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The map label for this gene is lpxB [H]

Identifier: 13470830

GI number: 13470830

Start: 498236

End: 499408

Strand: Reverse

Name: lpxB [H]

Synonym: mll0630

Alternate gene names: 13470830

Gene position: 499408-498236 (Counterclockwise)

Preceding gene: 13470831

Following gene: 13470827

Centisome position: 7.1

GC content: 64.02

Gene sequence:

>1173_bases
ATGGCTGACAGGGTGTTGAAGATCGCGATCGTCGCCGGCGAGGAATCGGGTGATCTGCTGGGCGCCGACATTGTGCGTTC
GCTCCGCCAGATCACCGGCCGCGAGGTGCGGCTCGTCGGCCTCGGCGGTCGCCATCTCGGGGAATTGGGCCTGGTGTCGC
CCTTTGATGCCGGCGAGATCGCGCTGATGGGTTTCAGTGCAGTCCTGCGCGATCTGCCGCGCCTCATCAGGCGGATCGGC
CAGCTGGCCAAAACCATCGCCGAGGAAAAGCCGGATTGCCTGGTCACCATCGACAGTCCGGACTTTTCCTTGCGCGTTGC
CAGGAAGGTGCGGGCGGCCAATCCGTCGATACCGATCATCCACTATGTCTGCCCGAGCGTCTGGGCCTGGCGGCCGGGCA
GGGCGGTGGCGATGAAGCCCTATGTCGACCATATCCTCTGCATCCTGCCGTTCGAGGTGAAGGAGCTCGATAGGCTGGGC
GGCCCGCCCGGCACTTATGTCGGGCATCGCCTGACGCATGATGTGGGCGTGCTTGCCGCCCAGAAGGCGCAGGCCTTGCC
GCGCGATCTTGCCCAGGACCGGATCAAGACATTGCTCGTCCTGCCAGGCTCGCGGCGCGGCGAGGTGCGGCGGTTGATCG
AACCGTTCGGCGAAACCGTATCGATGCTGCGCGCGCGCGGACATCGTCTGCGGCTGCAGCTGCCGACGGTTCCGCATGTC
GCCGATCTCGTCAAATCCTCGGTCAACCGTTGGGACGAAAAACCCGAAATCATCGTTGATCCGCAACGCAAATGGCAGGC
TTTCGGCAAGGCCGATGCCGCGCTGATCGCATCGGGGACCGTGTCGCTGGAACTGGCTTTGGCTGGTGTGCCGATGGTGT
CGTCCTACAGGCTCGATCCGATCGCCCGTGCCGTTGCGCCGTATCTTGTTTCGGTTTGGTCGGCGCTGCTGCCCAATCTC
ATCTCCGATCGCGCCCTTATCCCGGAGTTCTACAACGAGTACGTCAAGGCGAACAATCTGGCTCGCCAACTGGAAGCGTT
GTTCGCCGACAGCGGCATGCGCGCCTGGCAGAAAGACGGCTTTGCCGAGATCGCCAGGCGCATGGCGACGGACAAGCCGT
CGGGCGAGATCGCGGCGGGCGTGGTGCTGCGCCATATAAAAAAGGCGCCCTGA

Upstream 100 bases:

>100_bases
GAGGCGGGGCGCTCACTGATCCTCGAAGGCCCCGCAACCCTCTCACGGGCCAATGAACTTGGTCTGTTCATCGTCGGCCT
GGCCGCGGCGGAGCCTGCAT

Downstream 100 bases:

>100_bases
GAGGCGCCTTTTTTATGATCAAGACAGCTTCGGTCAGCGCTTGGCGATCGGCACGTAGTCGCGCTCCGGCGCACCCGTGT
AGAGCTGGCGCGGGCGGCCA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MADRVLKIAIVAGEESGDLLGADIVRSLRQITGREVRLVGLGGRHLGELGLVSPFDAGEIALMGFSAVLRDLPRLIRRIG
QLAKTIAEEKPDCLVTIDSPDFSLRVARKVRAANPSIPIIHYVCPSVWAWRPGRAVAMKPYVDHILCILPFEVKELDRLG
GPPGTYVGHRLTHDVGVLAAQKAQALPRDLAQDRIKTLLVLPGSRRGEVRRLIEPFGETVSMLRARGHRLRLQLPTVPHV
ADLVKSSVNRWDEKPEIIVDPQRKWQAFGKADAALIASGTVSLELALAGVPMVSSYRLDPIARAVAPYLVSVWSALLPNL
ISDRALIPEFYNEYVKANNLARQLEALFADSGMRAWQKDGFAEIARRMATDKPSGEIAAGVVLRHIKKAP

