Click here to switch to the map view.

The map label for this gene is ilvG [H]

Identifier: 15603493

GI number: 15603493

Start: 1838436

End: 1840085

Strand: Reverse

Name: ilvG [H]

Synonym: PM1628

Alternate gene names: 15603493

Gene position: 1840085-1838436 (Counterclockwise)

Preceding gene: 15603496

Following gene: 15603492

Centisome position: 81.51

GC content: 46.48

Gene sequence:

>1650_bases
ATGAATGGGGCAAGATTAGTAACCGAGAGTTTGAAAACACATGGCGTAACCACCGTTTTTGGCTATCCCGGTGGGGCGAT
TATGCCAGTTTATGATGCGCTGTATGATGCGGGCATAGAACATTTATTGTGTCGTAATGAGCAAGGTGCAGCGATGGCAG
CCATTGGCTATGCGCGTTCAAGTGGCAAAGTTGGCGTGTGTATCGCCACTTCTGGTCCGGGTGCAGCAAACTTGATCACC
GGCTTAGGGGATGCCTTAATGGATTCGATTCCAGTTGTTGCGATCACTGGGCAAGTGGCTTCTCCCTTGATCGGTACGGA
TGCGTTCCAAGAAGCGGATGTGCTCGGTTTATCTCTTGCTTGTACCAAACACAGCTTTTTAGTGCAAAGCATCGAAGAAT
TGCCAGACGTGATTGCTAAAGCCTTTGAAATTGCTGCCAGTGGGCGTCCGGGTCCAGTTTTGATCGATATTCCAAAAGAT
ATCCAAATTGCCCCAACCGATGTCACGCCGTTCACTTATTCTGTGGCAAAACCCACCGCACTTTCACAAGCGCATTTAAC
AGATGCACTTACGTTACTCAAACAAGCAAAACGCCCCGTGCTGTATGTCGGGGGCGGTGTAGGTATGGCGCAAGCCGTAC
CAGCGTTGCGTGAGTTTCTTGCAGTAACGCAAATGCCAAGTGTGTCCACCCTAAAAGGTTTAGGTTCAGTTCACCCGGAT
AATCCTTATTATATGGGCATGATTGGTATGCACGGCACCAAAGCCGCAAACTATGCGGTGCAAGAATGTGATTTATTATT
GGCATTTGGTGCACGCTTTGATGATCGTGTAACAGGTAAGCTGGATACGTTTGCCCCCCATGCCAAAGTGATCCATGCTG
ATATTGATATGGCTGAAATTGGGAAATTACGCCGTCCAGATGTGGCATTGTGTGGGGATATTGTTCAGGCTTTCAATGCC
CTAAGCATCCCGTTGAACATTGCTGAGTGGCAAGCACATATCAAACAACTCAAGCAAACACACGATTTTTGTTACTCGAC
AAACCAAGGGGATACTTTCATTAATCCGTTATGGTTGCTGAATTCATTATCAAAGAAGAAACCACAAAGTGCGGTGATTA
CCACCGATGTTGGACAGCATCAAATGTGGTCAGCCCAGCATATGCAACATTATGCTCCTGAAAACTACATTACCTCAGCC
GGTTACGGCACCATGGGCTTTGGTTTGCCAGCAGCAATTGGCGCGAAAAAAGCCCGTCCTGACGATGAGGTGATCTTAAT
TTCTGGCGATGGCTCTATCATGATGAATATTCAAGAATTAGGCACCTTCAAACGCGGAAAAACACCGGTGAAAATTGTGT
TGTTAGACAATCAACGTTTAGGCATGGTTCGTCAGTGGCAAGAGCTGTTCTTCAACGCCAGATTTAGTAATACGATTTTA
GATGACAACCCCGATTTCGTGATGCTTGCCGCTGCGTTCGGTATTCAAGGCGAACGCATCACCAAAGGAGAAGAAGTGGA
AGGTGCACTCGATCGTTTATTAGCGAGCAAAGAAGCCTATTTCTTACATGTGTGTATTTCAAGTAATGAAAACGTTTGGC
CATTGGTACCACCGAATGCCTGCAACCTTGATATGGTTGAACAAATGTAA

Upstream 100 bases:

>100_bases
TAATGTTTGACTGTCAATAAATAAAAAAGATCAAATTTAACCCTCGTCTGATAGCAGATGAGGGTTTTTTTTACTTACCA
ATTATGCAAGGGTGATAAAG

Downstream 100 bases:

>100_bases
AGTGCGGTCTGTTTTGACGAAATTTTAAGGAAAGATTATGCAAACCTATCAATTCACCCTCGACGTTAATCAACGTCCTG
AAACCCTAGAACGTATTTTA

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MNGARLVTESLKTHGVTTVFGYPGGAIMPVYDALYDAGIEHLLCRNEQGAAMAAIGYARSSGKVGVCIATSGPGAANLIT
GLGDALMDSIPVVAITGQVASPLIGTDAFQEADVLGLSLACTKHSFLVQSIEELPDVIAKAFEIAASGRPGPVLIDIPKD
IQIAPTDVTPFTYSVAKPTALSQAHLTDALTLLKQAKRPVLYVGGGVGMAQAVPALREFLAVTQMPSVSTLKGLGSVHPD
NPYYMGMIGMHGTKAANYAVQECDLLLAFGARFDDRVTGKLDTFAPHAKVIHADIDMAEIGKLRRPDVALCGDIVQAFNA
LSIPLNIAEWQAHIKQLKQTHDFCYSTNQGDTFINPLWLLNSLSKKKPQSAVITTDVGQHQMWSAQHMQHYAPENYITSA
GYGTMGFGLPAAIGAKKARPDDEVILISGDGSIMMNIQELGTFKRGKTPVKIVLLDNQRLGMVRQWQELFFNARFSNTIL
DDNPDFVMLAAAFGIQGERITKGEEVEGALDRLLASKEAYFLHVCISSNENVWPLVPPNACNLDMVEQM

Sequences:

>Translated_549_residues
MNGARLVTESLKTHGVTTVFGYPGGAIMPVYDALYDAGIEHLLCRNEQGAAMAAIGYARSSGKVGVCIATSGPGAANLIT
GLGDALMDSIPVVAITGQVASPLIGTDAFQEADVLGLSLACTKHSFLVQSIEELPDVIAKAFEIAASGRPGPVLIDIPKD
IQIAPTDVTPFTYSVAKPTALSQAHLTDALTLLKQAKRPVLYVGGGVGMAQAVPALREFLAVTQMPSVSTLKGLGSVHPD
NPYYMGMIGMHGTKAANYAVQECDLLLAFGARFDDRVTGKLDTFAPHAKVIHADIDMAEIGKLRRPDVALCGDIVQAFNA
LSIPLNIAEWQAHIKQLKQTHDFCYSTNQGDTFINPLWLLNSLSKKKPQSAVITTDVGQHQMWSAQHMQHYAPENYITSA
GYGTMGFGLPAAIGAKKARPDDEVILISGDGSIMMNIQELGTFKRGKTPVKIVLLDNQRLGMVRQWQELFFNARFSNTIL
DDNPDFVMLAAAFGIQGERITKGEEVEGALDRLLASKEAYFLHVCISSNENVWPLVPPNACNLDMVEQM
>Mature_549_residues
MNGARLVTESLKTHGVTTVFGYPGGAIMPVYDALYDAGIEHLLCRNEQGAAMAAIGYARSSGKVGVCIATSGPGAANLIT
GLGDALMDSIPVVAITGQVASPLIGTDAFQEADVLGLSLACTKHSFLVQSIEELPDVIAKAFEIAASGRPGPVLIDIPKD
IQIAPTDVTPFTYSVAKPTALSQAHLTDALTLLKQAKRPVLYVGGGVGMAQAVPALREFLAVTQMPSVSTLKGLGSVHPD
NPYYMGMIGMHGTKAANYAVQECDLLLAFGARFDDRVTGKLDTFAPHAKVIHADIDMAEIGKLRRPDVALCGDIVQAFNA
LSIPLNIAEWQAHIKQLKQTHDFCYSTNQGDTFINPLWLLNSLSKKKPQSAVITTDVGQHQMWSAQHMQHYAPENYITSA
GYGTMGFGLPAAIGAKKARPDDEVILISGDGSIMMNIQELGTFKRGKTPVKIVLLDNQRLGMVRQWQELFFNARFSNTIL
DDNPDFVMLAAAFGIQGERITKGEEVEGALDRLLASKEAYFLHVCISSNENVWPLVPPNACNLDMVEQM

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=543, Percent_Identity=26.5193370165746, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI21361361, Length=501, Percent_Identity=24.1516966067864, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI1790104, Length=553, Percent_Identity=45.0271247739602, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI87081685, Length=556, Percent_Identity=42.2661870503597, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI1786717, Length=545, Percent_Identity=31.743119266055, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1787096, Length=543, Percent_Identity=30.0184162062615, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1788716, Length=558, Percent_Identity=26.5232974910394, Blast_Score=138, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17542570, Length=576, Percent_Identity=25.5208333333333, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17531299, Length=476, Percent_Identity=28.3613445378151, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17531301, Length=476, Percent_Identity=28.3613445378151, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323755, Length=565, Percent_Identity=42.8318584070797, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6320588, Length=569, Percent_Identity=21.792618629174, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323163, Length=481, Percent_Identity=24.1164241164241, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320816, Length=480, Percent_Identity=24.1666666666667, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922626, Length=482, Percent_Identity=27.3858921161826, Blast_Score=161, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 58981; Mature: 58981

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGARLVTESLKTHGVTTVFGYPGGAIMPVYDALYDAGIEHLLCRNEQGAAMAAIGYARS
CCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCHHHHHHCCCCCCEEEEEEEECC
SGKVGVCIATSGPGAANLITGLGDALMDSIPVVAITGQVASPLIGTDAFQEADVLGLSLA
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCHHCCCCCCCCCCCCCHHEEEEE
CTKHSFLVQSIEELPDVIAKAFEIAASGRPGPVLIDIPKDIQIAPTDVTPFTYSVAKPTA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCEEECCCCCH
LSQAHLTDALTLLKQAKRPVLYVGGGVGMAQAVPALREFLAVTQMPSVSTLKGLGSVHPD
HHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
NPYYMGMIGMHGTKAANYAVQECDLLLAFGARFDDRVTGKLDTFAPHAKVIHADIDMAEI
CCEEEEEEECCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCEEEEECCCHHHH
GKLRRPDVALCGDIVQAFNALSIPLNIAEWQAHIKQLKQTHDFCYSTNQGDTFINPLWLL
CCCCCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHH
NSLSKKKPQSAVITTDVGQHQMWSAQHMQHYAPENYITSAGYGTMGFGLPAAIGAKKARP
HHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHCCCCCCC
DDEVILISGDGSIMMNIQELGTFKRGKTPVKIVLLDNQRLGMVRQWQELFFNARFSNTIL
CCCEEEEECCCCEEEEHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCC
DDNPDFVMLAAAFGIQGERITKGEEVEGALDRLLASKEAYFLHVCISSNENVWPLVPPNA
CCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEEECCCCC
CNLDMVEQM
CCCHHHHCC
>Mature Secondary Structure
MNGARLVTESLKTHGVTTVFGYPGGAIMPVYDALYDAGIEHLLCRNEQGAAMAAIGYARS
CCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCHHHHHHCCCCCCEEEEEEEECC
SGKVGVCIATSGPGAANLITGLGDALMDSIPVVAITGQVASPLIGTDAFQEADVLGLSLA
CCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCHHCCCCCCCCCCCCCHHEEEEE
CTKHSFLVQSIEELPDVIAKAFEIAASGRPGPVLIDIPKDIQIAPTDVTPFTYSVAKPTA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCEEECCCCCH
LSQAHLTDALTLLKQAKRPVLYVGGGVGMAQAVPALREFLAVTQMPSVSTLKGLGSVHPD
HHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
NPYYMGMIGMHGTKAANYAVQECDLLLAFGARFDDRVTGKLDTFAPHAKVIHADIDMAEI
CCEEEEEEECCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCEEEEECCCHHHH
GKLRRPDVALCGDIVQAFNALSIPLNIAEWQAHIKQLKQTHDFCYSTNQGDTFINPLWLL
CCCCCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHH
NSLSKKKPQSAVITTDVGQHQMWSAQHMQHYAPENYITSAGYGTMGFGLPAAIGAKKARP
HHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHCCCCCCC
DDEVILISGDGSIMMNIQELGTFKRGKTPVKIVLLDNQRLGMVRQWQELFFNARFSNTIL
CCCEEEEECCCCEEEEHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCC
DDNPDFVMLAAAFGIQGERITKGEEVEGALDRLLASKEAYFLHVCISSNENVWPLVPPNA
CCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEEECCCCC
CNLDMVEQM
CCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]