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The map label for this gene is fbaA [H]

Identifier: 15603238

GI number: 15603238

Start: 1565573

End: 1566457

Strand: Reverse

Name: fbaA [H]

Synonym: PM1373

Alternate gene names: 15603238

Gene position: 1566457-1565573 (Counterclockwise)

Preceding gene: 15603239

Following gene: 15603237

Centisome position: 69.39

GC content: 40.11

Gene sequence:

>885_bases
ATGGGATTATTGAACTTAAAGTCAATGCTTTCCATCGCAAATCAACATCAATTTGCGGTCGGGGCATTTAATGCGATTGA
CTCAAATTTTATTGATGCAGTGTTTACTGCAGCACAACAAAATCAGTCACCGGTAATTATTAATGTGGCTGAAGTGCATT
TAACGTATATTGATTTAGAATCCACTGCTGAATATATCAAGAAAAAAGCTATGTTAGCAGGCGTTCCCGTGTGCTTAAAT
TTAGATCATGGATTGACGTTTTCCACCGTTGAGCGTGCAATTAAATGTGGTTTTTCTTCCATTATGTTTGATGGTTCCTC
ACTTACTTACGCAGAAAATATTGCGCAAACTCGTAAAGTCGTCGAACTTTGTCAAAATTATGGCATTTCTGTTGAAGGTG
AACTTGGTGCAGTGGGGGGAGATGAACATGGCGCGTTAGAAAGTTGTGCTGATGTGGCGCTTTATACCAATGTTGAACAG
GCTGTGGAGTTTGTGCGCGAAACAGGTATTGATGCCCTCGCTGTTGCGATTGGGAATACCCATGGTAAATATAAAGGTGT
ACCTAAGTTAGATTTTGAACGTCTGGCGCAAATTCACCAAGCGGTATCTGTTCCGTTAGTCTTACATGGTGGATCAGGAT
TAAGTGCTGACGATTTCCGCAAAACGATTCAACGTGGCATTTGCAAAATTAATTTCTTTACAGGCATGTCACAAGCGGCG
TTACAGTCACTTGAAAAAGATATGCAACACGCCGATCTCGAAACAAAATATCATTATTACCTCATTATGATGAACCGTAT
GCAACAGGCGATTTCTGACACGGTTGCAGAACAGATGAATATCTTTAACAGCATTAATAAGGCGCATTTATATGCAACAA
CGTAA

Upstream 100 bases:

>100_bases
TTTTTAGCACCGTTGGGTCGTTTTTCACACATTGAGGAAGATGAACCCCCTCTTCATTTACTTTGTAGTGATTACCCTCA
GTATTTAGCAGGAGCATAAC

Downstream 100 bases:

>100_bases
TGGCATTCTCGCCATCGGTAATTTATTAGTGGATCGTGCCCTACTGATTTCGGATTATCCACAAGAGTCCATGTTAGCCA
CGATTTCTAACATGGAGCTC

Product: hypothetical protein

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MGLLNLKSMLSIANQHQFAVGAFNAIDSNFIDAVFTAAQQNQSPVIINVAEVHLTYIDLESTAEYIKKKAMLAGVPVCLN
LDHGLTFSTVERAIKCGFSSIMFDGSSLTYAENIAQTRKVVELCQNYGISVEGELGAVGGDEHGALESCADVALYTNVEQ
AVEFVRETGIDALAVAIGNTHGKYKGVPKLDFERLAQIHQAVSVPLVLHGGSGLSADDFRKTIQRGICKINFFTGMSQAA
LQSLEKDMQHADLETKYHYYLIMMNRMQQAISDTVAEQMNIFNSINKAHLYATT

Sequences:

>Translated_294_residues
MGLLNLKSMLSIANQHQFAVGAFNAIDSNFIDAVFTAAQQNQSPVIINVAEVHLTYIDLESTAEYIKKKAMLAGVPVCLN
LDHGLTFSTVERAIKCGFSSIMFDGSSLTYAENIAQTRKVVELCQNYGISVEGELGAVGGDEHGALESCADVALYTNVEQ
AVEFVRETGIDALAVAIGNTHGKYKGVPKLDFERLAQIHQAVSVPLVLHGGSGLSADDFRKTIQRGICKINFFTGMSQAA
LQSLEKDMQHADLETKYHYYLIMMNRMQQAISDTVAEQMNIFNSINKAHLYATT
>Mature_293_residues
GLLNLKSMLSIANQHQFAVGAFNAIDSNFIDAVFTAAQQNQSPVIINVAEVHLTYIDLESTAEYIKKKAMLAGVPVCLNL
DHGLTFSTVERAIKCGFSSIMFDGSSLTYAENIAQTRKVVELCQNYGISVEGELGAVGGDEHGALESCADVALYTNVEQA
VEFVRETGIDALAVAIGNTHGKYKGVPKLDFERLAQIHQAVSVPLVLHGGSGLSADDFRKTIQRGICKINFFTGMSQAAL
QSLEKDMQHADLETKYHYYLIMMNRMQQAISDTVAEQMNIFNSINKAHLYATT

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=278, Percent_Identity=38.1294964028777, Blast_Score=184, Evalue=4e-48,
Organism=Escherichia coli, GI1788072, Length=290, Percent_Identity=34.4827586206897, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789526, Length=287, Percent_Identity=33.4494773519164, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1789293, Length=300, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322790, Length=284, Percent_Identity=28.169014084507, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 32093; Mature: 31962

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLNLKSMLSIANQHQFAVGAFNAIDSNFIDAVFTAAQQNQSPVIINVAEVHLTYIDLE
CCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEHH
STAEYIKKKAMLAGVPVCLNLDHGLTFSTVERAIKCGFSSIMFDGSSLTYAENIAQTRKV
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCHHHEECCCCCHHHHHHHHHHHH
VELCQNYGISVEGELGAVGGDEHGALESCADVALYTNVEQAVEFVRETGIDALAVAIGNT
HHHHHHCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCC
HGKYKGVPKLDFERLAQIHQAVSVPLVLHGGSGLSADDFRKTIQRGICKINFFTGMSQAA
CCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCHHH
LQSLEKDMQHADLETKYHYYLIMMNRMQQAISDTVAEQMNIFNSINKAHLYATT
HHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure 
GLLNLKSMLSIANQHQFAVGAFNAIDSNFIDAVFTAAQQNQSPVIINVAEVHLTYIDLE
CCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEHH
STAEYIKKKAMLAGVPVCLNLDHGLTFSTVERAIKCGFSSIMFDGSSLTYAENIAQTRKV
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCHHHEECCCCCHHHHHHHHHHHH
VELCQNYGISVEGELGAVGGDEHGALESCADVALYTNVEQAVEFVRETGIDALAVAIGNT
HHHHHHCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCC
HGKYKGVPKLDFERLAQIHQAVSVPLVLHGGSGLSADDFRKTIQRGICKINFFTGMSQAA
CCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCHHH
LQSLEKDMQHADLETKYHYYLIMMNRMQQAISDTVAEQMNIFNSINKAHLYATT
HHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2457578; 1640835; 9353933; 9384377; 1556067 [H]