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The map label for this gene is holA [H]

Identifier: 15603081

GI number: 15603081

Start: 1408217

End: 1409296

Strand: Direct

Name: holA [H]

Synonym: PM1216

Alternate gene names: 15603081

Gene position: 1408217-1409296 (Clockwise)

Preceding gene: 15603080

Following gene: 15603082

Centisome position: 62.38

GC content: 39.91

Gene sequence:

>1080_bases
ATGCAACGGATTTTCACAGAACAATTAGGATCTGCTCTACAAAACAAACTAGCCAAGCTCTATTATTTCGTAGGGCAAGA
TCCGTTACTGTTAAGTGAAAATCAAGATCGCATAAATCAATATGCATTCAAGCAAGGTTTTGACGAAAAAAATGTCATCA
CAATTGATCAGAATACTAATTGGTCTGATCTCTTTGAACGCTGCCAATCCATTGGCTTGTTTTTCAATAAACAGATTTTG
TTTCTTAATTTACCGGAAAACCTCAGTGCAAGTTTACAAACTCGTTTACAAGAACTGATCTCACTCCTCAACGATGACAT
CCTGTTAATACTACAATTGCCTAAACTGAACAAAGCGACTGAAAAACAAACATGGTTTATCCAAGCTAATCAGTATGAAC
CGGAAGCCGTACTCGTGCATTGCCAAACCCCAACCATTGAACAATTGCCTCGTTGGATCGCGTTGCGTGCGAAAAGTATG
GGACTACAGATTGAAGAGCAAGCAATCCAACTTCTTTGTTATAGCCATGAAAATAACTTATTAGCCTTAAAACAAAGTTT
GCAGCTCCTTGCTTTACTCTATCCTGACAACAAAATCAGTTATGCACGAGTACAATCCACTATCGCTCAGACCTCAGTGT
TCACACCATTTCAATGGCTCGATGCGCTATTAGAAGGCAAAAGTAAACGCGCCCAACGTATTTTAGAAGGATTAAAAGCA
GAGGAAATGGAGCCCATTATTTTATTGCGGACGTTACAACGAGATTTGCTCACCTTATTAGGATTGGCGAAGCCATCACA
TCCTGTCACCCTTACCACGCCCCTCCCAGCTCATCAACTGCGTGAACAATTTGATCAATTAAAAGTGTGGCAAAATCGAC
GCCCTTTCTTTACTCAAGCCTTTAAACGCTTGAATTACAAACAGCTTTATTTGATTATTCAAGCGCTAGCAGAGATCGAA
CGTTTAGCGAAACACACATTTAGCCAAGATATTTGGGATCGTTTAGCCGAACTTTCTGCTTTCATTTGTTTACCAGATGA
TCCCAATCACCTACTATCTCTACCAACTTTCTCTCGTTGA

Upstream 100 bases:

>100_bases
CTGCCGAAAAAGAAGTGATTTGGCATGATATGCGCGAGCAAGCTGCACGTCAGTTAATTAATAAAATGGTTGCTCTTCAA
CATCAAGTTCAGACAAAATA

Downstream 100 bases:

>100_bases
TAAGCTAAATCAGCCTATTCTTACTCTCGCATTGGCATATTTTGTTTTTTACATTGCTTAATTATCCGTTATAATGCCTT
GCCTTTAGGCGATTTTTTAT

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MQRIFTEQLGSALQNKLAKLYYFVGQDPLLLSENQDRINQYAFKQGFDEKNVITIDQNTNWSDLFERCQSIGLFFNKQIL
FLNLPENLSASLQTRLQELISLLNDDILLILQLPKLNKATEKQTWFIQANQYEPEAVLVHCQTPTIEQLPRWIALRAKSM
GLQIEEQAIQLLCYSHENNLLALKQSLQLLALLYPDNKISYARVQSTIAQTSVFTPFQWLDALLEGKSKRAQRILEGLKA
EEMEPIILLRTLQRDLLTLLGLAKPSHPVTLTTPLPAHQLREQFDQLKVWQNRRPFFTQAFKRLNYKQLYLIIQALAEIE
RLAKHTFSQDIWDRLAELSAFICLPDDPNHLLSLPTFSR

Sequences:

>Translated_359_residues
MQRIFTEQLGSALQNKLAKLYYFVGQDPLLLSENQDRINQYAFKQGFDEKNVITIDQNTNWSDLFERCQSIGLFFNKQIL
FLNLPENLSASLQTRLQELISLLNDDILLILQLPKLNKATEKQTWFIQANQYEPEAVLVHCQTPTIEQLPRWIALRAKSM
GLQIEEQAIQLLCYSHENNLLALKQSLQLLALLYPDNKISYARVQSTIAQTSVFTPFQWLDALLEGKSKRAQRILEGLKA
EEMEPIILLRTLQRDLLTLLGLAKPSHPVTLTTPLPAHQLREQFDQLKVWQNRRPFFTQAFKRLNYKQLYLIIQALAEIE
RLAKHTFSQDIWDRLAELSAFICLPDDPNHLLSLPTFSR
>Mature_359_residues
MQRIFTEQLGSALQNKLAKLYYFVGQDPLLLSENQDRINQYAFKQGFDEKNVITIDQNTNWSDLFERCQSIGLFFNKQIL
FLNLPENLSASLQTRLQELISLLNDDILLILQLPKLNKATEKQTWFIQANQYEPEAVLVHCQTPTIEQLPRWIALRAKSM
GLQIEEQAIQLLCYSHENNLLALKQSLQLLALLYPDNKISYARVQSTIAQTSVFTPFQWLDALLEGKSKRAQRILEGLKA
EEMEPIILLRTLQRDLLTLLGLAKPSHPVTLTTPLPAHQLREQFDQLKVWQNRRPFFTQAFKRLNYKQLYLIIQALAEIE
RLAKHTFSQDIWDRLAELSAFICLPDDPNHLLSLPTFSR

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=345, Percent_Identity=45.5072463768116, Blast_Score=265, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 41687; Mature: 41687

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRIFTEQLGSALQNKLAKLYYFVGQDPLLLSENQDRINQYAFKQGFDEKNVITIDQNTN
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCCCEEEEECCCC
WSDLFERCQSIGLFFNKQILFLNLPENLSASLQTRLQELISLLNDDILLILQLPKLNKAT
HHHHHHHHHHHCHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
EKQTWFIQANQYEPEAVLVHCQTPTIEQLPRWIALRAKSMGLQIEEQAIQLLCYSHENNL
CCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCC
LALKQSLQLLALLYPDNKISYARVQSTIAQTSVFTPFQWLDALLEGKSKRAQRILEGLKA
HHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCC
EEMEPIILLRTLQRDLLTLLGLAKPSHPVTLTTPLPAHQLREQFDQLKVWQNRRPFFTQA
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHH
FKRLNYKQLYLIIQALAEIERLAKHTFSQDIWDRLAELSAFICLPDDPNHLLSLPTFSR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEECCCCCCC
>Mature Secondary Structure
MQRIFTEQLGSALQNKLAKLYYFVGQDPLLLSENQDRINQYAFKQGFDEKNVITIDQNTN
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCCCEEEEECCCC
WSDLFERCQSIGLFFNKQILFLNLPENLSASLQTRLQELISLLNDDILLILQLPKLNKAT
HHHHHHHHHHHCHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
EKQTWFIQANQYEPEAVLVHCQTPTIEQLPRWIALRAKSMGLQIEEQAIQLLCYSHENNL
CCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCC
LALKQSLQLLALLYPDNKISYARVQSTIAQTSVFTPFQWLDALLEGKSKRAQRILEGLKA
HHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCC
EEMEPIILLRTLQRDLLTLLGLAKPSHPVTLTTPLPAHQLREQFDQLKVWQNRRPFFTQA
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHH
FKRLNYKQLYLIIQALAEIERLAKHTFSQDIWDRLAELSAFICLPDDPNHLLSLPTFSR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]