Sequences:

>Translated_390_residues
MADRVLKIAIVAGEESGDLLGADIVRSLRQITGREVRLVGLGGRHLGELGLVSPFDAGEIALMGFSAVLRDLPRLIRRIG
QLAKTIAEEKPDCLVTIDSPDFSLRVARKVRAANPSIPIIHYVCPSVWAWRPGRAVAMKPYVDHILCILPFEVKELDRLG
GPPGTYVGHRLTHDVGVLAAQKAQALPRDLAQDRIKTLLVLPGSRRGEVRRLIEPFGETVSMLRARGHRLRLQLPTVPHV
ADLVKSSVNRWDEKPEIIVDPQRKWQAFGKADAALIASGTVSLELALAGVPMVSSYRLDPIARAVAPYLVSVWSALLPNL
ISDRALIPEFYNEYVKANNLARQLEALFADSGMRAWQKDGFAEIARRMATDKPSGEIAAGVVLRHIKKAP
>Mature_389_residues
ADRVLKIAIVAGEESGDLLGADIVRSLRQITGREVRLVGLGGRHLGELGLVSPFDAGEIALMGFSAVLRDLPRLIRRIGQ
LAKTIAEEKPDCLVTIDSPDFSLRVARKVRAANPSIPIIHYVCPSVWAWRPGRAVAMKPYVDHILCILPFEVKELDRLGG
PPGTYVGHRLTHDVGVLAAQKAQALPRDLAQDRIKTLLVLPGSRRGEVRRLIEPFGETVSMLRARGHRLRLQLPTVPHVA
DLVKSSVNRWDEKPEIIVDPQRKWQAFGKADAALIASGTVSLELALAGVPMVSSYRLDPIARAVAPYLVSVWSALLPNLI
SDRALIPEFYNEYVKANNLARQLEALFADSGMRAWQKDGFAEIARRMATDKPSGEIAAGVVLRHIKKAP

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=392, Percent_Identity=33.9285714285714, Blast_Score=165, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42801; Mature: 42669

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRVLKIAIVAGEESGDLLGADIVRSLRQITGREVRLVGLGGRHLGELGLVSPFDAGEI
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHCCCCCCCCCCCCCH
ALMGFSAVLRDLPRLIRRIGQLAKTIAEEKPDCLVTIDSPDFSLRVARKVRAANPSIPII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCC
HYVCPSVWAWRPGRAVAMKPYVDHILCILPFEVKELDRLGGPPGTYVGHRLTHDVGVLAA
EEHHCCHHCCCCCCEEEECHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHH
QKAQALPRDLAQDRIKTLLVLPGSRRGEVRRLIEPFGETVSMLRARGHRLRLQLPTVPHV
HHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHH
ADLVKSSVNRWDEKPEIIVDPQRKWQAFGKADAALIASGTVSLELALAGVPMVSSYRLDP
HHHHHHHHHHCCCCCCEEECCHHHHHHHCCCCCEEEECCCEEEEEEEECCCCHHCCCCCH
IARAVAPYLVSVWSALLPNLISDRALIPEFYNEYVKANNLARQLEALFADSGMRAWQKDG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
FAEIARRMATDKPSGEIAAGVVLRHIKKAP
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADRVLKIAIVAGEESGDLLGADIVRSLRQITGREVRLVGLGGRHLGELGLVSPFDAGEI
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHCCCCCCCCCCCCCH
ALMGFSAVLRDLPRLIRRIGQLAKTIAEEKPDCLVTIDSPDFSLRVARKVRAANPSIPII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCC
HYVCPSVWAWRPGRAVAMKPYVDHILCILPFEVKELDRLGGPPGTYVGHRLTHDVGVLAA
EEHHCCHHCCCCCCEEEECHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHH
QKAQALPRDLAQDRIKTLLVLPGSRRGEVRRLIEPFGETVSMLRARGHRLRLQLPTVPHV
HHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHH
ADLVKSSVNRWDEKPEIIVDPQRKWQAFGKADAALIASGTVSLELALAGVPMVSSYRLDP
HHHHHHHHHHCCCCCCEEECCHHHHHHHCCCCCEEEECCCEEEEEEEECCCCHHCCCCCH
IARAVAPYLVSVWSALLPNLISDRALIPEFYNEYVKANNLARQLEALFADSGMRAWQKDG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
FAEIARRMATDKPSGEIAAGVVLRHIKKAP
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA