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The map label for this gene is kynU [H]

Identifier: 13470821

GI number: 13470821

Start: 486639

End: 487886

Strand: Reverse

Name: kynU [H]

Synonym: mll0621

Alternate gene names: 13470821

Gene position: 487886-486639 (Counterclockwise)

Preceding gene: 13470822

Following gene: 13470818

Centisome position: 6.93

GC content: 64.42

Gene sequence:

>1248_bases
ATGCGTGCACCGCTCGATCTCGCAGCAGTCGAAGCCTTGGATGCGGCGGATCCGCTGCGTGCCATGCGCGACCGCTTCAT
TTTGCCGGAAGGCGTGATCTATCTCGACGGCAATTCGCTGGGTGCCGCGGCGCCTGCTGTCTTCAACGAGCTGCAAAAGG
CGGCGACGCAGGAATGGGCGCAGGACCTCATCCGCGCCTGGAACACCGCCAGCTGGTTCGACATGCCGGTCGCGCTCGGC
GACCAGCTCGGGCGTCTGATCGGCGCCGTTTCCGGCCAGACGGTGGTCTGCGACACGACCTCGATCAACATCTACAAGGT
GTTGCATGCGGCACTCGGCATGCGGCCGAACCGCTCGGTCATCGTCGCCGAGGGCGACAGTTTCCCGACCGACCTCTACA
TGGCTGAAGGCGTGGCCTCGACCCGGCCGGGCACCGTGCTGCGGCTCGAGGGCGTCGATGCGCCCACCATTGAGGAACTG
ATCGACGAGCGCGTCGCCGTCATCCTGGTGAACCACGTCAACTACAAAACCGGACAATTGCGCGACATGGCCGCGCTGAC
GTGCAAGGCCCATCAGGTCGGTGCGCTGATCGTCTGGGATCTCTGCCATACGGCCGGCGCACTGCCGGTCGAGCTCGATG
CGGCGAATGCCGATTTCGCCATCGGCTGCACCTACAAATATCTCAATGGCGGTCCGGGTGCGCCAGCCTTCATCTATGCC
GCGAAACGCCATCACGAAGATGTCCATCAGCCACTGAGCGGCTGGTGGGGCCATGCGCGGCCTTTCGCTTTTGAACAAAG
CTACACGGCCGGCAGCGGTATCCGCCGGTTCCTGTGCGGCACGCAGCCGGTGCTGTCGATGCGGGCGCTGAAAGGGGCGC
TGGATATCTGGGACGATGTCGACATGGCGGCGGTGCGCAAGAAAAGCATTGGGCTCACCGACCTGTTCATCCAGCTGGTC
GAAGCCAGATGCGGCGCCTACGGCCTCGAACTCGAAGGTCCGCGCGACGGCAATGCGCGCGGCAGCCAGGTCTCGTTCCT
CCACCCGCATGGCTACCAGGTGATGCGCGCCTTGATCGAGCGCGGCGTGATCGGTGATTTCCGCGCGCCCTCGACCATCC
GCTTCGGCTTTACGCCGCTCTATGTCGGCTACAAGGACGTCTGGCAAGCGGTCGAGGTGCTGGAGGACATTTTGCGTACC
GGCGCCTGGCAGGAAGCGCGTTTTGCCGTGAAGACGGCGGTGACCTGA

Upstream 100 bases:

>100_bases
CTTGCTTTGCCGAGCCTCAAGCGCAGCCGGGGACCCACGCCGGCTCGCGAAGCCATCCGCGAATAATCAGGACGTAAACA
ACCAGGGAATGTCACAAATC

Downstream 100 bases:

>100_bases
GACCTCAGAGCCGCGTGCGGACCGTCCACAGTTCGGGAAACAGCACGACCTCGAGCATCTTCTTCAGATAGGATGCGCCT
GAGGTGCCGCCGGTGCCGCG

Product: kynureninase (kyurenine hydrolase)

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MRAPLDLAAVEALDAADPLRAMRDRFILPEGVIYLDGNSLGAAAPAVFNELQKAATQEWAQDLIRAWNTASWFDMPVALG
DQLGRLIGAVSGQTVVCDTTSINIYKVLHAALGMRPNRSVIVAEGDSFPTDLYMAEGVASTRPGTVLRLEGVDAPTIEEL
IDERVAVILVNHVNYKTGQLRDMAALTCKAHQVGALIVWDLCHTAGALPVELDAANADFAIGCTYKYLNGGPGAPAFIYA
AKRHHEDVHQPLSGWWGHARPFAFEQSYTAGSGIRRFLCGTQPVLSMRALKGALDIWDDVDMAAVRKKSIGLTDLFIQLV
EARCGAYGLELEGPRDGNARGSQVSFLHPHGYQVMRALIERGVIGDFRAPSTIRFGFTPLYVGYKDVWQAVEVLEDILRT
GAWQEARFAVKTAVT

