCGAIVMAVVLPRVIPWLGEWKTAVIGLTFTAVSAFGYAFASQGWMIYAVIVVGCLE
ALADPPLRSLAAAKVPPSAQGELQGAMTSLFSITSIITPLLYTAIFSWFTGPSAPVTFGGAPYLVGACFLVLALIVFVTK
VARPATMTNATTVVAEDGAQA
>Mature_421_residues
MIDPKTARRGLALVFTTLLLDIIGFGIIMPVLPAYLQELTGVGVSEAAIEGGWLFFVYAAMQFFFAPIMGGLSDRFGRRP
ILLASVLTFSIDNLICAIAWSFPMLFIGRVLAGISGASYSTTSAFIADISNDENRAKNFGLLGIAFGVGFVIGPVLGGLL
GTFGPRVPFFFAAGLALVNFLIAMVFLPETLDEKHRRRFEWKRANPVGTLLQMRQYKGIGWIGLVFFLMTLGHMMYPAVW
SFVSSYRYGWSEQQIGFSLGAFGLCGAIVMAVVLPRVIPWLGEWKTAVIGLTFTAVSAFGYAFASQGWMIYAVIVVGCLE
ALADPPLRSLAAAKVPPSAQGELQGAMTSLFSITSIITPLLYTAIFSWFTGPSAPVTFGGAPYLVGACFLVLALIVFVTK
VARPATMTNATTVVAEDGAQA

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI94721311, Length=369, Percent_Identity=27.3712737127371, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI39753965, Length=326, Percent_Identity=25.7668711656442, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI225703104, Length=361, Percent_Identity=24.9307479224377, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI225703102, Length=361, Percent_Identity=24.9307479224377, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI217416366, Length=298, Percent_Identity=26.1744966442953, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87081738, Length=196, Percent_Identity=30.6122448979592, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17551570, Length=430, Percent_Identity=23.953488372093, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71996331, Length=337, Percent_Identity=22.8486646884273, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357569, Length=319, Percent_Identity=25.705329153605, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24656463, Length=329, Percent_Identity=25.2279635258359, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24656468, Length=329, Percent_Identity=25.2279635258359, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI161080926, Length=329, Percent_Identity=25.2279635258359, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI161080924, Length=329, Percent_Identity=25.2279635258359, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17738085, Length=296, Percent_Identity=28.3783783783784, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221513297, Length=321, Percent_Identity=23.6760124610592, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24667557, Length=188, Percent_Identity=26.063829787234, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667561, Length=202, Percent_Identity=24.2574257425743, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45225; Mature: 45225

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]