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The map label for this gene is ppi [H]

Identifier: 13470905

GI number: 13470905

Start: 572858

End: 573370

Strand: Reverse

Name: ppi [H]

Synonym: mll0727

Alternate gene names: 13470905

Gene position: 573370-572858 (Counterclockwise)

Preceding gene: 13470906

Following gene: 13470904

Centisome position: 8.15

GC content: 61.6

Gene sequence:

>513_bases
ATGGCCGAAATCAAGGACCGCGAGAACGCGCTCATCATGGAAACGACCAAGGGCAAGGTCGTCATCGAACTTTTCCCCGA
TCTGGCCCCCGGCCATGTCGCCCGCATCAAGGAACTGGCCAGGGAAGGCGCCTATGACGGGGTGGTTTTCCACCGCGTCA
TCGACGGCTTCATGGCGCAGACGGGCGACGTGAAGTTCGGCAATTCCTCGAAGCCCACCTTCGCGCCGTCGCGCGCGGGC
ATGGGCGGCTCGGACAAGCCGGACCTGAAAGCTGAGTTCTCCAACGCCAACCACGGCCGCGGCACCTGCTCGATGGCCCG
TTCACAGAACCCGAACTCGGCCAATTCGCAGTTCTTCATCTGCTTCGACGATGCCGCCTTCCTCAACCGTCAGTACACGG
TCTGGGGCCAGGTCATCGAAGGCATGGACAATGTCGATAAGATCAAGCGCGGCGAACCGGTCGTCGATCCCGACAAGATC
GTGTCGCTGAAGGTCGCGGCCGACGTCAAGTAA

Upstream 100 bases:

>100_bases
GACGAGGCGGACAACGGTACGGTCTCCGACCCCGACCGGATGATCAAGGTGCGCATCGCCGCCGACAAGTAATTTTTGTT
TTCTCAAAAGGATATCTGAC

Downstream 100 bases:

>100_bases
GGCGAAACGACAATGATGGGCGTCGTCTGGTCGCTTCTCGGCATCCTGTCCGGCGCCTTCATTGCCATTCAGGCACCGAT
CAATTCGCAGCTGGCGCGCG

Product: peptidyl prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MAEIKDRENALIMETTKGKVVIELFPDLAPGHVARIKELAREGAYDGVVFHRVIDGFMAQTGDVKFGNSSKPTFAPSRAG
MGGSDKPDLKAEFSNANHGRGTCSMARSQNPNSANSQFFICFDDAAFLNRQYTVWGQVIEGMDNVDKIKRGEPVVDPDKI
VSLKVAADVK

Sequences:

>Translated_170_residues
MAEIKDRENALIMETTKGKVVIELFPDLAPGHVARIKELAREGAYDGVVFHRVIDGFMAQTGDVKFGNSSKPTFAPSRAG
MGGSDKPDLKAEFSNANHGRGTCSMARSQNPNSANSQFFICFDDAAFLNRQYTVWGQVIEGMDNVDKIKRGEPVVDPDKI
VSLKVAADVK
>Mature_169_residues
AEIKDRENALIMETTKGKVVIELFPDLAPGHVARIKELAREGAYDGVVFHRVIDGFMAQTGDVKFGNSSKPTFAPSRAGM
GGSDKPDLKAEFSNANHGRGTCSMARSQNPNSANSQFFICFDDAAFLNRQYTVWGQVIEGMDNVDKIKRGEPVVDPDKIV
SLKVAADVK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=146, Percent_Identity=32.8767123287671, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI24308049, Length=144, Percent_Identity=36.1111111111111, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI22547215, Length=131, Percent_Identity=35.1145038167939, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI22547212, Length=131, Percent_Identity=35.1145038167939, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI7657473, Length=131, Percent_Identity=35.1145038167939, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI7706339, Length=148, Percent_Identity=31.7567567567568, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI5031987, Length=135, Percent_Identity=37.037037037037, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI10863927, Length=139, Percent_Identity=35.2517985611511, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1786736, Length=148, Percent_Identity=39.8648648648649, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1789763, Length=146, Percent_Identity=34.9315068493151, Blast_Score=77, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=144, Percent_Identity=35.4166666666667, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=144, Percent_Identity=35.4166666666667, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=157, Percent_Identity=32.484076433121, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=35.6643356643357, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=160, Percent_Identity=31.25, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=151, Percent_Identity=31.7880794701987, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17566266, Length=142, Percent_Identity=31.6901408450704, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=138, Percent_Identity=34.7826086956522, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559074, Length=154, Percent_Identity=31.1688311688312, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17565860, Length=173, Percent_Identity=33.5260115606936, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322492, Length=159, Percent_Identity=31.4465408805031, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=136, Percent_Identity=33.8235294117647, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17986117, Length=167, Percent_Identity=34.7305389221557, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45549139, Length=135, Percent_Identity=34.8148148148148, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922376, Length=144, Percent_Identity=32.6388888888889, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24652460, Length=145, Percent_Identity=32.4137931034483, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664125, Length=135, Percent_Identity=34.0740740740741, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357783, Length=135, Percent_Identity=34.0740740740741, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922912, Length=164, Percent_Identity=34.7560975609756, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18536; Mature: 18405

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKDRENALIMETTKGKVVIELFPDLAPGHVARIKELAREGAYDGVVFHRVIDGFMAQ
CCCCCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
TGDVKFGNSSKPTFAPSRAGMGGSDKPDLKAEFSNANHGRGTCSMARSQNPNSANSQFFI
CCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEHHCCCCCCCCCCEEEE
CFDDAAFLNRQYTVWGQVIEGMDNVDKIKRGEPVVDPDKIVSLKVAADVK
EECCHHHHCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
AEIKDRENALIMETTKGKVVIELFPDLAPGHVARIKELAREGAYDGVVFHRVIDGFMAQ
CCCCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
TGDVKFGNSSKPTFAPSRAGMGGSDKPDLKAEFSNANHGRGTCSMARSQNPNSANSQFFI
CCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEHHCCCCCCCCCCEEEE
CFDDAAFLNRQYTVWGQVIEGMDNVDKIKRGEPVVDPDKIVSLKVAADVK
EECCHHHHCCCHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA