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The map label for this gene is lrp [H]

Identifier: 13472210

GI number: 13472210

Start: 1974318

End: 1974803

Strand: Direct

Name: lrp [H]

Synonym: mlr2428

Alternate gene names: 13472210

Gene position: 1974318-1974803 (Clockwise)

Preceding gene: 13472206

Following gene: 13472211

Centisome position: 28.06

GC content: 61.32

Gene sequence:

>486_bases
ATGCCGATGAAAATGGAATCTGGAGCCATGAAGCTCGATGACATCGACAAGCGCATCCTGCGGGCGCTGCAACGCAACGG
CCGCATGGCCAACAACGATCTGGCCAGCGAGGTCGGCCTTTCGCCCTCGCCTTGCCTGCGGCGTGTGAAGCTGCTGGAGG
AGGCCGGCGTCATCGACCGCTATGTCGCCGTGCTCAACCCGGCCAGCATCGACAAGGGTCTAACCTTCTTCACCCGCATC
TGGCTGAAGACGCAGGACGAGGACACGGTCCAGCACTTCGCCACCGAAGTGGCCAAGCTGGCGCAGGTCATGGAATGCTA
TCTGATGCTCGGCGACTGCGATGCCCTGGTGCGCGTGGTGGCGGCCGACGTAAACGACTATCGCCGCTTCCAGTCGGAGC
ATCTGAGCCGCATCAAGGGCGTCCAGAACGTCAAGACCGACGTTCCCAGTTGGACGATCAAATACACCTCGGAACTGCCG
ATCTGA

Upstream 100 bases:

>100_bases
TGAACTCTCATGATACCGGCGGCAAACATACCCCCGGCCCTCCGCAATTTGCTTGCGAAGATTGTTGCATTTTCTCTTTT
CTTGGCACTGAATGTCTTAA

Downstream 100 bases:

>100_bases
CTGGTGCCACAGAGCGGCCCGCATGCCTGGAGCAGCGTTTCGGACTGGATAAAAAATGCAACCGGATTGTAGGATCGGTT
TCGGTGCCATCGTCCTTCGG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MPMKMESGAMKLDDIDKRILRALQRNGRMANNDLASEVGLSPSPCLRRVKLLEEAGVIDRYVAVLNPASIDKGLTFFTRI
WLKTQDEDTVQHFATEVAKLAQVMECYLMLGDCDALVRVVAADVNDYRRFQSEHLSRIKGVQNVKTDVPSWTIKYTSELP
I

Sequences:

>Translated_161_residues
MPMKMESGAMKLDDIDKRILRALQRNGRMANNDLASEVGLSPSPCLRRVKLLEEAGVIDRYVAVLNPASIDKGLTFFTRI
WLKTQDEDTVQHFATEVAKLAQVMECYLMLGDCDALVRVVAADVNDYRRFQSEHLSRIKGVQNVKTDVPSWTIKYTSELP
I
>Mature_160_residues
PMKMESGAMKLDDIDKRILRALQRNGRMANNDLASEVGLSPSPCLRRVKLLEEAGVIDRYVAVLNPASIDKGLTFFTRIW
LKTQDEDTVQHFATEVAKLAQVMECYLMLGDCDALVRVVAADVNDYRRFQSEHLSRIKGVQNVKTDVPSWTIKYTSELPI

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=150, Percent_Identity=41.3333333333333, Blast_Score=121, Evalue=2e-29,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=34, Blast_Score=92, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18216; Mature: 18085

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMKMESGAMKLDDIDKRILRALQRNGRMANNDLASEVGLSPSPCLRRVKLLEEAGVIDR
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHH
YVAVLNPASIDKGLTFFTRIWLKTQDEDTVQHFATEVAKLAQVMECYLMLGDCDALVRVV
HHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AADVNDYRRFQSEHLSRIKGVQNVKTDVPSWTIKYTSELPI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
>Mature Secondary Structure 
PMKMESGAMKLDDIDKRILRALQRNGRMANNDLASEVGLSPSPCLRRVKLLEEAGVIDR
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHH
YVAVLNPASIDKGLTFFTRIWLKTQDEDTVQHFATEVAKLAQVMECYLMLGDCDALVRVV
HHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AADVNDYRRFQSEHLSRIKGVQNVKTDVPSWTIKYTSELPI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]