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The map label for this gene is adh2 [H]

Identifier: 15603318

GI number: 15603318

Start: 1640533

End: 1643160

Strand: Direct

Name: adh2 [H]

Synonym: PM1453

Alternate gene names: 15603318

Gene position: 1640533-1643160 (Clockwise)

Preceding gene: 15603315

Following gene: 15603323

Centisome position: 72.67

GC content: 47.15

Gene sequence:

>2628_bases
ATGATGAGTCATACTGCTGAAATTGAAATCAGCCCAGCACAAGCAGAAGTGAATGTACTGGTTGAAAAAGGATTGCTGGC
ATTAGAAGCATTCCGTCAGCTTAATCAACAGCAAGTGGATTACATTGTGGCAAAAGCCTCAGTAGCTGCTTTAGATCAAC
ATGGGGTGCTTGCTATGCATGCTTATGAAGAAACAGGGCGCGGGGTATTTGAAGATAAAGCCACCAAAAATCTGTTTGCC
TGTGAATATGTAGTCAACAATATGCGGAATTTGAAAACCGTGGGGGTGATCAGTGAGGATGATGTCACAGGGATCACCGA
AATTGCAGACCCTGTTGGCGTGGTTTGCGGAATTACCCCAACGACCAACCCGACGTCCACCACCATTTTCAAAGCCCTTA
TCTCGCTAAAAACCCGTAACCCCATCGTCTTTGCATTCCATCCTTCCGCACAACAATGTTCTGCTCATGCGGCACGCGTA
GTCTATGAGGCAGCCGTTGCAGCGGGGGCGCCAGAACATTGTATTCAATGGATTGAAACCCCGTCGATGGAAGGCACCGC
AGCGCTGATGAAACACCCAGGCATTGCTACCATTCTTGCTACGGGCGGCAATGCGATGGTTGAGGCGGCGTATTCTTGTG
GTAAACCAGCTCTTGGCGTAGGAGCGGGTAACGTACCTGCTTATGTGGAAAAAAGCGCAAATATCAAACAAGCTACACAT
GATATTGTGATGTCAAAAGCCTTTGATAACGGCATGATTTGTGCCTCTGAACAAGCCGCCATTGTCGATCAAGAGGTGTA
CGATGAATTTGTGGCAGAAATGCAGTCTTATGGTGCTTACTTTGTAAATAAAAAAGAAAAAGCCTTGTTAGAAACATTTC
TTTTCGGCGTCAAAGCCAACAGTACAAATTGTGCTAACGCAAAATTAAATGCCGCGGTTGTGGGAAAACCTGCCACATGG
ATCGCCGAACAAGCGGGCTTCAAAGTGCCAGAAAAAACCAATATTTTGGTGGCAGCCTGTCAAGAAGTGGGCGAAAACGA
ACCCCTTACCCGTGAAAAACTTTCCCCAGTCCTCGCGATATTAAAATCCACGTCAACAGAACATGGCTTTGCGTTATCTG
AAGCCATGGTGAATTTCCATGGTTTAGGACATTCCGCCGCCATTCATACTAAAGAGGCAAGCATTGCCAAAGCCTTTGGC
GAACGCGTGAAAGCCATTCGTGTGATCTGGAACTCGCCTGCGACCTTTGGGGGCATTGGCGATGTGTATAATGCCTTCCT
CCCGTCACTCACACTCGGTTGTGGTTCCTACGGGAAAAACTCCGTCGGTAACAATGTCAGTGCAGCCAATTTATTAAATA
TTAAACGTGTGGGAAGACGGAGAAATAACATGCAATGGTTCAAAGTGCCTTCAAAAATCTATTTTGAACGCGATTCAATT
CAATATTTACAATCAATGAAAGGCATGGAACGCGTGGTGATTGTCACTGACAGAACCATGGTGGATCTAGGCTTTGTGGA
AAAAATTGCTAAACAAATTACCGCGCGTGGTAACCATGTGACCTACCAATTGTTTGCTGATGTAGAACCGGATCCATCTA
TCGAAACGGTACGCCGTGGCGCAGCATTAATTCGCAACTACCAACCCGATACGATTATTGCGTTAGGTGGTGGATCGGCA
ATGGATGCAGCAAAAGTCATGTGGTTGTTCTATGAACAACCTGAAGTGGATTTCCGTGATTTAGTCCAAAAATTCATGGA
TATTCGCAAACGGGCGTTCAAATTCCCACAATTAGGGCGCAAAGCGCGCTTTATCGGCATTCCAACGACTTCAGGCACAG
GTTCAGAAGTCACGCCATTTGCGGTCATCACCGAAGGCGATAAAAAATACCCGATCGCTGACTACTCGCTCACCCCAACA
GTCGCCATTGTGGATCCGGCTTTTGTGATGAGTGTGCCGGCACATGTTGCTGCGGATACCGGACTAGACGTGTTAACCCA
TGCCACGGAAGCTTATGTGTCAGTGCTCGCCAACGACTTTACCGACGGTTTAGCCCTACAAGCGATCAAGCTCGTGTTTG
AACATTTAGAACGCTCCGTGAAAGACAAAGATCCCGAAGCGCGTGAAAAAATGCACAATGCGTCCACCATGGCAGGGATG
GCATTTGCTAACGCCTTCTTGGGCATGAACCATTCCCTTGCACACAAAATTGGCGGGCGTTTCCACACTCCACATGGTCG
TACCAATGCGGTCTTAATGCCACATGTGATTCGTTATAACGGCACACGTCCACAAAAAACGGCAACGTGGCCAAAATACA
ATTACTACAAAGCGGATGTGAAATACCAAGATATCGCGCGTATGCTCGGTTTACCTTGTGCCACACCAGAAGAAGGGGTG
AAATCCTTTGCACAAGCGTGCTATGACTTAGCCATTCGCGTGGGTATCAAGATGTCCTTCAAAGAGCAAGGTATTGATGA
AAAAGAATGGATGGACGCTCGTCGCCAAGTCGCGTTACTCGCCTTTGAAGACCAATGTTCGCCAGCCAACCCACGTTTAC
CTGTGGTAAGCGATATGGAGGTGATCTTAACCAATGCCTACTATGGTTATGATGCCAATCAATACTGA

Upstream 100 bases:

>100_bases
ACTTTGGGCGGATTTTGCCAAATTTACTACTTTTCAGGTAGTGAATTGAATATAATTTTTTCAGTTTAAATAATTTATAT
TTGGAAAATTAGGAGAAATT

Downstream 100 bases:

>100_bases
TTACCTCTTAACCCCGAAGTGCGGTCACGTTTTGATAGCACGTTCACTCAAACAATGAAAAAAAGCGCTGTCTTTACAGC
GCTTTTATTTGTCCAAACCG

Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH; Pyruvate-formate-lyase deactivase; PFL deactivase [H]

Number of amino acids: Translated: 875; Mature: 875

Protein sequence:

>875_residues
MMSHTAEIEISPAQAEVNVLVEKGLLALEAFRQLNQQQVDYIVAKASVAALDQHGVLAMHAYEETGRGVFEDKATKNLFA
CEYVVNNMRNLKTVGVISEDDVTGITEIADPVGVVCGITPTTNPTSTTIFKALISLKTRNPIVFAFHPSAQQCSAHAARV
VYEAAVAAGAPEHCIQWIETPSMEGTAALMKHPGIATILATGGNAMVEAAYSCGKPALGVGAGNVPAYVEKSANIKQATH
DIVMSKAFDNGMICASEQAAIVDQEVYDEFVAEMQSYGAYFVNKKEKALLETFLFGVKANSTNCANAKLNAAVVGKPATW
IAEQAGFKVPEKTNILVAACQEVGENEPLTREKLSPVLAILKSTSTEHGFALSEAMVNFHGLGHSAAIHTKEASIAKAFG
ERVKAIRVIWNSPATFGGIGDVYNAFLPSLTLGCGSYGKNSVGNNVSAANLLNIKRVGRRRNNMQWFKVPSKIYFERDSI
QYLQSMKGMERVVIVTDRTMVDLGFVEKIAKQITARGNHVTYQLFADVEPDPSIETVRRGAALIRNYQPDTIIALGGGSA
MDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPQLGRKARFIGIPTTSGTGSEVTPFAVITEGDKKYPIADYSLTPT
VAIVDPAFVMSVPAHVAADTGLDVLTHATEAYVSVLANDFTDGLALQAIKLVFEHLERSVKDKDPEAREKMHNASTMAGM
AFANAFLGMNHSLAHKIGGRFHTPHGRTNAVLMPHVIRYNGTRPQKTATWPKYNYYKADVKYQDIARMLGLPCATPEEGV
KSFAQACYDLAIRVGIKMSFKEQGIDEKEWMDARRQVALLAFEDQCSPANPRLPVVSDMEVILTNAYYGYDANQY

Sequences:

>Translated_875_residues
MMSHTAEIEISPAQAEVNVLVEKGLLALEAFRQLNQQQVDYIVAKASVAALDQHGVLAMHAYEETGRGVFEDKATKNLFA
CEYVVNNMRNLKTVGVISEDDVTGITEIADPVGVVCGITPTTNPTSTTIFKALISLKTRNPIVFAFHPSAQQCSAHAARV
VYEAAVAAGAPEHCIQWIETPSMEGTAALMKHPGIATILATGGNAMVEAAYSCGKPALGVGAGNVPAYVEKSANIKQATH
DIVMSKAFDNGMICASEQAAIVDQEVYDEFVAEMQSYGAYFVNKKEKALLETFLFGVKANSTNCANAKLNAAVVGKPATW
IAEQAGFKVPEKTNILVAACQEVGENEPLTREKLSPVLAILKSTSTEHGFALSEAMVNFHGLGHSAAIHTKEASIAKAFG
ERVKAIRVIWNSPATFGGIGDVYNAFLPSLTLGCGSYGKNSVGNNVSAANLLNIKRVGRRRNNMQWFKVPSKIYFERDSI
QYLQSMKGMERVVIVTDRTMVDLGFVEKIAKQITARGNHVTYQLFADVEPDPSIETVRRGAALIRNYQPDTIIALGGGSA
MDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPQLGRKARFIGIPTTSGTGSEVTPFAVITEGDKKYPIADYSLTPT
VAIVDPAFVMSVPAHVAADTGLDVLTHATEAYVSVLANDFTDGLALQAIKLVFEHLERSVKDKDPEAREKMHNASTMAGM
AFANAFLGMNHSLAHKIGGRFHTPHGRTNAVLMPHVIRYNGTRPQKTATWPKYNYYKADVKYQDIARMLGLPCATPEEGV
KSFAQACYDLAIRVGIKMSFKEQGIDEKEWMDARRQVALLAFEDQCSPANPRLPVVSDMEVILTNAYYGYDANQY
>Mature_875_residues
MMSHTAEIEISPAQAEVNVLVEKGLLALEAFRQLNQQQVDYIVAKASVAALDQHGVLAMHAYEETGRGVFEDKATKNLFA
CEYVVNNMRNLKTVGVISEDDVTGITEIADPVGVVCGITPTTNPTSTTIFKALISLKTRNPIVFAFHPSAQQCSAHAARV
VYEAAVAAGAPEHCIQWIETPSMEGTAALMKHPGIATILATGGNAMVEAAYSCGKPALGVGAGNVPAYVEKSANIKQATH
DIVMSKAFDNGMICASEQAAIVDQEVYDEFVAEMQSYGAYFVNKKEKALLETFLFGVKANSTNCANAKLNAAVVGKPATW
IAEQAGFKVPEKTNILVAACQEVGENEPLTREKLSPVLAILKSTSTEHGFALSEAMVNFHGLGHSAAIHTKEASIAKAFG
ERVKAIRVIWNSPATFGGIGDVYNAFLPSLTLGCGSYGKNSVGNNVSAANLLNIKRVGRRRNNMQWFKVPSKIYFERDSI
QYLQSMKGMERVVIVTDRTMVDLGFVEKIAKQITARGNHVTYQLFADVEPDPSIETVRRGAALIRNYQPDTIIALGGGSA
MDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPQLGRKARFIGIPTTSGTGSEVTPFAVITEGDKKYPIADYSLTPT
VAIVDPAFVMSVPAHVAADTGLDVLTHATEAYVSVLANDFTDGLALQAIKLVFEHLERSVKDKDPEAREKMHNASTMAGM
AFANAFLGMNHSLAHKIGGRFHTPHGRTNAVLMPHVIRYNGTRPQKTATWPKYNYYKADVKYQDIARMLGLPCATPEEGV
KSFAQACYDLAIRVGIKMSFKEQGIDEKEWMDARRQVALLAFEDQCSPANPRLPVVSDMEVILTNAYYGYDANQY

Specific function: This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=279, Percent_Identity=29.3906810035842, Blast_Score=99, Evalue=2e-20,
Organism=Escherichia coli, GI1787493, Length=872, Percent_Identity=47.8211009174312, Blast_Score=783, Evalue=0.0,
Organism=Escherichia coli, GI1789163, Length=393, Percent_Identity=33.3333333333333, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI48994951, Length=393, Percent_Identity=33.0788804071247, Blast_Score=190, Evalue=4e-49,
Organism=Escherichia coli, GI87082107, Length=412, Percent_Identity=32.7669902912621, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI1788797, Length=370, Percent_Identity=31.8918918918919, Blast_Score=158, Evalue=2e-39,
Organism=Escherichia coli, GI1789386, Length=388, Percent_Identity=22.9381443298969, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17537053, Length=276, Percent_Identity=31.5217391304348, Blast_Score=125, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6321181, Length=418, Percent_Identity=32.5358851674641, Blast_Score=190, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24657991, Length=294, Percent_Identity=32.9931972789116, Blast_Score=102, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR012079 [H]

Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]

EC number: =1.1.1.1; =1.2.1.10 [H]

Molecular weight: Translated: 95416; Mature: 95416

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSHTAEIEISPAQAEVNVLVEKGLLALEAFRQLNQQQVDYIVAKASVAALDQHGVLAMH
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEE
AYEETGRGVFEDKATKNLFACEYVVNNMRNLKTVGVISEDDVTGITEIADPVGVVCGITP
EHHHHCCCCCHHHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCCCEEEECCC
TTNPTSTTIFKALISLKTRNPIVFAFHPSAQQCSAHAARVVYEAAVAAGAPEHCIQWIET
CCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
PSMEGTAALMKHPGIATILATGGNAMVEAAYSCGKPALGVGAGNVPAYVEKSANIKQATH
CCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCHHHHHH
DIVMSKAFDNGMICASEQAAIVDQEVYDEFVAEMQSYGAYFVNKKEKALLETFLFGVKAN
HHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHEECC
STNCANAKLNAAVVGKPATWIAEQAGFKVPEKTNILVAACQEVGENEPLTREKLSPVLAI
CCCCCCCEECEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
LKSTSTEHGFALSEAMVNFHGLGHSAAIHTKEASIAKAFGERVKAIRVIWNSPATFGGIG
HHCCCCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHEEEEEECCCCCCCCHH
DVYNAFLPSLTLGCGSYGKNSVGNNVSAANLLNIKRVGRRRNNMQWFKVPSKIYFERDSI
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHEEECHHH
QYLQSMKGMERVVIVTDRTMVDLGFVEKIAKQITARGNHVTYQLFADVEPDPSIETVRRG
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHH
AALIRNYQPDTIIALGGGSAMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPQLGR
HHHHHCCCCCEEEEECCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCC
KARFIGIPTTSGTGSEVTPFAVITEGDKKYPIADYSLTPTVAIVDPAFVMSVPAHVAADT
CEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHCCHHHHHCC
GLDVLTHATEAYVSVLANDFTDGLALQAIKLVFEHLERSVKDKDPEAREKMHNASTMAGM
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AFANAFLGMNHSLAHKIGGRFHTPHGRTNAVLMPHVIRYNGTRPQKTATWPKYNYYKADV
HHHHHHHCCCHHHHHHHCCEEECCCCCCCCEECCHHEEECCCCCCCCCCCCCCCEEECCC
KYQDIARMLGLPCATPEEGVKSFAQACYDLAIRVGIKMSFKEQGIDEKEWMDARRQVALL
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEHHHCCCCHHHHHHHHHHEEEE
AFEDQCSPANPRLPVVSDMEVILTNAYYGYDANQY
EEECCCCCCCCCCCCCCCCCEEEEECEECCCCCCC
>Mature Secondary Structure
MMSHTAEIEISPAQAEVNVLVEKGLLALEAFRQLNQQQVDYIVAKASVAALDQHGVLAMH
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEE
AYEETGRGVFEDKATKNLFACEYVVNNMRNLKTVGVISEDDVTGITEIADPVGVVCGITP
EHHHHCCCCCHHHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCCCEEEECCC
TTNPTSTTIFKALISLKTRNPIVFAFHPSAQQCSAHAARVVYEAAVAAGAPEHCIQWIET
CCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
PSMEGTAALMKHPGIATILATGGNAMVEAAYSCGKPALGVGAGNVPAYVEKSANIKQATH
CCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCHHHHHH
DIVMSKAFDNGMICASEQAAIVDQEVYDEFVAEMQSYGAYFVNKKEKALLETFLFGVKAN
HHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHEECC
STNCANAKLNAAVVGKPATWIAEQAGFKVPEKTNILVAACQEVGENEPLTREKLSPVLAI
CCCCCCCEECEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
LKSTSTEHGFALSEAMVNFHGLGHSAAIHTKEASIAKAFGERVKAIRVIWNSPATFGGIG
HHCCCCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHEEEEEECCCCCCCCHH
DVYNAFLPSLTLGCGSYGKNSVGNNVSAANLLNIKRVGRRRNNMQWFKVPSKIYFERDSI
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHEEECHHH
QYLQSMKGMERVVIVTDRTMVDLGFVEKIAKQITARGNHVTYQLFADVEPDPSIETVRRG
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHH
AALIRNYQPDTIIALGGGSAMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPQLGR
HHHHHCCCCCEEEEECCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCC
KARFIGIPTTSGTGSEVTPFAVITEGDKKYPIADYSLTPTVAIVDPAFVMSVPAHVAADT
CEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHCCHHHHHCC
GLDVLTHATEAYVSVLANDFTDGLALQAIKLVFEHLERSVKDKDPEAREKMHNASTMAGM
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AFANAFLGMNHSLAHKIGGRFHTPHGRTNAVLMPHVIRYNGTRPQKTATWPKYNYYKADV
HHHHHHHCCCHHHHHHHCCEEECCCCCCCCEECCHHEEECCCCCCCCCCCCCCCEEECCC
KYQDIARMLGLPCATPEEGVKSFAQACYDLAIRVGIKMSFKEQGIDEKEWMDARRQVALL
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEHHHCCCCHHHHHHHHHHEEEE
AFEDQCSPANPRLPVVSDMEVILTNAYYGYDANQY
EEECCCCCCCCCCCCCCCCCEEEEECEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]