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The map label for this gene is ppi [H]

Identifier: 13470906

GI number: 13470906

Start: 573399

End: 573893

Strand: Reverse

Name: ppi [H]

Synonym: mll0728

Alternate gene names: 13470906

Gene position: 573893-573399 (Counterclockwise)

Preceding gene: 13470907

Following gene: 13470905

Centisome position: 8.16

GC content: 62.63

Gene sequence:

>495_bases
ATGATCATCACGCTGAAGGATGGCGACGTCACCATCGCTCTGCGGCCCGATCTGGCGCCCAAGCACGTCGCGCAGATCAA
GAAGCTCGTGCGTGACCATGCCTATGACAATGTCGCTTTCCACCGCGTCATCGACGGCTTCATGGCGCAGACCGGCGACG
TCAAGTTCGGCAACATGAAGAAGGGCTTCAACTCCCAGGCCGTCGGCACCGGCGGTTCGGACCTGCCCGACCTGCCGGCC
GAATTCTCGCAGACCGAGCACTATAAGCGCGGCGTGGTCGGCATGGCCCGCTCACAGGATCCGAACTCCGCCAATTCGCA
GTTCTTCATCATGTTCGCGCCGGCGCCGCCGCTCGACGGCCAGTACACCATCGTCGGCAATGTCGTCAGCGGCATGGAGT
TGGTGGACCACATCAAGAAGGGCGACGAGGCGGACAACGGTACGGTCTCCGACCCCGACCGGATGATCAAGGTGCGCATC
GCCGCCGACAAGTAA

Upstream 100 bases:

>100_bases
AAATCCCATGCAGCTCAAAAGGCTCGCCTCGTTCCTCGTCGTGCTTGCCGGTCTTGTGACCGCCTCGGCCTCGGCCTATG
CCGCCGACCCGGAAAACACC

Downstream 100 bases:

>100_bases
TTTTTGTTTTCTCAAAAGGATATCTGACATGGCCGAAATCAAGGACCGCGAGAACGCGCTCATCATGGAAACGACCAAGG
GCAAGGTCGTCATCGAACTT

Product: peptidyl prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIITLKDGDVTIALRPDLAPKHVAQIKKLVRDHAYDNVAFHRVIDGFMAQTGDVKFGNMKKGFNSQAVGTGGSDLPDLPA
EFSQTEHYKRGVVGMARSQDPNSANSQFFIMFAPAPPLDGQYTIVGNVVSGMELVDHIKKGDEADNGTVSDPDRMIKVRI
AADK

Sequences:

>Translated_164_residues
MIITLKDGDVTIALRPDLAPKHVAQIKKLVRDHAYDNVAFHRVIDGFMAQTGDVKFGNMKKGFNSQAVGTGGSDLPDLPA
EFSQTEHYKRGVVGMARSQDPNSANSQFFIMFAPAPPLDGQYTIVGNVVSGMELVDHIKKGDEADNGTVSDPDRMIKVRI
AADK
>Mature_164_residues
MIITLKDGDVTIALRPDLAPKHVAQIKKLVRDHAYDNVAFHRVIDGFMAQTGDVKFGNMKKGFNSQAVGTGGSDLPDLPA
EFSQTEHYKRGVVGMARSQDPNSANSQFFIMFAPAPPLDGQYTIVGNVVSGMELVDHIKKGDEADNGTVSDPDRMIKVRI
AADK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=145, Percent_Identity=35.1724137931034, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI24308049, Length=139, Percent_Identity=33.8129496402878, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI4505991, Length=137, Percent_Identity=33.5766423357664, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI5031987, Length=137, Percent_Identity=33.5766423357664, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1786736, Length=140, Percent_Identity=33.5714285714286, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789763, Length=152, Percent_Identity=34.2105263157895, Blast_Score=67, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=142, Percent_Identity=38.0281690140845, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=144, Percent_Identity=35.4166666666667, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=144, Percent_Identity=35.4166666666667, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=147, Percent_Identity=29.9319727891156, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539498, Length=173, Percent_Identity=31.7919075144509, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=162, Percent_Identity=32.0987654320988, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=137, Percent_Identity=34.3065693430657, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322492, Length=158, Percent_Identity=32.2784810126582, Blast_Score=64, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17986117, Length=158, Percent_Identity=34.8101265822785, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24652460, Length=143, Percent_Identity=37.0629370629371, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24664125, Length=148, Percent_Identity=32.4324324324324, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21357783, Length=148, Percent_Identity=32.4324324324324, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17136360, Length=136, Percent_Identity=30.8823529411765, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17813; Mature: 17813

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITLKDGDVTIALRPDLAPKHVAQIKKLVRDHAYDNVAFHRVIDGFMAQTGDVKFGNMK
CEEEEECCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCC
KGFNSQAVGTGGSDLPDLPAEFSQTEHYKRGVVGMARSQDPNSANSQFFIMFAPAPPLDG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEECCCCCCCCCCCCEEEEEECCCCCCCC
QYTIVGNVVSGMELVDHIKKGDEADNGTVSDPDRMIKVRIAADK
CEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MIITLKDGDVTIALRPDLAPKHVAQIKKLVRDHAYDNVAFHRVIDGFMAQTGDVKFGNMK
CEEEEECCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCC
KGFNSQAVGTGGSDLPDLPAEFSQTEHYKRGVVGMARSQDPNSANSQFFIMFAPAPPLDG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEECCCCCCCCCCCCEEEEEECCCCCCCC
QYTIVGNVVSGMELVDHIKKGDEADNGTVSDPDRMIKVRIAADK
CEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA