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The map label for this gene is degP [H]

Identifier: 13470577

GI number: 13470577

Start: 224211

End: 225497

Strand: Direct

Name: degP [H]

Synonym: mlr0328

Alternate gene names: 13470577

Gene position: 224211-225497 (Clockwise)

Preceding gene: 13470576

Following gene: 13470578

Centisome position: 3.19

GC content: 64.57

Gene sequence:

>1287_bases
GTGCAGCTTTCGTTCGCGCCGCTGGTCAAGCAGACGGCGCCGGCCGTGGTCAACGTCTATGCCTCGCAGACGGCCAAGGT
CACATCGCCTTTTGAAGGCGATCCGTTCTTCGAGGAGTTTTTCGGCCGTGCCCAGCCGCGCGCGCAGTCCTCGCTGGGCT
CGGGCGTGCTCGTTGATCCAAGCGGTGTCATCGTCACCAATTTCCATGTCATCAAGGATGCCGACGAGGTCAAGGTGGCG
ACCGCCGACGGCCGTGAGTTCACCAGCAAGGTGATGCTCAAGGACGAGACGCTCGATCTCGCCGTGCTCAAGATCGAATC
CGACAAGCCGTTCCCGGTCATCGCCATTGGCGATTCCGACGCGCTCGAGGTCGGCGACCTGGTGCTGGCCATCGGCAATC
CCTTCGGCGTCGGCCAGACCACCACCAGCGGCATTGTTTCCGCACTTGCCCGCAGCCATATCGGGGTCTCGGATTCGGGC
TATTTCATCCAGACCGACGCGGCCATCAATCCCGGCAATTCCGGCGGCGCGCTGATCAACATGGGCGGTCAGCTGGTCGG
TATCAACACCGCCATCTACAGCCGCAGCGGCGGCTCAATCGGGATCGGCTTCGCCATTCCCGCCAACATGGTGCGGGCTT
TCGCCGATGCGGCAAAGGCCGGCCTCGACTTCTTCGAACGCCCCTATATCGGCGCCGAGTTCGAGGCGGTGACGCCGCAG
ATCGCCGACTCGCTCGGCATGGAAAAGCCGACCGGTGCGCTGGTCTCTTCGGTCGACGCGACCGGGCCAGCCGGTAAGGC
CGGGCTGAAGGCAGGCGATGTCGTGCTGCAGATCAACGGCAAGCCGGTCGAGAGCATCGAGGCGCTGGACTATCGCATGG
CGACGCTGTCGATCGGCACAAAGGCGAATTTCGCGGTCCTGACCAAGGGCCAGAAAGCGGCCATGGACATCGCGCTGGAG
CGGGCGCCGGAAGGTGCGAAAGCCTCGGAAGTGACGCTGCATGGCCGCAGCCCGTTCTCGGGCGCCAAGGTCGCGGAACT
GTCGCCGCGGCTTGCCCAGAAGCTTGGCCTGCGCACCGATCTCAAAGGCGTGACGGTGATCGATATCAACCGCGATTCGC
CAGCCGCCGATTTCGGCTTCCTGCCAGGCGACATCGTGCGCGAGGTCAACGGCACCACGATCGATACCGCCGCGACGCTG
GCGCAGGTAGCCCAGCAGGATACGCGCTGGTGGCGCTTTACCGTCGAGCGCGGCGGGCAGATACTGCGCCAGGTGTTGCG
TTACTGA

Upstream 100 bases:

>100_bases
TCCTGGTCTCTCCGATGTGCTGACCGATCTGCTGCATGGCGTCGAAGGCGAGAATGCCACCTCCGGGCCTGACAAGCGCG
TGCCGTTCGGTCGCGAGGAG

Downstream 100 bases:

>100_bases
GTTCGGTCTGAAGGGATCGCGCTCCAAACCAAAAGAAGTGCATGGCCGATCTGTTCAGTGTCGATGAACCGGAAAAGGCG
CCGCCCGGGCGGCCGCTGGC

Product: heat shock protein htrA like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MQLSFAPLVKQTAPAVVNVYASQTAKVTSPFEGDPFFEEFFGRAQPRAQSSLGSGVLVDPSGVIVTNFHVIKDADEVKVA
TADGREFTSKVMLKDETLDLAVLKIESDKPFPVIAIGDSDALEVGDLVLAIGNPFGVGQTTTSGIVSALARSHIGVSDSG
YFIQTDAAINPGNSGGALINMGGQLVGINTAIYSRSGGSIGIGFAIPANMVRAFADAAKAGLDFFERPYIGAEFEAVTPQ
IADSLGMEKPTGALVSSVDATGPAGKAGLKAGDVVLQINGKPVESIEALDYRMATLSIGTKANFAVLTKGQKAAMDIALE
RAPEGAKASEVTLHGRSPFSGAKVAELSPRLAQKLGLRTDLKGVTVIDINRDSPAADFGFLPGDIVREVNGTTIDTAATL
AQVAQQDTRWWRFTVERGGQILRQVLRY

Sequences:

>Translated_428_residues
MQLSFAPLVKQTAPAVVNVYASQTAKVTSPFEGDPFFEEFFGRAQPRAQSSLGSGVLVDPSGVIVTNFHVIKDADEVKVA
TADGREFTSKVMLKDETLDLAVLKIESDKPFPVIAIGDSDALEVGDLVLAIGNPFGVGQTTTSGIVSALARSHIGVSDSG
YFIQTDAAINPGNSGGALINMGGQLVGINTAIYSRSGGSIGIGFAIPANMVRAFADAAKAGLDFFERPYIGAEFEAVTPQ
IADSLGMEKPTGALVSSVDATGPAGKAGLKAGDVVLQINGKPVESIEALDYRMATLSIGTKANFAVLTKGQKAAMDIALE
RAPEGAKASEVTLHGRSPFSGAKVAELSPRLAQKLGLRTDLKGVTVIDINRDSPAADFGFLPGDIVREVNGTTIDTAATL
AQVAQQDTRWWRFTVERGGQILRQVLRY
>Mature_428_residues
MQLSFAPLVKQTAPAVVNVYASQTAKVTSPFEGDPFFEEFFGRAQPRAQSSLGSGVLVDPSGVIVTNFHVIKDADEVKVA
TADGREFTSKVMLKDETLDLAVLKIESDKPFPVIAIGDSDALEVGDLVLAIGNPFGVGQTTTSGIVSALARSHIGVSDSG
YFIQTDAAINPGNSGGALINMGGQLVGINTAIYSRSGGSIGIGFAIPANMVRAFADAAKAGLDFFERPYIGAEFEAVTPQ
IADSLGMEKPTGALVSSVDATGPAGKAGLKAGDVVLQINGKPVESIEALDYRMATLSIGTKANFAVLTKGQKAAMDIALE
RAPEGAKASEVTLHGRSPFSGAKVAELSPRLAQKLGLRTDLKGVTVIDINRDSPAADFGFLPGDIVREVNGTTIDTAATL
AQVAQQDTRWWRFTVERGGQILRQVLRY

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=255, Percent_Identity=36.078431372549, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI22129776, Length=295, Percent_Identity=32.8813559322034, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4506141, Length=294, Percent_Identity=35.7142857142857, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI7019477, Length=301, Percent_Identity=35.2159468438538, Blast_Score=143, Evalue=4e-34,
Organism=Escherichia coli, GI1786356, Length=442, Percent_Identity=35.7466063348416, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1789629, Length=435, Percent_Identity=37.4712643678161, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1789630, Length=326, Percent_Identity=36.5030674846626, Blast_Score=179, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24646839, Length=270, Percent_Identity=34.0740740740741, Blast_Score=128, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 44815; Mature: 44815

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSFAPLVKQTAPAVVNVYASQTAKVTSPFEGDPFFEEFFGRAQPRAQSSLGSGVLVDP
CCCCHHHHHHHCCCCEEEEECCCCEEECCCCCCCCHHHHHHCCCCCHHHHHCCCCEEECC
SGVIVTNFHVIKDADEVKVATADGREFTSKVMLKDETLDLAVLKIESDKPFPVIAIGDSD
CCEEEEEEEEEECCCCEEEEECCCHHHHHEEEEECCCEEEEEEEECCCCCEEEEEECCCC
ALEVGDLVLAIGNPFGVGQTTTSGIVSALARSHIGVSDSGYFIQTDAAINPGNSGGALIN
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCEECCCCCCCEEEE
MGGQLVGINTAIYSRSGGSIGIGFAIPANMVRAFADAAKAGLDFFERPYIGAEFEAVTPQ
CCCEEEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHH
IADSLGMEKPTGALVSSVDATGPAGKAGLKAGDVVLQINGKPVESIEALDYRMATLSIGT
HHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHEEEEEEEECC
KANFAVLTKGQKAAMDIALERAPEGAKASEVTLHGRSPFSGAKVAELSPRLAQKLGLRTD
CCCEEEEECCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHCCHHHHHHCCCCCC
LKGVTVIDINRDSPAADFGFLPGDIVREVNGTTIDTAATLAQVAQQDTRWWRFTVERGGQ
CCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCEEHHHHHHHHHHHHCCCEEEEEHHHHHH
ILRQVLRY
HHHHHHCC
>Mature Secondary Structure
MQLSFAPLVKQTAPAVVNVYASQTAKVTSPFEGDPFFEEFFGRAQPRAQSSLGSGVLVDP
CCCCHHHHHHHCCCCEEEEECCCCEEECCCCCCCCHHHHHHCCCCCHHHHHCCCCEEECC
SGVIVTNFHVIKDADEVKVATADGREFTSKVMLKDETLDLAVLKIESDKPFPVIAIGDSD
CCEEEEEEEEEECCCCEEEEECCCHHHHHEEEEECCCEEEEEEEECCCCCEEEEEECCCC
ALEVGDLVLAIGNPFGVGQTTTSGIVSALARSHIGVSDSGYFIQTDAAINPGNSGGALIN
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCEECCCCCCCEEEE
MGGQLVGINTAIYSRSGGSIGIGFAIPANMVRAFADAAKAGLDFFERPYIGAEFEAVTPQ
CCCEEEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHH
IADSLGMEKPTGALVSSVDATGPAGKAGLKAGDVVLQINGKPVESIEALDYRMATLSIGT
HHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHEEEEEEEECC
KANFAVLTKGQKAAMDIALERAPEGAKASEVTLHGRSPFSGAKVAELSPRLAQKLGLRTD
CCCEEEEECCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHCCHHHHHHCCCCCC
LKGVTVIDINRDSPAADFGFLPGDIVREVNGTTIDTAATLAQVAQQDTRWWRFTVERGGQ
CCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCEEHHHHHHHHHHHHCCCEEEEEHHHHHH
ILRQVLRY
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]