Click here to switch to the map view.

The map label for this gene is htrA [H]

Identifier: 13472201

GI number: 13472201

Start: 1968629

End: 1969666

Strand: Direct

Name: htrA [H]

Synonym: mlr2417

Alternate gene names: 13472201

Gene position: 1968629-1969666 (Clockwise)

Preceding gene: 13472197

Following gene: 13472203

Centisome position: 27.98

GC content: 67.92

Gene sequence:

>1038_bases
GTGCCGCCCAAAAGTGCTCAGCGGTTTTGGGATAACGGCACGAACAGGAAAAAATCACGATCAAGCCTGAAAACACGGAG
CCCATCCATGGCCCTCGCTGCCGCCAAATTCCAATCTGACGAGACGTTGCTCGACGCCTATTCGACCACGGTCGCCGACG
CGGTCGACCGCATCGGTCCGGCCGTCTGCCGCATCGAGCGCATTGGCGGCCAGGGCGGCCATGGCTCGGGCTTCGTGATT
GCGCCGGACGGGCTGGTCGTCACCAATTTCCATGTCGTCGGCGATGCCAGGACGGTGCGCGTGTCGATGCCGGACGGCGC
CTCAAGCGAGGGCCGCGTGCTCGGCCGCGATCCCGACACCGACATCGCGCTGGTGCGCGCCGATGGCAGCTTCACCGACG
TGGCGCCGCTCGGCGATTCCAAGCGGCTGCGGCGCGGCCAGATCGCCATCGCCATCGGCAATCCGCTTGGCTTCGAATGG
ACGGTCACATCGGGTGTCGTCTCGGCGCTTGGCCGCTCGATGCGCGCTTCGACCGGACGGCTGATCGACGATGTCATCCA
GACCGATGCGGCACTCAACCCCGGCAATTCCGGCGGGCCGCTGGTGTCGTCGGCCGGCGAGGTCATCGGCGTCAACACCG
CCATGATCCACGGCGCGCAAGGCATTGCCTTCGCGGTCGCCTCCAACACCGCCAATTTCGTCATCTCGGAGATCATCCGC
TTCGGCCGCGTCCGCCGAGCCTTCATCGGCGTCTCGGCCGACACCACCAATCTGCCGCGCCGCGCGGCGCTGTTGTCGCA
AGTGTCGACCAGCACGGCCGTGCGGCTGCGCAGCGTCGAGAAGAACGGCCCGGCGGCCAAGGCCGGCCTGAAGGAGGGTG
ACATCATCGCCGCCATCGATGGCCGCCCGGTCACCGGCGTCGACGACCTCGTGCGCATGCTCGACGCCGAGCGCATCGGC
CGCGAGACGCTGTGCACGGTGGTGCGCCGCACCGGCGTCAGCCAGGTGACGGTGACGCCAGTGGCAAGGGCGGGCTGA

Upstream 100 bases:

>100_bases
CGACGGCGCCCCTGGAGGTACTCGCCTGACGGCTAGTTGGCGGTTTGACTGGCCATCTGGTCAGGTCGCGGCCGTTCCAG
CCGCTCCGCACATATAGTGC

Downstream 100 bases:

>100_bases
GGGTCAAGCCCCTGCCGCACCCTCCGCGTACTGAGCCAGAAATTCCTCGCTGGGCGGGATCGGCTTGATGACGTCGATCA
GCACGCCGTTGGGATCCCTG

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MPPKSAQRFWDNGTNRKKSRSSLKTRSPSMALAAAKFQSDETLLDAYSTTVADAVDRIGPAVCRIERIGGQGGHGSGFVI
APDGLVVTNFHVVGDARTVRVSMPDGASSEGRVLGRDPDTDIALVRADGSFTDVAPLGDSKRLRRGQIAIAIGNPLGFEW
TVTSGVVSALGRSMRASTGRLIDDVIQTDAALNPGNSGGPLVSSAGEVIGVNTAMIHGAQGIAFAVASNTANFVISEIIR
FGRVRRAFIGVSADTTNLPRRAALLSQVSTSTAVRLRSVEKNGPAAKAGLKEGDIIAAIDGRPVTGVDDLVRMLDAERIG
RETLCTVVRRTGVSQVTVTPVARAG

Sequences:

