Click here to switch to the map view.

The map label for this gene is cobQ

Identifier: 13471275

GI number: 13471275

Start: 1006926

End: 1008401

Strand: Reverse

Name: cobQ

Synonym: mll1198

Alternate gene names: 13471275

Gene position: 1008401-1006926 (Counterclockwise)

Preceding gene: 13471276

Following gene: 13471270

Centisome position: 14.33

GC content: 65.51

Gene sequence:

>1476_bases
ATGGCCAGGGCGATCATGCTGCAAGGCACGGGTTCGGATGTCGGCAAGACGGTGCTGGTCGCCGGCCTGTGCCGCGCCGC
GAAGAAGCGCGGGCTCAAGGTGCGGCCGTTCAAGCCGCAGAACATGTCGAACAACGCCGCGGTCGCCGACATTCCGGGCG
ACAACAACCATGGCGGCGGCGAGATCGGCCGCGCGCAGTGGCTGCAGGCGATCGCTTGCGGCGTTGCGCCGTCGGTTCAC
ATGAACCCGGTGCTGCTCAAGCCGCAGAGCGATGTCGGCGCGCAGGTCATCGTGCAAGGCAAGGTGTTCGGCGAGGCGCG
CGCGCGCGATTACCAGGCGCTGAAGGGTCGGTTGATGGACGCCGTGCTCGACTCCTGGGCGAAAGTCGGCGAGGGCGCCG
ATCTGGTCATCGTCGAGGGCGCCGGCTCGCCGGCCGAGATCAATTTGCGCAGCCGAGACATTGCCAATATGGGCTTTGCC
ACGCGTGCAGATGTGCCGGTGGTGCTGGTTGGCGACATCGACCGGGGCGGTGTCATCGCCTCGGTCGCGGGCACGCATCT
GATCCTGCCGGAAGAGGACCGGCGCATGATCGTCGGCTACCTCATCAACAAGTTCCGCGGCGATGTTTCGCTTTTCGATG
ACGGCCTCAAGGCGATCGAGAAATTCACCGGCTGGCGCTGCTTTGGCGTCGTGCCGTGGCTGAAGGCGGCGGCGCGGCTG
CCTTCGGAGGATTCGGTGGTGCTGGAGCGACTGGCATCCGGCGAGGCGCGGGCGCTGAAGGTGGCGGTGCCGGTGCTCGG
CCGCATCGCCAATTTCGACGATCTAGATCCGCTCAAGGCCGAACCGCAGGTCGAGGTGGTGTTCGTGCCGCCGGGAAAGC
CGCTGCCATCAGATGCCGGGCTGGTGGTCATTCCCGGCTCCAAATCGACGATCGGCGATCTCATAAGATTCCGCGAGAAT
GGCTGGGACAGGGATCTTGCCACACATCGCAAGCGCGGCGGCCATGTCGTCGGCATTTGCGGTGGGTTTCAGATGCTTGG
CCGCAGGGTGCGCGATCCCGACGGGATCGAAGGCAGCGTCACCGAGGCCGAAGGGCTTGGCCTGCTCGATATCGAAACGA
TGATGGAGCCGGAGAAGACGGTGCGCAATGTCAGCGCCCGCTCGGTGCAATTCGACCTGCCCCTCGAAGGCTACGAAATC
CATCTCGGCCGCACCACCGGCCCGGACACGATGCGGCCGTCGGCGATCATCAATGGCGTTGCGGACGGTGCGATCTCCGC
CGATGGCAAGGTGATCGGCACCTATATGCACGGCCTGTTCGGCGCCGACGCCTTTCGCGGAAAATTCCTCGAAAGCCTTG
GCATCAAGGGCGGCGGCATCGACTATCGCGTCGAAGTCGAGCGGGCGCTGGACGACGTCGCGGCCGAGTTGGAGGGCCAC
CTCGACTGTGACGCGCTTTTCGGCCTGGCGCGCTAA

Upstream 100 bases:

>100_bases
GAACAGGCAACGAGCCGCTTTTGGCGCTCTACATCTGGCGCGGCGGGCCGCTGGCGCAGAAATCCACGATCACGGGAACC
GCGATGCAGGGCCGAAGCTG

Downstream 100 bases:

>100_bases
GGCGTGCCGAGGTTCAAACTCGCTGGTCGATCGACGGTTTTTGCGAGAAGATGGACGCAACTGCGCCGAAGGCAGGCCGC
GCAGGGGAGATGGAGTTCGC

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MARAIMLQGTGSDVGKTVLVAGLCRAAKKRGLKVRPFKPQNMSNNAAVADIPGDNNHGGGEIGRAQWLQAIACGVAPSVH
MNPVLLKPQSDVGAQVIVQGKVFGEARARDYQALKGRLMDAVLDSWAKVGEGADLVIVEGAGSPAEINLRSRDIANMGFA
TRADVPVVLVGDIDRGGVIASVAGTHLILPEEDRRMIVGYLINKFRGDVSLFDDGLKAIEKFTGWRCFGVVPWLKAAARL
PSEDSVVLERLASGEARALKVAVPVLGRIANFDDLDPLKAEPQVEVVFVPPGKPLPSDAGLVVIPGSKSTIGDLIRFREN
GWDRDLATHRKRGGHVVGICGGFQMLGRRVRDPDGIEGSVTEAEGLGLLDIETMMEPEKTVRNVSARSVQFDLPLEGYEI
HLGRTTGPDTMRPSAIINGVADGAISADGKVIGTYMHGLFGADAFRGKFLESLGIKGGGIDYRVEVERALDDVAAELEGH
LDCDALFGLAR

Sequences:

>Translated_491_residues
MARAIMLQGTGSDVGKTVLVAGLCRAAKKRGLKVRPFKPQNMSNNAAVADIPGDNNHGGGEIGRAQWLQAIACGVAPSVH
MNPVLLKPQSDVGAQVIVQGKVFGEARARDYQALKGRLMDAVLDSWAKVGEGADLVIVEGAGSPAEINLRSRDIANMGFA
TRADVPVVLVGDIDRGGVIASVAGTHLILPEEDRRMIVGYLINKFRGDVSLFDDGLKAIEKFTGWRCFGVVPWLKAAARL
PSEDSVVLERLASGEARALKVAVPVLGRIANFDDLDPLKAEPQVEVVFVPPGKPLPSDAGLVVIPGSKSTIGDLIRFREN
GWDRDLATHRKRGGHVVGICGGFQMLGRRVRDPDGIEGSVTEAEGLGLLDIETMMEPEKTVRNVSARSVQFDLPLEGYEI
HLGRTTGPDTMRPSAIINGVADGAISADGKVIGTYMHGLFGADAFRGKFLESLGIKGGGIDYRVEVERALDDVAAELEGH
LDCDALFGLAR
>Mature_490_residues
ARAIMLQGTGSDVGKTVLVAGLCRAAKKRGLKVRPFKPQNMSNNAAVADIPGDNNHGGGEIGRAQWLQAIACGVAPSVHM
NPVLLKPQSDVGAQVIVQGKVFGEARARDYQALKGRLMDAVLDSWAKVGEGADLVIVEGAGSPAEINLRSRDIANMGFAT
RADVPVVLVGDIDRGGVIASVAGTHLILPEEDRRMIVGYLINKFRGDVSLFDDGLKAIEKFTGWRCFGVVPWLKAAARLP
SEDSVVLERLASGEARALKVAVPVLGRIANFDDLDPLKAEPQVEVVFVPPGKPLPSDAGLVVIPGSKSTIGDLIRFRENG
WDRDLATHRKRGGHVVGICGGFQMLGRRVRDPDGIEGSVTEAEGLGLLDIETMMEPEKTVRNVSARSVQFDLPLEGYEIH
LGRTTGPDTMRPSAIINGVADGAISADGKVIGTYMHGLFGADAFRGKFLESLGIKGGGIDYRVEVERALDDVAAELEGHL
DCDALFGLAR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_RHILO (Q98L33)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102844.1
- ProteinModelPortal:   Q98L33
- SMR:   Q98L33
- GeneID:   1225507
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll1198
- NMPDR:   fig|266835.1.peg.949
- HOGENOM:   HBG302271
- OMA:   RGDIANM
- ProtClustDB:   PRK00784
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 52243; Mature: 52111

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 340-340 ACT_SITE 437-437

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARAIMLQGTGSDVGKTVLVAGLCRAAKKRGLKVRPFKPQNMSNNAAVADIPGDNNHGGG
CCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEEECCCCCCCCCC
EIGRAQWLQAIACGVAPSVHMNPVLLKPQSDVGAQVIVQGKVFGEARARDYQALKGRLMD
CHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
AVLDSWAKVGEGADLVIVEGAGSPAEINLRSRDIANMGFATRADVPVVLVGDIDRGGVIA
HHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHCCCCCCCCCCEEEEECCCCCCEEE
SVAGTHLILPEEDRRMIVGYLINKFRGDVSLFDDGLKAIEKFTGWRCFGVVPWLKAAARL
EECCCEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCC
PSEDSVVLERLASGEARALKVAVPVLGRIANFDDLDPLKAEPQVEVVFVPPGKPLPSDAG
CCCHHHHHHHHHCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
LVVIPGSKSTIGDLIRFRENGWDRDLATHRKRGGHVVGICGGFQMLGRRVRDPDGIEGSV
EEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCCCCCC
TEAEGLGLLDIETMMEPEKTVRNVSARSVQFDLPLEGYEIHLGRTTGPDTMRPSAIINGV
CCCCCCCEEEHHHHCCHHHHHHCCHHCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHH
ADGAISADGKVIGTYMHGLFGADAFRGKFLESLGIKGGGIDYRVEVERALDDVAAELEGH
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCC
LDCDALFGLAR
CCHHHHHCCCC
>Mature Secondary Structure 
ARAIMLQGTGSDVGKTVLVAGLCRAAKKRGLKVRPFKPQNMSNNAAVADIPGDNNHGGG
CCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEEECCCCCCCCCC
EIGRAQWLQAIACGVAPSVHMNPVLLKPQSDVGAQVIVQGKVFGEARARDYQALKGRLMD
CHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
AVLDSWAKVGEGADLVIVEGAGSPAEINLRSRDIANMGFATRADVPVVLVGDIDRGGVIA
HHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHCCCCCCCCCCEEEEECCCCCCEEE
SVAGTHLILPEEDRRMIVGYLINKFRGDVSLFDDGLKAIEKFTGWRCFGVVPWLKAAARL
EECCCEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCC
PSEDSVVLERLASGEARALKVAVPVLGRIANFDDLDPLKAEPQVEVVFVPPGKPLPSDAG
CCCHHHHHHHHHCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
LVVIPGSKSTIGDLIRFRENGWDRDLATHRKRGGHVVGICGGFQMLGRRVRDPDGIEGSV
EEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCCCCCC
TEAEGLGLLDIETMMEPEKTVRNVSARSVQFDLPLEGYEIHLGRTTGPDTMRPSAIINGV
CCCCCCCEEEHHHHCCHHHHHHCCHHCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHH
ADGAISADGKVIGTYMHGLFGADAFRGKFLESLGIKGGGIDYRVEVERALDDVAAELEGH
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCC
LDCDALFGLAR
CCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968