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The map label for this gene is ydgK [H]

Identifier: 13471486

GI number: 13471486

Start: 1223358

End: 1224563

Strand: Reverse

Name: ydgK [H]

Synonym: mll1470

Alternate gene names: 13471486

Gene position: 1224563-1223358 (Counterclockwise)

Preceding gene: 13471491

Following gene: 13471484

Centisome position: 17.4

GC content: 65.09

Gene sequence:

>1206_bases
ATGAGTCCCAAATTCCTCCGCATCGCGGTCGTGCTCGGCCTGTTGTCCGCCATCGGCCCCTTCGCAATCGACATGTATCT
TCCCGCTTTGCCGTCGATCGGCGCGGATCTGCACGCCGGCACCGCCGCTGTGCAGATGAGCCTGCTGATCTTCTTCCTGT
CGATGGGTTTCGGCCAGATCGTCGTCGGGCCGATCTCCGACATGGTCGGCCGCAAGCTGCCGCTCTATGGCGGGCTTGGG
CTGTTTATGGTCGGTGGCATCGGTTCGGCCATGGCGCCGACCATCGAGTGGCTGATCGCCTTCCGCTTCCTGCAGGGCCT
TGGCGCCAGCGCCGGTATGGCGGTGCCTCGCGCCATCGTGCGTGACCTGCACACCGGCAATGAGGCGGCCAAGCTGATGT
CCTTGCTGATGCTGGTGTTCTCGGTGTCGCCGATCCTGGCGCCGCTGACCGGCAGCCAGATCATCGAGAATTTCGGCTGG
CGCGCCGTGTTCTGGACGGTGACTGGTGCGGCAGCCCTTGCCACCATCCTGCTCGCCACCTCGCTCAAGGAGACGCGACC
GGCTGAAGAACGCGTCGGTTCCTCCTTCGGCACCGCGCTTGCCGGCTACCGCTTCCTGATGGGTGACCGCAACTTCCTTG
GCCTGGTGGCGATCGCCGGCTTCGGCATTGCGAGCTTCTTCGTCTATCTGTCGAGTTCGTCCTTCATCCTGATCGACCAC
TACGGGCTGTCGCCTTCGGTCTACAGCGTGTTCTTCTCGATCAACGCGGTGGCCTTTATTGGCATGTCGCAGCTGACGGG
CCTGCTGGCCGAGCGTTTTGGGCTGCGGCGCGTGGTGCGTGTCGCTGTGACCGGCTACGCCTCGACGATGGTGGTGCTGC
TCGCGATCATGGCGACGGGCGTCGATCGGCTCGACGTGATGGCAGCCCTGCTGTTCGTTGGTTATGGCTTCCTTGGCCTG
GTCATTCCGACCACCTCGGTGCTGGCCATGGAAGAGCATGGCGAGATCGCCGGCACGGCCTCGGCGCTGATGGGCACGCT
GCACTTCGCCATCGGCGCGCTCGCCATGGGCGTCGCCGGCGTGTTCTTCGACGGCACGCCGCTGCCGATGGTCGCCGGCA
TTACGCTCTGCGCAGTGATTTCCTTCACGCTGGCCAAGGTCACGCTCGGCCGTTCGCGCGAGGCGGTGGAAGCGCCGGCG
GAGTAG

Upstream 100 bases:

>100_bases
CAGAATTCGCTGCTGGAGTGTCGGAACCTCACGGGATGGAACGTCCTTGGGTTAGACGTCGCCTGGCGGCGGCAACCAGA
ATTCGAAAGAAGCCAATATC

Downstream 100 bases:

>100_bases
GCACTGCTCGCAAGCGCATGAAAAGGCCGGGTTTTCCCGGCCTTTTTTAATTCAACCCTGCGTCGGCCAATACGAAACGC
AGCCTTGTCTCGACCGGCGC

Product: membrane transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSPKFLRIAVVLGLLSAIGPFAIDMYLPALPSIGADLHAGTAAVQMSLLIFFLSMGFGQIVVGPISDMVGRKLPLYGGLG
LFMVGGIGSAMAPTIEWLIAFRFLQGLGASAGMAVPRAIVRDLHTGNEAAKLMSLLMLVFSVSPILAPLTGSQIIENFGW
RAVFWTVTGAAALATILLATSLKETRPAEERVGSSFGTALAGYRFLMGDRNFLGLVAIAGFGIASFFVYLSSSSFILIDH
YGLSPSVYSVFFSINAVAFIGMSQLTGLLAERFGLRRVVRVAVTGYASTMVVLLAIMATGVDRLDVMAALLFVGYGFLGL
VIPTTSVLAMEEHGEIAGTASALMGTLHFAIGALAMGVAGVFFDGTPLPMVAGITLCAVISFTLAKVTLGRSREAVEAPA
E

Sequences:

>Translated_401_residues
MSPKFLRIAVVLGLLSAIGPFAIDMYLPALPSIGADLHAGTAAVQMSLLIFFLSMGFGQIVVGPISDMVGRKLPLYGGLG
LFMVGGIGSAMAPTIEWLIAFRFLQGLGASAGMAVPRAIVRDLHTGNEAAKLMSLLMLVFSVSPILAPLTGSQIIENFGW
RAVFWTVTGAAALATILLATSLKETRPAEERVGSSFGTALAGYRFLMGDRNFLGLVAIAGFGIASFFVYLSSSSFILIDH
YGLSPSVYSVFFSINAVAFIGMSQLTGLLAERFGLRRVVRVAVTGYASTMVVLLAIMATGVDRLDVMAALLFVGYGFLGL
VIPTTSVLAMEEHGEIAGTASALMGTLHFAIGALAMGVAGVFFDGTPLPMVAGITLCAVISFTLAKVTLGRSREAVEAPA
E
>Mature_400_residues
SPKFLRIAVVLGLLSAIGPFAIDMYLPALPSIGADLHAGTAAVQMSLLIFFLSMGFGQIVVGPISDMVGRKLPLYGGLGL
FMVGGIGSAMAPTIEWLIAFRFLQGLGASAGMAVPRAIVRDLHTGNEAAKLMSLLMLVFSVSPILAPLTGSQIIENFGWR
AVFWTVTGAAALATILLATSLKETRPAEERVGSSFGTALAGYRFLMGDRNFLGLVAIAGFGIASFFVYLSSSSFILIDHY
GLSPSVYSVFFSINAVAFIGMSQLTGLLAERFGLRRVVRVAVTGYASTMVVLLAIMATGVDRLDVMAALLFVGYGFLGLV
IPTTSVLAMEEHGEIAGTASALMGTLHFAIGALAMGVAGVFFDGTPLPMVAGITLCAVISFTLAKVTLGRSREAVEAPAE

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=376, Percent_Identity=31.6489361702128, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI48994889, Length=393, Percent_Identity=30.0254452926209, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790146, Length=237, Percent_Identity=30.8016877637131, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082312, Length=334, Percent_Identity=30.2395209580838, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787065, Length=384, Percent_Identity=24.7395833333333, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081738, Length=391, Percent_Identity=26.5984654731458, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319517, Length=187, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319480, Length=175, Percent_Identity=28, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41909; Mature: 41778

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS01331 THYMIDYLATE_KINASE ; PS00178 AA_TRNA_LIGASE_I ; PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPKFLRIAVVLGLLSAIGPFAIDMYLPALPSIGADLHAGTAAVQMSLLIFFLSMGFGQI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCE
VVGPISDMVGRKLPLYGGLGLFMVGGIGSAMAPTIEWLIAFRFLQGLGASAGMAVPRAIV
EEECHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
RDLHTGNEAAKLMSLLMLVFSVSPILAPLTGSQIIENFGWRAVFWTVTGAAALATILLAT
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHH
SLKETRPAEERVGSSFGTALAGYRFLMGDRNFLGLVAIAGFGIASFFVYLSSSSFILIDH
HHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
YGLSPSVYSVFFSINAVAFIGMSQLTGLLAERFGLRRVVRVAVTGYASTMVVLLAIMATG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VDRLDVMAALLFVGYGFLGLVIPTTSVLAMEEHGEIAGTASALMGTLHFAIGALAMGVAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VFFDGTPLPMVAGITLCAVISFTLAKVTLGRSREAVEAPAE
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SPKFLRIAVVLGLLSAIGPFAIDMYLPALPSIGADLHAGTAAVQMSLLIFFLSMGFGQI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCE
VVGPISDMVGRKLPLYGGLGLFMVGGIGSAMAPTIEWLIAFRFLQGLGASAGMAVPRAIV
EEECHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
RDLHTGNEAAKLMSLLMLVFSVSPILAPLTGSQIIENFGWRAVFWTVTGAAALATILLAT
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHH
SLKETRPAEERVGSSFGTALAGYRFLMGDRNFLGLVAIAGFGIASFFVYLSSSSFILIDH
HHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
YGLSPSVYSVFFSINAVAFIGMSQLTGLLAERFGLRRVVRVAVTGYASTMVVLLAIMATG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VDRLDVMAALLFVGYGFLGLVIPTTSVLAMEEHGEIAGTASALMGTLHFAIGALAMGVAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VFFDGTPLPMVAGITLCAVISFTLAKVTLGRSREAVEAPAE
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]