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The map label for this gene is 13471462

Identifier: 13471462

GI number: 13471462

Start: 1201784

End: 1202935

Strand: Reverse

Name: 13471462

Synonym: mll1440

Alternate gene names: NA

Gene position: 1202935-1201784 (Counterclockwise)

Preceding gene: 13471465

Following gene: 13471461

Centisome position: 17.1

GC content: 64.15

Gene sequence:

>1152_bases
ATGCTCACCCACGCGCTGATTGGCGACGAAGGCAGAACGATCGAACTTGGCTGGCAGGGCGGGAGGCGCACCCGCTTTCA
CGCCATGTGGCTGCGCGACAATGCGCTCGACGACAAGACGCGCAGCGCTGGCAATGGCCAGCGGCTGATCACCATCCTCG
ACATTCCGGCCGAGACGAGGATCGGCGCGGCCGAGATCAAGGGCGGCGCGCTGGAAGTCAGTTTCGTGCCGGAAGGAAAG
ACGGTCAGCTTTCCCGCGCAGTGGCTCAGCGCCAACGCCTATGATCGCGACGAGCTTCGTGAGCCCGGCTGGACGGGCGA
TGTCATCCAGCGCTGGACCAAGGCGACGATGCAGAATTCGGTGCCGCGCGCCAGCTACAAGGCGGCCTTTCACGGCCGCA
GCGTCCTGCGCGAATGGCTTTCGGCGGTGCGAACCTACGGCTTTGCGGTGATGGACGGACTGCCGGCCGAATCCGGCGCG
TTGTGCAAGGTCTCCGACCTGTTCGGCTATATCAGGGAGACCAATTACGGCCGCTGGTTCGAAGTGCGCGCCGAGGTCAA
TCCGAACAATCTCGCCTACACCAATCTCGGCCTCCAGGCGCACACCGACAATCCCTATCGCGATCCGGTGCCGACGTTGC
AGATCCTGGCCTGTGTCGAGAATACGGTGGAGGGTGGCGAGTCGAGCGTCATCGACGGTTTTGCCGTCGCGGCCGCGCTG
CAGGCCGAAAACCCTGAAGGCTTCCGGCTGTTGAGTTCCTGTCCGGCGCGCTTCGAATATGCCGGCTCGTCCGGCGTGCG
GCTGCAGGCGAAGCGGCCGATGATCGAGCTCGGGCCGGATGGCGAGCTGATCTGCATCCGCTTCAACAACCGCTCGCTGG
CGCCTGTCGTCGACGTGCCCTTCGCCGATATGGACGCCTACTATGCCGCCTATCGCCGGTTCGCCGAGCTGATCGAGGAT
CCCGATTTCGAAGTGACGTTCAAACTTCAACCTGGCCAGGCCTTCATCGTCGACAACACGCGTGTCATGCATGCCCGCAA
GGCGTTTTCCGGCACCGGCAAGCGCTGGCTGCAGGGTTGCTACGCCGACAAGGACGGCCTGCTGTCGACGCTCGCCGCGA
TCGAGCACAGCTTCAAGGAGGCCGCCGAATGA

Upstream 100 bases:

>100_bases
GGCCAAAAAATGATAATTTGAGTTATGCCTTTCTTGTCGCCAACATGCAATCGAAACCCTGCGGACCGGGCCGCGGGGCG
TAGAGGACAGGAACGGATCC

Downstream 100 bases:

>100_bases
GCGGCCAGGATCTGAACGCCGACAACATCGTCGAATTCATCGCCGACATTTTTGAGCGCCGGGGCGCGGAATCTTATCTC
GGCGAGCCGGTGACCATGTC

Product: gamma-butyrobetaine hydroxylase

Products: NA

Alternate protein names: Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MLTHALIGDEGRTIELGWQGGRRTRFHAMWLRDNALDDKTRSAGNGQRLITILDIPAETRIGAAEIKGGALEVSFVPEGK
TVSFPAQWLSANAYDRDELREPGWTGDVIQRWTKATMQNSVPRASYKAAFHGRSVLREWLSAVRTYGFAVMDGLPAESGA
LCKVSDLFGYIRETNYGRWFEVRAEVNPNNLAYTNLGLQAHTDNPYRDPVPTLQILACVENTVEGGESSVIDGFAVAAAL
QAENPEGFRLLSSCPARFEYAGSSGVRLQAKRPMIELGPDGELICIRFNNRSLAPVVDVPFADMDAYYAAYRRFAELIED
PDFEVTFKLQPGQAFIVDNTRVMHARKAFSGTGKRWLQGCYADKDGLLSTLAAIEHSFKEAAE

Sequences:

>Translated_383_residues
MLTHALIGDEGRTIELGWQGGRRTRFHAMWLRDNALDDKTRSAGNGQRLITILDIPAETRIGAAEIKGGALEVSFVPEGK
TVSFPAQWLSANAYDRDELREPGWTGDVIQRWTKATMQNSVPRASYKAAFHGRSVLREWLSAVRTYGFAVMDGLPAESGA
LCKVSDLFGYIRETNYGRWFEVRAEVNPNNLAYTNLGLQAHTDNPYRDPVPTLQILACVENTVEGGESSVIDGFAVAAAL
QAENPEGFRLLSSCPARFEYAGSSGVRLQAKRPMIELGPDGELICIRFNNRSLAPVVDVPFADMDAYYAAYRRFAELIED
PDFEVTFKLQPGQAFIVDNTRVMHARKAFSGTGKRWLQGCYADKDGLLSTLAAIEHSFKEAAE
>Mature_383_residues
MLTHALIGDEGRTIELGWQGGRRTRFHAMWLRDNALDDKTRSAGNGQRLITILDIPAETRIGAAEIKGGALEVSFVPEGK
TVSFPAQWLSANAYDRDELREPGWTGDVIQRWTKATMQNSVPRASYKAAFHGRSVLREWLSAVRTYGFAVMDGLPAESGA
LCKVSDLFGYIRETNYGRWFEVRAEVNPNNLAYTNLGLQAHTDNPYRDPVPTLQILACVENTVEGGESSVIDGFAVAAAL
QAENPEGFRLLSSCPARFEYAGSSGVRLQAKRPMIELGPDGELICIRFNNRSLAPVVDVPFADMDAYYAAYRRFAELIED
PDFEVTFKLQPGQAFIVDNTRVMHARKAFSGTGKRWLQGCYADKDGLLSTLAAIEHSFKEAAE

Specific function: Catalyzes the formation of L-carnitine from gamma- butyrobetaine

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-BBH/TMLD family

Homologues:

Organism=Homo sapiens, GI4502369, Length=380, Percent_Identity=30, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI8922625, Length=357, Percent_Identity=28.2913165266106, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI296317249, Length=275, Percent_Identity=25.4545454545455, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17534641, Length=374, Percent_Identity=29.144385026738, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71992672, Length=365, Percent_Identity=24.6575342465753, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI221329931, Length=368, Percent_Identity=27.9891304347826, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24639015, Length=381, Percent_Identity=28.6089238845144, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922166, Length=393, Percent_Identity=26.7175572519084, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24648401, Length=345, Percent_Identity=25.5072463768116, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BODG_RHILO (Q98KK0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_103028.1
- ProteinModelPortal:   Q98KK0
- GeneID:   1225691
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll1440
- NMPDR:   fig|266835.1.peg.1133
- HOGENOM:   HBG715615
- OMA:   IRFNNRS
- ProtClustDB:   CLSK505490
- BRENDA:   1.14.11.1
- GO:   GO:0005737
- InterPro:   IPR012775
- InterPro:   IPR003819
- TIGRFAMs:   TIGR02409

Pfam domain/function: PF02668 TauD

EC number: =1.14.11.1

Molecular weight: Translated: 42394; Mature: 42394

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTHALIGDEGRTIELGWQGGRRTRFHAMWLRDNALDDKTRSAGNGQRLITILDIPAETR
CCCCEEECCCCCEEEEECCCCCCEEEEEEEEECCCCCCHHCCCCCCCEEEEEEECCCCCC
IGAAEIKGGALEVSFVPEGKTVSFPAQWLSANAYDRDELREPGWTGDVIQRWTKATMQNS
CCHHHCCCCEEEEEECCCCCEEECCHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCC
VPRASYKAAFHGRSVLREWLSAVRTYGFAVMDGLPAESGALCKVSDLFGYIRETNYGRWF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEEHHHHHHHHHHCCCCEEE
EVRAEVNPNNLAYTNLGLQAHTDNPYRDPVPTLQILACVENTVEGGESSVIDGFAVAAAL
EEEEEECCCCEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QAENPEGFRLLSSCPARFEYAGSSGVRLQAKRPMIELGPDGELICIRFNNRSLAPVVDVP
CCCCCCCHHHHHCCCCCEEECCCCCEEEEECCCEEEECCCCCEEEEEECCCCCCCEECCC
FADMDAYYAAYRRFAELIEDPDFEVTFKLQPGQAFIVDNTRVMHARKAFSGTGKRWLQGC
CCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCEEEHHHHHHCCCCHHHHHHH
YADKDGLLSTLAAIEHSFKEAAE
CCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLTHALIGDEGRTIELGWQGGRRTRFHAMWLRDNALDDKTRSAGNGQRLITILDIPAETR
CCCCEEECCCCCEEEEECCCCCCEEEEEEEEECCCCCCHHCCCCCCCEEEEEEECCCCCC
IGAAEIKGGALEVSFVPEGKTVSFPAQWLSANAYDRDELREPGWTGDVIQRWTKATMQNS
CCHHHCCCCEEEEEECCCCCEEECCHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCC
VPRASYKAAFHGRSVLREWLSAVRTYGFAVMDGLPAESGALCKVSDLFGYIRETNYGRWF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEEHHHHHHHHHHCCCCEEE
EVRAEVNPNNLAYTNLGLQAHTDNPYRDPVPTLQILACVENTVEGGESSVIDGFAVAAAL
EEEEEECCCCEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
QAENPEGFRLLSSCPARFEYAGSSGVRLQAKRPMIELGPDGELICIRFNNRSLAPVVDVP
CCCCCCCHHHHHCCCCCEEECCCCCEEEEECCCEEEECCCCCEEEEEECCCCCCCEECCC
FADMDAYYAAYRRFAELIEDPDFEVTFKLQPGQAFIVDNTRVMHARKAFSGTGKRWLQGC
CCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCEEEHHHHHHCCCCHHHHHHH
YADKDGLLSTLAAIEHSFKEAAE
CCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968