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The map label for this gene is fkpA

Identifier: 15603432

GI number: 15603432

Start: 1774081

End: 1774680

Strand: Direct

Name: fkpA

Synonym: PM1567

Alternate gene names: 15603432

Gene position: 1774081-1774680 (Clockwise)

Preceding gene: 15603431

Following gene: 15603439

Centisome position: 78.59

GC content: 42.67

Gene sequence:

>600_bases
ATGAAAATTGCAAAAAATGTTGTAGTGAGCATTGCTTATCAAGTGCGCACAGAAGACGGTGTATTAGTTGATGAGGCGCC
AGTAAACCAACCTTTAGAATATTTACAAGGTCATAATAATTTAGTGATTGGTTTAGAAAATGCACTCGAAGGTAAAGCAG
TCGGTGATAAATTTGAAGTTCGCGTTAAACCAGAAGAAGCATACGGTGAATATAACGAAAACATGGTACAACGTGTACCA
AAAGACGTTTTCCAAGGCGTAGATGAGCTTGTTGTGGGCATGCGTTTTATTGCGGACACAGACATTGGTCCATTACCAGT
GGTGATTACCGAAGTGGCAGAAAACGATGTTGTTGTGGACGGTAACCATATGTTAGCAGGTCAAGAGTTACTATTTAGTG
TTGAAGTCGTGGCGACACGTGAAGCAACATTAGAAGAAATCGCCCATGGTCATATCCATCAAGAAGGTGGATGTTGTGGT
GGTCATCATCACGACAGTGATGAAGAAGGACATGGCTGTGGCTGTGGAAGTCATCACCATCATGAACATGAGCATCATGC
ACATGATGGCTGTTGTGGCAACGGTGGCTGTAAGCACTAA

Upstream 100 bases:

>100_bases
CGTTGTGCAAGCGAAAATTGAATTAATCAACGATTAGCTTTCTAAGCAATGATATTTCTTATACAATACACGAATTCATT
CGCGAAAAATTGGAGTAATA

Downstream 100 bases:

>100_bases
TTCTAGAAATTTGATAAAAAAGAACCGCACTTTACAGTGCGGTTTTTTTATATTTATTTATGTTTCTTTAATATCACATA
GATTTCATCTTTTAAGCGGA

Product: FkpA

Products: NA

Alternate protein names: PPIase; Metallochaperone slyD

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MKIAKNVVVSIAYQVRTEDGVLVDEAPVNQPLEYLQGHNNLVIGLENALEGKAVGDKFEVRVKPEEAYGEYNENMVQRVP
KDVFQGVDELVVGMRFIADTDIGPLPVVITEVAENDVVVDGNHMLAGQELLFSVEVVATREATLEEIAHGHIHQEGGCCG
GHHHDSDEEGHGCGCGSHHHHEHEHHAHDGCCGNGGCKH

Sequences:

>Translated_199_residues
MKIAKNVVVSIAYQVRTEDGVLVDEAPVNQPLEYLQGHNNLVIGLENALEGKAVGDKFEVRVKPEEAYGEYNENMVQRVP
KDVFQGVDELVVGMRFIADTDIGPLPVVITEVAENDVVVDGNHMLAGQELLFSVEVVATREATLEEIAHGHIHQEGGCCG
GHHHDSDEEGHGCGCGSHHHHEHEHHAHDGCCGNGGCKH
>Mature_199_residues
MKIAKNVVVSIAYQVRTEDGVLVDEAPVNQPLEYLQGHNNLVIGLENALEGKAVGDKFEVRVKPEEAYGEYNENMVQRVP
KDVFQGVDELVVGMRFIADTDIGPLPVVITEVAENDVVVDGNHMLAGQELLFSVEVVATREATLEEIAHGHIHQEGGCCG
GHHHDSDEEGHGCGCGSHHHHEHEHHAHDGCCGNGGCKH

Specific function: Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Escherichia coli, GI1789748, Length=148, Percent_Identity=70.9459459459459, Blast_Score=209, Evalue=8e-56,
Organism=Escherichia coli, GI1786211, Length=139, Percent_Identity=30.9352517985612, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SLYD_PASMU (Q9CKP2)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246506.1
- HSSP:   O52980
- ProteinModelPortal:   Q9CKP2
- SMR:   Q9CKP2
- GeneID:   1244914
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1567
- NMPDR:   fig|272843.1.peg.1568
- HOGENOM:   HBG731200
- OMA:   HGHIHAH
- ProtClustDB:   CLSK2517351
- BioCyc:   PMUL272843:PM1567-MONOMER
- GO:   GO:0005737
- InterPro:   IPR001179
- PANTHER:   PTHR10516

Pfam domain/function: PF00254 FKBP_C

EC number: =5.2.1.8

Molecular weight: Translated: 21612; Mature: 21612

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAKNVVVSIAYQVRTEDGVLVDEAPVNQPLEYLQGHNNLVIGLENALEGKAVGDKFEV
CCCHHHEEEEEEEEEECCCCEEEECCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCEEEE
RVKPEEAYGEYNENMVQRVPKDVFQGVDELVVGMRFIADTDIGPLPVVITEVAENDVVVD
EECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEC
GNHMLAGQELLFSVEVVATREATLEEIAHGHIHQEGGCCGGHHHDSDEEGHGCGCGSHHH
CCCEEECHHHEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HEHEHHAHDGCCGNGGCKH
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIAKNVVVSIAYQVRTEDGVLVDEAPVNQPLEYLQGHNNLVIGLENALEGKAVGDKFEV
CCCHHHEEEEEEEEEECCCCEEEECCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCEEEE
RVKPEEAYGEYNENMVQRVPKDVFQGVDELVVGMRFIADTDIGPLPVVITEVAENDVVVD
EECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEC
GNHMLAGQELLFSVEVVATREATLEEIAHGHIHQEGGCCGGHHHDSDEEGHGCGCGSHHH
CCCEEECHHHEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HEHEHHAHDGCCGNGGCKH
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100