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The map label for this gene is srlD [H]

Identifier: 15603833

GI number: 15603833

Start: 2205659

End: 2206438

Strand: Reverse

Name: srlD [H]

Synonym: PM1968

Alternate gene names: 15603833

Gene position: 2206438-2205659 (Counterclockwise)

Preceding gene: 15603834

Following gene: 15603832

Centisome position: 97.74

GC content: 38.97

Gene sequence:

>780_bases
ATGTCAAAAGTTGCAGTCGTTATTGGTGGAGGACAAACATTAGGTGCCTTCTTATCCGAAGGGCTTGCTGAAGCAGGATA
CCGTGTTGTCGTGGCTGATCTTAATGGCGAAAATGCGAAGCAAGTGGCTACTCGTATCAATACACAACAAGGGATAGGAC
ATGCAATTGGGTTGCAAGTTGATGCCGCAGATGAAACGAGCGTAGAAACTCTTGTGCATGCTACAGATCAAGCTTTTGGA
AAAATTGATCTCTTGGTTTATAGCGCCGGCACCGCCAAAGCTTCACCAATTTATGATTTCGATTTGAAAGATTTTGATTT
ATCCGTAAAAGTCAATTTAACGGGTTACTTCCTTTGCGCGAAGCATTTTTCTCGTTTAATGATCAGAGACGGTATCAAAG
GTCGTATTATTCAAATCAACTCAAAATCTGGTAAAGTCGGTAGTAAACATAATTCGGGTTATAGTGCCGCAAAATTTGGT
GGTGTAGGTCTAACTCAATCTCTTGCATTAGATCTTGCAGATTACGGCATTACAGTACATTCATTAATGTTAGGTAACTT
ACTCAAATCACCTATGTTCCAATCTTTAATTCCCCAATATGCGAAGAAATTAGGTATTCCTGAAGAAGAAGTAGAGCAAG
TTTACATTGATAAAGTGCCACTTAAACGTGGATGTGATTATCAAGATGTCCTAAATGTCTTGAAATTTTATGCCAGTGAA
GAAGCATCTTATTGTACTGGTCAGTCAATTAATATCACTGGTGGACAAGTGATGTTCTAA

Upstream 100 bases:

>100_bases
TCTACAAGGTCCTCCACCTGAAAGTGTGGCAATCAATAGTTTATTCACGATCAAACGTGATGAAAAATAATTTATTTTAG
TTTTAAAGAAGGAAAAAATT

Downstream 100 bases:

>100_bases
ATGAACAAAAGTGCGGTGACTTTTAGCCTAGTTGAGAAAATGTGCATTCTTCTTAGAAATGAACGAGATACAAAACTGGG
CTAAAAGTTATTTCAATTTT

Product: sorbitol-6-phosphate dehydrogenase

Products: NA

Alternate protein names: Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSKVAVVIGGGQTLGAFLSEGLAEAGYRVVVADLNGENAKQVATRINTQQGIGHAIGLQVDAADETSVETLVHATDQAFG
KIDLLVYSAGTAKASPIYDFDLKDFDLSVKVNLTGYFLCAKHFSRLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLADYGITVHSLMLGNLLKSPMFQSLIPQYAKKLGIPEEEVEQVYIDKVPLKRGCDYQDVLNVLKFYASE
EASYCTGQSINITGGQVMF

Sequences:

>Translated_259_residues
MSKVAVVIGGGQTLGAFLSEGLAEAGYRVVVADLNGENAKQVATRINTQQGIGHAIGLQVDAADETSVETLVHATDQAFG
KIDLLVYSAGTAKASPIYDFDLKDFDLSVKVNLTGYFLCAKHFSRLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLADYGITVHSLMLGNLLKSPMFQSLIPQYAKKLGIPEEEVEQVYIDKVPLKRGCDYQDVLNVLKFYASE
EASYCTGQSINITGGQVMF
>Mature_258_residues
SKVAVVIGGGQTLGAFLSEGLAEAGYRVVVADLNGENAKQVATRINTQQGIGHAIGLQVDAADETSVETLVHATDQAFGK
IDLLVYSAGTAKASPIYDFDLKDFDLSVKVNLTGYFLCAKHFSRLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFGG
VGLTQSLALDLADYGITVHSLMLGNLLKSPMFQSLIPQYAKKLGIPEEEVEQVYIDKVPLKRGCDYQDVLNVLKFYASEE
ASYCTGQSINITGGQVMF

Specific function: Sorbitol metabolism. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=29.6577946768061, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI19923817, Length=265, Percent_Identity=30.188679245283, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI40254992, Length=255, Percent_Identity=27.4509803921569, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI59889578, Length=233, Percent_Identity=27.8969957081545, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4758504, Length=228, Percent_Identity=29.8245614035088, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=27.027027027027, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI4504505, Length=218, Percent_Identity=29.3577981651376, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7705925, Length=188, Percent_Identity=26.063829787234, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI66933014, Length=222, Percent_Identity=27.4774774774775, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI83715985, Length=217, Percent_Identity=29.0322580645161, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=74.5173745173745, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1787335, Length=261, Percent_Identity=29.1187739463602, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082160, Length=259, Percent_Identity=28.1853281853282, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=27.4509803921569, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788459, Length=255, Percent_Identity=26.6666666666667, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=28.8461538461538, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=23.6220472440945, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=29.1828793774319, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789208, Length=256, Percent_Identity=26.5625, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789378, Length=260, Percent_Identity=23.8461538461538, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=28.3464566929134, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25147288, Length=261, Percent_Identity=29.8850574712644, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17508895, Length=172, Percent_Identity=28.4883720930233, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17568967, Length=217, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=259, Percent_Identity=23.9382239382239, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=270, Percent_Identity=24.0740740740741, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=27.8195488721804, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=257, Percent_Identity=25.2918287937743, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=270, Percent_Identity=24.4444444444444, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=228, Percent_Identity=30.7017543859649, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=271, Percent_Identity=25.830258302583, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=25.6410256410256, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=29.1338582677165, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=23.9852398523985, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=23.1660231660232, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=219, Percent_Identity=31.0502283105023, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=26.2745098039216, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737361, Length=228, Percent_Identity=29.8245614035088, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=26.6409266409266, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=27.5590551181102, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=27.5193798449612, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI18859837, Length=211, Percent_Identity=32.7014218009479, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=26.3565891472868, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24581726, Length=190, Percent_Identity=23.1578947368421, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.140 [H]

Molecular weight: Translated: 27780; Mature: 27649

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVAVVIGGGQTLGAFLSEGLAEAGYRVVVADLNGENAKQVATRINTQQGIGHAIGLQV
CCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCHHHCCCEEEEEEE
DAADETSVETLVHATDQAFGKIDLLVYSAGTAKASPIYDFDLKDFDLSVKVNLTGYFLCA
ECCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCEEECCCCCCEEEEEEEEEEEHHHH
KHFSRLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLADYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHCCHHHH
SLMLGNLLKSPMFQSLIPQYAKKLGIPEEEVEQVYIDKVPLKRGCDYQDVLNVLKFYASE
HHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
EASYCTGQSINITGGQVMF
CCCCCCCCEEECCCCEEEC
>Mature Secondary Structure 
SKVAVVIGGGQTLGAFLSEGLAEAGYRVVVADLNGENAKQVATRINTQQGIGHAIGLQV
CEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCHHHCCCEEEEEEE
DAADETSVETLVHATDQAFGKIDLLVYSAGTAKASPIYDFDLKDFDLSVKVNLTGYFLCA
ECCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCEEECCCCCCEEEEEEEEEEEHHHH
KHFSRLMIRDGIKGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLADYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHCCHHHH
SLMLGNLLKSPMFQSLIPQYAKKLGIPEEEVEQVYIDKVPLKRGCDYQDVLNVLKFYASE
HHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
EASYCTGQSINITGGQVMF
CCCCCCCCEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3553176; 9205837; 9278503; 6384188 [H]