>Translated_345_residues
MPPKSAQRFWDNGTNRKKSRSSLKTRSPSMALAAAKFQSDETLLDAYSTTVADAVDRIGPAVCRIERIGGQGGHGSGFVI
APDGLVVTNFHVVGDARTVRVSMPDGASSEGRVLGRDPDTDIALVRADGSFTDVAPLGDSKRLRRGQIAIAIGNPLGFEW
TVTSGVVSALGRSMRASTGRLIDDVIQTDAALNPGNSGGPLVSSAGEVIGVNTAMIHGAQGIAFAVASNTANFVISEIIR
FGRVRRAFIGVSADTTNLPRRAALLSQVSTSTAVRLRSVEKNGPAAKAGLKEGDIIAAIDGRPVTGVDDLVRMLDAERIG
RETLCTVVRRTGVSQVTVTPVARAG
>Mature_344_residues
PPKSAQRFWDNGTNRKKSRSSLKTRSPSMALAAAKFQSDETLLDAYSTTVADAVDRIGPAVCRIERIGGQGGHGSGFVIA
PDGLVVTNFHVVGDARTVRVSMPDGASSEGRVLGRDPDTDIALVRADGSFTDVAPLGDSKRLRRGQIAIAIGNPLGFEWT
VTSGVVSALGRSMRASTGRLIDDVIQTDAALNPGNSGGPLVSSAGEVIGVNTAMIHGAQGIAFAVASNTANFVISEIIRF
GRVRRAFIGVSADTTNLPRRAALLSQVSTSTAVRLRSVEKNGPAAKAGLKEGDIIAAIDGRPVTGVDDLVRMLDAERIGR
ETLCTVVRRTGVSQVTVTPVARAG

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=344, Percent_Identity=34.0116279069767, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI22129776, Length=286, Percent_Identity=33.5664335664336, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI24308541, Length=294, Percent_Identity=30.6122448979592, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI7019477, Length=309, Percent_Identity=36.5695792880259, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1786356, Length=236, Percent_Identity=41.5254237288136, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789629, Length=282, Percent_Identity=36.8794326241135, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789630, Length=300, Percent_Identity=32.3333333333333, Blast_Score=134, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24646839, Length=287, Percent_Identity=32.0557491289199, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35983; Mature: 35852

Theoretical pI: Translated: 10.81; Mature: 10.81

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPKSAQRFWDNGTNRKKSRSSLKTRSPSMALAAAKFQSDETLLDAYSTTVADAVDRIGP
CCCCHHHHHHCCCCCCHHHHHHHHCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHCH
AVCRIERIGGQGGHGSGFVIAPDGLVVTNFHVVGDARTVRVSMPDGASSEGRVLGRDPDT
HHHHHHHCCCCCCCCCEEEECCCCEEEEEEEEECCCEEEEEECCCCCCCCCEEECCCCCC
DIALVRADGSFTDVAPLGDSKRLRRGQIAIAIGNPLGFEWTVTSGVVSALGRSMRASTGR
CEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCH
LIDDVIQTDAALNPGNSGGPLVSSAGEVIGVNTAMIHGAQGIAFAVASNTANFVISEIIR
HHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCHHEEECCCCEEEEEECCCHHHHHHHHHH
FGRVRRAFIGVSADTTNLPRRAALLSQVSTSTAVRLRSVEKNGPAAKAGLKEGDIIAAID
HHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHCCCCCCCEEEEEC
GRPVTGVDDLVRMLDAERIGRETLCTVVRRTGVSQVTVTPVARAG
CCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEECCCCCCC
>Mature Secondary Structure 
PPKSAQRFWDNGTNRKKSRSSLKTRSPSMALAAAKFQSDETLLDAYSTTVADAVDRIGP
CCCHHHHHHCCCCCCHHHHHHHHCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHCH
AVCRIERIGGQGGHGSGFVIAPDGLVVTNFHVVGDARTVRVSMPDGASSEGRVLGRDPDT
HHHHHHHCCCCCCCCCEEEECCCCEEEEEEEEECCCEEEEEECCCCCCCCCEEECCCCCC
DIALVRADGSFTDVAPLGDSKRLRRGQIAIAIGNPLGFEWTVTSGVVSALGRSMRASTGR
CEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCH
LIDDVIQTDAALNPGNSGGPLVSSAGEVIGVNTAMIHGAQGIAFAVASNTANFVISEIIR
HHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCHHEEECCCCEEEEEECCCHHHHHHHHHH
FGRVRRAFIGVSADTTNLPRRAALLSQVSTSTAVRLRSVEKNGPAAKAGLKEGDIIAAID
HHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHCCCCCCCEEEEEC
GRPVTGVDDLVRMLDAERIGRETLCTVVRRTGVSQVTVTPVARAG
CCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]