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The map label for this gene is ilvC [H]

Identifier: 15603149

GI number: 15603149

Start: 1477997

End: 1479472

Strand: Direct

Name: ilvC [H]

Synonym: PM1284

Alternate gene names: 15603149

Gene position: 1477997-1479472 (Clockwise)

Preceding gene: 15603147

Following gene: 15603151

Centisome position: 65.47

GC content: 42.89

Gene sequence:

>1476_bases
ATGGCTAACTATTTCAATACATTAAATTTACGCCAACAATTAGATCAATTAGGGCGTTGTCGCTTTATGGATCGCAATGA
ATTTGCGAATGAAGCAGATTACCTAAAAGGAAAAAAAATTGTCATCGTCGGTTGCGGGGCACAAGGCTTGAATCAGGGCT
TGAACATGCGTGATTCGGGGCTAGATATTAGCTATGCCTTACGTGCAGAAGCCATTGCAGAAAAACGCGCGTCTTTCCAA
CGTGCGACGGAAAATGGCTTTAAAGTGGGGACGTATGATGAATTAATTCCAAGTGCAGATTTAGTGGTGAATTTAACCCC
TGACAAACAGCACTCGAAAGTGGTGGCAGATGTCATGCCGTTAATGAAACAAGGTGCCGCACTCGGTTATTCACATGGTT
TAAATATCGTGGAAGTAGGTGAACAAATCCGTAAAGATATTACAGTGGTGATGGTGGCACCAAAATGTCCGGGCACGGAA
GTACGTGAAGAATATAAACGTGGCTTTGGTGTACCGACCTTGATCGCGGTGCATCCAGAAAATGATCCAAATGGTGATGG
TTTAGAAATTGCTAAAGCCTGGGCGGCAGCAACGGGTGGTCATCGTGCGGGCGTGCTTGAGTCGTCTTTTGTTGCAGAAG
TGAAATCGGATTTAATGGGTGAACAGACTATTCTGTGTGGTATGTTACAAGCGGGTTCTATCGTTTGTTATGATAAGCTT
GTGGCGGACGGCAAAGATCCTGCGTATGCCGGTAAATTAATCCAGTACGGTTGGGAAACCATTACTGAAGCGCTGAAACA
AGGTGGGATTACGTTGATGATGGATCGTTTATCCAATTCTGCGAAGTTACGTGCTTTCGAACTTTCAGAGCAAATCAAAG
CGAAATTAACGTTCTTATTTGAAAAACACATGGACGATATTATCAGTGGCGAATTTTCTGCCACGATGATGGCGGATTGG
GCAAACGGTGATGCAAATCTTTTAAAATGGCGTGAAGAAACCGGCAAAACGGCATTTGAAAATGCACCAAAATATGAAGG
TAAAATCAGCGAGCAAGAGTATTTTGATCACGGTGTATTGATGGTGGCAATGGTGAAAGCAGGCGTAGAGTTAGCCTTTG
ATACCATGGTCGCGAGCGGGATTTATGAAGAGTCAGCCTATTATGAGTCATTGCATGAATTACCACTAATCGCTAATACG
ATTGCGCGTAAGCGTTTATATGAAATGAATGTGGTGATTTCTGATACGGCAGAATATGGTAACTACTTATTTGCTAATGT
GGCGACGCCAATTTTGGCAAAAGAGATTATGCCGACCTTACAAAAAGGGGATTTAGGTGAGCCTACGCCTACGGTTGAGA
TTGATAATATTACGCTACGTGATGTGAATGACGCGATTCGCAATCATCCAATTGAATTGATCGGGCAAGAATTACGTGGT
TATATGACAGATATGAAACGTATTTCCTCTCATTAA

Upstream 100 bases:

>100_bases
TTTACGCAATGATAAAAATCGTTATAATCAGAACAAAGTACAAATAATGTGCAAACACAATCTCATATGAATACACAACA
TCAATGTTAAGGACACAAGC

Downstream 100 bases:

>100_bases
GCGAAAAAATAGTCTAAAAATAAGGTGCTTAGAGCACCTTATTTTTTTCTTCTCGTTTGACTTCATCCCATAATAAGTCC
ATTTCCATTAACGAGCTTTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MANYFNTLNLRQQLDQLGRCRFMDRNEFANEADYLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRAEAIAEKRASFQ
RATENGFKVGTYDELIPSADLVVNLTPDKQHSKVVADVMPLMKQGAALGYSHGLNIVEVGEQIRKDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPNGDGLEIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
VADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELSEQIKAKLTFLFEKHMDDIISGEFSATMMADW
ANGDANLLKWREETGKTAFENAPKYEGKISEQEYFDHGVLMVAMVKAGVELAFDTMVASGIYEESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFANVATPILAKEIMPTLQKGDLGEPTPTVEIDNITLRDVNDAIRNHPIELIGQELRG
YMTDMKRISSH

Sequences:

>Translated_491_residues
MANYFNTLNLRQQLDQLGRCRFMDRNEFANEADYLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRAEAIAEKRASFQ
RATENGFKVGTYDELIPSADLVVNLTPDKQHSKVVADVMPLMKQGAALGYSHGLNIVEVGEQIRKDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPNGDGLEIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
VADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELSEQIKAKLTFLFEKHMDDIISGEFSATMMADW
ANGDANLLKWREETGKTAFENAPKYEGKISEQEYFDHGVLMVAMVKAGVELAFDTMVASGIYEESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFANVATPILAKEIMPTLQKGDLGEPTPTVEIDNITLRDVNDAIRNHPIELIGQELRG
YMTDMKRISSH
>Mature_490_residues
ANYFNTLNLRQQLDQLGRCRFMDRNEFANEADYLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRAEAIAEKRASFQR
ATENGFKVGTYDELIPSADLVVNLTPDKQHSKVVADVMPLMKQGAALGYSHGLNIVEVGEQIRKDITVVMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPNGDGLEIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLV
ADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELSEQIKAKLTFLFEKHMDDIISGEFSATMMADWA
NGDANLLKWREETGKTAFENAPKYEGKISEQEYFDHGVLMVAMVKAGVELAFDTMVASGIYEESAYYESLHELPLIANTI
ARKRLYEMNVVISDTAEYGNYLFANVATPILAKEIMPTLQKGDLGEPTPTVEIDNITLRDVNDAIRNHPIELIGQELRGY
MTDMKRISSH

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=489, Percent_Identity=82.2085889570552, Blast_Score=816, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=286, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 54205; Mature: 54073

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLNLRQQLDQLGRCRFMDRNEFANEADYLKGKKIVIVGCGAQGLNQGLNMRDSG
CCCCHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHCCCCEEEEEECCCHHHHCCCCCCCCC
LDISYALRAEAIAEKRASFQRATENGFKVGTYDELIPSADLVVNLTPDKQHSKVVADVMP
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKQGAALGYSHGLNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHHCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPNGDGLEIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEHHH
VADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELSEQIKAKLTFLF
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHH
EKHMDDIISGEFSATMMADWANGDANLLKWREETGKTAFENAPKYEGKISEQEYFDHGVL
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHCHHH
MVAMVKAGVELAFDTMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEEECCHHHC
NYLFANVATPILAKEIMPTLQKGDLGEPTPTVEIDNITLRDVNDAIRNHPIELIGQELRG
CEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEECHHHHHHCCCHHHHHHHHHH
YMTDMKRISSH
HHHHHHHHHCC
>Mature Secondary Structure 
ANYFNTLNLRQQLDQLGRCRFMDRNEFANEADYLKGKKIVIVGCGAQGLNQGLNMRDSG
CCCHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHCCCCEEEEEECCCHHHHCCCCCCCCC
LDISYALRAEAIAEKRASFQRATENGFKVGTYDELIPSADLVVNLTPDKQHSKVVADVMP
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKQGAALGYSHGLNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHHCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPNGDGLEIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEHHH
VADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELSEQIKAKLTFLF
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHH
EKHMDDIISGEFSATMMADWANGDANLLKWREETGKTAFENAPKYEGKISEQEYFDHGVL
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHCHHH
MVAMVKAGVELAFDTMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEEECCHHHC
NYLFANVATPILAKEIMPTLQKGDLGEPTPTVEIDNITLRDVNDAIRNHPIELIGQELRG
CEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEECHHHHHHCCCHHHHHHHHHH
YMTDMKRISSH
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA