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The map label for this gene is ilvD [H]

Identifier: 15603490

GI number: 15603490

Start: 1835362

End: 1837197

Strand: Reverse

Name: ilvD [H]

Synonym: PM1625

Alternate gene names: 15603490

Gene position: 1837197-1835362 (Counterclockwise)

Preceding gene: 15603491

Following gene: 15603489

Centisome position: 81.38

GC content: 47.22

Gene sequence:

>1836_bases
ATGCCTAAATTACGTTCAGCGACCAGTACACAGGGTCGTAATATGGCGGGTGCCCGTGCCTTGTGGCGTGCCACGGGAAT
GAAAGAAAACGACTTTGGTAAACCGATTATTGCCGTCGTCAACTCCTTTACGCAATTTGTGCCCGGTCATGTGCATTTAA
AAGACATGGGGCAACTTGTCGCCCGTGAAATTGAAAAAGCCGGTGGTGTGGCGAAAGAGTTTAATACCATTGCGGTGGAT
GATGGGATTGCCATGGGGCATGGTGGGATGCTCTATTCTTTACCAAGCCGTGATTTGATTGCCGATAGTGTGGAATATAT
GGTCAACGCACACTGTGCCGATGCCATGGTGTGTATTTCTAACTGCGACAAAATCACCCCGGGGATGCTCATGGCGGCGT
TACGCTTGAATATTCCTTGTGTGTTTGTCTCGGGCGGACCGATGGAAGCGGGCAAAACTAAACTGTCTGATAAAATCATC
AAACTGGATTTAGTAGATGCCATGATCCAAGGTGCCAACCCAAATGTATCAGACGAAGACAGCGCCCAGATCGAACGCTC
TGCTTGTCCAACCTGTGGCTCTTGCTCGGGTATGTTTACCGCAAATTCAATGAACTGCTTAACAGAAGCCCTTGGCTTAA
GTCTGCCGGGCAACGGATCCTGCCTTGCAACCCACGCAGATCGTAAACAACTGTTCCTTGATGCGGGGAAACAAGTGGTC
GAATTGTGCAAACGCTACTATGAACAAGAGGATGACAGCGTCTTACCTCGTTCTATCGCCAACAAAAAGGCCTTTGAAAA
TGCCATGAGCTTAGATATTGCCATGGGCGGGTCAACCAATACCGTCTTGCATTTATTAGCCGCGGCACAAGAAGCGGAAG
TGGATTTCACCATGGCTGATATTGATCGCCTATCACGTCAAGTGCCTTGTTTAAGCAAAGTCGCGCCAAATACGCAAAAA
TACCACATGGAAGATGTACACCGTGCAGGAGGTATTATGGCGATTTTAGGGGAATTAGATCGTGCCAATTTATTACATAA
TGATACTCGCACAGTATTAGGCATGAGTCTCGCTGAGCAAATTGCCAAATATGACATTGTGCTCACTAAAGATGAAGCCG
TACACAAATTCTTCCGCGCTGGTCCCGCAGGAATTCGTACGACCGAAGCTTTTTCACAAGATTGCCGTTGGGATACAGTG
GATGATGATCGTGAAAATGGCTGTATTCGTAGTAAAACATTTGCCTATAGCCAAGATGGCGGGCTTGCCATGTTATCAGG
CAACTTAGCGATGGACGGTTGTATTGTGAAAACCGCTGGAGTAGATGAGAGCATTTTAAAATTCACTGGCGATGCCATTG
TGTTTGAAAGCCAAGAAGATGCGGTGGCAGGGATTTTAGGTGGCAAAGTACAAGCAGGTCATGTGGTCGTGATTCGCTAC
GAAGGACCAAAAGGCGGACCGGGTATGCAAGAAATGCTGTATCCCACCAGTTATTTAAAATCCATGGGCTTAGGTAAAGC
CTGTGCCTTATTAACAGACGGGCGTTTCTCTGGCGGGACATCGGGGTTATCTATTGGGCATTGCTCACCAGAAGCCGCCG
CGGGTGGATTAATTGGCTTAGTAAAAGACGGTGATAAGATTGAAATTGATATTCCAAATCGATCCATTCAATTATGTGTC
GCGGAAGAAGAACTCGCTCAGCGCCGAGCAGAACAAGACAAACTGGGTTGGCAACCAGTAAACCGCCAACGTGAAGTGTC
CTTTGCCTTGAAAGTATATGGTCATTTTGCGACCTCGGCAGATAAAGGCGCGGTAAGAGATAAAACCAAAATTTAA

Upstream 100 bases:

>100_bases
TAAAAACGCTTAAAGATAACCATTAACAGACAACAGACAAATTGGCTCATTGTTACAGAAAGATGAGCTATCATACCTAC
TTACTGTACTTGGAGAGATT

Downstream 100 bases:

>100_bases
ATCTTTAAGTCGGGTGGGTAAGCTTGCCCACCGTTTTCTCATTGATAAATTGATTACGATTTTTTTCTTGCTGAAACAAG
AAAATTTAAAAAAATAACGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MPKLRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAREIEKAGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPCVFVSGGPMEAGKTKLSDKII
KLDLVDAMIQGANPNVSDEDSAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSCLATHADRKQLFLDAGKQVV
ELCKRYYEQEDDSVLPRSIANKKAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRQVPCLSKVAPNTQK
YHMEDVHRAGGIMAILGELDRANLLHNDTRTVLGMSLAEQIAKYDIVLTKDEAVHKFFRAGPAGIRTTEAFSQDCRWDTV
DDDRENGCIRSKTFAYSQDGGLAMLSGNLAMDGCIVKTAGVDESILKFTGDAIVFESQEDAVAGILGGKVQAGHVVVIRY
EGPKGGPGMQEMLYPTSYLKSMGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGLIGLVKDGDKIEIDIPNRSIQLCV
AEEELAQRRAEQDKLGWQPVNRQREVSFALKVYGHFATSADKGAVRDKTKI

Sequences:

>Translated_611_residues
MPKLRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAREIEKAGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPCVFVSGGPMEAGKTKLSDKII
KLDLVDAMIQGANPNVSDEDSAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSCLATHADRKQLFLDAGKQVV
ELCKRYYEQEDDSVLPRSIANKKAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRQVPCLSKVAPNTQK
YHMEDVHRAGGIMAILGELDRANLLHNDTRTVLGMSLAEQIAKYDIVLTKDEAVHKFFRAGPAGIRTTEAFSQDCRWDTV
DDDRENGCIRSKTFAYSQDGGLAMLSGNLAMDGCIVKTAGVDESILKFTGDAIVFESQEDAVAGILGGKVQAGHVVVIRY
EGPKGGPGMQEMLYPTSYLKSMGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGLIGLVKDGDKIEIDIPNRSIQLCV
AEEELAQRRAEQDKLGWQPVNRQREVSFALKVYGHFATSADKGAVRDKTKI
>Mature_610_residues
PKLRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAREIEKAGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPCVFVSGGPMEAGKTKLSDKIIK
LDLVDAMIQGANPNVSDEDSAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSCLATHADRKQLFLDAGKQVVE
LCKRYYEQEDDSVLPRSIANKKAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRQVPCLSKVAPNTQKY
HMEDVHRAGGIMAILGELDRANLLHNDTRTVLGMSLAEQIAKYDIVLTKDEAVHKFFRAGPAGIRTTEAFSQDCRWDTVD
DDRENGCIRSKTFAYSQDGGLAMLSGNLAMDGCIVKTAGVDESILKFTGDAIVFESQEDAVAGILGGKVQAGHVVVIRYE
GPKGGPGMQEMLYPTSYLKSMGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGLIGLVKDGDKIEIDIPNRSIQLCVA
EEELAQRRAEQDKLGWQPVNRQREVSFALKVYGHFATSADKGAVRDKTKI

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=614, Percent_Identity=80.2931596091205, Blast_Score=1033, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=562, Percent_Identity=29.1814946619217, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI2367371, Length=541, Percent_Identity=30.3142329020333, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI1786464, Length=518, Percent_Identity=30.1158301158301, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=605, Percent_Identity=37.3553719008264, Blast_Score=348, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65474; Mature: 65342

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPCVFVSGGPMEAGKTKLSDKIIKLDLVDAMIQGANPNVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHEEEHHHHHHHHCCCCCCCCCCH
SAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSCLATHADRKQLFLDAGKQVV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCHHHH
ELCKRYYEQEDDSVLPRSIANKKAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMAD
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCEEHHH
IDRLSRQVPCLSKVAPNTQKYHMEDVHRAGGIMAILGELDRANLLHNDTRTVLGMSLAEQ
HHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCEEEHHCCHHHHHHHCCHHHHHHHHHHHH
IAKYDIVLTKDEAVHKFFRAGPAGIRTTEAFSQDCRWDTVDDDRENGCIRSKTFAYSQDG
HHHEEEEEECHHHHHHHHHCCCCCCEEHHHHHHCCCCCCCCCCCCCCCEECCEEEEECCC
GLAMLSGNLAMDGCIVKTAGVDESILKFTGDAIVFESQEDAVAGILGGKVQAGHVVVIRY
CEEEEECCEEECCEEEEECCCCHHHHHHCCCEEEEECCCCHHHHHHCCCEECCEEEEEEE
EGPKGGPGMQEMLYPTSYLKSMGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGLIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCHHHCCCEEEE
VKDGDKIEIDIPNRSIQLCVAEEELAQRRAEQDKLGWQPVNRQREVSFALKVYGHFATSA
EECCCEEEEECCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEEHHHHHCCC
DKGAVRDKTKI
CCCCCCCCCCC
>Mature Secondary Structure 
PKLRSATSTQGRNMAGARALWRATGMKENDFGKPIIAVVNSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPCVFVSGGPMEAGKTKLSDKIIKLDLVDAMIQGANPNVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHEEEHHHHHHHHCCCCCCCCCCH
SAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSCLATHADRKQLFLDAGKQVV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCHHHH
ELCKRYYEQEDDSVLPRSIANKKAFENAMSLDIAMGGSTNTVLHLLAAAQEAEVDFTMAD
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCEEHHH
IDRLSRQVPCLSKVAPNTQKYHMEDVHRAGGIMAILGELDRANLLHNDTRTVLGMSLAEQ
HHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCEEEHHCCHHHHHHHCCHHHHHHHHHHHH
IAKYDIVLTKDEAVHKFFRAGPAGIRTTEAFSQDCRWDTVDDDRENGCIRSKTFAYSQDG
HHHEEEEEECHHHHHHHHHCCCCCCEEHHHHHHCCCCCCCCCCCCCCCEECCEEEEECCC
GLAMLSGNLAMDGCIVKTAGVDESILKFTGDAIVFESQEDAVAGILGGKVQAGHVVVIRY
CEEEEECCEEECCEEEEECCCCHHHHHHCCCEEEEECCCCHHHHHHCCCEECCEEEEEEE
EGPKGGPGMQEMLYPTSYLKSMGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGLIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCHHHCCCEEEE
VKDGDKIEIDIPNRSIQLCVAEEELAQRRAEQDKLGWQPVNRQREVSFALKVYGHFATSA
EECCCEEEEECCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEEHHHHHCCC
DKGAVRDKTKI
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA