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The map label for this gene is hemU [C]

Identifier: 15603173

GI number: 15603173

Start: 1502800

End: 1503792

Strand: Direct

Name: hemU [C]

Synonym: PM1308

Alternate gene names: 15603173

Gene position: 1502800-1503792 (Clockwise)

Preceding gene: 15603172

Following gene: 15603174

Centisome position: 66.57

GC content: 43.61

Gene sequence:

>993_bases
ATGAATGTGACCGCTCGTTTATGGCTGCCACCGATATTATTAGTGTTGGTTGCCATATCCGCTTGCTTGATTGGGCAGTA
TCACATCGCCTTGCAAGATGTTTGGCAAGCGGTATTGCATATTGCGGCGGATAATCCTCGTACCGATGCCGAAACGGTCT
TATGGAATATTCGTTTACCGCGTATTTTTACCGCCATTATTGTCGGTGCGGCGTTATCTGTTGCCGGGGCAACTTACCAA
GGGATGTTTAAAAATCCCTTGGTCTCCCCAGATATTTTAGGCGTGACAGCAGGCGCAGGACTGGGGGCGGTTACGGCGAT
TTATTTTGGCGGTTCGTTATTCACGATTCAAGTCGTTGCATTTTTAGGTGGATTACTAGCAGTATTTTTAGTCTATTTAA
TCTCACGTACGGCACCCCACCACTCACCGACCTTAGCCTTAGTGTTAGCAGGCATTGCGATTGCATCGTTATTAAGTGCG
GGCATCTCGTTATTAAAAATCTTATCGGATCCTTATAGTCAATTAACAACGATCACTTTTTGGTTAATGGGCGGATTAAA
TATGGCAACCTTAAATGATCTTGCTTTAGTTGCCCCTTTAATTTGTGCTAGTTTGATTCCTTTAATTTTATTACGTTGGC
GGATGAATTTACTCAGTTTAGATGACGAGGAAGCTGAAACATTGGGTATTAATACGAAACGTACACGGCTTATTTTTATC
TTATCCGCAACACTCATGACTTCAGCTGCGGTGTCTATTACAGGGATTATTGGTTGGGTTGGCTTGATCATTCCGCATAT
TGCGCGTTTATGGATTGGTGCGGATTTCCGGCGTTTATTGCCAACGAGTTTATTTATCGGTGCCACTTTTTTGCTACTCA
CTGATACCATTGCCCGTTCAATTTTCTCCATAGAAGTCCCTTTAGGCATTATTACCTCTCTGGTCGGTGCGCCCTTCTTT
TTGAGTTTACTCATTCAAGGAGGGAAGCGATGA

Upstream 100 bases:

>100_bases
GAAACAGTATGCGATGTTAATTAATGACTACTTTGCGTTGTTCTATGGTCATCAATTAGATCAAAAAGCACAGGCAAAGT
TTGGCATTAAATAATTCGTT

Downstream 100 bases:

>100_bases
GTTTGGTCACTTTGAAGCATGTGAGTATAGGCTATAAAAAACAGGTGTTAGCTTCGGATCTTAATTTACAGCTTGAGCCG
AATCAGGTGGTCTGTTTACT

Product: HemU

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNVTARLWLPPILLVLVAISACLIGQYHIALQDVWQAVLHIAADNPRTDAETVLWNIRLPRIFTAIIVGAALSVAGATYQ
GMFKNPLVSPDILGVTAGAGLGAVTAIYFGGSLFTIQVVAFLGGLLAVFLVYLISRTAPHHSPTLALVLAGIAIASLLSA
GISLLKILSDPYSQLTTITFWLMGGLNMATLNDLALVAPLICASLIPLILLRWRMNLLSLDDEEAETLGINTKRTRLIFI
LSATLMTSAAVSITGIIGWVGLIIPHIARLWIGADFRRLLPTSLFIGATFLLLTDTIARSIFSIEVPLGIITSLVGAPFF
LSLLIQGGKR

Sequences:

>Translated_330_residues
MNVTARLWLPPILLVLVAISACLIGQYHIALQDVWQAVLHIAADNPRTDAETVLWNIRLPRIFTAIIVGAALSVAGATYQ
GMFKNPLVSPDILGVTAGAGLGAVTAIYFGGSLFTIQVVAFLGGLLAVFLVYLISRTAPHHSPTLALVLAGIAIASLLSA
GISLLKILSDPYSQLTTITFWLMGGLNMATLNDLALVAPLICASLIPLILLRWRMNLLSLDDEEAETLGINTKRTRLIFI
LSATLMTSAAVSITGIIGWVGLIIPHIARLWIGADFRRLLPTSLFIGATFLLLTDTIARSIFSIEVPLGIITSLVGAPFF
LSLLIQGGKR
>Mature_330_residues
MNVTARLWLPPILLVLVAISACLIGQYHIALQDVWQAVLHIAADNPRTDAETVLWNIRLPRIFTAIIVGAALSVAGATYQ
GMFKNPLVSPDILGVTAGAGLGAVTAIYFGGSLFTIQVVAFLGGLLAVFLVYLISRTAPHHSPTLALVLAGIAIASLLSA
GISLLKILSDPYSQLTTITFWLMGGLNMATLNDLALVAPLICASLIPLILLRWRMNLLSLDDEEAETLGINTKRTRLIFI
LSATLMTSAAVSITGIIGWVGLIIPHIARLWIGADFRRLLPTSLFIGATFLLLTDTIARSIFSIEVPLGIITSLVGAPFF
LSLLIQGGKR

Specific function: Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=320, Percent_Identity=35.3125, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1790741, Length=284, Percent_Identity=33.4507042253521, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788004, Length=295, Percent_Identity=34.9152542372881, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1786804, Length=330, Percent_Identity=31.8181818181818, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1786805, Length=290, Percent_Identity=35.5172413793103, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1786347, Length=279, Percent_Identity=29.3906810035842, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35239; Mature: 35239

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTARLWLPPILLVLVAISACLIGQYHIALQDVWQAVLHIAADNPRTDAETVLWNIRLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCHH
RIFTAIIVGAALSVAGATYQGMFKNPLVSPDILGVTAGAGLGAVTAIYFGGSLFTIQVVA
HHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCHHEEECCCCHHHHHHHHHCCHHHHHHHHH
FLGGLLAVFLVYLISRTAPHHSPTLALVLAGIAIASLLSAGISLLKILSDPYSQLTTITF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
WLMGGLNMATLNDLALVAPLICASLIPLILLRWRMNLLSLDDEEAETLGINTKRTRLIFI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHEEEE
LSATLMTSAAVSITGIIGWVGLIIPHIARLWIGADFRRLLPTSLFIGATFLLLTDTIARS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IFSIEVPLGIITSLVGAPFFLSLLIQGGKR
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNVTARLWLPPILLVLVAISACLIGQYHIALQDVWQAVLHIAADNPRTDAETVLWNIRLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCHH
RIFTAIIVGAALSVAGATYQGMFKNPLVSPDILGVTAGAGLGAVTAIYFGGSLFTIQVVA
HHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCHHEEECCCCHHHHHHHHHCCHHHHHHHHH
FLGGLLAVFLVYLISRTAPHHSPTLALVLAGIAIASLLSAGISLLKILSDPYSQLTTITF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
WLMGGLNMATLNDLALVAPLICASLIPLILLRWRMNLLSLDDEEAETLGINTKRTRLIFI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHEEEE
LSATLMTSAAVSITGIIGWVGLIIPHIARLWIGADFRRLLPTSLFIGATFLLLTDTIARS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IFSIEVPLGIITSLVGAPFFLSLLIQGGKR
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]