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The map label for this gene is degP [H]

Identifier: 13472200

GI number: 13472200

Start: 1967615

End: 1968619

Strand: Reverse

Name: degP [H]

Synonym: mll2416

Alternate gene names: 13472200

Gene position: 1968619-1967615 (Counterclockwise)

Preceding gene: 13472202

Following gene: 13472199

Centisome position: 27.98

GC content: 69.25

Gene sequence:

>1005_bases
GTGCGGAGCGGCTGGAACGGCCGCGACCTGACCAGATGGCCAGTCAAACCGCCAACTAGCCGTCAGGCGAGTACCTCCAG
GGGCGCCGTCGGGCGATATCTGGGACATGACGAACCCCAGGAGACAGCCATGAGTGATTTCAATCTGAATGCGTTTTCGC
AAGCCGTTGCCGACCTTGCCGCGAAGGCGGCGCCGGCAATGGCGAGCTTCGCCACCCACCACCATCGCACGGCAAGCGCC
TTCCACTGGAGCGACGGCTATTTCGTCACCGCCGAGGAGGCTGTCGAGGCCGGCGAGGAGATCGAGCTGACGCTGGCTTC
GGGCGTGACGGTGAAAGCCGAACTGGTCGGCCGCGATCCGTCGACGGGCGTTGCCTTGTTGAAGCCCGCGGATGCGGCCG
CCGGCGTGCCTGTCCTTGCCAGGGCCGACACCGTTCGGCCGGGAAACATCGCCATCGCCATCGGCAACAGCCAGGGCTCG
GCGCTGGCGGTATCGGGCTCGGTCGGCGAAGTCGGCCCGGCCTGGCGCTCGATGCGCGGCGGCACGATCGACAGGCGCAT
CCATCTGGCCGTCGGCGCCGGCGGCCGCTTCGAGGGCGGCCCGGTGCTCGACGCCAAGGGCGCGCTGATCGGCATGCTGT
TGTTCGGGCCGCGCGGCCGTGCGCTGGTCATGCCCTATGAGACGATCGAGCGGGCGGTGGCGACATTGCGTGAAAAGGGC
CATGTGGCGCGCGGCTATCTCGGCGCTGGCCTGCATCCGGTGCGCGACCGCGACGCCCATGGCGCGATGGTGATGAGCCT
CGACGACGCCGGTCCGGCCAAGGCCGCCGGCCTGTCGCTGGGCGACATCATCGTGGCGTGGAACGGCGAGGCCGTGCACG
GCCCGCGCGACCTGATCCGCAGGCTCGGCCCTGACAGCGCCGGTGCTTCCGTGACGCTTGGCGTGGTGCGTGGCGGTGAA
CAGCGCGACGTGACATTGACCATCGGCGAAAAGCCGCTGAGCTGA

Upstream 100 bases:

>100_bases
CCATGGATGGGCTCCGTGTTTTCAGGCTTGATCGTGATTTTTTCCTGTTCGTGCCGTTATCCCAAAACCGCTGAGCACTT
TTGGGCGGCACGCACTATAT

Downstream 100 bases:

>100_bases
GAGGATCGATGGAAACGCTCGCCGGCGACCGGATAGTGAGCAACAGTGCCGCTTCGCGGCAACTGGTGGTGCTGATTGCG
CTTGGCGATGCCGCGCGCGC

Product: serine protease

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MRSGWNGRDLTRWPVKPPTSRQASTSRGAVGRYLGHDEPQETAMSDFNLNAFSQAVADLAAKAAPAMASFATHHHRTASA
FHWSDGYFVTAEEAVEAGEEIELTLASGVTVKAELVGRDPSTGVALLKPADAAAGVPVLARADTVRPGNIAIAIGNSQGS
ALAVSGSVGEVGPAWRSMRGGTIDRRIHLAVGAGGRFEGGPVLDAKGALIGMLLFGPRGRALVMPYETIERAVATLREKG
HVARGYLGAGLHPVRDRDAHGAMVMSLDDAGPAKAAGLSLGDIIVAWNGEAVHGPRDLIRRLGPDSAGASVTLGVVRGGE
QRDVTLTIGEKPLS

Sequences:

>Translated_334_residues
MRSGWNGRDLTRWPVKPPTSRQASTSRGAVGRYLGHDEPQETAMSDFNLNAFSQAVADLAAKAAPAMASFATHHHRTASA
FHWSDGYFVTAEEAVEAGEEIELTLASGVTVKAELVGRDPSTGVALLKPADAAAGVPVLARADTVRPGNIAIAIGNSQGS
ALAVSGSVGEVGPAWRSMRGGTIDRRIHLAVGAGGRFEGGPVLDAKGALIGMLLFGPRGRALVMPYETIERAVATLREKG
HVARGYLGAGLHPVRDRDAHGAMVMSLDDAGPAKAAGLSLGDIIVAWNGEAVHGPRDLIRRLGPDSAGASVTLGVVRGGE
QRDVTLTIGEKPLS
>Mature_334_residues
MRSGWNGRDLTRWPVKPPTSRQASTSRGAVGRYLGHDEPQETAMSDFNLNAFSQAVADLAAKAAPAMASFATHHHRTASA
FHWSDGYFVTAEEAVEAGEEIELTLASGVTVKAELVGRDPSTGVALLKPADAAAGVPVLARADTVRPGNIAIAIGNSQGS
ALAVSGSVGEVGPAWRSMRGGTIDRRIHLAVGAGGRFEGGPVLDAKGALIGMLLFGPRGRALVMPYETIERAVATLREKG
HVARGYLGAGLHPVRDRDAHGAMVMSLDDAGPAKAAGLSLGDIIVAWNGEAVHGPRDLIRRLGPDSAGASVTLGVVRGGE
QRDVTLTIGEKPLS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Escherichia coli, GI1786356, Length=261, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789629, Length=265, Percent_Identity=27.5471698113208, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789630, Length=310, Percent_Identity=24.8387096774194, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 34621; Mature: 34621

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSGWNGRDLTRWPVKPPTSRQASTSRGAVGRYLGHDEPQETAMSDFNLNAFSQAVADLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHH
AKAAPAMASFATHHHRTASAFHWSDGYFVTAEEAVEAGEEIELTLASGVTVKAELVGRDP
HHHHHHHHHHHHHCCCCCCEEEECCCEEEEHHHHHCCCCEEEEEEECCCEEEEEEECCCC
STGVALLKPADAAAGVPVLARADTVRPGNIAIAIGNSQGSALAVSGSVGEVGPAWRSMRG
CCCEEEEECCCCCCCCCEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHCC
GTIDRRIHLAVGAGGRFEGGPVLDAKGALIGMLLFGPRGRALVMPYETIERAVATLREKG
CCCCEEEEEEEECCCCCCCCCEECCCCCEEEEEEECCCCCEEEECHHHHHHHHHHHHHCC
HVARGYLGAGLHPVRDRDAHGAMVMSLDDAGPAKAAGLSLGDIIVAWNGEAVHGPRDLIR
CEEECHHCCCCCCCCCCCCCCEEEEEECCCCCCHHCCCCCCCEEEEECCCCCCCHHHHHH
RLGPDSAGASVTLGVVRGGEQRDVTLTIGEKPLS
HCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCC
>Mature Secondary Structure
MRSGWNGRDLTRWPVKPPTSRQASTSRGAVGRYLGHDEPQETAMSDFNLNAFSQAVADLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHH
AKAAPAMASFATHHHRTASAFHWSDGYFVTAEEAVEAGEEIELTLASGVTVKAELVGRDP
HHHHHHHHHHHHHCCCCCCEEEECCCEEEEHHHHHCCCCEEEEEEECCCEEEEEEECCCC
STGVALLKPADAAAGVPVLARADTVRPGNIAIAIGNSQGSALAVSGSVGEVGPAWRSMRG
CCCEEEEECCCCCCCCCEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHCC
GTIDRRIHLAVGAGGRFEGGPVLDAKGALIGMLLFGPRGRALVMPYETIERAVATLREKG
CCCCEEEEEEEECCCCCCCCCEECCCCCEEEEEEECCCCCEEEECHHHHHHHHHHHHHCC
HVARGYLGAGLHPVRDRDAHGAMVMSLDDAGPAKAAGLSLGDIIVAWNGEAVHGPRDLIR
CEEECHHCCCCCCCCCCCCCCEEEEEECCCCCCHHCCCCCCCEEEEECCCCCCCHHHHHH
RLGPDSAGASVTLGVVRGGEQRDVTLTIGEKPLS
HCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]