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The map label for this gene is garR [H]

Identifier: 13471653

GI number: 13471653

Start: 1414539

End: 1415477

Strand: Direct

Name: garR [H]

Synonym: mlr1689

Alternate gene names: 13471653

Gene position: 1414539-1415477 (Clockwise)

Preceding gene: 13471643

Following gene: 13471656

Centisome position: 20.1

GC content: 64.43

Gene sequence:

>939_bases
ATGAACACCACCACCGCGCGCGAAAAGATCGGCTTCATCGGCCTTGGCCTGATGGGGCACGGCATTGCCAAGAACATCGT
CGACAAGGGCTATCCCCTGACATTCCTTGGCCGCAAGAACCGCAAGCCGGCGGAGGACCTGCTTGGCCGCGGCGCCAGGG
AAGCATCGACCTCGCGCGATGTGGCAGTGGCGTCCGATATCGTCTTCATCTGCGTCACCGGTTCGCGCGAAGTGGAAGCC
ATCATCCGTGGCCCCGGCGGCCTCAAGGAAGGCTTGAAGAAAGGCTCGGTCGTCGTCGATTGTTCGACCTCGGACCCGGT
CTCGACCGTGGCGCTAGCGGCCGAACTCAAGGCGCTGGGCATCGACTATGTCGACGCGCCGCTGAGCCGCACGCCGAAGG
AAGCCTGGGAAGGCACGCTCGACGCCATGGTCGGCGCCCCCGACGCCGTCTTTGCCAGGGTCAAGCCGGTGATCGAGACC
TGGGCCGGCCGCATCGTCCATATCGGCGACACCGGCGACGGCCACCGCATGAAGCTGCTCAACAATTTCATCTCGCTGGG
CTACGCCGCCATCTATTCCGAGGCGCTGGCCCTGGCCGAAAAGGTCGGCATCTCGCCGCCGCGTTTCGACAGCGTCATCC
GCAACGGCCGCATGGATTGCGGCTTCTACCAGACCTTCATGCGCTGGACGCTGGAAGGCGACCGCGACGCCCACAAATTC
ACCATCGCCAACGCCTTCAAGGACCTGACCTATCTGGAATCGATGGCGGGAGCCGCCGGCATTGCCAACCCGCTCGGCAA
CGCCACCAAGAACGCCTTCGCCGGCGCCCATGCCACCGGCCCGGCCGAACAGTTCGTGCCGATGCTGGCGACGCATATCG
GCAAGGTCAACGGCGTCGACCTGATGCCGACCAAGGATGGCAAGAAGCAGACGATCTAA

Upstream 100 bases:

>100_bases
CTCTGGAATTACCGTCTATTGTCAGACAATATTGCTTTCTGCAACCGCATATGGCTAAAACATCGGCGCAATTATCGATA
ATCCGGGATAGGACGACGAC

Downstream 100 bases:

>100_bases
GGCTCTAACTCTTTATTTTGACGCAATTCCCTCGGGAAAGCGCCACGCGCTTTCCCGGGAAAACCGTCTCACACTTTTCC
TGGAATTGCTCTGACGGCCG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNTTTAREKIGFIGLGLMGHGIAKNIVDKGYPLTFLGRKNRKPAEDLLGRGAREASTSRDVAVASDIVFICVTGSREVEA
IIRGPGGLKEGLKKGSVVVDCSTSDPVSTVALAAELKALGIDYVDAPLSRTPKEAWEGTLDAMVGAPDAVFARVKPVIET
WAGRIVHIGDTGDGHRMKLLNNFISLGYAAIYSEALALAEKVGISPPRFDSVIRNGRMDCGFYQTFMRWTLEGDRDAHKF
TIANAFKDLTYLESMAGAAGIANPLGNATKNAFAGAHATGPAEQFVPMLATHIGKVNGVDLMPTKDGKKQTI

Sequences:

>Translated_312_residues
MNTTTAREKIGFIGLGLMGHGIAKNIVDKGYPLTFLGRKNRKPAEDLLGRGAREASTSRDVAVASDIVFICVTGSREVEA
IIRGPGGLKEGLKKGSVVVDCSTSDPVSTVALAAELKALGIDYVDAPLSRTPKEAWEGTLDAMVGAPDAVFARVKPVIET
WAGRIVHIGDTGDGHRMKLLNNFISLGYAAIYSEALALAEKVGISPPRFDSVIRNGRMDCGFYQTFMRWTLEGDRDAHKF
TIANAFKDLTYLESMAGAAGIANPLGNATKNAFAGAHATGPAEQFVPMLATHIGKVNGVDLMPTKDGKKQTI
>Mature_312_residues
MNTTTAREKIGFIGLGLMGHGIAKNIVDKGYPLTFLGRKNRKPAEDLLGRGAREASTSRDVAVASDIVFICVTGSREVEA
IIRGPGGLKEGLKKGSVVVDCSTSDPVSTVALAAELKALGIDYVDAPLSRTPKEAWEGTLDAMVGAPDAVFARVKPVIET
WAGRIVHIGDTGDGHRMKLLNNFISLGYAAIYSEALALAEKVGISPPRFDSVIRNGRMDCGFYQTFMRWTLEGDRDAHKF
TIANAFKDLTYLESMAGAAGIANPLGNATKNAFAGAHATGPAEQFVPMLATHIGKVNGVDLMPTKDGKKQTI

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=275, Percent_Identity=25.8181818181818, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI23308751, Length=226, Percent_Identity=30.0884955752212, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI145693186, Length=208, Percent_Identity=37.9807692307692, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1786719, Length=298, Percent_Identity=34.5637583892617, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790315, Length=279, Percent_Identity=28.673835125448, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1789092, Length=279, Percent_Identity=27.5985663082437, Blast_Score=78, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17557316, Length=218, Percent_Identity=28.8990825688073, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24655230, Length=275, Percent_Identity=30.5454545454545, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922568, Length=275, Percent_Identity=30.5454545454545, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=24.822695035461, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 33176; Mature: 33176

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTTAREKIGFIGLGLMGHGIAKNIVDKGYPLTFLGRKNRKPAEDLLGRGAREASTSRD
CCCCCHHHHHCEEEEHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHCCCCCCCCCCCC
VAVASDIVFICVTGSREVEAIIRGPGGLKEGLKKGSVVVDCSTSDPVSTVALAAELKALG
CEEECCEEEEEEECCCCEEHEEECCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHC
IDYVDAPLSRTPKEAWEGTLDAMVGAPDAVFARVKPVIETWAGRIVHIGDTGDGHRMKLL
CCHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
NNFISLGYAAIYSEALALAEKVGISPPRFDSVIRNGRMDCGFYQTFMRWTLEGDRDAHKF
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHH
TIANAFKDLTYLESMAGAAGIANPLGNATKNAFAGAHATGPAEQFVPMLATHIGKVNGVD
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCE
LMPTKDGKKQTI
ECCCCCCCCCCC
>Mature Secondary Structure
MNTTTAREKIGFIGLGLMGHGIAKNIVDKGYPLTFLGRKNRKPAEDLLGRGAREASTSRD
CCCCCHHHHHCEEEEHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHCCCCCCCCCCCC
VAVASDIVFICVTGSREVEAIIRGPGGLKEGLKKGSVVVDCSTSDPVSTVALAAELKALG
CEEECCEEEEEEECCCCEEHEEECCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHC
IDYVDAPLSRTPKEAWEGTLDAMVGAPDAVFARVKPVIETWAGRIVHIGDTGDGHRMKLL
CCHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
NNFISLGYAAIYSEALALAEKVGISPPRFDSVIRNGRMDCGFYQTFMRWTLEGDRDAHKF
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHH
TIANAFKDLTYLESMAGAAGIANPLGNATKNAFAGAHATGPAEQFVPMLATHIGKVNGVD
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCE
LMPTKDGKKQTI
ECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]