Sequences:

>Translated_415_residues
MRAPLDLAAVEALDAADPLRAMRDRFILPEGVIYLDGNSLGAAAPAVFNELQKAATQEWAQDLIRAWNTASWFDMPVALG
DQLGRLIGAVSGQTVVCDTTSINIYKVLHAALGMRPNRSVIVAEGDSFPTDLYMAEGVASTRPGTVLRLEGVDAPTIEEL
IDERVAVILVNHVNYKTGQLRDMAALTCKAHQVGALIVWDLCHTAGALPVELDAANADFAIGCTYKYLNGGPGAPAFIYA
AKRHHEDVHQPLSGWWGHARPFAFEQSYTAGSGIRRFLCGTQPVLSMRALKGALDIWDDVDMAAVRKKSIGLTDLFIQLV
EARCGAYGLELEGPRDGNARGSQVSFLHPHGYQVMRALIERGVIGDFRAPSTIRFGFTPLYVGYKDVWQAVEVLEDILRT
GAWQEARFAVKTAVT
>Mature_415_residues
MRAPLDLAAVEALDAADPLRAMRDRFILPEGVIYLDGNSLGAAAPAVFNELQKAATQEWAQDLIRAWNTASWFDMPVALG
DQLGRLIGAVSGQTVVCDTTSINIYKVLHAALGMRPNRSVIVAEGDSFPTDLYMAEGVASTRPGTVLRLEGVDAPTIEEL
IDERVAVILVNHVNYKTGQLRDMAALTCKAHQVGALIVWDLCHTAGALPVELDAANADFAIGCTYKYLNGGPGAPAFIYA
AKRHHEDVHQPLSGWWGHARPFAFEQSYTAGSGIRRFLCGTQPVLSMRALKGALDIWDDVDMAAVRKKSIGLTDLFIQLV
EARCGAYGLELEGPRDGNARGSQVSFLHPHGYQVMRALIERGVIGDFRAPSTIRFGFTPLYVGYKDVWQAVEVLEDILRT
GAWQEARFAVKTAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=448, Percent_Identity=26.1160714285714, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI74101437, Length=280, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17550466, Length=442, Percent_Identity=26.9230769230769, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323261, Length=447, Percent_Identity=25.7270693512304, Blast_Score=133, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45163; Mature: 45163

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPLDLAAVEALDAADPLRAMRDRFILPEGVIYLDGNSLGAAAPAVFNELQKAATQEWA
CCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
QDLIRAWNTASWFDMPVALGDQLGRLIGAVSGQTVVCDTTSINIYKVLHAALGMRPNRSV
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCEE
IVAEGDSFPTDLYMAEGVASTRPGTVLRLEGVDAPTIEELIDERVAVILVNHVNYKTGQL
EEECCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHCCEEEEEEECCCCCCCCH
RDMAALTCKAHQVGALIVWDLCHTAGALPVELDAANADFAIGCTYKYLNGGPGAPAFIYA
HHHHHHHHHHHHCCHHHEEEHHHHCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCEEHH
AKRHHEDVHQPLSGWWGHARPFAFEQSYTAGSGIRRFLCGTQPVLSMRALKGALDIWDDV
HHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
DMAAVRKKSIGLTDLFIQLVEARCGAYGLELEGPRDGNARGSQVSFLHPHGYQVMRALIE
HHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEEECCCHHHHHHHHHH
RGVIGDFRAPSTIRFGFTPLYVGYKDVWQAVEVLEDILRTGAWQEARFAVKTAVT
CCCCCCCCCCCEEEECCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MRAPLDLAAVEALDAADPLRAMRDRFILPEGVIYLDGNSLGAAAPAVFNELQKAATQEWA
CCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
QDLIRAWNTASWFDMPVALGDQLGRLIGAVSGQTVVCDTTSINIYKVLHAALGMRPNRSV
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCEE
IVAEGDSFPTDLYMAEGVASTRPGTVLRLEGVDAPTIEELIDERVAVILVNHVNYKTGQL
EEECCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHCCEEEEEEECCCCCCCCH
RDMAALTCKAHQVGALIVWDLCHTAGALPVELDAANADFAIGCTYKYLNGGPGAPAFIYA
HHHHHHHHHHHHCCHHHEEEHHHHCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCEEHH
AKRHHEDVHQPLSGWWGHARPFAFEQSYTAGSGIRRFLCGTQPVLSMRALKGALDIWDDV
HHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
DMAAVRKKSIGLTDLFIQLVEARCGAYGLELEGPRDGNARGSQVSFLHPHGYQVMRALIE
HHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEEECCCHHHHHHHHHH
RGVIGDFRAPSTIRFGFTPLYVGYKDVWQAVEVLEDILRTGAWQEARFAVKTAVT
CCCCCCCCCCCEEEECCCEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA